| Influence of GPRC5A-Regulated ABCB1 Expression on Lung Adenocarcinoma Proliferation. | Influence of GPRC5A-Regulated ABCB1 Expression on Lung Adenocarcinoma Proliferation.
Li Y, Cui WW, Yang ZF, Liu WH, Bian MW, Deng J, Wang T. | 05/7/2024 |
| Role of ABCB1 and ABCB4 in renal and biliary excretion of perfluorooctanoic acid in mice. | Role of ABCB1 and ABCB4 in renal and biliary excretion of perfluorooctanoic acid in mice.
Furukawa K, Okamoto-Matsuda K, Harada KH, Minata M, Hitomi T, Kobayashi H, Koizumi A., Free PMC Article | 03/26/2024 |
| Long non-coding RNA LUCAT1 regulates the RAS pathway to promote the proliferation and invasion of malignant glioma cells through ABCB1. | Long non-coding RNA LUCAT1 regulates the RAS pathway to promote the proliferation and invasion of malignant glioma cells through ABCB1.
Wu X, Song L, Chen X, Zhang Y, Li S, Tang X. | 12/3/2022 |
| Influence of MDR1 gene polymorphism (2677G>T) on expression and function of P-glycoprotein at the blood-brain barrier: utilizing novel P-glycoprotein humanized mice with mutation. | Influence of MDR1 gene polymorphism (2677G>T) on expression and function of P-glycoprotein at the blood-brain barrier: utilizing novel P-glycoprotein humanized mice with mutation.
Yamasaki Y, Moriwaki T, Ogata S, Ito S, Ohtsuki S, Minegishi G, Abe S, Ohta Y, Kazuki K, Kobayashi K, Kazuki Y. | 09/24/2022 |
| Limited Impact of Murine Placental MDR1 on Fetal Exposure of Certain Drugs Explained by Bypass Transfer Between Adjacent Syncytiotrophoblast Layers. | Limited Impact of Murine Placental MDR1 on Fetal Exposure of Certain Drugs Explained by Bypass Transfer Between Adjacent Syncytiotrophoblast Layers.
Fujita A, Noguchi S, Hamada R, Inoue S, Shimada T, Katakura S, Maruyama T, Sai Y, Nishimura T, Tomi M., Free PMC Article | 07/9/2022 |
| Role of the efflux transporters Abcb1 and Abcg2 in the brain distribution of olaparib in mice. | Role of the efflux transporters Abcb1 and Abcg2 in the brain distribution of olaparib in mice.
Song YK, Kim MJ, Kim MS, Lee JH, Chung SJ, Song JS, Chae YJ, Lee KR. | 05/7/2022 |
| ABCB1 and ABCG2 limit brain penetration and, together with CYP3A4, total plasma exposure of abemaciclib and its active metabolites. | ABCB1 and ABCG2 limit brain penetration and, together with CYP3A4, total plasma exposure of abemaciclib and its active metabolites.
Martínez-Chávez A, Loos NHC, Lebre MC, Tibben MM, Rosing H, Beijnen JH, Schinkel AH. | 04/30/2022 |
| Systemic Inflammation Induced Changes in Protein Expression of ABC Transporters and Ionotropic Glutamate Receptor Subunit 1 in the Cerebral Cortex of Familial Alzheimer's Disease Mouse Model. | Systemic Inflammation Induced Changes in Protein Expression of ABC Transporters and Ionotropic Glutamate Receptor Subunit 1 in the Cerebral Cortex of Familial Alzheimer`s Disease Mouse Model.
Puris E, Auriola S, Korhonen P, Loppi S, Kanninen KM, Malm T, Koistinaho J, Gynther M. | 03/5/2022 |
| ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost. | ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost.
de Gooijer MC, Kemper EM, Buil LCM, Çitirikkaya CH, Buckle T, Beijnen JH, van Tellingen O., Free PMC Article | 02/26/2022 |
| P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss. | P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss.
Ge C, Xu D, Yu P, Fang M, Guo J, Xu D, Qiao Y, Chen S, Zhang Y, Wang H., Free PMC Article | 01/29/2022 |
| Neural Progenitor Cell-Derived Extracellular Vesicles Enhance Blood-Brain Barrier Integrity by NF-kappaB (Nuclear Factor-kappaB)-Dependent Regulation of ABCB1 (ATP-Binding Cassette Transporter B1) in Stroke Mice. | Neural Progenitor Cell-Derived Extracellular Vesicles Enhance Blood-Brain Barrier Integrity by NF-κB (Nuclear Factor-κB)-Dependent Regulation of ABCB1 (ATP-Binding Cassette Transporter B1) in Stroke Mice.
Zhang L, Graf I, Kuang Y, Zheng X, Haupt M, Majid A, Kilic E, Hermann DM, Psychogios MN, Weber MS, Ochs J, Bähr M, Doeppner TR., Free PMC Article | 03/20/2021 |
| Physiological expression and function of the MDR1 transporter in cytotoxic T lymphocytes. | Physiological expression and function of the MDR1 transporter in cytotoxic T lymphocytes.
Chen ML, Sun A, Cao W, Eliason A, Mendez KM, Getzler AJ, Tsuda S, Diao H, Mukori C, Bruno NE, Kim SY, Pipkin ME, Koralov SB, Sundrud MS., Free PMC Article | 12/26/2020 |
| Sex-, feeding-, and circadian time-dependency of P-glycoprotein expression and activity - implications for mechanistic pharmacokinetics modeling. | Sex-, feeding-, and circadian time-dependency of P-glycoprotein expression and activity - implications for mechanistic pharmacokinetics modeling.
Okyar A, Kumar SA, Filipski E, Piccolo E, Ozturk N, Xandri-Monje H, Pala Z, Abraham K, Gomes ARGJ, Orman MN, Li XM, Dallmann R, Lévi F, Ballesta A., Free PMC Article | 11/21/2020 |
| Brain region-specific regulation of histone acetylation and efflux transporters in mice. | Brain region-specific regulation of histone acetylation and efflux transporters in mice.
You D, Shin HM, Mosaad F, Richardson JR, Aleksunes LM., Free PMC Article | 08/13/2020 |
| ABCB1 is involved in neo-absorbed vitamin D efflux by the enterocytes and that it also contributes to vitamin D transintestinal excretion and likely impacts vitamin D status. | ABCB1 (P-glycoprotein) regulates vitamin D absorption and contributes to its transintestinal efflux.
Margier M, Collet X, le May C, Desmarchelier C, André F, Lebrun C, Defoort C, Bluteau A, Borel P, Lespine A, Reboul E. | 08/10/2019 |
| esults suggest that P-gp plays important role in mediating rivastigmine non-cholinergic beneficial effects, including Abeta brain load reduction, neuroprotective and anti-inflammatory effects in the AD mouse models. | Role of P-glycoprotein in mediating rivastigmine effect on amyloid-β brain load and related pathology in Alzheimer's disease mouse model.
Mohamed LA, Keller JN, Kaddoumi A., Free PMC Article | 03/30/2019 |
| this study shows that MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation | MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation.
Ho GT, Aird RE, Liu B, Boyapati RK, Kennedy NA, Dorward DA, Noble CL, Shimizu T, Carter RN, Chew ETS, Morton NM, Rossi AG, Sartor RB, Iredale JP, Satsangi J., Free PMC Article | 08/18/2018 |
| A panel of 18 P-gp substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp can affect the pulmonary kinetics of a subset of P-gp substrates. | The Differential Absorption of a Series of P-Glycoprotein Substrates in Isolated Perfused Lungs from Mdr1a/1b Genetic Knockout Mice can be Attributed to Distinct Physico-Chemical Properties: an Insight into Predicting Transporter-Mediated, Pulmonary Specific Disposition.
Price DF, Luscombe CN, Eddershaw PJ, Edwards CD, Gumbleton M., Free PMC Article | 08/4/2018 |
| Data suggest that the overexpression of P-gp in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl. | L1210 Cells Overexpressing ABCB1 Drug Transporters Are Resistant to Inhibitors of the N- and O-glycosylation of Proteins.
Pavlikova L, Seres M, Hano M, Bohacova V, Sevcikova I, Kyca T, Breier A, Sulova Z., Free PMC Article | 03/31/2018 |
| We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary. | Multidrug resistance transporter-1 and breast cancer resistance protein protect against ovarian toxicity, and are essential in ovarian physiology.
Brayboy LM, Oulhen N, Long S, Voigt N, Raker C, Wessel GM., Free PMC Article | 02/24/2018 |
| Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp, multi-drug resistance protein, MDR1).Drugs with ER < 1 almost do not bind the main binding cavity (MBC) of P-gp. | On the mechanism of substrate/non-substrate recognition by P-glycoprotein.
Mukhametov A, Raevsky OA. | 02/10/2018 |
| conclusion, MDR1 and BCRP are expressed on apical membranes of the rodent placental SynT-II layer. | Layer II of placental syncytiotrophoblasts expresses MDR1 and BCRP at the apical membrane in rodents.
Akashi T, Nishimura T, Takaki Y, Takahashi M, Shin BC, Tomi M, Nakashima E. | 01/13/2018 |
| Mdr1 enforces T Cell homeostasis in the presence of intestinal bile acids. | The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids.
Cao W, Kayama H, Chen ML, Delmas A, Sun A, Kim SY, Rangarajan ES, McKevitt K, Beck AP, Jackson CB, Crynen G, Oikonomopoulos A, Lacey PN, Martinez GJ, Izard T, Lorenz RG, Rodriguez-Palacios A, Cominelli F, Abreu MT, Hommes DW, Koralov SB, Takeda K, Sundrud MS., Free PMC Article | 12/30/2017 |
| Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia. | Modulation of bilirubin neurotoxicity by the Abcb1 transporter in the Ugt1-/- lethal mouse model of neonatal hyperbilirubinemia.
Bockor L, Bortolussi G, Vodret S, Iaconcig A, Jašprová J, Zelenka J, Vitek L, Tiribelli C, Muro AF. | 09/30/2017 |
| the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity | Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions.
Shukla S, Abel B, Chufan EE, Ambudkar SV., Free PMC Article | 07/15/2017 |