| PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells. | PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells.
Katerndahl CDS, Rogers ORS, Day RB, Xu Z, Helton NM, Ramakrishnan SM, Miller CA, Ley TJ., Free PMC Article | 05/7/2024 |
| JAK2V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML. | JAK2V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML.
Dagher T, Maslah N, Edmond V, Cassinat B, Vainchenker W, Giraudier S, Pasquier F, Verger E, Niwa-Kawakita M, Lallemand-Breitenbach V, Plo I, Kiladjian JJ, Villeval JL, de Thé H., Free PMC Article | 09/11/2021 |
| we uncovered a novel reciprocal loop of TGF-beta1/PML SUMOylation/Pin1 leading to myocardial fibrosis. | TGF-β1-PML SUMOylation-peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) form a positive feedback loop to regulate cardiac fibrosis.
Wu D, Huang D, Li LL, Ni P, Li XX, Wang B, Han YN, Shao XQ, Zhao D, Chu WF, Li BY. | 03/28/2020 |
| Loss of PML increases H3.3 deposition in subtelomeric, telomeric, pericentric and centromeric repeats in mouse embryonic fibroblasts, while other repeat classes are not affected. | PML modulates H3.3 targeting to telomeric and centromeric repeats in mouse fibroblasts.
Spirkoski J, Shah A, Reiner AH, Collas P, Delbarre E. | 01/18/2020 |
| Pml Nuclear bodies (NB) are critical for DNA damage responses, and Pml NB disruption is a central contributor to Acute promyelocytic leukemia pathogenesis. | Pml nuclear body disruption cooperates in APL pathogenesis and impairs DNA damage repair pathways in mice.
Voisset E, Moravcsik E, Stratford EW, Jaye A, Palgrave CJ, Hills RK, Salomoni P, Kogan SC, Solomon E, Grimwade D., Free PMC Article | 02/9/2019 |
| PML mediates the binding of PER2 to BMAL1 in the BMAL1/CLOCK heterodimer and is an important component in the organization of a functional clock complex in the nucleus. | Interactive Organization of the Circadian Core Regulators PER2, BMAL1, CLOCK and PML.
Miki T, Zhao Z, Lee CC., Free PMC Article | 05/26/2018 |
| Promyelocytic leukemia protein Pml -/- cells showed a higher proliferation rate, compared to Pml +/+ cells. | A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche.
Guarnerio J, Mendez LM, Asada N, Menon AV, Fung J, Berry K, Frenette PS, Ito K, Pandolfi PP., Free PMC Article | 03/10/2018 |
| PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX and DAXX. | PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX.
Delbarre E, Ivanauskiene K, Spirkoski J, Shah A, Vekterud K, Moskaug JØ, Bøe SO, Wong LH, Küntziger T, Collas P., Free PMC Article | 03/10/2018 |
| Data indicate that promyelocytic leukemia protein knockout (Pml-/-) animals fail to properly activate oxidative stress-responsive p53 targets, whereas the NRF2 response is amplified and accelerated. | PML is a ROS sensor activating p53 upon oxidative stress.
Niwa-Kawakita M, Ferhi O, Soilihi H, Le Bras M, Lallemand-Breitenbach V, de Thé H., Free PMC Article | 12/9/2017 |
| data support a model in which activation of myogenic differentiation results in PML NB loss, chromatin reorganization and DAXX relocalization, and provides a paradigm for understanding the consequence of PML loss in other cellular contexts, such as during cancer development and progression | Myogenic differentiation triggers PML nuclear body loss and DAXX relocalization to chromocentres.
Salsman J, Rapkin LM, Margam NN, Duncan R, Bazett-Jones DP, Dellaire G., Free PMC Article | 11/25/2017 |
| a regulatory role of ZNF451-1 in fine-tuning physiological PML levels | The SUMO2/3 specific E3 ligase ZNF451-1 regulates PML stability.
Koidl S, Eisenhardt N, Fatouros C, Droescher M, Chaugule VK, Pichler A. | 11/18/2017 |
| PML loss promotes tumor development, providing a growth advantage to tumor cells that use autophagy as a cell survival strategy during stress conditions. | PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development.
Missiroli S, Bonora M, Patergnani S, Poletti F, Perrone M, Gafà R, Magri E, Raimondi A, Lanza G, Tacchetti C, Kroemer G, Pandolfi PP, Pinton P, Giorgi C., Free PMC Article | 11/18/2017 |
| The data demonstrate a dual role of PML in protection and recovery after brain injury. | PML regulates neuroprotective innate immunity and neuroblast commitment in a hypoxic-ischemic encephalopathy model.
Palibrk V, Suganthan R, Scheffler K, Wang W, Bjørås M, Bøe SO., Free PMC Article | 09/30/2017 |
| This study designates PML protein and PML-NBs to be major cellular components involved in the control of Herpes simplex virus 1 (HSV-1) latency, probably during the entire life of an individual. | Latency Entry of Herpes Simplex Virus 1 Is Determined by the Interaction of Its Genome with the Nuclear Environment.
Maroui MA, Callé A, Cohen C, Streichenberger N, Texier P, Takissian J, Rousseau A, Poccardi N, Welsch J, Corpet A, Schaeffer L, Labetoulle M, Lomonte P., Free PMC Article | 09/30/2017 |
| Study found that Promyelocytic leukemia protein (PML) is broadly expressed across the gray matter, with the highest levels in the cerebral and cerebellar cortices. PML bodies are broadly involved in activity-dependent nuclear phenomena in adult neurons | Localization and regulation of PML bodies in the adult mouse brain.
Hall MH, Magalska A, Malinowska M, Ruszczycki B, Czaban I, Patel S, Ambrożek-Latecka M, Zołocińska E, Broszkiewicz H, Parobczak K, Nair RR, Rylski M, Pawlak R, Bramham CR, Wilczyński GM. | 09/23/2017 |
| These findings suggest that the UBC9/PML/RNF4 axis plays a critical role as an important SUMO pathway in cardiac fibrosis. Modulating the protein levels of the pathway provides an attractive therapeutic target for the treatment of cardiac fibrosis and heart failure. | Manipulating PML SUMOylation via Silencing UBC9 and RNF4 Regulates Cardiac Fibrosis.
Liu Y, Zhao D, Qiu F, Zhang LL, Liu SK, Li YY, Liu MT, Wu D, Wang JX, Ding XQ, Liu YX, Dong CJ, Shao XQ, Yang BF, Chu WF., Free PMC Article | 06/10/2017 |
| PML contributes to the intrinsic restriction of HIV-1 infections in a cell type-dependent manner. | TRIM19/PML Restricts HIV Infection in a Cell Type-Dependent Manner.
Kahle T, Volkmann B, Eissmann K, Herrmann A, Schmitt S, Wittmann S, Merkel L, Reuter N, Stamminger T, Gramberg T., Free PMC Article | 10/8/2016 |
| both the PML-RARA-driven competitive transplantation advantage and development of acute promyelocytic leukemia (APL) required DNMT3A | PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.
Cole CB, Verdoni AM, Ketkar S, Leight ER, Russler-Germain DA, Lamprecht TL, Demeter RT, Magrini V, Ley TJ., Free PMC Article | 06/28/2016 |
| PML IV enhances global SUMO-1 conjugation, particularly that of p53, resulting in p53 stabilization and activation. | PML IV/ARF interaction enhances p53 SUMO-1 conjugation, activation, and senescence.
Ivanschitz L, Takahashi Y, Jollivet F, Ayrault O, Le Bras M, de Thé H., Free PMC Article | 02/27/2016 |
| our findings challenge the predominant model in the field and we propose that PML/RARA initiates leukemia by subtly shifting cell fate decisions within the promyelocyte compartment. | Transcription and methylation analyses of preleukemic promyelocytes indicate a dual role for PML/RARA in leukemia initiation.
Gaillard C, Tokuyasu TA, Rosen G, Sotzen J, Vitaliano-Prunier A, Roy R, Passegué E, de Thé H, Figueroa ME, Kogan SC., Free PMC Article | 02/27/2016 |
| DNA-binding-defective PML/RARA mutants could not repress the transcription of retinoic acid regulated genes. | The DNA binding property of PML/RARA but not the integrity of PML nuclear bodies is indispensable for leukemic transformation.
Liu X, Yuan H, Peres L, Chen S, Chen Z, de The H, Zhou J, Zhu J., Free PMC Article | 12/26/2015 |
| A novel antioxidative mechanism by which PML regulates cellular oxidant homeostasis by controlling complex II integrity and Nrf2 activity and identified PML as an indispensable mediator of SFN activity. | Control of antioxidative response by the tumor suppressor protein PML through regulating Nrf2 activity.
Guo S, Cheng X, Lim JH, Liu Y, Kao HY., Free PMC Article | 10/24/2015 |
| pRB can interact with PML specifically during senescence, suggesting that signaling events in senescence regulate assembly of PML and pRB to establish heterochromatin and create a permanent cell cycle arrest. | The retinoblastoma protein and PML collaborate to organize heterochromatin and silence E2F-responsive genes during senescence.
Talluri S, Dick FA. | 04/18/2015 |
| Data suggest that acute promyelocytic leukemia (APL) differentiation is a default program triggered by clearance of promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein PML/RARA-bound promoters. | Clearance of PML/RARA-bound promoters suffice to initiate APL differentiation.
Vitaliano-Prunier A, Halftermeyer J, Ablain J, de Reynies A, Peres L, Le Bras M, Metzger D, de Thé H. | 02/21/2015 |
| Our results add PML/TRIM19 to the growing list of TRIM proteins implicated in both intrinsic and innate immunity. | Implication of PMLIV in both intrinsic and innate immunity.
El Asmi F, Maroui MA, Dutrieux J, Blondel D, Nisole S, Chelbi-Alix MK., Free PMC Article | 10/4/2014 |