| The Furin Protease Dependence and Antiviral GBP2 Sensitivity of Murine Leukemia Virus Infection Are Determined by the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site. | The Furin Protease Dependence and Antiviral GBP2 Sensitivity of Murine Leukemia Virus Infection Are Determined by the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site.
Kubo Y, Hans MB, Nakamura T, Hayashi H., Free PMC Article | 10/5/2024 |
| Furin Regulates the Alveolarization of Neonatal Lungs in a Mouse Model of Hyperoxic Lung Injury. | Furin Regulates the Alveolarization of Neonatal Lungs in a Mouse Model of Hyperoxic Lung Injury.
Kato S, Iwata O, Kato H, Fukaya S, Imai Y, Saitoh S., Free PMC Article | 11/28/2023 |
| FURIN regulates cytotoxic T-lymphocyte effector function and memory cell transition in mice. | FURIN regulates cytotoxic T-lymphocyte effector function and memory cell transition in mice.
Ojanen MJT, Caro FM, Aittomäki S, Ploquin MJ, Ortutay Z, Pekkarinen M, Kesseli J, Vähätupa M, Määttä J, Nykter M, Junttila IS, Järvinen TAH, O Shea JJ, Biron CA, Pesu M. | 06/9/2023 |
| FURIN suppresses the progression of atherosclerosis by promoting macrophage autophagy. | FURIN suppresses the progression of atherosclerosis by promoting macrophage autophagy.
Chen H, Zhang L, Mi S, Wang H, Wang C, Jia W, Gong L, Dong H, Xu B, Jing Y, Ge P, Pei Z, Zhong L, Yang J. | 04/26/2023 |
| Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice. | Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice.
Coppola I, Brouwers B, Walker L, Alar C, Meulemans S, White A, Ramos-Molina B, Creemers JWM., Free PMC Article | 01/14/2023 |
| Neuropilin-1 Facilitates Pseudorabies Virus Replication and Viral Glycoprotein B Promotes Its Degradation in a Furin-Dependent Manner. | Neuropilin-1 Facilitates Pseudorabies Virus Replication and Viral Glycoprotein B Promotes Its Degradation in a Furin-Dependent Manner.
Chen M, Wang MH, Shen XG, Liu H, Zhang YY, Peng JM, Meng F, Wang TY, Bai YZ, Sun MX, Tian ZJ, Yin X, Cai XH, Tang YD., Free PMC Article | 11/5/2022 |
| In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23. | In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23.
Al Rifai O, Susan-Resiga D, Essalmani R, Creemers JWM, Seidah NG, Ferron M., Free PMC Article | 12/25/2021 |
| Identification of Novel Genetic Regulatory Region for Proprotein Convertase FURIN and Interferon Gamma in T Cells. | Identification of Novel Genetic Regulatory Region for Proprotein Convertase FURIN and Interferon Gamma in T Cells.
Ortutay Z, Grönholm A, Laitinen M, Keresztes-Andrei M, Hermelo I, Pesu M., Free PMC Article | 09/25/2021 |
| Differential Effects of Furin Deficiency on Insulin Receptor Processing and Glucose Control in Liver and Pancreatic beta Cells of Mice. | Differential Effects of Furin Deficiency on Insulin Receptor Processing and Glucose Control in Liver and Pancreatic β Cells of Mice.
Coppola I, Brouwers B, Meulemans S, Ramos-Molina B, Creemers JWM., Free PMC Article | 07/17/2021 |
| Loss of Furin in beta-Cells Induces an mTORC1-ATF4 Anabolic Pathway That Leads to beta-Cell Dysfunction. | Loss of Furin in β-Cells Induces an mTORC1-ATF4 Anabolic Pathway That Leads to β-Cell Dysfunction.
Brouwers B, Coppola I, Vints K, Dislich B, Jouvet N, Van Lommel L, Segers C, Gounko NV, Thorrez L, Schuit F, Lichtenthaler SF, Estall JL, Declercq J, Ramos-Molina B, Creemers JWM. | 05/15/2021 |
| Loss of the proprotein convertase Furin in T cells represses mammary tumorigenesis in oncogene-driven triple negative breast cancer. | Loss of the proprotein convertase Furin in T cells represses mammary tumorigenesis in oncogene-driven triple negative breast cancer.
He Z, Khatib AM, Creemers JWM. | 02/2/2021 |
| Administering the furin inhibitor alpha-1-PDX to Apoe(-/-) mice harboring a wire injury in the common carotid artery caused decreased carotid intimal thickness and lower plaque cellularity, smooth muscle cell, macrophage, and inflammatory marker content, suggesting protection against vascular remodeling. FURIN overexpression increased intimal plaque thickness 67%.FURIN levels directly correlate with atherosclerosis. | FURIN Inhibition Reduces Vascular Remodeling and Atherosclerotic Lesion Progression in Mice.
Yakala GK, Cabrera-Fuentes HA, Crespo-Avilan GE, Rattanasopa C, Burlacu A, George BL, Anand K, Mayan DC, Corlianò M, Hernández-Reséndiz S, Wu Z, Schwerk AMK, Tan ALJ, Trigueros-Motos L, Chèvre R, Chua T, Kleemann R, Liehn EA, Hausenloy DJ, Ghosh S, Singaraja RR., Free PMC Article | 01/18/2020 |
| Study shows that Nkx2-5 directly represses cardiac Furin expression. Furthermore, Furin is required for the maturation of the cardiac progenitor cells and for the correct formation of the atrioventricular junction where it is expressed. Finally, study shows that this function is, at least in part, mediated by modulation of the BMP pathway. | Furin, a transcriptional target of NKX2-5, has an essential role in heart development and function.
Dupays L, Towers N, Wood S, David A, Stuckey DJ, Mohun T., Free PMC Article | 12/14/2019 |
| The results showed that a protein called Furin activates Dispatched by splitting it at a specific point. When the break-point on Dispatch was genetically modified, Furin could no longer cleave the protein. As a consequence, Dispatched did not reach the correct location within cells to help Hedgehog move away from signal-releasing cells. | Cleavage activates dispatched for Sonic Hedgehog ligand release.
Stewart DP, Marada S, Bodeen WJ, Truong A, Sakurada SM, Pandit T, Pruett-Miller SM, Ogden SK., Free PMC Article | 08/10/2019 |
| Coronary artery disease-associated genetic variant increases FURIN expression, promoting monocyte/macrophage migration and proliferation while inhibiting apoptosis. | Influence of a Coronary Artery Disease-Associated Genetic Variant on FURIN Expression and Effect of Furin on Macrophage Behavior.
Zhao G, Yang W, Wu J, Chen B, Yang X, Chen J, McVey DG, Andreadi C, Gong P, Webb TR, Samani NJ, Ye S., Free PMC Article | 07/27/2019 |
| for the immune regulatory pathway necessary for TGF-beta production by T cells, our results support a two-step model, composed of STAT6 and furin | STAT6 and Furin Are Successive Triggers for the Production of TGF-β by T Cells.
Li Y, Liu W, Guan X, Truscott J, Creemers JW, Chen HL, Pesu M, El Abiad RG, Karacay B, Urban JF Jr, Elliott DE, Kaplan MH, Blazar BR, Ince MN., Free PMC Article | 07/20/2019 |
| Upon meiosis onset, active furin/IGF-1 receptor relocates into the cytoplasm to activate (phosphorylate) Akt to promote meiosis. In summary, our finding suggests that Plac1, a protein that is crucial for placentation, is also essential for oocyte meiosis and fertilization. | Placenta-specific 1 regulates oocyte meiosis and fertilization through furin.
Shi LY, Ma Y, Zhu GY, Liu JW, Zhou CX, Chen LJ, Wang Y, Li RC, Yang ZX, Zhang D. | 04/6/2019 |
| The developmental arrest of early secondary follicles following furin disruption might be rooted in the loss of the mature form of ADAMTS1 and compromised proliferation of granulosa cells in mutant mice. | Oocyte-specific deletion of furin leads to female infertility by causing early secondary follicle arrest in mice.
Meng TG, Hu MW, Ma XS, Huang L, Liang QX, Yuan Y, Hou Y, Wang H, Schatten H, Wang ZB, Sun QY., Free PMC Article | 03/10/2018 |
| FURIN has an anti-inflammatory function in LysM+ myeloid cells in vivo. | Myeloid cell expressed proprotein convertase FURIN attenuates inflammation.
Cordova ZM, Grönholm A, Kytölä V, Taverniti V, Hämäläinen S, Aittomäki S, Niininen W, Junttila I, Ylipää A, Nykter M, Pesu M., Free PMC Article | 02/17/2018 |
| The proprotein convertase furin is responsible for pro-OCN maturation in vitro and in vivo. | Proprotein convertase furin regulates osteocalcin and bone endocrine function.
Al Rifai O, Chow J, Lacombe J, Julien C, Faubert D, Susan-Resiga D, Essalmani R, Creemers JW, Seidah NG, Ferron M., Free PMC Article | 11/25/2017 |
| Furin plays an important role in the malignant phenotype of rhabdomyosarcoma cells by activating proteins involved in tumor growth, vascularization, metastasis and invasion. | The Proprotein Convertase Furin Contributes to Rhabdomyosarcoma Malignancy by Promoting Vascularization, Migration and Invasion.
Jaaks P, D'Alessandro V, Grob N, Büel S, Hajdin K, Schäfer BW, Bernasconi M., Free PMC Article | 08/5/2017 |
| Studied the impact of Furin inhibition on the development and progression of hepatocellular carcinoma. | Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth.
Declercq J, Brouwers B, Pruniau VP, Stijnen P, Tuand K, Meulemans S, Prat A, Seidah NG, Khatib AM, Creemers JW., Free PMC Article | 04/16/2016 |
| PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation. | PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation.
Bessonnard S, Mesnard D, Constam DB., Free PMC Article | 12/26/2015 |
| work confirms the hypothesis that the TCR-regulated protease FURIN plays an important role in T cell activation and that it can specifically modulate TCR-activated transactivation | Proprotein convertase FURIN regulates T cell receptor-induced transactivation.
Ortutay Z, Oksanen A, Aittomäki S, Ortutay C, Pesu M. | 10/3/2015 |
| the role of serpinB8/furin in obesity-associated chronic inflammation | Proprotein convertase subtilisin/kexin type 3 promotes adipose tissue-driven macrophage chemotaxis and is increased in obesity.
Kappert K, Meyborg H, Fritzsche J, Urban D, Krüger J, Wellnhofer E, Kintscher U, Fleck E, Stawowy P., Free PMC Article | 04/5/2014 |