| cGMP-dependent kinase 2, Na[+]/H[+] exchanger NHE3, and PDZ-adaptor NHERF2 co-assemble in apical membrane microdomains. | cGMP-dependent kinase 2, Na(+)/H(+) exchanger NHE3, and PDZ-adaptor NHERF2 co-assemble in apical membrane microdomains.
Luo M, Liu Y, Nikolovska K, Riederer B, Patrucco E, Hofmann F, Seidler U. | 04/27/2024 |
| Protein Kinase G2 Is Essential for Skeletal Homeostasis and Adaptation to Mechanical Loading in Male but Not Female Mice. | Protein Kinase G2 Is Essential for Skeletal Homeostasis and Adaptation to Mechanical Loading in Male but Not Female Mice.
Kalyanaraman H, Pal China S, Cabriales JA, Moininazeri J, Casteel DE, Garcia JJ, Wong VW, Chen A, Sah RL, Boss GR, Pilz RB., Free PMC Article | 01/14/2023 |
| Type-2 cGMP-dependent protein kinase suppresses proliferation and carcinogenesis in the colon epithelium. | Type-2 cGMP-dependent protein kinase suppresses proliferation and carcinogenesis in the colon epithelium.
Islam BN, Sharman SK, Hou Y, Wang R, Ashby J, Li H, Liu K, Vega KJ, Browning DD., Free PMC Article | 07/2/2022 |
| Loss of cGMP-dependent protein kinase II alters ultrasonic vocalizations in mice, a model for speech impairment in human microdeletion 4q21 syndrome. | Loss of cGMP-dependent protein kinase II alters ultrasonic vocalizations in mice, a model for speech impairment in human microdeletion 4q21 syndrome.
Tran TM, Sherwood JK, Doolittle MJ, Sathler MF, Hofmann F, Stone-Roy LM, Kim S., Free PMC Article | 01/8/2022 |
| Phosphorylation of myelin regulatory factor by PRKG2 mediates demyelination in Huntington's disease. | Phosphorylation of myelin regulatory factor by PRKG2 mediates demyelination in Huntington's disease.
Yin P, Liu Q, Pan Y, Yang W, Yang S, Wei W, Chen X, Hong Y, Bai D, Li XJ, Li S., Free PMC Article | 05/8/2021 |
| Protein synthesis inhibition promotes nitric oxide generation and activation of CGKII-dependent downstream signaling pathways in the retina. | Protein synthesis inhibition promotes nitric oxide generation and activation of CGKII-dependent downstream signaling pathways in the retina.
Cossenza M, Socodato R, Mejía-García TA, Domith I, Portugal CC, Gladulich LFH, Duarte-Silva AT, Khatri L, Antoine S, Hofmann F, Ziff EB, Paes-de-Carvalho R. | 10/31/2020 |
| Prkg2 determines beta-catenin accumulation that is essential for uterine decidualization in mice. | cGMP-dependent protein kinase II determines β-catenin accumulation that is essential for uterine decidualization in mice.
Zhang Y, Yan L, Liu J, Cui S, Qiu J. | 04/11/2020 |
| PKG2 is a key regulator of osteoblast proliferation and post-natal bone formation. | cGMP-dependent protein kinase-2 regulates bone mass and prevents diabetic bone loss.
Ramdani G, Schall N, Kalyanaraman H, Wahwah N, Moheize S, Lee JJ, Sah RL, Pfeifer A, Casteel DE, Pilz RB., Free PMC Article | 08/24/2019 |
| Study shows that there are brain region-specific effects of cGMP-dependent protein kinase II knock-out on AMPA receptor trafficking that affects animal behavior. Study shows that GluA1 phosphorylation levels differ in various brain regions, and specific behaviors are altered according to region-specific changes in GluA1 phosphorylation. | Brain region-specific effects of cGMP-dependent kinase II knockout on AMPA receptor trafficking and animal behavior.
Kim S, Pick JE, Abera S, Khatri L, Ferreira DD, Sathler MF, Morison SL, Hofmann F, Ziff EB., Free PMC Article | 01/20/2018 |
| cGKII may play a role in the integration of information that conveys both anxiety-provoking stimuli as well as the spatial and environmental cues that facilitate functional memory processes and appropriate behavioral response. | cGMP-dependent protein kinase type II knockout mice exhibit working memory impairments, decreased repetitive behavior, and increased anxiety-like traits.
Wincott CM, Abera S, Vunck SA, Tirko N, Choi Y, Titcombe RF, Antoine SO, Tukey DS, DeVito LM, Hofmann F, Hoeffer CA, Ziff EB., Free PMC Article | 05/23/2015 |
| urine volume was decreased significantly in cGKII-KO subjected to volume load. | Function of cGMP-dependent protein kinase II in volume load-induced diuresis.
Schramm A, Schinner E, Huettner JP, Kees F, Tauber P, Hofmann F, Schlossmann J. | 05/23/2015 |
| Cyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites | Cyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites: identification of a multifunctional phosphorylation site.
Chen T, Kocinsky HS, Cha B, Murtazina R, Yang J, Tse CM, Singh V, Cole R, Aronson PS, de Jonge H, Sarker R, Donowitz M., Free PMC Article | 04/25/2015 |
| Increased PKG2 activity alters homeostasis by suppressing proliferation and apoptosis while promoting differentiation. The PKG2-dependent mechanism was shown to involve increased DUSP10 and subsequent inhibition of JNK activity. | Type 2 cGMP-dependent protein kinase regulates homeostasis by blocking c-Jun N-terminal kinase in the colon epithelium.
Wang R, Kwon IK, Singh N, Islam B, Liu K, Sridhar S, Hofmann F, Browning DD., Free PMC Article | 01/17/2015 |
| cGKII KO mice are significantly deficient in spatial learning while exhibiting facilitated motor coordination. Data suggest that the role of cGKII may be more robust in particular regions. | Spatial memory deficits and motor coordination facilitation in cGMP-dependent protein kinase type II-deficient mice.
Wincott CM, Kim S, Titcombe RF, Tukey DS, Girma HK, Pick JE, Devito LM, Hofmann F, Hoeffer C, Ziff EB., Free PMC Article | 06/22/2013 |
| The work presented here demonstrates a novel antiproliferative and prodifferentiation role for PKG2 in the colon. | Type 2 cGMP-dependent protein kinase regulates proliferation and differentiation in the colonic mucosa.
Wang R, Kwon IK, Thangaraju M, Singh N, Liu K, Jay P, Hofmann F, Ganapathy V, Browning DD. | 10/6/2012 |
| cGKII and HCN2 interact and colocalize with each other | The cGMP-dependent protein kinase II Is an inhibitory modulator of the hyperpolarization-activated HCN2 channel.
Hammelmann V, Zong X, Hofmann F, Michalakis S, Biel M., Free PMC Article | 04/7/2012 |
| The homeobox gene Nkx family is critical for the transcriptional regulation of cGK-II during chondrogenesis. | Transcriptional regulation of cGMP-dependent protein kinase II (cGK-II) in chondrocytes.
Yuasa K, Uehara S, Nagahama M, Tsuji A. | 04/12/2010 |
| A novel function for PKG II in osteoblast mechanotransduction, is reported. | Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction.
Rangaswami H, Marathe N, Zhuang S, Chen Y, Yeh JC, Frangos JA, Boss GR, Pilz RB., Free PMC Article | 01/21/2010 |
| Basal plasma renin and aldosterone levels were similar in wild-type and cGKII(-/-) mice. In vivo injection of atrio-natriuretic peptide decreased ACTH-stimulated aldosterone secretion in wild-type mice, but had no effect in cGKII-deficient mice. | cGMP-dependent protein kinase II and aldosterone secretion.
Spiessberger B, Bernhard D, Herrmann S, Feil S, Werner C, Luppa PB, Hofmann F. | 01/21/2010 |
| These data indicate that Rab11b is necessary for the trafficking of cGK-II and that the cGMP/cGK-II signaling pathway is closely related to Rab11b recycling pathway. | Trafficking of cGMP-dependent protein kinase II via interaction with Rab11.
Yuasa K, Yamagami S, Nagahama M, Tsuji A. | 01/21/2010 |
| Activation of cGKII by cGMP increases the surface expression of AMPARs at extrasynaptic sites. Inhibition of cGKII activity blocks the surface increase of GluR1 during chemLTP and reduces LTP in the hippocampal slice. | A GluR1-cGKII interaction regulates AMPA receptor trafficking.
Serulle Y, Zhang S, Ninan I, Puzzo D, McCarthy M, Khatri L, Arancio O, Ziff EB., Free PMC Article | 01/21/2010 |
| results show that the fast phase of autophosphorylation of cGMP dependent protein kinase II has a small effect on its activity, whereas the secondary phase involving Ser126 phosphorylation may generate an active form | Autophosphorylation of cGMP-dependent protein kinase type II.
Vaandrager AB, Hogema BM, Edixhoven M, van den Burg CM, Bot AG, Klatt P, Ruth P, Hofmann F, Van Damme J, Vandekerckhove J, de Jonge HR. | 01/21/2010 |
| study provides in vivo and in vitro genetic evidence that cGKII plays a critical role in C-type natriuretic peptide-mediated endochondral ossification | Cyclic GMP-dependent protein kinase II plays a critical role in C-type natriuretic peptide-mediated endochondral ossification.
Miyazawa T, Ogawa Y, Chusho H, Yasoda A, Tamura N, Komatsu Y, Pfeifer A, Hofmann F, Nakao K. | 01/21/2010 |
| Inhibition of cGMP-dependent protein kinase II by its own splice isoform | Inhibition of cGMP-dependent protein kinase II by its own splice isoform.
Gambaryan S, Palmetshofer A, Glazova M, Smolenski A, Kristjansson GI, Zimmer M, Lohmann SM. | 01/21/2010 |
| In terms of acute responses to ethanol, cGKII-deficient mice are hyposensitive to hypnotic doses of ethanol as measured by the loss of righting reflex. In a two-bottle free choice test, cGKII-/- mice showed elevated alcohol consumption. | Importance of NO/cGMP signalling via cGMP-dependent protein kinase II for controlling emotionality and neurobehavioural effects of alcohol.
Werner C, Raivich G, Cowen M, Strekalova T, Sillaber I, Buters JT, Spanagel R, Hofmann F. | 01/21/2010 |