| Dysregulated autotaxin expression by T cells in multiple sclerosis. | Dysregulated autotaxin expression by T cells in multiple sclerosis.
Petersen-Cherubini CL, Liu Y, Deffenbaugh JL, Murphy SP, Xin M, Rau CN, Yang Y, Lovett-Racke AE., | 02/20/2024 |
| Autotaxin in encephalitogenic CD4 T cells as a therapeutic target for multiple sclerosis. | Autotaxin in encephalitogenic CD4 T cells as a therapeutic target for multiple sclerosis.
Petersen-Cherubini CL, Murphy SP, Xin M, Liu Y, Deffenbaugh JL, Jahan I, Rau CN, Yang Y, Lovett-Racke AE., | 02/7/2024 |
| Autotaxin-lysophosphatidic acid receptor 5 axis evokes endothelial dysfunction via reactive oxygen species signaling. | Autotaxin-lysophosphatidic acid receptor 5 axis evokes endothelial dysfunction via reactive oxygen species signaling.
Janovicz A, Majer A, Kosztelnik M, Geiszt M, Chun J, Ishii S, Tigyi GJ, Benyó Z, Ruisanchez É., Free PMC Article | 01/6/2024 |
| The autotaxin-LPA axis promotes membrane trafficking and secretion in yolk sac visceral endoderm cells. | The autotaxin-LPA axis promotes membrane trafficking and secretion in yolk sac visceral endoderm cells.
Koike S, Keino-Masu K, Tanimoto Y, Takahashi S, Masu M., Free PMC Article | 11/13/2023 |
| E2F7 drives autotaxin/Enpp2 transcription via chromosome looping: Repression by p53 in murine but not in human carcinomas. | E2F7 drives autotaxin/Enpp2 transcription via chromosome looping: Repression by p53 in murine but not in human carcinomas.
Lin KH, Lee SC, Dacheux MA, Norman DD, Balogh A, Bavaria M, Lee H, Tigyi G., Free PMC Article | 06/29/2023 |
| Autotaxin (ATX) inhibits autophagy leading to exaggerated disruption of intestinal epithelial barrier in colitis. | Autotaxin (ATX) inhibits autophagy leading to exaggerated disruption of intestinal epithelial barrier in colitis.
Shi W, Peng K, Yu H, Wang Z, Xia S, Xiao S, Tian D, Vallance BA, Yu Q. | 03/7/2023 |
| Endothelial Specific Deletion of Autotaxin Improves Stroke Outcomes. | Endothelial Specific Deletion of Autotaxin Improves Stroke Outcomes.
Bhattarai S, Subedi U, Manikandan S, Sharma S, Sharma P, Miller C, Bhuiyan MS, Kidambi S, Aidinis V, Sun H, Miriyala S, Panchatcharam M., Free PMC Article | 02/16/2023 |
| Hepatocyte-Secreted Autotaxin Exacerbates Nonalcoholic Fatty Liver Disease Through Autocrine Inhibition of the PPARalpha/FGF21 Axis. | Hepatocyte-Secreted Autotaxin Exacerbates Nonalcoholic Fatty Liver Disease Through Autocrine Inhibition of the PPARα/FGF21 Axis.
Qiu H, Song E, Hu Y, Li T, Ku KC, Wang C, Cheung BMY, Cheong LY, Wang Q, Wu X, Hoo RLC, Wang Y, Xu A., Free PMC Article | 10/29/2022 |
| Endothelial ENPP2 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 2) Increases Atherosclerosis in Female and Male Mice. | Endothelial ENPP2 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 2) Increases Atherosclerosis in Female and Male Mice.
Karshovska E, Mohibullah R, Zhu M, Zahedi F, Thomas D, Magkrioti C, Geissler C, Megens RTA, Bianchini M, Nazari-Jahantigh M, Ferreirós N, Aidinis V, Schober A. | 08/6/2022 |
| Atx regulates skeletal muscle regeneration via LPAR1 and promotes hypertrophy. | Atx regulates skeletal muscle regeneration via LPAR1 and promotes hypertrophy.
Ray R, Sinha S, Aidinis V, Rai V. | 01/29/2022 |
| Autotaxin inhibition reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction. | Autotaxin inhibition reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction.
Tripathi H, Al-Darraji A, Abo-Aly M, Peng H, Shokri E, Chelvarajan L, R Donahue R, Levitan BM, Gao E, Hernandez G, Morris AJ, Smyth SS, Abdel-Latif A., Free PMC Article | 10/9/2021 |
| Inhibition of Autotaxin and Lysophosphatidic Acid Receptor 5 Attenuates Neuroinflammation in LPS-Activated BV-2 Microglia and a Mouse Endotoxemia Model. | Inhibition of Autotaxin and Lysophosphatidic Acid Receptor 5 Attenuates Neuroinflammation in LPS-Activated BV-2 Microglia and a Mouse Endotoxemia Model.
Joshi L, Plastira I, Bernhart E, Reicher H, Triebl A, Köfeler HC, Sattler W., Free PMC Article | 09/18/2021 |
| Relative expression and regulation by short-term fasting of lysophosphatidic acid receptors and autotaxin in white and brown adipose tissue depots. | Relative expression and regulation by short-term fasting of lysophosphatidic acid receptors and autotaxin in white and brown adipose tissue depots.
M'Hiri I, Diaguarachchige De Silva KH, Duncan RE. | 06/12/2021 |
| NSun2 regulates aneurysm formation by promoting autotaxin expression and T cell recruitment. | NSun2 regulates aneurysm formation by promoting autotaxin expression and T cell recruitment.
Miao Y, Zhao Y, Han L, Ma X, Deng J, Yang J, Lü S, Shao F, Kong W, Wang W, Xu Q, Wang X, Feng J., Free PMC Article | 03/6/2021 |
| Ectonucleotide pyrophosphatase 2 (ENPP2) plays a crucial role in myogenic differentiation through the regulation by WNT/beta-Catenin signaling. | Ectonucleotide pyrophosphatase 2 (ENPP2) plays a crucial role in myogenic differentiation through the regulation by WNT/β-Catenin signaling.
Sah JP, Hao NTT, Han X, Tran TTT, McCarthy S, Oh Y, Yoon JK. | 10/10/2020 |
| ATX-LPA axis affects the differentiation of Th17 cells in chronic ulcerative colitis . | Autotaxin-Lysophosphatidic Acid Axis Blockade Improves Inflammation by Regulating Th17 Cell Differentiation in DSS-Induced Chronic Colitis Mice.
Dong YL, Duan XY, Liu YJ, Fan H, Xu M, Chen QY, Nan Z, Wu H, Deng SJ. | 02/22/2020 |
| Results identify ATX as a novel osteoclast factor that specifically controls inflammation-induced bone erosions and systemic bone loss. | Osteoclast-Derived Autotaxin, a Distinguishing Factor for Inflammatory Bone Loss.
Flammier S, Peyruchaud O, Bourguillault F, Duboeuf F, Davignon JL, Norman DD, Isaac S, Marotte H, Tigyi G, Machuca-Gayet I, Coury F., Free PMC Article | 02/22/2020 |
| ATX deletion suppresses experimental colitis. | Autotaxin determines colitis severity in mice and is secreted by B cells in the colon.
Lin S, Haque A, Raeman R, Guo L, He P, Denning TL, El-Rayes B, Moolenaar WH, Yun CC., Free PMC Article | 11/16/2019 |
| Both models of Enpp2- deficiency exhibited marked protection from high fat diet-induced hepatic steatosis. | Adipose-derived autotaxin regulates inflammation and steatosis associated with diet-induced obesity.
Brandon JA, Kraemer M, Vandra J, Halder S, Ubele M, Morris AJ, Smyth SS., Free PMC Article | 11/2/2019 |
| Autotaxin-LPA signaling contributes to obesity-induced insulin resistance in muscle and impairs mitochondrial metabolism | Autotaxin-LPA signaling contributes to obesity-induced insulin resistance in muscle and impairs mitochondrial metabolism.
D'Souza K, Nzirorera C, Cowie AM, Varghese GP, Trivedi P, Eichmann TO, Biswas D, Touaibia M, Morris AJ, Aidinis V, Kane DA, Pulinilkunnil T, Kienesberger PC., Free PMC Article | 08/24/2019 |
| Deficiency of alkaline SMase enhances dextran sulfate sodium-induced colitis in mice with upregulation of autotaxin | Deficiency of alkaline SMase enhances dextran sulfate sodium-induced colitis in mice with upregulation of autotaxin.
Zhang P, Chen Y, Zhang T, Zhu J, Zhao L, Li J, Wang G, Li Y, Xu S, Nilsson Å, Duan RD., Free PMC Article | 08/24/2019 |
| ENPP2 was in silico discovered to be genetically altered in some patients with lung cancer, whereas increased autotaxin (ATX) staining and activity were detected in patients and mouse models, accompanied by a downregulation of PLPP3 expression. Most importantly, genetic deletion of Enpp2 or Lpar1 in mice resulted in disease attenuation, thus confirming a pro-carcinogenic role of ATX/LPA in the lung. | The Autotaxin-Lysophosphatidic Acid Axis Promotes Lung Carcinogenesis.
Magkrioti C, Oikonomou N, Kaffe E, Mouratis MA, Xylourgidis N, Barbayianni I, Megadoukas P, Harokopos V, Valavanis C, Chun J, Kosma A, Stathopoulos GT, Bouros E, Bouros D, Syrigos K, Aidinis V. | 08/10/2019 |
| Data show that autotaxin (ATX)-mediated autocrine lipid signaling promotes naive pluripotency by intersecting with LIF and BMP4 signaling. | Autotaxin-mediated lipid signaling intersects with LIF and BMP signaling to promote the naive pluripotency transcription factor program.
Kime C, Sakaki-Yumoto M, Goodrich L, Hayashi Y, Sami S, Derynck R, Asahi M, Panning B, Yamanaka S, Tomoda K., Free PMC Article | 03/31/2018 |
| ENPP2 links Activin-A enhanced mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva | Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva.
Hino K, Horigome K, Nishio M, Komura S, Nagata S, Zhao C, Jin Y, Kawakami K, Yamada Y, Ohta A, Toguchida J, Ikeya M., Free PMC Article | 10/28/2017 |
| This study showed that alternative autotaxin-independent pathways are likely responsible for local generation of lysophosphatidic acid in the injured lung. | Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis.
Black KE, Berdyshev E, Bain G, Castelino FV, Shea BS, Probst CK, Fontaine BA, Bronova I, Goulet L, Lagares D, Ahluwalia N, Knipe RS, Natarajan V, Tager AM., Free PMC Article | 08/19/2017 |