| Exercise training attenuates angiotensin II-induced cardiac fibrosis by reducing POU2F1 expression. | Exercise training attenuates angiotensin II-induced cardiac fibrosis by reducing POU2F1 expression.
Feng N, Yu H, Wang Y, Zhang Y, Xiao H, Gao W., Free PMC Article | 07/10/2023 |
| Oct1 cooperates with the Smad family of transcription factors to promote mesodermal lineage specification. | Oct1 cooperates with the Smad family of transcription factors to promote mesodermal lineage specification.
Perovanovic J, Wu Y, Abewe H, Shen Z, Hughes EP, Gertz J, Chandrasekharan MB, Tantin D., Free PMC Article | 05/19/2023 |
| 5-Azacytidine Suppresses the Expression of Tissue-Specific Oct-1 Isoform in Namalwa Burkitt's Lymphoma Cell Culture. | 5-Azacytidine Suppresses the Expression of Tissue-Specific Oct-1 Isoform in Namalwa Burkitt's Lymphoma Cell Culture.
Kotnova AP, Stepchenko AG, Ilyin YV, Georgieva SG, Pankratova EV., Free PMC Article | 05/14/2022 |
| LncRNA NEAT1 Promotes Inflammatory Response in Sepsis via the miR-31-5p/POU2F1 Axis. | LncRNA NEAT1 Promotes Inflammatory Response in Sepsis via the miR-31-5p/POU2F1 Axis.
Yang Y, Xue J, Qin L, Zhang J, Liu J, Yu J., Free PMC Article | 12/25/2021 |
| OBF1 and Oct factors control the germinal center transcriptional program. | OBF1 and Oct factors control the germinal center transcriptional program.
Song S, Cao C, Choukrallah MA, Tang F, Christofori G, Kohler H, Wu F, Fodor BD, Frederiksen M, Willis SN, Jackson JT, Nutt SL, Dirnhofer S, Stadler MB, Matthias P. | 12/11/2021 |
| Pathological matrix stiffness promotes cardiac fibroblast differentiation through the POU2F1 signaling pathway. | Pathological matrix stiffness promotes cardiac fibroblast differentiation through the POU2F1 signaling pathway.
Li M, Wu J, Hu G, Song Y, Shen J, Xin J, Li Z, Liu W, Dong E, Xu M, Zhang Y, Xiao H. | 12/11/2021 |
| Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-Mediated Uptake. | Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-Mediated Uptake.
Morse BL, Kolur A, Hudson LR, Hogan AT, Chen LH, Brackman RM, Sawada GA, Fallon JK, Smith PC, Hillgren KM. | 06/5/2021 |
| Pou2f1 and Pou2f2 cooperate to control the timing of cone photoreceptor production in the developing mouse retina. | Pou2f1 and Pou2f2 cooperate to control the timing of cone photoreceptor production in the developing mouse retina.
Javed A, Mattar P, Lu S, Kruczek K, Kloc M, Gonzalez-Cordero A, Bremner R, Ali RR, Cayouette M. | 04/13/2021 |
| In MLL-AF9-driven mouse models, partial loss of Oct1 protects from myeloid leukemia. Complete Oct1 loss completely suppresses leukemia but results in lethality from bone marrow failure. Loss of Oct1 in normal hematopoietic transplants results in superficially normal long-term reconstitution; however, animals become acutely sensitive to 5-fluorouracil, indicating that Oct1 is dispensable for normal hematopoiesis. | Transcription factor Oct1 protects against hematopoietic stress and promotes acute myeloid leukemia.
Jafek JL, Shakya A, Tai PY, Ibarra A, Kim H, Maddox J, Chumley J, Spangrude GJ, Miles RR, Kelley TW, Tantin D., Free PMC Article | 02/22/2020 |
| Oct1-deficient T cells mitigated reduced infiltrating T cells and cytokine production in an autoimmune neuroinflammation disease model. | T cell-selective deletion of Oct1 protects animals from autoimmune neuroinflammation while maintaining neurotropic pathogen response.
Kim H, Dickey L, Stone C, Jafek JL, Lane TE, Tantin D., Free PMC Article | 01/11/2020 |
| Oct1 is selectively required for colon regeneration and regulates colon malignancy. | Oct1/Pou2f1 is selectively required for colon regeneration and regulates colon malignancy.
Vázquez-Arreguín K, Bensard C, Schell JC, Swanson E, Chen X, Rutter J, Tantin D., Free PMC Article | 12/7/2019 |
| This findings of this study indicated that OCT1 may participate in neuropathic pain at least in part by transcriptionally activating Dnmt3a and subsequently epigenetic silencing of Oprm1 and Kcan2 in the DRG. | Contribution of dorsal root ganglion octamer transcription factor 1 to neuropathic pain after peripheral nerve injury.
Yuan J, Wen J, Wu S, Mao Y, Mo K, Li Z, Su S, Gu H, Ai Y, Bekker A, Zhang W, Tao YX., Free PMC Article | 06/29/2019 |
| CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGgamma. | CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ.
Fan J, Liu L, Liu Q, Cui Y, Yao B, Zhang M, Gao Y, Fu Y, Dai H, Pan J, Qiu Y, Liu CH, He F, Wang Y, Zhang L., Free PMC Article | 02/16/2019 |
| In embryonic stem cells, Oct1 co-occupies a specific set of targets with Oct4, but does not occupy differentially expressed developmental targets. Instead, Oct1 occupies these targets as cells differentiate and Oct4 declines. | Enforcement of developmental lineage specificity by transcription factor Oct1.
Shen Z, Kang J, Shakya A, Tabaka M, Jarboe EA, Regev A, Tantin D., Free PMC Article | 02/24/2018 |
| At low oxLDL levels LOX-1 activates the protective Oct-1/SIRT1 pathway, while at higher levels of the lipoprotein switches to the thrombogenic ERK1/2 pathway. | Endothelial LOX-1 activation differentially regulates arterial thrombus formation depending on oxLDL levels: role of the Oct-1/SIRT1 and ERK1/2 pathways.
Akhmedov A, Camici GG, Reiner MF, Bonetti NR, Costantino S, Holy EW, Spescha RD, Stivala S, Schaub Clerigué A, Speer T, Breitenstein A, Manz J, Lohmann C, Paneni F, Beer JH, Lüscher TF. | 10/14/2017 |
| Study conclude that pentamidine interacts with multiple transporters, is taken into brain endothelial cells by OCT1 transporter and is extruded into the blood by ATP-dependent mechanisms. These interactions along with the predominant presence of OCT1 in the luminal membrane of the BBB contribute to the limited entry of pentamidine into the brain. | Organic cation transporter 1 (OCT1) is involved in pentamidine transport at the human and mouse blood-brain barrier (BBB).
Sekhar GN, Georgian AR, Sanderson L, Vizcay-Barrena G, Brown RC, Muresan P, Fleck RA, Thomas SA., Free PMC Article | 09/2/2017 |
| These results suggest that Oct-1 and GATA-3/Oct-2 direct Th2 cytokine gene expression in a cooperative manner. | Transcription Factors Oct-1 and GATA-3 Cooperatively Regulate Th2 Cytokine Gene Expression via the RHS5 within the Th2 Locus Control Region.
Kim K, Kim N, Lee GR., Free PMC Article | 07/16/2016 |
| Findings indicate octamer transcription factor-1 (Oct1) and Oct binding factor 1 protein (OCA-B) as central mediators of CD4(+) T cell memory. | Oct1 and OCA-B are selectively required for CD4 memory T cell function.
Shakya A, Goren A, Shalek A, German CN, Snook J, Kuchroo VK, Yosef N, Chan RC, Regev A, Williams MA, Tantin D., Free PMC Article | 04/16/2016 |
| levels of microRNA-451 (miR-451) are negatively regulated through the phosphorylation and inactivation of its direct transcriptional activator OCT1 by 5' AMP-activated protein kinase | Glucose-based regulation of miR-451/AMPK signaling depends on the OCT1 transcription factor.
Ansari KI, Ogawa D, Rooj AK, Lawler SE, Krichevsky AM, Johnson MD, Chiocca EA, Bronisz A, Godlewski J., Free PMC Article | 02/20/2016 |
| Oct1 mRNA expression was decreased in mice with both ob/ob and methionine/choline deficiency models of nonalcoholic steatohepatitis. | Mechanism of Altered Metformin Distribution in Nonalcoholic Steatohepatitis.
Clarke JD, Dzierlenga AL, Nelson NR, Li H, Werts S, Goedken MJ, Cherrington NJ., Free PMC Article | 11/21/2015 |
| OCT1 is a driver of synbindin-mediated ERK signalling and a promising marker for the prognosis and molecular subtyping of gastric cancer. | OCT1 is a determinant of synbindin-related ERK signalling with independent prognostic significance in gastric cancer.
Qian J, Kong X, Deng N, Tan P, Chen H, Wang J, Li Z, Hu Y, Zou W, Xu J, Fang JY., Free PMC Article | 02/21/2015 |
| studies implicate OCT1 as well as metformin in thiamine disposition, suggesting an intriguing and parallel mechanism for metformin and its major hepatic transporter in metabolic function. | OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.
Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM., Free PMC Article | 09/20/2014 |
| Th17 lineage differentiation is restrained by the Th2 locus via interchromosomal associations organized by Oct-1 and CTCF. | Oct-1 regulates IL-17 expression by directing interchromosomal associations in conjunction with CTCF in T cells.
Kim LK, Esplugues E, Zorca CE, Parisi F, Kluger Y, Kim TH, Galjart NJ, Flavell RA., Free PMC Article | 05/31/2014 |
| inhibition of the DNA binding activity of transcriptional repressor OCT-1 is a mechanism by which ethanol up-regulates Slc711 expression. | A novel transcription mechanism activated by ethanol: induction of Slc7a11 gene expression via inhibition of the DNA-binding activity of transcriptional repressor octamer-binding transcription factor 1 (OCT-1).
Lin X, Yang H, Zhang H, Zhou L, Guo Z., Free PMC Article | 08/10/2013 |
| mammary cells express beta-casein in response to prolactin in a pathway that involves gap junction intracellular communication and OCT-1 and is independent of STAT5 nuclear translocation | Gap junctions mediate STAT5-independent β-casein expression in CID-9 mammary epithelial cells.
Talhouk RS, Khalil AA, Bajjani R, Rahme GJ, El-Sabban ME. | 03/31/2012 |