| Effect of deletion of the protein kinase PRKD1 on development of the mouse embryonic heart. | Effect of deletion of the protein kinase PRKD1 on development of the mouse embryonic heart.
Waheed-Ullah Q, Wilsdon A, Abbad A, Rochette S, Bu'Lock F, Hitz MP, Dombrowsky G, Cuello F, Brook JD, Loughna S., Free PMC Article | 06/18/2024 |
| Protein Kinase D Plays a Crucial Role in Maintaining Cardiac Homeostasis by Regulating Post-Translational Modifications of Myofilament Proteins. | Protein Kinase D Plays a Crucial Role in Maintaining Cardiac Homeostasis by Regulating Post-Translational Modifications of Myofilament Proteins.
Herwig M, Begovic M, Budde H, Delalat S, Zhazykbayeva S, Sieme M, Schneider L, Jaquet K, Mügge A, Akin I, El-Battrawy I, Fielitz J, Hamdani N., Free PMC Article | 03/14/2024 |
| Cardiac Protein Kinase D1 ablation alters the myocytes beta-adrenergic response. | Cardiac Protein Kinase D1 ablation alters the myocytes β-adrenergic response.
Mira Hernandez J, Ko CY, Mandel AR, Shen EY, Baidar S, Christensen AR, Hellgren K, Morotti S, Martin JL, Hegyi B, Bossuyt J, Bers DM., Free PMC Article | 06/15/2023 |
| IL-33 via PKCmu/PRKD1 Mediated alpha-Catenin Phosphorylation Regulates Endothelial Cell-Barrier Integrity and Ischemia-Induced Vascular Leakage. | IL-33 via PKCμ/PRKD1 Mediated α-Catenin Phosphorylation Regulates Endothelial Cell-Barrier Integrity and Ischemia-Induced Vascular Leakage.
Sharma D, Kaur G, Bisen S, Sharma A, Ibrahim AS, Singh NK., Free PMC Article | 03/14/2023 |
| Protein kinase D1 (Prkd1) deletion in brown adipose tissue leads to altered myogenic gene expression after cold exposure, while thermogenesis remains intact. | Protein kinase D1 (Prkd1) deletion in brown adipose tissue leads to altered myogenic gene expression after cold exposure, while thermogenesis remains intact.
Crowder MK, Shrestha S, Cartailler JP, Collins S., Free PMC Article | 02/28/2023 |
| Protein Kinase D1 Regulates Cardiac Hypertrophy, Potassium Channel Remodeling, and Arrhythmias in Heart Failure. | Protein Kinase D1 Regulates Cardiac Hypertrophy, Potassium Channel Remodeling, and Arrhythmias in Heart Failure.
Bossuyt J, Borst JM, Verberckmoes M, Bailey LRJ, Bers DM, Hegyi B., Free PMC Article | 10/15/2022 |
| Protein kinase D1 variant associated with human epilepsy and peripheral nerve hypermyelination. | Protein kinase D1 variant associated with human epilepsy and peripheral nerve hypermyelination.
Omer S, Jin SC, Koumangoye R, Robert SM, Duran D, Nelson-Williams C, Huttner A, DiLuna M, Kahle KT, Delpire E. | 01/1/2022 |
| The L1 cell adhesion molecule affects protein kinase D1 activity in the cerebral cortex in a mouse model of Alzheimer's disease. | The L1 cell adhesion molecule affects protein kinase D1 activity in the cerebral cortex in a mouse model of Alzheimer's disease.
Chen S, Jiang Q, Huang P, Hu C, Shen H, Schachner M, Zhao W. | 10/2/2021 |
| Adipose-specific knockout of Protein Kinase D1 suppresses de novo lipogenesis in mice via SREBP1c-dependent signaling. | Adipose-specific knockout of Protein Kinase D1 suppresses de novo lipogenesis in mice via SREBP1c-dependent signaling.
Li G, Xing Z, Wang W, Luo W, Ma Z, Wu Z, Chen H, Li Y, Wang C, Zeng F, Deng F. | 09/11/2021 |
| Loss of protein kinase D activity demonstrates redundancy in cardiac glucose metabolism and preserves cardiac function in obesity. | Loss of protein kinase D activity demonstrates redundancy in cardiac glucose metabolism and preserves cardiac function in obesity.
De Jong KA, Hall LG, Renton MC, Connor T, Martin SD, Kowalski GM, Shaw CS, Bruce CR, Howlett KF, McGee SL., Free PMC Article | 09/11/2021 |
| PKD1 mediates the PKC effects on KV11.1 and we found that PKD targets S284 in the N-terminus of the channel. | PKD Phosphorylation as Novel Pathway of KV11.1 Regulation.
Steffensen AB, Bomholtz SH, Andersen MN, Olsen JV, Mutsaers N, Lundegaard PR, Lundby A, Schmitt N. | 08/10/2021 |
| PAK-mediated phosphorylation of PKD1 at Ser203 triggers its membrane dissociation and subsequent entry into the nucleus, thereby regulating the phosphorylation of PKD1 nuclear targets, including class IIa histone deacetylases. | Protein kinase D1 (PKD1) phosphorylation on Ser(203) by type I p21-activated kinase (PAK) regulates PKD1 localization.
Chang JK, Ni Y, Han L, Sinnett-Smith J, Jacamo R, Rey O, Young SH, Rozengurt E., Free PMC Article | 08/10/2021 |
| Protein Kinase D1 (PKD1) Signaling Induces Growth-Promoting Effects in Murine Enteroids. | Protein Kinase D1 (PKD1) Signaling Induces Growth-Promoting Effects in Murine Enteroids.
Shimizu Y, Sinnett-Smith J, Tenggara M, Martin MG, Rozengurt E., Free PMC Article | 07/10/2021 |
| Inhibition of protein kinase D by CID755673 promotes maintenance of the pluripotency of embryonic stem cells. | Inhibition of protein kinase D by CID755673 promotes maintenance of the pluripotency of embryonic stem cells.
Zhu Z, Zhang Y, Wang X, Wang X, Ye SD. | 03/27/2021 |
| A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets. | A role for PKD1 in insulin secretion downstream of P2Y(1) receptor activation in mouse and human islets.
Khan S, Ferdaoussi M, Bautista A, Bergeron V, Smith N, Poitout V, MacDonald PE., Free PMC Article | 09/5/2020 |
| Prkd1 knockdown was enough to block dissemination of murine mammary tumor organoids. Prkd1 knockdown in vivo blocked primary tumor invasion and distant metastasis in a mouse model of basal breast cancer. Findings suggest a novel molecular framework whereby Twist1 directly drives the transcriptional upregulation of Prkd1, whose activity promotes ECM-directed invasion, and metastasis without loss of epithelial identity. | Twist1-Induced Epithelial Dissemination Requires Prkd1 Signaling.
Georgess D, Padmanaban V, Sirka OK, Coutinho K, Choi A, Frid G, Neumann NM, Inoue T, Ewald AJ., Free PMC Article | 06/20/2020 |
| PKC mu is one key factor for oocyte maturation through its roles on the spindle organization and actin filament distribution. | Loss of PKC mu function induces cytoskeletal defects in mouse oocyte meiosis.
Zhang Y, Wu LL, Wan X, Wang HH, Li XH, Pan ZN, Sun SC. | 05/30/2020 |
| deletion of PKD1 promotes expression of the beta3-adrenergic receptor (ADRB3) in a CCAAT/enhancer binding protein (C/EBP)-alpha- and delta-dependent manner, which leads to the elevated expression of beige markers in adipocytes and subcutaneous adipose tissue. | Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity.
Löffler MC, Mayer AE, Trujillo Viera J, Loza Valdes A, El-Merahbi R, Ade CP, Karwen T, Schmitz W, Slotta A, Erk M, Janaki-Raman S, Matesanz N, Torres JL, Marcos M, Sabio G, Eilers M, Schulze A, Sumara G., Free PMC Article | 10/5/2019 |
| These results suggest the potential importance of PRKD1 in response to estrogen loss in bone. | Protein kinase D1 conditional null mice show minimal bone loss following ovariectomy.
Bollag WB, Ding KH, Choudhary V, Xu J, Zhong Q, Elsayed R, Bailey LJ, Elsalanty M, Yu K, Johnson MH, McGee-Lawrence ME, Isales CM., Free PMC Article | 05/11/2019 |
| these results suggest a potentially important role for PRKD1 in bone formation. | Deletion of protein kinase D1 in osteoprogenitor cells results in decreased osteogenesis in vitro and reduced bone mineral density in vivo.
Bollag WB, Choudhary V, Zhong Q, Ding KH, Xu J, Elsayed R, Yu K, Su Y, Bailey LJ, Shi XM, Elsalanty M, Johnson MH, McGee-Lawrence ME, Isales CM., Free PMC Article | 02/16/2019 |
| The study demonstrates an essential role for PKD1 in the beta-cell adaptive secretory response to high-fat feeding in mice. | Deletion of Protein Kinase D1 in Pancreatic β-Cells Impairs Insulin Secretion in High-Fat Diet-Fed Mice.
Bergeron V, Ghislain J, Vivot K, Tamarina N, Philipson LH, Fielitz J, Poitout V., Free PMC Article | 01/13/2018 |
| These findings imply that PKD1 plays a critical regulatory role in Group B streptococci (GBS)-induced proinflammatory reactions and sepsis, and inhibition of PKD1 activation together with antibiotic treatment in GBS-infected neonates could be an effective way to control GBS diseases. | Group B Streptococci Induce Proinflammatory Responses via a Protein Kinase D1-Dependent Pathway.
Upadhyay K, Park JE, Yoon TW, Halder P, Kim YI, Metcalfe V, Talati AJ, English BK, Yi AK., Free PMC Article | 09/23/2017 |
| Lysophosphatidic acid/PKD-1 signaling leads to nuclear accumulation of histone deacetylase 7, where it interacts with forkhead box protein O1 to suppress endothelial CD36 transcription and mediates silencing of antiangiogenic switch, resulting in proangiogenic and proarteriogenic reprogramming. | LPA/PKD-1-FoxO1 Signaling Axis Mediates Endothelial Cell CD36 Transcriptional Repression and Proangiogenic and Proarteriogenic Reprogramming.
Ren B, Best B, Ramakrishnan DP, Walcott BP, Storz P, Silverstein RL., Free PMC Article | 06/24/2017 |
| Our studies demonstrate that PKD1/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha effect on MVB secretory traffic. | Protein kinase D1/2 is involved in the maturation of multivesicular bodies and secretion of exosomes in T and B lymphocytes.
Mazzeo C, Calvo V, Alonso R, Mérida I, Izquierdo M., Free PMC Article | 09/10/2016 |
| Our results show that AKAP13-PKD1 signaling is critical for transcriptional regulation of key contractile, cell death, and metabolic pathways during the development of compensatory hypertrophy in vivo. | Genome-Wide Gene Expression Analysis Shows AKAP13-Mediated PKD1 Signaling Regulates the Transcriptional Response to Cardiac Hypertrophy.
Johnson KR, Nicodemus-Johnson J, Spindler MJ, Carnegie GK., Free PMC Article | 04/23/2016 |