| NUP98-BPTF promotes oncogenic transformation through PIM1 upregulation. | NUP98-BPTF promotes oncogenic transformation through PIM1 upregulation.
Noura M, Tomita S, Yasuda T, Tsuzuki S, Kiyoi H, Hayakawa F., Free PMC Article | 07/3/2024 |
| PIM1 alleviated liver oxidative stress and NAFLD by regulating the NRF2/HO-1/NQO1 pathway. | PIM1 alleviated liver oxidative stress and NAFLD by regulating the NRF2/HO-1/NQO1 pathway.
Yang K, Yu X, Guo Z, Fang Z, Zhang H, Zhang W, Liu C, Ji Y, Dong Z, Gu Q, Yao J, Liu C. | 06/10/2024 |
| Mesenchymal stem cells attenuate systemic lupus erythematosus by inhibiting NLRP3 inflammasome activation through Pim-1 kinase. | Mesenchymal stem cells attenuate systemic lupus erythematosus by inhibiting NLRP3 inflammasome activation through Pim-1 kinase.
Yu H, Li Q, Zhu H, Liu C, Chen W, Sun L. | 01/4/2024 |
| PIM1 attenuates cisplatin-induced AKI by inhibiting Drp1 activation. | PIM1 attenuates cisplatin-induced AKI by inhibiting Drp1 activation.
Li Y, Shi L, Zhao F, Luo Y, Zhang M, Wu X, Zhu J. | 12/6/2023 |
| Pim1 promotes IFN-beta production by interacting with IRF3. | Pim1 promotes IFN-β production by interacting with IRF3.
Ko R, Seo J, Park H, Lee N, Lee SY., Free PMC Article | 12/17/2022 |
| Genetic ablation of Pim1 or pharmacologic inhibition with TP-3654 ameliorates myelofibrosis in murine models. | Genetic ablation of Pim1 or pharmacologic inhibition with TP-3654 ameliorates myelofibrosis in murine models.
Dutta A, Nath D, Yang Y, Le BT, Rahman MF, Faughnan P, Wang Z, Stuver M, He R, Tan W, Hutchison RE, Foulks JM, Warner SL, Zang C, Mohi G., Free PMC Article | 03/12/2022 |
| PIM1 accelerates prostate cancer cell motility by phosphorylating actin capping proteins. | PIM1 accelerates prostate cancer cell motility by phosphorylating actin capping proteins.
Santio NM, Vainio V, Hoikkala T, Mung KL, Lång M, Vahakoski R, Zdrojewska J, Coffey ET, Kremneva E, Rainio EM, Koskinen PJ., Free PMC Article | 08/14/2021 |
| MiR-195 suppression alleviates apoptosis and oxidative stress in CCl4-induced ALI in mice by targeting Pim-1. | MiR-195 suppression alleviates apoptosis and oxidative stress in CCl4-induced ALI in mice by targeting Pim-1.
Yang K, Zou Z, Wu Y, Hu G. | 10/31/2020 |
| Inhibition of PIM1 kinase attenuates bleomycin-induced pulmonary fibrosis in mice by modulating the ZEB1/E-cadherin pathway in alveolar epithelial cells. | Inhibition of PIM1 kinase attenuates bleomycin-induced pulmonary fibrosis in mice by modulating the ZEB1/E-cadherin pathway in alveolar epithelial cells.
Zhang X, Zou Y, Liu Y, Cao Y, Zhu J, Zhang J, Chen X, Zhang R, Li J. | 10/10/2020 |
| The role of dorsal root ganglia PIM1 in peripheral nerve injury-induced neuropathic pain. | The role of dorsal root ganglia PIM1 in peripheral nerve injury-induced neuropathic pain.
Zou Y, Cao Y, Liu Y, Zhang X, Li J, Xiong Y. | 09/26/2020 |
| Pim1 kinase positively regulates myoblast behaviors and skeletal muscle regeneration. | Pim1 kinase positively regulates myoblast behaviors and skeletal muscle regeneration.
Liu Y, Shang Y, Yan Z, Li H, Wang Z, Liu Z, Li Z., Free PMC Article | 08/29/2020 |
| Pim-1 is a novel kinase that phosphorylates cTnI primarily at Ser23/24 and Ser150 in cardiomyocytes, which in turn may modulate myofilament function under a variety of physiological and pathophysiological conditions. | Pim-1 Kinase Phosphorylates Cardiac Troponin I and Regulates Cardiac Myofilament Function.
Zhu N, Yi B, Guo Z, Zhang G, Huang S, Qin Y, Zhao X, Sun J. | 06/23/2018 |
| this study shows that Pim-1 dysregulation has developmental-stage-specific effects on B lymphopoiesis and early myeloid, but not erythroid progenitors | Developmental stage-specific effects of Pim-1 dysregulation on murine bone marrow B cell development.
Xu Z, Gwin KA, Li Y, Medina KL., Free PMC Article | 10/14/2017 |
| Results show that elevated miR-15b as an early response to Dicer depletion silenced Pim-1 kinase resulting in mitochondrial dysfunction. Rescue experiments demonstrated that suppression of miRNA-15b induction in Dicer-deleted adult hearts result in marked amelioration of cardiac dysfunction. | Suppression of Induced microRNA-15b Prevents Rapid Loss of Cardiac Function in a Dicer Depleted Model of Cardiac Dysfunction.
Roy S, Banerjee J, Gnyawali SC, Khanna S, He G, Pfeiffer D, Zweier JL, Sen CK., Free PMC Article | 10/14/2017 |
| Pim-1L protects hepatic ABCA1 from lysosomal degradation by facilitating the physical interaction between ABCA1 and liver X receptor beta and subsequent stabilization of the ABCA1-Pim-1L complex and thereby regulates the circulating level of high-density lipoprotein. | Pim-1L Protects Cell Surface-Resident ABCA1 From Lysosomal Degradation in Hepatocytes and Thereby Regulates Plasma High-Density Lipoprotein Level.
Katsube A, Hayashi H, Kusuhara H. | 06/24/2017 |
| Pim1 kinase activity maintains airway epithelial integrity and protects against house dust mite-induced proinflammatory activation of the airway epithelium. | Pim1 kinase activity preserves airway epithelial integrity upon house dust mite exposure.
de Vries M, Hesse L, Jonker MR, van den Berge M, van Oosterhout AJ, Heijink IH, Nawijn MC. | 05/14/2016 |
| Pim kinases prevent premature cardiac aging and maintain a healthy pool of functional mitochondria leading to efficient cellular energetics. | Metabolic dysfunction consistent with premature aging results from deletion of Pim kinases.
Din S, Konstandin MH, Johnson B, Emathinger J, Völkers M, Toko H, Collins B, Ormachea L, Samse K, Kubli DA, De La Torre A, Kraft AS, Gustafsson AB, Kelly DP, Sussman MA., Free PMC Article | 09/20/2014 |
| Pim-1 kinase activity regulates hepatocyte growth factor-induced tumor cell migration, invasion, and cell scattering. | The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling.
Cen B, Xiong Y, Song JH, Mahajan S, DuPont R, McEachern K, DeAngelo DJ, Cortes JE, Minden MD, Ebens A, Mims A, LaRue AC, Kraft AS., Free PMC Article | 08/9/2014 |
| these results identify Pim1 as a novel effector molecule sufficient to drive CD4( ) alphabeta T-cell development and survival in the absence of gammac cytokine receptor signaling. | Pim1 permits generation and survival of CD4+ T cells in the absence of γc cytokine receptor signaling.
Linowes BA, Ligons DL, Nam AS, Hong C, Keller HR, Tai X, Luckey MA, Park JH., Free PMC Article | 11/23/2013 |
| Our data suggest that Pim1 might contribute to progression rather than initiation in prostate neoplasia. | Conditional transgenic expression of PIM1 kinase in prostate induces inflammation-dependent neoplasia.
Narlik-Grassow M, Blanco-Aparicio C, Cecilia Y, Perez M, Muñoz-Galvan S, Cañamero M, Renner O, Carnero A., Free PMC Article | 11/2/2013 |
| Loss of PIM1 is associated with abnormal hematopoietic phenotypes. | Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice.
An N, Kraft AS, Kang Y., Free PMC Article | 07/27/2013 |
| Pim-1 activity prevents Drp1 compartmentalization to the mitochondria and preserves reticular mitochondrial morphology in response to sI | Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation.
Din S, Mason M, Völkers M, Johnson B, Cottage CT, Wang Z, Joyo AY, Quijada P, Erhardt P, Magnuson NS, Konstandin MH, Sussman MA., Free PMC Article | 07/13/2013 |
| Pim1 kinase deletion and inhibition slows endothelial cell detachment by trypsinization and increases cell adhesion. | Loss of pim1 imposes a hyperadhesive phenotype on endothelial cells.
Walpen T, Peier M, Haas E, Kalus I, Schwaller J, Battegay E, Humar R. | 06/15/2013 |
| Telomere elongation consistent with a young phenotype is observed following Pim-1 overexpression. | Increased mitotic rate coincident with transient telomere lengthening resulting from pim-1 overexpression in cardiac progenitor cells.
Cottage CT, Neidig L, Sundararaman B, Din S, Joyo AY, Bailey B, Gude N, Hariharan N, Sussman MA., Free PMC Article | 03/23/2013 |
| demonstrated that over-expression of miR-16 mimics suppressed Pim-1 expression in FD-FLT3/ITD cells suggesting that increased miR-16 expression contributes to depletion of Pim-1 after FLT3 inhibition | MicroRNA-16 is down-regulated in mutated FLT3 expressing murine myeloid FDC-P1 cells and interacts with Pim-1.
Kim KT, Carroll AP, Mashkani B, Cairns MJ, Small D, Scott RJ., Free PMC Article | 03/9/2013 |