| Transcription factor E4F1 as a regulator of cell life and disease progression. | Transcription factor E4F1 as a regulator of cell life and disease progression.
Sun S, Zhong B, Zeng X, Li J, Chen Q., Free PMC Article | 10/5/2023 |
| Multi-Level Control of the ATM/ATR-CHK1 Axis by the Transcription Factor E4F1 in Triple-Negative Breast Cancer. | Multi-Level Control of the ATM/ATR-CHK1 Axis by the Transcription Factor E4F1 in Triple-Negative Breast Cancer.
Batnini K, Houles T, Kirsh O, Du Manoir S, Zaroual M, Delpech H, Fallet C, Lacroix M, Le Cam L, Theillet C, Sardet C, Rodier G., Free PMC Article | 09/3/2022 |
| The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes. | The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes.
Lacroix M, Linares LK, Rueda-Rincon N, Bloch K, Di Michele M, De Blasio C, Fau C, Gayte L, Blanchet E, Mairal A, Derua R, Cardona F, Beuzelin D, Annicotte JS, Pirot N, Torro A, Tinahones FJ, Bernex F, Bertrand-Michel J, Langin D, Fajas L, Swinnen JV, Le Cam L., Free PMC Article | 01/8/2022 |
| Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair. | Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair.
Moison C, Chagraoui J, Caron MC, Gagné JP, Coulombe Y, Poirier GG, Masson JY, Sauvageau G., Free PMC Article | 09/11/2021 |
| E4F1 silencing inhibits the cell growth through cell-cycle arrest in malignant transformed cells induced by hydroquinone | E4F1 silencing inhibits the cell growth through cell-cycle arrest in malignant transformed cells induced by hydroquinone.
Tan Q, Li J, Peng J, Liu Z, Liu J, Zhang H, Yuan Q, Pan Z, Liu L. | 06/8/2019 |
| Whole exome sequencing has unraveled the presence of pathogenic mutations in genes encoding non-mitochondrial proteins, such as in the transcription factor E4F1. | New genes and pathomechanisms in mitochondrial disorders unraveled by NGS technologies.
Legati A, Reyes A, Nasca A, Invernizzi F, Lamantea E, Tiranti V, Garavaglia B, Lamperti C, Ardissone A, Moroni I, Robinson A, Ghezzi D, Zeviani M. | 08/20/2016 |
| results suggest that E4F1 may neutralize the capacity of HBx to activate a p53-dependent, metabolic and growth arrest phenotype in liver cells, thus possibly contributing to the viability and proliferation of HBV-infected cells | Downregulation of transcription factor E4F1 in hepatocarcinoma cells: HBV-dependent effects on autophagy, proliferation and metabolism.
Dai Y, Cros MP, Pontoizeau C, Elena-Hermann B, Bonn GK, Hainaut P. | 05/17/2014 |
| Short hairpin RNA-mediated depletion of E4F1 induced mitochondrial defects and ROS-mediated death in several myeloid leukemia cell lines. | E4F1 deficiency results in oxidative stress-mediated cell death of leukemic cells.
Hatchi E, Rodier G, Lacroix M, Caramel J, Kirsh O, Jacquet C, Schrepfer E, Lagarrigue S, Linares LK, Lledo G, Tondeur S, Dubus P, Sardet C, Le Cam L., Free PMC Article | 09/10/2011 |
| LANP and ATAXN1 interact in E4F-mediated transcriptional repression. | The role of LANP and ataxin 1 in E4F-mediated transcriptional repression.
Cvetanovic M, Rooney RJ, Garcia JJ, Toporovskaya N, Zoghbi HY, Opal P., Free PMC Article | 01/21/2010 |
| Specific inactivation of RASSF1A by short interfering RNA disrupts binding of RASSF1A to p120(E4F) in tumor cells. | Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene.
Fenton SL, Dallol A, Agathanggelou A, Hesson L, Ahmed-Choudhury J, Baksh S, Sardet C, Dammann R, Minna JD, Downward J, Maher ER, Latif F. | 01/21/2010 |
| E4F1 function involves ER alpha-mediated inhibition of VSMC proliferation and estrogen-related atheroprotection of human | E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis.
Nakamura Y, Igarashi K, Suzuki T, Kanno J, Inoue T, Tazawa C, Saruta M, Ando T, Moriyama N, Furukawa T, Ono M, Moriya T, Ito K, Saito H, Ishibashi T, Takahashi S, Yamada S, Sasano H., Free PMC Article | 01/21/2010 |
| E4F1 is a key posttranslational regulator of p53, which modulates its effector functions involved in alternative cell fates: growth arrest or apoptosis. | E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation.
Le Cam L, Linares LK, Paul C, Julien E, Lacroix M, Hatchi E, Triboulet R, Bossis G, Shmueli A, Rodriguez MS, Coux O, Sardet C. | 01/21/2010 |
| association of p120E4F with p14ARF enhances cell cycle inhibition | Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition.
Rizos H, Diefenbach E, Badhwar P, Woodruff S, Becker TM, Rooney RJ, Kefford RF. | 01/21/2010 |
| findings show that full-length E4F1 protein but not its E1A-activated & truncated form interacts in vitro & in vivo with FHL2; this E4F1-FHL2 association occurs in the nuclear compartment & inhibits the capacity of E4F1 to block cell proliferation | The LIM-only protein FHL2 is a negative regulator of E4F1.
Paul C, Lacroix M, Iankova I, Julien E, Schäfer BW, Labalette C, Wei Y, Le Cam A, Le Cam L, Sardet C. | 01/21/2010 |