| Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A. | Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A.
Svarcbahs R, Jäntti M, Kilpeläinen T, Julku UH, Urvas L, Kivioja S, Norrbacka S, Myöhänen TT. | 01/9/2021 |
| POP regulates progesterone secretion by stimulating the expression of CYP11A, 3beta-HSD, and StAR in luteal cells. ERK signaling and downstream SF1 expression contribute to this process. | Prolyl oligopeptidase regulates progesterone secretion via the ERK signaling pathway in murine luteal cells.
Xu P, Bao R, Zhang Y, Lu E, Feng F, Zhang L, Li J, Wang J, Tan X, Tang M, Hu C, Li G, Zhang C. | 05/2/2020 |
| Results strongly suggest that there is a pivotal role for Prolyl endopeptidase (PREP) in vesicle exocytosis, as well as in the physiology of mouse seminal vesicles. | Study on PREP localization in mouse seminal vesicles and its possible involvement during regulated exocytosis.
Venditti M, Aniello F, Santillo A, Minucci S. | 12/21/2019 |
| Prolyl oligopeptidase expression and role in the placental spongiotrophoblast differentiation. | A molecular mechanism of mouse placental spongiotrophoblast differentiation regulated by prolyl oligopeptidase.
Maruyama Y, Kimura AP. | 04/20/2019 |
| PREP regulates the function of dopamine transporter, possibly by controlling the phosphorylation and transport of dopamine transporter into the striatum or synaptic membrane. | Prolyl Oligopeptidase Regulates Dopamine Transporter Phosphorylation in the Nigrostriatal Pathway of Mouse.
Julku UH, Panhelainen AE, Tiilikainen SE, Svarcbahs R, Tammimäki AE, Piepponen TP, Savolainen MH, Myöhänen TT. | 12/22/2018 |
| Taken together, these data suggest that PREP can enhance alpha-synuclein toxicity in vivo. | Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo.
Svarcbahs R, Julku UH, Norrbacka S, Myöhänen TT., Free PMC Article | 12/22/2018 |
| involved in trophoblast stem cell differentiation in placenta | Mouse prolyl oligopeptidase plays a role in trophoblast stem cell differentiation into trophoblast giant cell and spongiotrophoblast.
Maruyama Y, Matsubara S, Kimura AP. | 03/17/2018 |
| These findings might be explained as possible alteration in brain plasticity caused by PREP deficiency, which in turn affect behaviour and brain development | Deficiency of prolyl oligopeptidase in mice disturbs synaptic plasticity and reduces anxiety-like behaviour, body weight, and brain volume.
Höfling C, Kulesskaya N, Jaako K, Peltonen I, Männistö PT, Nurmi A, Vartiainen N, Morawski M, Zharkovsky A, Võikar V, Roßner S, García-Horsman JA. | 01/6/2018 |
| Lung ischemia-reperfusion injury causes a dysregulation of circulating Ang 2 levels and plasma PREP activity, although no direct link between both phenomena could be shown. | Dysregulation of the renin-angiotensin system during lung ischemia-reperfusion injury.
Kehoe K, Gielis JF, Vliegen G, Van Elzen R, Verkerk R, Driessens E, Domen A, Lambeir AM, Maes L, Cos P, De Meester I, Van Schil PE. | 12/16/2017 |
| TLR4 activation releases prolyl endopeptidase containing exosomes from airway epithelial cells. | Toll-Like Receptor 4 Engagement Mediates Prolyl Endopeptidase Release from Airway Epithelia via Exosomes.
Szul T, Bratcher PE, Fraser KB, Kong M, Tirouvanziam R, Ingersoll S, Sztul E, Rangarajan S, Blalock JE, Xu X, Gaggar A., Free PMC Article | 07/16/2016 |
| the expression of prolyl endopeptidase could be necessary for a correct reproductive function | Prolyl Endopeptidase (PREP) is Associated With Male Reproductive Functions and Gamete Physiology in Mice.
Dotolo R, Kim JD, Pariante P, Minucci S, Diano S. | 03/26/2016 |
| As PREP inhibition also enhances autophagic clearance of aSyn, PREP inhibitors may reduce accumulation of aSyn inclusions via a dual mechanism and are thus a novel therapeutic candidate for synucleinopathies. | Prolyl oligopeptidase enhances α-synuclein dimerization via direct protein-protein interaction.
Savolainen MH, Yan X, Myöhänen TT, Huttunen HJ., Free PMC Article | 05/9/2015 |
| lncPrep+96kb could play a role in the POP gene activation in the granulosa cell. | A long non-coding RNA transcribed from conserved non-coding sequences contributes to the mouse prolyl oligopeptidase gene activation.
Matsubara S, Kurihara M, Kimura AP. | 12/6/2014 |
| PREP knockdown mice (Prep(gt/gt)) exhibited glucose intolerance, decreased fasting insulin, increased fasting glucagon levels, and reduced glucose-induced insulin secretion compared with wild-type controls. | Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice.
Kim JD, Toda C, D'Agostino G, Zeiss CJ, DiLeone RJ, Elsworth JD, Kibbey RG, Chan O, Harvey BK, Richie CT, Savolainen M, Myöhänen T, Jeong JK, Diano S., Free PMC Article | 10/25/2014 |
| The study reveals a role for prolyl endopeptidase in mediating hippocampal plasticity and spatial memory formation. | Prolyl endopeptidase-deficient mice have reduced synaptic spine density in the CA1 region of the hippocampus, impaired LTP, and spatial learning and memory.
D'Agostino G, Kim JD, Liu ZW, Jeong JK, Suyama S, Calignano A, Gao XB, Schwartz M, Diano S., Free PMC Article | 03/1/2014 |
| The POP promoter was sufficient for the appropriate localization in the placenta if it was not subject to position effect. | A 914-bp promoter is sufficient to reproduce the endogenous prolyl oligopeptidase gene localization in the mouse placenta if not subject to position effect.
Matsubara S, Maruyama Y, Kimura AP. | 08/10/2013 |
| the cytoplasmic and membrane-associated POP have distinct roles in different types of placental cells. | Localization and subcellular distribution of prolyl oligopeptidase in the mouse placenta.
Matsubara S, Takahashi T, Kimura AP. | 09/24/2011 |
| alpha-MSH(1-13) is an in vivo substrate of PREP. | In vivo multiplex quantitative analysis of 3 forms of alpha melanocyte stimulating hormone in pituitary of prolyl endopeptidase deficient mice.
Perroud B, Alvarado RJ, Espinal GM, Morado AR, Phinney BS, Warden CH., Free PMC Article | 05/7/2011 |
| Cigarette smoke-induced lung emphysema is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown. | Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown.
Braber S, Koelink PJ, Henricks PA, Jackson PL, Nijkamp FP, Garssen J, Kraneveld AD, Blalock JE, Folkerts G., Free PMC Article | 03/19/2011 |
| in vitro reporter analysis indicated that CGI-2 enhanced POP promoter activity and its effect was significantly reduced by DNA methylation | Epigenetic patterns at the mouse prolyl oligopeptidase gene locus suggest the CpG island in the gene body to be a novel regulator for gene expression.
Matsubara S, Takahashi T, Kimura AP. | 09/6/2010 |
| peptidase activity is not required for PO function in neurons and suggest that PO instead acts by binding to cytosolic proteins that control growth cone and synaptic function. | Prolyl oligopeptidase binds to GAP-43 and functions without its peptidase activity.
Di Daniel E, Glover CP, Grot E, Chan MK, Sanderson TH, White JH, Ellis CL, Gallagher KT, Uney J, Thomas J, Maycox PR, Mudge AW. | 01/21/2010 |
| Report distribution of prolyl oligopeptidase in the mouse whole-body sections and peripheral tissues. | Distribution of prolyl oligopeptidase in the mouse whole-body sections and peripheral tissues.
Myöhänen TT, Venäläinen JI, García-Horsman JA, Piltonen M, Männistö PT. | 01/21/2010 |
| Murine T cells expressing high activity of prolyl endopeptidase are susceptible to activation-induced cell death. | Murine T cells expressing high activity of prolyl endopeptidase are susceptible to activation-induced cell death.
Odaka C, Mizuochi T, Shirasawa T, Morain P, Checler F. | 01/21/2010 |