| PIK3CA inhibition in models of proliferative glomerulonephritis and lupus nephritis. | PIK3CA inhibition in models of proliferative glomerulonephritis and lupus nephritis.
Yamaguchi J, Isnard P, Robil N, de la Grange P, Hoguin C, Schmitt A, Hummel A, Megret J, Goudin N, Luka M, Ménager MM, Masson C, Zarhrate M, Bôle-Feysot C, Janiszewska M, Polyak K, Dairou J, Baldassari S, Baulac S, Broissand C, Legendre C, Terzi F, Canaud G., Free PMC Article | 08/4/2024 |
| Generating a Murine PTEN Null Cell Line to Discover the Key Role of p110beta-PAK1 in Castration-Resistant Prostate Cancer Invasion. | Generating a Murine PTEN Null Cell Line to Discover the Key Role of p110β-PAK1 in Castration-Resistant Prostate Cancer Invasion.
Wang H, Zhou Y, Chu C, Xiao J, Zheng S, Korpal M, Korn JM, Penaloza T, Drake RR, Gan W, Gao X., Free PMC Article | 12/5/2023 |
| Urothelium-Specific Expression of Mutationally Activated Pik3ca Initiates Early Lesions of Noninvasive Bladder Cancer. | Urothelium-Specific Expression of Mutationally Activated Pik3ca Initiates Early Lesions of Noninvasive Bladder Cancer.
Shuman L, Pham J, Wildermuth T, Wu XR, Walter V, Warrick JI, DeGraff DJ. | 11/20/2023 |
| Respective roles of Pik3ca mutations and cyproterone acetate impregnation in mouse meningioma tumorigenesis. | Respective roles of Pik3ca mutations and cyproterone acetate impregnation in mouse meningioma tumorigenesis.
Cômes PC, Le Van T, Tran S, Huard S, Abi-Jaoude S, Venot Q, Marijon P, Boetto J, Blouin A, Bielle F, Ducos Y, Teranishi Y, Kalamarides M, Peyre M. | 08/17/2023 |
| JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study. | JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study.
Liberale L, Puspitasari YM, Ministrini S, Akhmedov A, Kraler S, Bonetti NR, Beer G, Vukolic A, Bongiovanni D, Han J, Kirmes K, Bernlochner I, Pelisek J, Beer JH, Jin ZG, Pedicino D, Liuzzo G, Stellos K, Montecucco F, Crea F, Lüscher TF, Camici GG., Free PMC Article | 05/30/2023 |
| Endothelial hyperactivation of mutant MAP3K3 induces cerebral cavernous malformation enhanced by PIK3CA GOF mutation. | Endothelial hyperactivation of mutant MAP3K3 induces cerebral cavernous malformation enhanced by PIK3CA GOF mutation.
Huo R, Yang Y, Sun Y, Zhou Q, Zhao S, Mo Z, Xu H, Wang J, Weng J, Jiao Y, Zhang J, He Q, Wang S, Zhao J, Wang J, Cao Y. | 04/24/2023 |
| Irisin ameliorates D-galactose-induced skeletal muscle fibrosis via the PI3K/Akt pathway. | Irisin ameliorates D-galactose-induced skeletal muscle fibrosis via the PI3K/Akt pathway.
Wu Y, Wu Y, Yu J, Zhang Y, Li Y, Fu R, Sun Y, Zhao K, Xiao Q. | 02/11/2023 |
| PIK3CA gain-of-function mutation in adipose tissue induces metabolic reprogramming with Warburg-like effect and severe endocrine disruption. | PIK3CA gain-of-function mutation in adipose tissue induces metabolic reprogramming with Warburg-like effect and severe endocrine disruption.
Ladraa S, Zerbib L, Bayard C, Fraissenon A, Venot Q, Morin G, Garneau AP, Isnard P, Chapelle C, Hoguin C, Fraitag S, Duong JP, Guibaud L, Besançon A, Kaltenbach S, Villarese P, Asnafi V, Broissand C, Goudin N, Dussiot M, Nemazanyy I, Viel T, Autret G, Cruciani-Guglielmacci C, Denom J, Bruneau J, Tavitian B, Legendre C, Dairou J, Lacorte JM, Levy P, Pende M, Polak M, Canaud G., Free PMC Article | 12/31/2022 |
| Double Deletion of PI3K and PTEN Modifies Lens Postnatal Growth and Homeostasis. | Double Deletion of PI3K and PTEN Modifies Lens Postnatal Growth and Homeostasis.
Sellitto C, Li L, White TW., Free PMC Article | 10/8/2022 |
| PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment. | PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment.
Collins NB, Al Abosy R, Miller BC, Bi K, Zhao Q, Quigley M, Ishizuka JJ, Yates KB, Pope HW, Manguso RT, Shrestha Y, Wadsworth M, Hughes T, Shalek AK, Boehm JS, Hahn WC, Doench JG, Haining WN., Free PMC Article | 05/14/2022 |
| RASSF1A independence and early galectin-1 upregulation in PIK3CA-induced hepatocarcinogenesis: new therapeutic venues. | RASSF1A independence and early galectin-1 upregulation in PIK3CA-induced hepatocarcinogenesis: new therapeutic venues.
Scheiter A, Evert K, Reibenspies L, Cigliano A, Annweiler K, Müller K, Pöhmerer LM, Xu H, Cui G, Itzel T, Materna-Reichelt S, Coluccio A, Honarnejad K, Teufel A, Brochhausen C, Dombrowski F, Chen X, Evert M, Calvisi DF, Utpatel K., Free PMC Article | 04/16/2022 |
| Overcoming resistance to immune checkpoint therapy in PTEN-null prostate cancer by intermittent anti-PI3Kalpha/beta/delta treatment. | Overcoming resistance to immune checkpoint therapy in PTEN-null prostate cancer by intermittent anti-PI3Kα/β/δ treatment.
Qi Z, Xu Z, Zhang L, Zou Y, Li J, Yan W, Li C, Liu N, Wu H., Free PMC Article | 02/12/2022 |
| Paternal Exercise Improves the Metabolic Health of Offspring via Epigenetic Modulation of the Germline. | Paternal Exercise Improves the Metabolic Health of Offspring via Epigenetic Modulation of the Germline.
Costa-Júnior JM, Ferreira SM, Kurauti MA, Bernstein DL, Ruano EG, Kameswaran V, Schug J, Freitas-Dias R, Zoppi CC, Boschero AC, Oliveira CAM, Santos GJ, Carneiro EM, Kaestner KH., Free PMC Article | 02/5/2022 |
| Pharmacological and cell-specific genetic PI3Kalpha inhibition worsens cardiac remodeling after myocardial infarction. | Pharmacological and cell-specific genetic PI3Kα inhibition worsens cardiac remodeling after myocardial infarction.
Chen X, Zhabyeyev P, Azad AK, Vanhaesebroeck B, Grueter CE, Murray AG, Kassiri Z, Oudit GY. | 01/15/2022 |
| Somatic PIK3CA Mutations in Sporadic Cerebral Cavernous Malformations. | Somatic PIK3CA Mutations in Sporadic Cerebral Cavernous Malformations.
Peyre M, Miyagishima D, Bielle F, Chapon F, Sierant M, Venot Q, Lerond J, Marijon P, Abi-Jaoude S, Le Van T, Labreche K, Houlston R, Faisant M, Clémenceau S, Boch AL, Nouet A, Carpentier A, Boetto J, Louvi A, Kalamarides M., Free PMC Article | 11/22/2021 |
| PI3-Kinase p110alpha Deficiency Modulates T Cell Homeostasis and Function and Attenuates Experimental Allergic Encephalitis in Mature Mice. | PI3-Kinase p110α Deficiency Modulates T Cell Homeostasis and Function and Attenuates Experimental Allergic Encephalitis in Mature Mice.
Rojo JM, Montes-Casado M, Aragoneses-Fenoll L, Ojeda G, Dianzani U, Portolés P., Free PMC Article | 09/18/2021 |
| Acute physical exercise increases PI3K-p110alpha protein content in the hypothalamus of obese mice. | Acute physical exercise increases PI3K-p110α protein content in the hypothalamus of obese mice.
Gaspar RC, Nakandakari SCBR, Muñoz VR, Vieira RFL, da Silva ASR, Cintra DE, de Moura LP, Ropelle ER, Pauli JR., Free PMC Article | 08/14/2021 |
| PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism. | PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.
Ren AA, Snellings DA, Su YS, Hong CC, Castro M, Tang AT, Detter MR, Hobson N, Girard R, Romanos S, Lightle R, Moore T, Shenkar R, Benavides C, Beaman MM, Müller-Fielitz H, Chen M, Mericko P, Yang J, Sung DC, Lawton MT, Ruppert JM, Schwaninger M, Körbelin J, Potente M, Awad IA, Marchuk DA, Kahn ML., Free PMC Article | 08/14/2021 |
| The role of the PIK3CA gene in the development and aging of the brain. | The role of the PIK3CA gene in the development and aging of the brain.
Xie S, Ni J, Guo H, Luu V, Wang Y, Zhao JJ, Roberts TM., Free PMC Article | 08/7/2021 |
| The PI-3-Kinase P110alpha Catalytic Subunit of T Lymphocytes Modulates Collagen-Induced Arthritis. | The PI-3-Kinase P110α Catalytic Subunit of T Lymphocytes Modulates Collagen-Induced Arthritis.
Montes-Casado M, Ojeda G, Criado G, Rojo JM, Portolés P., Free PMC Article | 07/17/2021 |
| Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kalpha and PI3Kgamma. | Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3Kγ.
Martinez NG, Thieker DF, Carey LM, Rasquinha JA, Kistler SK, Kuhlman BA, Campbell SL., Free PMC Article | 06/26/2021 |
| FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K. | FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K.
Weeks KL, Tham YK, Yildiz SG, Alexander Y, Donner DG, Kiriazis H, Harmawan CA, Hsu A, Bernardo BC, Matsumoto A, DePinho RA, Abel ED, Woodcock EA, McMullen JR. | 04/24/2021 |
| Mutation-Associated Phenotypic Heterogeneity in Novel and Canonical PIK3CA Helical and Kinase Domain Mutants. | Mutation-Associated Phenotypic Heterogeneity in Novel and Canonical PIK3CA Helical and Kinase Domain Mutants.
Ghodsinia AA, Lego JMT, Garcia RL., Free PMC Article | 03/20/2021 |
| Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation. | Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation.
Stark AK, Davenport ECM, Patton DT, Scudamore CL, Vanhaesebroeck B, Veldhoen M, Garden OA, Okkenhaug K., Free PMC Article | 03/13/2021 |
| Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation. | Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation.
Martinez-Corral I, Zhang Y, Petkova M, Ortsäter H, Sjöberg S, Castillo SD, Brouillard P, Libbrecht L, Saur D, Graupera M, Alitalo K, Boon L, Vikkula M, Mäkinen T., Free PMC Article | 08/22/2020 |