| Depletion of Paraoxonase 1 (Pon1) Dysregulates mTOR, Autophagy, and Accelerates Amyloid Beta Accumulation in Mice. | Depletion of Paraoxonase 1 (Pon1) Dysregulates mTOR, Autophagy, and Accelerates Amyloid Beta Accumulation in Mice.
Witucki Ł, Jakubowski H., Free PMC Article | 03/14/2023 |
| Changes in redox plasma proteome of Pon1-/- mice are exacerbated by a hyperhomocysteinemic diet. | Changes in redox plasma proteome of Pon1-/- mice are exacerbated by a hyperhomocysteinemic diet.
Sikora M, Jakubowski H. | 08/21/2021 |
| Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults. | Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults.
Kofman O, Lan A, Raykin E, Zega K, Brodski C., Free PMC Article | 11/21/2020 |
| Ccl2 gene ablation protects LDL receptor and PON1 double deficient mice from liver injury, oxidative stress and inflammation. | Chemokine (C-C motif) ligand 2 gene ablation protects low-density lipoprotein and paraoxonase-1 double deficient mice from liver injury, oxidative stress and inflammation.
Luciano-Mateo F, Cabré N, Fernández-Arroyo S, Baiges-Gaya G, Hernández-Aguilera A, Rodríguez-Tomàs E, Mercado-Gómez M, Menendez JA, Camps J, Joven J. | 02/8/2020 |
| Study shows that PON1 can significantly relieve airway inflammation and airway remolding in asthma mice, and inhibit the secretion of LPS induced macrophage inflammatory cytokines and the proliferation of lung fibroblasts. These results suggest that PON1 may be involved in airway inflammation and remodeling in asthma. | Influences of PON1 on airway inflammation and remodeling in bronchial asthma.
Chen WQ, Xie ZZ, Wang X, Zhao JH, Hu Q, Chen YH, Gao WY, Liu Y. | 07/7/2018 |
| PON1 overexpression protects against AAA progression by reducing oxidative stress, apoptosis and inflammation | Paraoxonase-1 overexpression prevents experimental abdominal aortic aneurysm progression.
Burillo E, Tarin C, Torres-Fonseca MM, Fernandez-García CE, Martinez-Pinna R, Martinez-Lopez D, Llamas-Granda P, Camafeita E, Lopez JA, Vega de Ceniga M, Aviram M, Egido J, Blanco-Colio LM, Martín-Ventura JL. | 04/15/2017 |
| Paraoxonase 1 (PON1) influence circadian gene expression and period length | Paraoxonase 1 (PON1) and pomegranate influence circadian gene expression and period length.
Loizides-Mangold U, Koren-Gluzer M, Skarupelova S, Makhlouf AM, Hayek T, Aviram M, Dibner C. | 02/18/2017 |
| results suggest that Hyperhomocysteinemia plays an intricate role in dysfunctional HDL, owing to the lack of PON1. This contributes to vascular endothelial impairment and atherosclerosis. | Hyperhomocysteinemia: a missing link to dysfunctional HDL via paraoxanase-1.
Givvimani S, Kundu S, Pushpakumar S, Doyle V, Narayanan N, Winchester LJ, Veeranki S, Metreveli N, Tyagi SC. | 09/24/2016 |
| Maternal PON1 status modulates the effects of repeated gestational chlorpyrifos oxon exposure on fetal-brain gene expression and on inhibition of both maternal and fetal biomarker enzymes. | Repeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1) modulated effects in maternal and fetal tissues.
Cole TB, Li WF, Co AL, Hay AM, MacDonald JW, Bammler TK, Farin FM, Costa LG, Furlong CE., Free PMC Article | 11/7/2015 |
| 5,6-dihydroxyeicosatrienoate-1,5-lactone, a stable metabolite of arachidonic acid, is a potential substrate for PON1. | 5,6-δ-DHTL, a stable metabolite of arachidonic acid, is a potential substrate for paraoxonase 1.
Eryanni-Levin S, Khatib S, Levy-Rosenzvig R, Tamir S, Szuchman-Sapir A. | 10/3/2015 |
| HDL (mostly HDL3), stimulates PON1 antiatherogenic activities in mouse macrophages. | HDL3 stimulates paraoxonase 1 antiatherogenic catalytic and biological activities in a macrophage model system: in vivo and in vitro studies.
Rosenblat M, Volkova N, Aviram M. | 07/25/2015 |
| Findings suggest that Pon1 interacts with diverse cellular processes from energy metabolism and anti-oxidative defenses to cell cycle, cytoskeleton dynamics, and synaptic plasticity essential for normal brain homeostasis | Inactivation of the paraoxonase 1 gene affects the expression of mouse brain proteins involved in neurodegeneration.
Suszyńska-Zajczyk J, Luczak M, Marczak L, Jakubowski H. | 05/16/2015 |
| The study demonstrated a significant decline in PON1 activity which correlates with increased LDL oxidation after 8 months of age in Wistar rats. | Age-dependent paraoxonase 1 (PON1) activity and LDL oxidation in Wistar rats during their entire lifespan.
Kumar D, Rizvi SI., Free PMC Article | 03/7/2015 |
| PON1 plays a protective role against hepatic derangements, secondary to fat and cholesterol overnutrition. PON1 deficiency is associated with oxidative stress and metabolic alterations leading to liver steatosis. | Paraoxonase-1 deficiency is associated with severe liver steatosis in mice fed a high-fat high-cholesterol diet: a metabolomic approach.
García-Heredia A, Kensicki E, Mohney RP, Rull A, Triguero I, Marsillach J, Tormos C, Mackness B, Mackness M, Shih DM, Pedro-Botet J, Joven J, Sáez G, Camps J. | 11/8/2014 |
| PON1 is not essential for normal development, function, ageing, and the defense against light damage of the mouse retina. | Lack of paraoxonase 1 alters phospholipid composition, but not morphology and function of the mouse retina.
Oczos J, Sutter I, Kloeckener-Gruissem B, Berger W, Riwanto M, Rentsch K, Hornemann T, von Eckardstein A, Grimm C. | 10/18/2014 |
| Suggest that PON1 decreases sustained pro-inflammatory reactions, which subsequently can attenuate plaque progression. | Paraoxonase 1 (PON1) reduces macrophage inflammatory responses.
Aharoni S, Aviram M, Fuhrman B. | 10/26/2013 |
| PON1 plays a beneficial role in glucose regulation and metabolism and may serve as an important tool in diabetes control. | Paraoxonase1 (PON1) reduces insulin resistance in mice fed a high-fat diet, and promotes GLUT4 overexpression in myocytes, via the IRS-1/Akt pathway.
Koren-Gluzer M, Aviram M, Hayek T. | 10/26/2013 |
| PON1 activity was found to be increased in diabetic mice after administration of aqueous Murraya koenigii leaves extract. | An aqueous extract of Murraya koenigii leaves induces paraoxonase 1 activity in streptozotocin induced diabetic mice.
Saha A, Mazumder S. | 09/21/2013 |
| Pon1 protects mice against Hcy-thiolactone neurotoxicity by hydrolyzing it in the brain. | Metabolism and neurotoxicity of homocysteine thiolactone in mice: evidence for a protective role of paraoxonase 1.
Borowczyk K, Shih DM, Jakubowski H., Free PMC Article | 09/22/2012 |
| PON1 is a potent anti-diabetic enzyme that exerts this protection against diabetes through its antioxidative, as well as via its insulin stimulation properties on beta-cells. | The antioxidant HDL-associated paraoxonase-1 (PON1) attenuates diabetes development and stimulates β-cell insulin release.
Koren-Gluzer M, Aviram M, Meilin E, Hayek T. | 04/7/2012 |
| antiatherosclerotic properties of HDL can be attributed to two major mechanisms of action of PON1: protecting macrophages from TG-induced oxidative modification and (ii) reduction of peroxide levels in oxidized TGs. | Paraoxonase 1 protects macrophages from atherogenicity of a specific triglyceride isolated from human carotid lesion.
Tavori H, Aviram M, Khatib S, Musa R, Mannheim D, Karmeli R, Vaya J. | 12/24/2011 |
| PON1 status plays a critical role in modulating the effects of neonatal chlor- pyrifos oxon exposure in the developing brain. | Repeated developmental exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects on cerebellar gene expression.
Cole TB, Beyer RP, Bammler TK, Park SS, Farin FM, Costa LG, Furlong CE., Free PMC Article | 12/24/2011 |
| PON1 is affectd by HDL mimetic peptide 4F [review] | The effect of HDL mimetic peptide 4F on PON1.
Vakili L, Hama S, Kim JB, Tien D, Safarpoor S, Ly N, Vakili G, Hough G, Navab M. | 09/17/2011 |
| paraoxonase 1 has a role in the detoxification of homocysteine thiolactone [review] | The role of paraoxonase 1 in the detoxification of homocysteine thiolactone.
Jakubowski H. | 09/17/2011 |
| analysis of PON1 and oxidative stress in human sepsis and an animal model of sepsis [review] | PON1 and oxidative stress in human sepsis and an animal model of sepsis.
Draganov D, Teiber J, Watson C, Bisgaier C, Nemzek J, Remick D, Standiford T, La Du B. | 09/17/2011 |