| PIM2 Promotes the Development of Ovarian Endometriosis by Enhancing Glycolysis and Fibrosis. | PIM2 Promotes the Development of Ovarian Endometriosis by Enhancing Glycolysis and Fibrosis.
Wang M, Fan R, Jiang J, Sun F, Sun Y, Wang Q, Jiang A, Yu Z, Yang T. | 09/8/2023 |
| An XBP1s-PIM-2 positive feedback loop controls IL-15-mediated survival of natural killer cells. | An XBP1s-PIM-2 positive feedback loop controls IL-15-mediated survival of natural killer cells.
Ma S, Han J, Li Z, Xiao S, Zhang J, Yan J, Tang T, Barr T, Kraft AS, Caligiuri MA, Yu J., Free PMC Article | 03/21/2023 |
| Pim-2 regulates bone resorptive activity of osteoclasts via V-ATPase a3 isoform expression in periodontal disease. | Pim-2 regulates bone resorptive activity of osteoclasts via V-ATPase a3 isoform expression in periodontal disease.
Heo SC, You JC, Jung S, Kim YN, Shin SH, Lee JY, Kim HJ. | 08/20/2022 |
| PIM2-mediated phosphorylation contributes to granulosa cell survival via resisting apoptosis during folliculogenesis. | PIM2-mediated phosphorylation contributes to granulosa cell survival via resisting apoptosis during folliculogenesis.
Wang L, Chen Y, Wu S, Wang L, Tan F, Li F., Free PMC Article | 01/15/2022 |
| PIM2 deletion alleviates lipopolysaccharide (LPS)-induced respiratory distress syndrome (ARDS) by suppressing NLRP3 inflammasome. | PIM2 deletion alleviates lipopolysaccharide (LPS)-induced respiratory distress syndrome (ARDS) by suppressing NLRP3 inflammasome.
Wang F, Xu L, Dong G, Zhu M, Liu L, Wang B. | 03/28/2021 |
| TRAF3 regulates the oncogenic proteins Pim2 and c-Myc to restrain survival in normal and malignant B cells. | TRAF3 regulates the oncogenic proteins Pim2 and c-Myc to restrain survival in normal and malignant B cells.
Whillock AL, Mambetsariev N, Lin WW, Stunz LL, Bishop GA., Free PMC Article | 11/21/2020 |
| T cells deficient in PIM-2 demonstrated increased T cell differentiation toward Th1 subset, proliferation, and migration to target organs after allogeneic bone marrow transplantation, resulting in dramatically accelerated graft-versus-host disease (GVHD) severity. Restoration of PIM-2 expression markedly attenuated the pathogenicity of PIM-2-deficient T cells to induce GVHD. | PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity.
Daenthanasanmak A, Wu Y, Iamsawat S, Nguyen HD, Bastian D, Zhang M, Sofi MH, Chatterjee S, Hill EG, Mehrotra S, Kraft AS, Yu XZ., Free PMC Article | 09/21/2019 |
| PIM2 might function as an important oncogene in gastric cancer | Proviral insertion in murine lymphomas 2 promotes stomach cancer progression by regulating apoptosis via reactive oxygen species-triggered endoplasmic reticulum stress.
Xin H, Deng Y, Cao J. | 05/25/2019 |
| studies define a pathway for limiting the regulation of Foxp3 function because the Pim-2 kinase represents a potential therapeutic target for modulating the Treg cell suppressive activities in controlling immune responses | Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation.
Deng G, Nagai Y, Xiao Y, Li Z, Dai S, Ohtani T, Banham A, Li B, Wu SL, Hancock W, Samanta A, Zhang H, Greene MI., Free PMC Article | 12/12/2015 |
| Pim2 facilitated allograft rejection primarily by modulating the apoptosis of effector T cells and the function of regulatory T cells. | Inhibition of Pim2-prolonged skin allograft survival through the apoptosis regulation pathway.
Liu H, Zhang C, Liang T, Song J, Hao J, Hou G., Free PMC Article | 08/3/2013 |
| Loss of PIM2 is associated with abnormal hematopoietic phenotypes. | Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice.
An N, Kraft AS, Kang Y., Free PMC Article | 07/27/2013 |
| signals from IL-7 and RAG DSBs activate distinct Pim kinase family members that have context-dependent activities in regulating pre-B cell proliferation and survival. | RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation.
Bednarski JJ, Nickless A, Bhattacharya D, Amin RH, Schlissel MS, Sleckman BP., Free PMC Article | 04/14/2012 |
| Targeting cap-dependent translation blocks converging survival signals by AKT and PIM 1, 2 kinases in lymphoma | Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma.
Schatz JH, Oricchio E, Wolfe AL, Jiang M, Linkov I, Maragulia J, Shi W, Zhang Z, Rajasekhar VK, Pagano NC, Porco JA Jr, Teruya-Feldstein J, Rosen N, Zelenetz AD, Pelletier J, Wendel HG., Free PMC Article | 10/29/2011 |
| PIM2 controls the expression of the pro-inflammatory cytokine IL-6. | Proviral integration site 2 is required for interleukin-6 expression induced by interleukin-1, tumour necrosis factor-α and lipopolysaccharide.
Yang J, Li X, Hanidu A, Htut TM, Sellati R, Wang L, Jiang H, Li J., Free PMC Article | 01/15/2011 |
| results support the hypothesis that Pim2, which is also a known target of Flt3-ITD (another gene that cooperates with PML-RARalpha), cooperates with PRalpha to induce acute promyelocytic leukemia-like disease | Pim2 cooperates with PML-RARalpha to induce acute myeloid leukemia in a bone marrow transplantation model.
Agrawal-Singh S, Koschmieder S, Gelsing S, Stocking C, Stehling M, Thiede C, Thoennissen NH, Köhler G, Valk PJ, Delwel R, Mills K, Bäumer N, Tickenbrock L, Hansen K, Berdel WE, Müller-Tidow C, Serve H. | 06/28/2010 |
| PIM2 triggered significant p65 nuclear factor -kappaB (NF-kappaB) nuclear translocation that was dependent on activation of PI3K or Notch1 signaling | PIM2 Induced COX-2 and MMP-9 expression in macrophages requires PI3K and Notch1 signaling.
Bansal K, Kapoor N, Narayana Y, Puzo G, Gilleron M, Balaji KN., Free PMC Article | 01/21/2010 |
| through stabilizing c-Myc, Pim-1/Pim-2 kinases enhance the transcriptional activity of c-Myc. Also knocking down either Pim-1 or Pim-2 dramatically decreases the endogenous levels of c-Myc and thus, its transcriptional activity | Pim kinase-dependent inhibition of c-Myc degradation.
Zhang Y, Wang Z, Li X, Magnuson NS. | 01/21/2010 |
| expression of the Myc and Pim proto-oncogenes by Jak2V617F was found to be FERM domain dependent. | The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes.
Wernig G, Gonneville JR, Crowley BJ, Rodrigues MS, Reddy MM, Hudon HE, Walz C, Reiter A, Podar K, Royer Y, Constantinescu SN, Tomasson MH, Griffin JD, Gilliland DG, Sattler M., Free PMC Article | 01/21/2010 |
| Pim kinases play a key role in the v-Abl transformation, possibly via participating in modulation of SOCS-1 and via regulating the apoptotic signaling | Pim-1 and Pim-2 kinases are required for efficient pre-B-cell transformation by v-Abl oncogene.
Chen JL, Limnander A, Rothman PB. | 01/21/2010 |
| BLyS stimulation activates 2 independent signaling pathways, Akt/mTOR and Pim 2, associated with cell growth and survival. | Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival.
Woodland RT, Fox CJ, Schmidt MR, Hammerman PS, Opferman JT, Korsmeyer SJ, Hilbert DM, Thompson CB., Free PMC Article | 01/21/2010 |
| Overexpression of Pim2 together with Flt3-Wt or D835Y receptor is associated with neoplastic transformation | Pim2 complements Flt3 wild-type receptor in hematopoietic progenitor cell transformation.
Agrawal S, Koschmieder S, Bäumer N, Reddy NG, Berdel WE, Müller-Tidow C, Serve H. | 01/21/2010 |
| PIM-2 regulates a new intermediate stage in the differentiation pathway, the induction of autophagy. | PIM-2 is an independent regulator of chondrocyte survival and autophagy in the epiphyseal growth plate.
Bohensky J, Shapiro IM, Leshinsky S, Watanabe H, Srinivas V. | 01/21/2010 |
| Pim-2 is a direct link between growth factor-induced transcription and a novel, kinase-dependent pathway that promotes cell-autonomous survival | The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor.
Fox CJ, Hammerman PS, Cinalli RM, Master SR, Chodosh LA, Thompson CB., Free PMC Article | 01/21/2010 |
| Pim-2 and Akt-1 are critical components of overlapping but independent pathways, either of which is sufficient to promote the growth and survival of nontransformed hematopoietic cells | Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival.
Hammerman PS, Fox CJ, Birnbaum MJ, Thompson CB., Free PMC Article | 01/21/2010 |
| pim-2 functions similarly to pim-1 as a pro-survival kinase; BAD is a legitimate PIM-2 substrate | The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death.
Yan B, Zemskova M, Holder S, Chin V, Kraft A, Koskinen PJ, Lilly M. | 01/21/2010 |