| Pancreatic Ppy-expressing gamma-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production. | Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production.
Perez-Frances M, van Gurp L, Abate MV, Cigliola V, Furuyama K, Bru-Tari E, Oropeza D, Carreaux T, Fujitani Y, Thorel F, Herrera PL., Free PMC Article | 08/7/2021 |
| GPR120 Regulates Pancreatic Polypeptide Secretion From Male Mouse Islets via PLC-Mediated Calcium Mobilization. | GPR120 Regulates Pancreatic Polypeptide Secretion From Male Mouse Islets via PLC-Mediated Calcium Mobilization.
Zhao YF, Li XC, Liang XY, Zhao YY, Xie R, Zhang LJ, Zhang XC, Chen C. | 02/6/2021 |
| These data demonstrate glucose-regulated secretion of PP and its effects on glucagon release through PPYR1 receptors expressed by alpha-cells. | Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells.
Aragón F, Karaca M, Novials A, Maldonado R, Maechler P, Rubí B. | 03/21/2015 |
| PP-initiated signaling through Npy6r in vasoactive intestinal peptide neurons regulates the growth hormone axis and body composition. | Pancreatic polypeptide controls energy homeostasis via Npy6r signaling in the suprachiasmatic nucleus in mice.
Yulyaningsih E, Loh K, Lin S, Lau J, Zhang L, Shi Y, Berning BA, Enriquez R, Driessler F, Macia L, Khor EC, Qi Y, Baldock P, Sainsbury A, Herzog H. | 06/14/2014 |
| investigated the role of metalloendopeptidases in PYY(3-36) degradation and determined whether modulation of these enzymes enhanced PYY(3-36) plasma levels and bioactivity in vivo. | A role for metalloendopeptidases in the breakdown of the gut hormone, PYY 3-36.
Addison ML, Minnion JS, Shillito JC, Suzuki K, Tan TM, Field BC, Germain-Zito N, Becker-Pauly C, Ghatei MA, Bloom SR, Murphy KG. | 02/18/2012 |
| Pancreatic polypeptide enhances colonic contractile activity and fecal output through neuropeptide Y Y(4) receptor, and a neuropeptide Y Y(4) receptor agonist might offer a novel therapeutic approach to ameliorate constipation. | Pancreatic polypeptide enhances colonic muscle contraction and fecal output through neuropeptide Y Y4 receptor in mice.
Moriya R, Fujikawa T, Ito J, Shirakura T, Hirose H, Suzuki J, Fukuroda T, Macneil DJ, Kanatani A. | 04/12/2010 |
| 67.74% A-cells (glucagon-secreting cells) had PP (pancreatic polypeptide) immunoreactivity, 70.92% PP-cells contained glucagon immunoreactivity with immunofluorescence double staining | Immunohistochemical localization of glucagon and pancreatic polypeptide on rat endocrine pancreas: coexistence in rat islet cells.
Huang YH, Sun MJ, Jiang M, Fu BY., Free PMC Article | 01/21/2010 |
| In adult mice, the misexpression of Arx, rather than its overexpression, promotes a conversion of beta cells into glucagon- or PP-producing cells in vivo. | Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.
Collombat P, Hecksher-Sørensen J, Krull J, Berger J, Riedel D, Herrera PL, Serup P, Mansouri A., Free PMC Article | 01/21/2010 |
| Pancreatic polypeptide may influence food intake, energy metabolism, and the expression of hypothalamic peptides and gastric ghrelin. | Characterization of the effects of pancreatic polypeptide in the regulation of energy balance.
Asakawa A, Inui A, Yuzuriha H, Ueno N, Katsuura G, Fujimiya M, Fujino MA, Niijima A, Meguid MM, Kasuga M. | 01/21/2010 |
| impaired glucose tolerance in overexprsesing mice | Impaired glucose tolerance in pancreatic polypeptide-overexpressing mice.
Ueno N, Inui A, Asakawa A, Yuzuriha H, Kasuga M, Fujimiya M. | 01/21/2010 |
| PP has a role in development of pancreatic islets | Development of pancreatic islets in pancreatic polypeptide-overexpressing mice.
Yuzuriha H, Inui A, Asakawa A, Ueno N, Sakamaki R, Shinfuku N, Kasuga M, Fujimiya M. | 01/21/2010 |
| Roles of pancreatic polypeptide in regulation of food intake | Roles of pancreatic polypeptide in regulation of food intake.
Katsuura G, Asakawa A, Inui A. | 01/21/2010 |
| Increased circulating cholecystokinin contributes to anorexia and anxiety behavior in mice overexpressing Ppy. | Increased circulating cholecystokinin contributes to anorexia and anxiety behavior in mice overexpressing pancreatic polypeptide.
Ueno N, Asakawa A, Satoh Y, Inui A. | 01/21/2010 |