| In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23. | In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23.
Al Rifai O, Susan-Resiga D, Essalmani R, Creemers JWM, Seidah NG, Ferron M., Free PMC Article | 12/25/2021 |
| Activation of proprotein convertase in the mouse habenula causes depressive-like behaviors through remodeling of extracellular matrix. | Activation of proprotein convertase in the mouse habenula causes depressive-like behaviors through remodeling of extracellular matrix.
Ito H, Nozaki K, Sakimura K, Abe M, Yamawaki S, Aizawa H., Free PMC Article | 08/7/2021 |
| this study demonstrates that Pcsk5 is expressed in bone-forming cells, and that OPN is a novel substrate for PC5/6 | Osteopontin as a novel substrate for the proprotein convertase 5/6 (PCSK5) in bone.
Hoac B, Susan-Resiga D, Essalmani R, Marcinkiweicz E, Seidah NG, McKee MD. | 03/23/2019 |
| Pcsk5 may have an essential and early role in the cranio-cardiac mesoderm for heart development. | Pcsk5 is required in the early cranio-cardiac mesoderm for heart development.
Szumska D, Cioroch M, Keeling A, Prat A, Seidah NG, Bhattacharya S., Free PMC Article | 04/14/2018 |
| loss of the convertase furin or PC5/6 in hepatocytes results in a approximately 30% decrease in APC levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin activation. | Thrombin activation of protein C requires prior processing by a liver proprotein convertase.
Essalmani R, Susan-Resiga D, Guillemot J, Kim W, Sachan V, Awan Z, Chamberland A, Asselin MC, Ly K, Desjardins R, Day R, Prat A, Seidah NG., Free PMC Article | 07/8/2017 |
| overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner | Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.
Kato S, Zhang R, Roberts JD Jr., Free PMC Article | 09/28/2013 |
| Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy. | Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy.
Marchesi C, Essalmani R, Lemarié CA, Leibovitz E, Ebrahimian T, Paradis P, Seidah NG, Schiffrin EL, Prat A. | 02/4/2012 |
| PCSK5 and GDF11 expression during hindgut morphogenesis could be key factors for normal anorectal development, which can be disturbed by the administration of an overdose of all-trans retinoic acid, leading to anorectal malformations. | PCSK5 and GDF11 expression in the hindgut region of mouse embryos with anorectal malformations.
Tsuda T, Iwai N, Deguchi E, Kimura O, Ono S, Furukawa T, Sasaki Y, Fumino S, Kubota Y. | 01/14/2012 |
| Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A. | Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.
Sun X, Essalmani R, Susan-Resiga D, Prat A, Seidah NG., Free PMC Article | 10/22/2011 |
| These data support the role of proconvertase PCSK5 in the processing of ovarian inhibin subunits during folliculogenesis. | Role of PCSK5 expression in mouse ovarian follicle development: identification of the inhibin α- and β-subunits as candidate substrates.
Antenos M, Lei L, Xu M, Malipatil A, Kiesewetter S, Woodruff TK., Free PMC Article | 07/9/2011 |
| Data suggest that intestinal PC5/6 is protective towards tumorigenesis, especially in mouse duodenum, and possibly in human colon. | The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model.
Sun X, Essalmani R, Seidah NG, Prat A., Free PMC Article | 02/22/2010 |
| These results provide the first direct evidence that PC5 is involved in CCK processing | Inhibition of PC5 expression decreases CCK secretion and increases PC2 expression.
Reynolds NA, Blum A, Kitagawa K, Beinfeld MC. | 01/21/2010 |
| mouse G-cells express PC1/3, 2 and 5/6. we conclude that PC5/6 is without effect on progastrin. | Prohormone convertases 1/3 and 2 together orchestrate the site-specific cleavages of progastrin to release gastrin-34 and gastrin-17.
Rehfeld JF, Zhu X, Norrbom C, Bundgaard JR, Johnsen AH, Nielsen JE, Vikesaa J, Stein J, Dey A, Steiner DF, Friis-Hansen L. | 01/21/2010 |
| We propose that Pcsk5, at least in part via GDF11, coordinately regulates caudal Hox paralogs, to control anteroposterior patterning, nephrogenesis, skeletal, and anorectal development. | VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5.
Szumska D, Pieles G, Essalmani R, Bilski M, Mesnard D, Kaur K, Franklyn A, El Omari K, Jefferis J, Bentham J, Taylor JM, Schneider JE, Arnold SJ, Johnson P, Tymowska-Lalanne Z, Stammers D, Clarke K, Neubauer S, Morris A, Brown SD, Shaw-Smith C, Cama A, Capra V, Ragoussis J, Constam D, Seidah NG, Prat A, Bhattacharya S., Free PMC Article | 01/21/2010 |
| the selectivity of PC5/6 for Gdf11 essentially resides in the presence of a P1' Asn in the RSRR downward arrowN cleavage motif | In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate.
Essalmani R, Zaid A, Marcinkiewicz J, Chamberland A, Pasquato A, Seidah NG, Prat A., Free PMC Article | 01/21/2010 |
| PC1/3 governs the endocrine and PC2 the neuronal processing of proCCK, whereas PC5/6 contributes only to a modest endocrine synthesis of CCK-22. | The cell-specific pattern of cholecystokinin peptides in endocrine cells versus neurons is governed by the expression of prohormone convertases 1/3, 2, and 5/6.
Rehfeld JF, Bundgaard JR, Hannibal J, Zhu X, Norrbom C, Steiner DF, Friis-Hansen L., Free PMC Article | 01/21/2010 |
| after stimulation, the protease activity of PC5A is enhanced, as evidenced by the cleavage of the PC5A substrates Lefty, ADAMTS-4, endothelial lipase, and PCSK9. | The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates.
Mayer G, Hamelin J, Asselin MC, Pasquato A, Marcinkiewicz E, Tang M, Tabibzadeh S, Seidah NG. | 01/21/2010 |
| Analysis of the subcellular distribution of fusion proteins containing the C-terminal domains of PC1/3, PC2 and PC5/6A confirmed that all three domains have the capacity to redirect secreted protein to the granule-containing cytoplasmic extensions. | PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism.
Dikeakos JD, Mercure C, Lacombe MJ, Seidah NG, Reudelhuber TL. | 01/21/2010 |
| the CRD of PC5A and PACE4 functions as a cell surface anchor favoring the processing of their cognate surface-anchored substrates, including endothelial lipase | The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases.
Nour N, Mayer G, Mort JS, Salvas A, Mbikay M, Morrison CJ, Overall CM, Seidah NG., Free PMC Article | 01/21/2010 |
| The proprotein convertase PC5A and a metalloprotease are involved in the proteolytic processing of the neural adhesion molecule L1. | The proprotein convertase PC5A and a metalloprotease are involved in the proteolytic processing of the neural adhesion molecule L1.
Kalus I, Schnegelsberg B, Seidah NG, Kleene R, Schachner M. | 01/21/2010 |
| PC6 is an essential molecule in modulating uterine function to support the establishment of embryo implantation | Inhibiting uterine PC6 blocks embryo implantation: an obligatory role for a proprotein convertase in fertility.
Nie G, Li Y, Wang M, Liu YX, Findlay JK, Salamonsen LA. | 01/21/2010 |
| These data demonstrate that Pcsk5 is an essential gene. | Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse.
Essalmani R, Hamelin J, Marcinkiewicz J, Chamberland A, Mbikay M, Chrétien M, Seidah NG, Prat A., Free PMC Article | 01/21/2010 |
| findings show that decidualized differentiation of stroma, which is a prerequisite for embryo implantation, leads to processing of lefty by PC5/6A | Decidual differentiation of stromal cells promotes Proprotein Convertase 5/6 expression and lefty processing.
Tang M, Mikhailik A, Pauli I, Giudice LC, Fazelabas AT, Tulac S, Carson DD, Kaufman DG, Barbier C, Creemers JW, Tabibzadeh S. | 01/21/2010 |
| large cysteine-rich region acts as an important part of functional domain of PC6 | Identification of the role of a cysteine-rich region of PC6B by determining the enzymatic characteristics of its mutants.
Wang L, Yang G, Wu X. | 01/21/2010 |
| in binding VEGFR-2, furin and PC5 promote cleavage of N-and C-terminal VEGF-D propeptides, whereas PC7 promotes cleavage of the C-terminal propeptide only | Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2.
McColl BK, Paavonen K, Karnezis T, Harris NC, Davydova N, Rothacker J, Nice EC, Harder KW, Roufail S, Hibbs ML, Rogers PA, Alitalo K, Stacker SA, Achen MG. | 01/21/2010 |