| Genetic deletion of astrocytic calcineurin B1 prevents cognitive impairment and neuropathology development in acute and chronic mouse models of Alzheimer's disease. | Genetic deletion of astrocytic calcineurin B1 prevents cognitive impairment and neuropathology development in acute and chronic mouse models of Alzheimer's disease.
Tapella L, Dematteis G, La Vitola P, Leva S, Tonelli E, Raddi M, Delconti M, Dacomo L, La Macchia A, Murari E, Talmon M, Malecka J, Chrostek G, Grilli M, Colombo L, Salmona M, Forloni G, Genazzani AA, Balducci C, Lim D. | 08/7/2024 |
| The Protective Effects of Calcineurin on Pancreatitis in Mice Depend on the Cellular Source. | The Protective Effects of Calcineurin on Pancreatitis in Mice Depend on the Cellular Source.
Wen L, Javed TA, Dobbs AK, Brown R, Niu M, Li L, Khalid A, Barakat MT, Xiao X, Yimlamai D, Konnikova L, Yu M, Byersdorfer CA, Husain SZ., Free PMC Article | 04/17/2021 |
| Deletion of Calcineurin in Schwann Cells Does Not Affect Developmental Myelination, But Reduces Autophagy and Delays Myelin Clearance after Peripheral Nerve Injury. | Deletion of Calcineurin in Schwann Cells Does Not Affect Developmental Myelination, But Reduces Autophagy and Delays Myelin Clearance after Peripheral Nerve Injury.
Reed CB, Frick LR, Weaver A, Sidoli M, Schlant E, Feltri ML, Wrabetz L., Free PMC Article | 01/9/2021 |
| this study shows that calcineurin B in CD4(+) T cells prevents autoimmune colitis by negatively regulating the JAK/STAT pathway | Calcineurin B in CD4(+) T Cells Prevents Autoimmune Colitis by Negatively Regulating the JAK/STAT Pathway.
Mencarelli A, Vacca M, Khameneh HJ, Acerbi E, Tay A, Zolezzi F, Poidinger M, Mortellaro A., Free PMC Article | 04/13/2019 |
| Calcineurin B1 deficiency in glial cells impairs the small intestine and leads to malnutrition and eventual death in mice, suggesting that calcineurin plays a novel and important role in enteric glial cells. | Calcineurin B1 Deficiency in Glial Cells Induces Mucosal Degeneration and Inflammation in Mouse Small Intestine.
Fujita M, Yagi T, Okura U, Tanaka J, Hirashima N, Tanaka M. | 09/29/2018 |
| Expression of the RNA-binding protein, tristetraprolin (TTP) was down-regulated in response to calcineurin inhibition. | The ARE-binding protein Tristetraprolin (TTP) is a novel target and mediator of calcineurin tumor suppressing function in the skin.
Wu X, Tommasi di Vignano A, Zhou Q, Michel-Dziunycz PJ, Bai F, Mi J, Qin J, Zu T, Hofbauer GFL., Free PMC Article | 06/30/2018 |
| Mice lacking Calcineurin B in CD11c(high)MHCII(+) cells (Cnb1 (CD11c) mice) spontaneously develop intestinal inflammation and are susceptible to induced colitis. | Calcineurin-mediated IL-2 production by CD11c(high)MHCII(+) myeloid cells is crucial for intestinal immune homeostasis.
Mencarelli A, Khameneh HJ, Fric J, Vacca M, El Daker S, Janela B, Tang JP, Nabti S, Balachander A, Lim TS, Ginhoux F, Ricciardi-Castagnoli P, Mortellaro A., Free PMC Article | 06/2/2018 |
| These results suggest that the PDZ domain of PICK1 directly interacts with calcineurin B in osteoclast progenitor cells and promotes osteoclast differentiation through activation of calcineurin-NFAT signaling. | Binding of PICK1 PDZ domain with calcineurin B regulates osteoclast differentiation.
Kamano Y, Watanabe J, Iida T, Kondo T, Okawa H, Yatani H, Saeki M, Egusa H. | 02/17/2018 |
| global deficiency of catalytic subunit Ppp3cb, and tissue-specific ablation of regulatory subunit Ppp3r1 from skeletal muscle, but not adipose tissue or liver, led to protection from high-fat-diet-induced obesity | Calcineurin Links Mitochondrial Elongation with Energy Metabolism.
Pfluger PT, Kabra DG, Aichler M, Schriever SC, Pfuhlmann K, García VC, Lehti M, Weber J, Kutschke M, Rozman J, Elrod JW, Hevener AL, Feuchtinger A, Hrabě de Angelis M, Walch A, Rollmann SM, Aronow BJ, Müller TD, Perez-Tilve D, Jastroch M, De Luca M, Molkentin JD, Tschöp MH. | 09/10/2016 |
| data demonstrate that decreasing calcineurin activity in the amygdala increases anxiety-like behaviors and to some extent depression-like behaviors. | Calcineurin downregulation in the amygdala is sufficient to induce anxiety-like and depression-like behaviors in C57BL/6J male mice.
Mineur YS, Taylor SR, Picciotto MR., Free PMC Article | 11/14/2015 |
| necessary for the development of the smooth muscle wall of coronary arteries | Epicardial calcineurin-NFAT signals through Smad2 to direct coronary smooth muscle cell and arterial wall development.
Yang J, Zeini M, Lin CY, Lin CJ, Xiong Y, Shang C, Han P, Li W, Quertermous T, Zhou B, Chang CP., Free PMC Article | 08/30/2014 |
| Macrophage Wnt-Calcineurin-Flt1 signaling regulates mouse wound angiogenesis and repair. | Macrophage Wnt-Calcineurin-Flt1 signaling regulates mouse wound angiogenesis and repair.
Stefater JA 3rd, Rao S, Bezold K, Aplin AC, Nicosia RF, Pollard JW, Ferrara N, Lang RA., Free PMC Article | 06/8/2013 |
| Pancreatic beta cells lacking Cnb1 fail to express genes revealed to be direct NFAT targets required for replication, insulin storage, and secretion. | Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT.
Goodyer WR, Gu X, Liu Y, Bottino R, Crabtree GR, Kim SK., Free PMC Article | 10/13/2012 |
| intact calcineurin/NFAT signalling is critically required for p53 and senescence-associated mechanisms that protect against skin squamous cancer development | Opposing roles for calcineurin and ATF3 in squamous skin cancer.
Wu X, Nguyen BC, Dziunycz P, Chang S, Brooks Y, Lefort K, Hofbauer GF, Dotto GP., Free PMC Article | 07/5/2010 |
| Mechanistically, loss of Heart-specific CnB1 reduced expression of key Ca(2+)-handling genes that likely lead to arrhythmia and reduced contractility | Heart-specific deletion of CnB1 reveals multiple mechanisms whereby calcineurin regulates cardiac growth and function.
Maillet M, Davis J, Auger-Messier M, York A, Osinska H, Piquereau J, Lorenz JN, Robbins J, Ventura-Clapier R, Molkentin JD., Free PMC Article | 03/29/2010 |
| Report impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice. | Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice.
Schaeffer PJ, Desantiago J, Yang J, Flagg TP, Kovacs A, Weinheimer CJ, Courtois M, Leone TC, Nichols CG, Bers DM, Kelly DP., Free PMC Article | 01/21/2010 |
| gene deficiency results in reduced responsiveness of macrophages to LPS | Calcineurin inactivation leads to decreased responsiveness to LPS in macrophages and dendritic cells and protects against LPS-induced toxicity in vivo.
Jennings C, Kusler B, Jones PP., Free PMC Article | 01/21/2010 |
| studies demonstrate that calcineurin and NFAT are essential for neuregulin and ErbB signaling, neural crest diversification, and differentiation of Schwann cells | Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation.
Kao SC, Wu H, Xie J, Chang CP, Ranish JA, Graef IA, Crabtree GR., Free PMC Article | 01/21/2010 |
| the inhibition of Cnb1 in osteoblasts increases bone mass by directly increasing osteoblast differentiation and indirectly decreasing osteoclastogenesis | Conditional disruption of calcineurin B1 in osteoblasts increases bone formation and reduces bone resorption.
Yeo H, Beck LH, Thompson SR, Farach-Carson MC, McDonald JM, Clemens TL, Zayzafoon M. | 01/21/2010 |
| results indicate that early calcineurin/NFAT signalling produces a developmental period of ERK hypersensitivity, allowing very weak signals to induce positive selection | Calcineurin sets the bandwidth for discrimination of signals during thymocyte development.
Gallo EM, Winslow MM, Canté-Barrett K, Radermacher AN, Ho L, McGinnis L, Iritani B, Neilson JR, Crabtree GR., Free PMC Article | 01/21/2010 |
| Calcineurin B1 is essential for positive selection during thymocyte development. | Calcineurin B1 is essential for positive but not negative selection during thymocyte development.
Neilson JR, Winslow MM, Hur EM, Crabtree GR. | 01/21/2010 |
| interconnection exists between Notch 1 and Calcineurin-NFAT pathways in keratinocyte growth/differentiation control | Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control.
Mammucari C, Tommasi di Vignano A, Sharov AA, Neilson J, Havrda MC, Roop DR, Botchkarev VA, Crabtree GR, Dotto GP. | 01/21/2010 |
| gene expression of peroxisome proliferator-activated receptor gamma coactivator 1alpha and peroxisome proliferator-activated receptor alpha was reduced in the hearts of mice with cardiac-specific ablation of the Cn regulatory subunit. | Calcineurin and calcium/calmodulin-dependent protein kinase activate distinct metabolic gene regulatory programs in cardiac muscle.
Schaeffer PJ, Wende AR, Magee CJ, Neilson JR, Leone TC, Chen F, Kelly DP. | 01/21/2010 |
| Deletion substantially reduced skeletal muscle degeneration and histopathology compared with the sarcoglycan-null genotype alone. | Genetic disruption of calcineurin improves skeletal muscle pathology and cardiac disease in a mouse model of limb-girdle muscular dystrophy.
Parsons SA, Millay DP, Sargent MA, Naya FJ, McNally EM, Sweeney HL, Molkentin JD., Free PMC Article | 01/21/2010 |
| The calcineurin/Nfat pathway controls the morphologic maturation of lungs prior to birth and regulates expression of genes involved in surfactant homeostasis that are critical for adaptation to air breathing. | Calcineurin/Nfat signaling is required for perinatal lung maturation and function.
Davé V, Childs T, Xu Y, Ikegami M, Besnard V, Maeda Y, Wert SE, Neilson JR, Crabtree GR, Whitsett JA., Free PMC Article | 01/21/2010 |