| Carbon monoxide enhances calcium transients and glucose-stimulated insulin secretion from pancreatic beta-cells by activating Phospholipase C signal pathway in diabetic mice. | Carbon monoxide enhances calcium transients and glucose-stimulated insulin secretion from pancreatic β-cells by activating Phospholipase C signal pathway in diabetic mice.
Liang S, Zhao J, Wang Q, Yang M, Wang X, Chen S, Chen M, Sun C. | 01/1/2022 |
| PLCdelta1 Plays Central Roles in the Osmotic Activation of DeltaN-TRPV1 Channels in Mouse Supraoptic Neurons and in Murine Osmoregulation. | PLCδ1 Plays Central Roles in the Osmotic Activation of ΔN-TRPV1 Channels in Mouse Supraoptic Neurons and in Murine Osmoregulation.
Park SJ, Haan KD, Nakamura Y, Fukami K, Fisher TE., Free PMC Article | 11/22/2021 |
| Intracellular acidification facilitates receptor-operated TRPC4 activation through PLCdelta1 in a Ca(2+) -dependent manner. | Intracellular acidification facilitates receptor-operated TRPC4 activation through PLCδ1 in a Ca(2+) -dependent manner.
Thakur DP, Wang Q, Jeon J, Tian JB, Zhu MX., Free PMC Article | 02/20/2021 |
| PLCD1-modified mice (F0) showed progressive hair loss after birth and the genotype of CRISPR/Cas9-induced mutations in exon 2 of PLCD1 locus, suggesting the guide RNA is effective to cause mutations that lead to hair growth defect. | Abnormalities of hair structure and skin histology derived from CRISPR/Cas9-based knockout of phospholipase C-delta 1 in mice.
Liu YM, Liu W, Jia JS, Chen BZ, Chen HW, Liu Y, Bie YN, Gu P, Sun Y, Xiao D, Gu WW., Free PMC Article | 06/15/2019 |
| Results show that de novo polarisation of the embryo at the 8-cell stage is directed by phospholipase C (PLC) and protein kinase C (PKC). | Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo.
Zhu M, Leung CY, Shahbazi MN, Zernicka-Goetz M., Free PMC Article | 03/10/2018 |
| PLCd1 negatively regulates lipopolysaccharide-induced production of IL-1b and Fc gamma receptor-mediated phagocytosis in macrophages. | Phospholipase C δ1 in macrophages negatively regulates TLR4-induced proinflammatory cytokine production and Fcγ receptor-mediated phagocytosis.
Kudo K, Uchida T, Sawada M, Nakamura Y, Yoneda A, Fukami K. | 11/18/2017 |
| Data show that phospholipase C delta1 (PLCD1) transfection can induce the apoptosis of CAPAN-1 and BXPC-3 pancreatic cancer cells, arrest the cell cycle in G0 /G1 phase. | [Phospholipase C δ1 (PLCD1) inhibits the proliferation, invasion and migration of CAPAN-1 and BXPC-3 pancreatic cancer cells].
Hu D, Jiang Z. | 01/14/2017 |
| the Ca(2+) dependence of the interaction between PRIP-C2 and Syt1-C2A was attributed to Ca(2+) binding with Syt1-C2A, but not PRIP-C2, using a series of mutants prepared from both C2 domains. | Hetero-oligomerization of C2 domains of phospholipase C-related but catalytically inactive protein and synaptotagmin-1.
Wang D, Takeuchi H, Gao J, Zhang Z, Hirata M. | 09/26/2015 |
| Results indicate that PLCdelta1 and PLCdelta3 are required for cardiomyocyte survival and normal cardiac function. | Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy.
Nakamura Y, Kanemaru K, Kojima R, Hashimoto Y, Marunouchi T, Oka N, Ogura T, Tanonaka K, Fukami K., Free PMC Article | 10/25/2014 |
| Expression of PLCdelta1 is increased in ALS mouse spinal cord and in neurons from ALS mice. Genetic ablation of this protein in ALS mice significantly increases survival | Genetic ablation of phospholipase C delta 1 increases survival in SOD1(G93A) mice.
Staats KA, Van Helleputte L, Jones AR, Bento-Abreu A, Van Hoecke A, Shatunov A, Simpson CL, Lemmens R, Jaspers T, Fukami K, Nakamura Y, Brown RH Jr, Van Damme P, Liston A, Robberecht W, Al-Chalabi A, Van Den Bosch L. | 06/21/2014 |
| Identification, characterization and regulatory properties of a novel PLCD1 isoform in mouse. | PLC-δ1-Lf, a novel N-terminal extended phospholipase C-δ1.
Kim NY, Ahn SJ, Kim MS, Seo JS, Kim BS, Bak HJ, Lee JY, Park MA, Park JH, Lee HH, Chung JK. | 11/16/2013 |
| Plcd1 and Plcd3 have synergistic effects on the murine hair follicle in specific regions of the body surface. | Alopecia in a viable phospholipase C delta 1 and phospholipase C delta 3 double mutant.
Runkel F, Hintze M, Griesing S, Michels M, Blanck B, Fukami K, Guénet JL, Franz T., Free PMC Article | 12/22/2012 |
| Loss of phospholipase Cdelta1 from keratinocytes causes features of interleukin-17-associated inflammatory skin diseases. | Epidermal phospholipase Cδ1 regulates granulocyte counts and systemic interleukin-17 levels in mice.
Kanemaru K, Nakamura Y, Sato K, Kojima R, Takahashi S, Yamaguchi M, Ichinohe M, Kiyonari H, Shioi G, Kabashima K, Nakahigashi K, Asagiri M, Jamora C, Yamaguchi H, Fukami K. | 11/3/2012 |
| PLCdelta1 has essential roles in thermogenesis and adipogenesis and thereby contributes to the development of obesity. | Genetic defect in phospholipase Cδ1 protects mice from obesity by regulating thermogenesis and adipogenesis.
Hirata M, Suzuki M, Ishii R, Satow R, Uchida T, Kitazumi T, Sasaki T, Kitamura T, Yamaguchi H, Nakamura Y, Fukami K., Free PMC Article | 09/3/2011 |
| PLCd1 is essential for normal hair formation, and PLCd1 KO mice displayed symptoms of skin inflammation. PLCdelta 1 KO mice possess skin phenotype similar to nude mice. | Physiological functions of phospholipase C delta-type.
Fukami K, Ichinohe M, Hirata M, Nakamura Y. | 01/21/2010 |
| These results indicate that PLC-delta1 is an essential molecule downstream of Foxn1 in normal hair formation, and strongly suggest that hairlessness in nude mice is caused by insufficient expression of PLC-delta1. | Phospholipase C-delta1 is an essential molecule downstream of Foxn1, the gene responsible for the nude mutation, in normal hair development.
Nakamura Y, Ichinohe M, Hirata M, Matsuura H, Fujiwara T, Igarashi T, Nakahara M, Yamaguchi H, Yasugi S, Takenawa T, Fukami K. | 01/21/2010 |
| PLCdelta(1) and PLCdelta(4) are probably differentially regulated in distinct cellular compartments by PI(4,5)P(2) | The pleckstrin homology domain of phosphoinositide-specific phospholipase Cdelta4 is not a critical determinant of the membrane localization of the enzyme.
Lee SB, Várnai P, Balla A, Jalink K, Rhee SG, Balla T. | 01/21/2010 |
| Results suggest that phospholipase C delta(1) is required for skin stem cell lineage commitment. | Phospholipase Cdelta1 is required for skin stem cell lineage commitment.
Nakamura Y, Fukami K, Yu H, Takenaka K, Kataoka Y, Shirakata Y, Nishikawa S, Hashimoto K, Yoshida N, Takenawa T., Free PMC Article | 01/21/2010 |
| Nuclear translocation of phospholipase C-delta1 is linked to the cell cycle and nuclear phosphatidylinositol 4,5-bisphosphate | Nuclear translocation of phospholipase C-delta1 is linked to the cell cycle and nuclear phosphatidylinositol 4,5-bisphosphate.
Stallings JD, Tall EG, Pentyala S, Rebecchi MJ. | 01/21/2010 |
| the PLC-delta1 promoter is under the control of NF-kappaB, which mediates the expression of PLC-delta due to Abeta42 | Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site.
Kim JY, Kim H, Lee SG, Choi BH, Kim YH, Huh PW, Lee KH, Han H, Rha HK. | 01/21/2010 |
| Data indicate that receptor-triggered phospholipase C activity is enhanced by positive feedback from Ca2+ entering the cytoplasm from intracellular stores and via store-operated channels in the plasma membrane. | Feedback activation of phospholipase C via intracellular mobilization and store-operated influx of Ca2+ in insulin-secreting beta-cells.
Thore S, Dyachok O, Gylfe E, Tengholm A. | 01/21/2010 |
| PLCdelta1 and PLCdelta3 are essential in trophoblasts for placental development. | Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development.
Nakamura Y, Hamada Y, Fujiwara T, Enomoto H, Hiroe T, Tanaka S, Nose M, Nakahara M, Yoshida N, Takenawa T, Fukami K., Free PMC Article | 01/21/2010 |
| Taken together, these results indicate that lack of PLC-delta1 induces skin inflammation and that the epidermal hyperplasia in PLC-delta1 KO mice is caused by skin inflammation. | Lack of phospholipase C-delta1 induces skin inflammation.
Ichinohe M, Nakamura Y, Sai K, Nakahara M, Yamaguchi H, Fukami K. | 01/21/2010 |