| Replication Activities of Major 5' Terminally Deleted Group-B Coxsackievirus RNA Forms Decrease PCSK2 mRNA Expression Impairing Insulin Maturation in Pancreatic Beta Cells. | Replication Activities of Major 5' Terminally Deleted Group-B Coxsackievirus RNA Forms Decrease PCSK2 mRNA Expression Impairing Insulin Maturation in Pancreatic Beta Cells.
Callon D, Guedra A, Lebreil AL, Heng L, Bouland N, Fornès P, Berri F, Andreoletti L., Free PMC Article | 01/11/2023 |
| A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing. | A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing.
Dowsett GKC, Lam BYH, Tadross JA, Cimino I, Rimmington D, Coll AP, Polex-Wolf J, Knudsen LB, Pyke C, Yeo GSH., Free PMC Article | 03/26/2022 |
| Hippocampal changes in mice lacking an active prohormone convertase 2. | Hippocampal changes in mice lacking an active prohormone convertase 2.
Chang SY, DeVera C, Yang Z, Yang T, Song L, McDowell A, Xiong ZG, Simon R, Zhou A. | 09/4/2021 |
| Translation of insulin granule proteins are regulated by PDI and PABP. | Translation of insulin granule proteins are regulated by PDI and PABP.
Sarwade RD, Khalique A, Kulkarni SD, Pandey PR, Gaikwad N, Seshadri V. | 12/5/2020 |
| Study reveals a significant reduction of tachykinin and opioid neuropeptides level in proprotein convertase 1 and proprotein convertase 2 mutant mouse spinal cords. | Targeted high-resolution quadrupole-Orbitrap mass spectrometry analyses reveal a significant reduction of tachykinin and opioid neuropeptides level in PC1 and PC2 mutant mouse spinal cords.
Saidi M, Beaudry F. | 06/16/2018 |
| Study reports that PC2 null mice had increased number of mu opioid receptors in different brain areas. These mice also exhibited enhanced morphine-induced antinociception but reduced tolerance to and dependence on morphine. | Prohormone convertase 2 (PC2) null mice have increased mu opioid receptor levels accompanied by altered morphine-induced antinociception, tolerance and dependence.
Lutfy K, Parikh D, Lee DL, Liu Y, Ferrini MG, Hamid A, Friedman TC., Free PMC Article | 07/29/2017 |
| PC1 and PC2 are involved in the C-terminal processing of protachykinin peptides and suggest a major role in the maturation of the protachykinin-1 protein | Tachykinins Processing is Significantly Impaired in PC1 and PC2 Mutant Mouse Spinal Cord S9 Fractions.
Saidi M, Kamali S, Ruiz AO, Beaudry F. | 08/27/2016 |
| activation of the hypothalamic GPR40/FFA1 signaling pathway may regulate beta-endorphin release via PC2, and regulate the endogenous pain control system | Regulation of prohormone convertase 2 protein expression via GPR40/FFA1 in the hypothalamus.
Nakamoto K, Aizawa F, Nishinaka T, Tokuyama S. | 05/28/2016 |
| Verified the roles of proprotein convertase subtilisin/kexin type 2 in regulating IGF1 and female sexual maturation, it also might be involved in the regulation of aging. | Genetic Regulation of Female Sexual Maturation and Longevity Through Circulating IGF1.
Yuan R, Gatti DM, Krier R, Malay E, Schultz D, Peters LL, Churchill GA, Harrison DE, Paigen B., Free PMC Article | 08/29/2015 |
| Islets of Langerhans from prohormone convertase-2 knockout mice show alpha-cell hyperplasia and tumorigenesis with elevated alpha-cell neogenesis. | Islets of Langerhans from prohormone convertase-2 knockout mice show α-cell hyperplasia and tumorigenesis with elevated α-cell neogenesis.
Jones HB, Reens J, Brocklehurst SR, Betts CJ, Bickerton S, Bigley AL, Jenkins RP, Whalley NM, Morgan D, Smith DM., Free PMC Article | 03/22/2014 |
| Pc2 activity can be downregulated by mutant PAX6. | Mutant PAX6 downregulates prohormone convertase 2 expression in mouse islets.
Chen Y, Cao W, Zhou S, Shen L, Wen J. | 01/11/2014 |
| PC2 alone is responsible for catalyzing the conversion of pFE(22) to pFQ(7) and pSE(14), all peptides implicated in regulation of suckling-induced prolactin release. | Biosynthesis of proTRH-derived peptides in prohormone convertase 1 and 2 knockout mice.
Cyr NE, Stuart RC, Zhu X, Steiner DF, Nillni EA. | 08/11/2012 |
| Dynamic modulation of prohormone convertase 2 (PC2)-mediated precursor processing by 7B2 protein has a preferential effect on glucagon synthesis | Dynamic modulation of prohormone convertase 2 (PC2)-mediated precursor processing by 7B2 protein: preferential effect on glucagon synthesis.
Helwig M, Lee SN, Hwang JR, Ozawa A, Medrano JF, Lindberg I., Free PMC Article | 02/25/2012 |
| PCSK2 is needed for normal food intake and processing | PCSK2-null mice exhibit delayed intestinal motility, reduced refeeding response and altered plasma levels of several regulatory peptides.
Gagnon J, Mayne J, Chen A, Raymond A, Woulfe J, Mbikay M, Chrétien M. | 03/12/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| These results demonstrate a prominent role for cathepsin L, jointly with PC1/3 and PC2, for production of dynorphins in brain. | Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression.
Minokadeh A, Funkelstein L, Toneff T, Hwang SR, Beinfeld M, Reinheckel T, Peters C, Zadina J, Hook V. | 05/3/2010 |
| The presence of PC and GOAT in the cells, as well as n-octanoic acid in the culture medium, was necessary to produce n-octanoyl ghrelin. | Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid.
Takahashi T, Ida T, Sato T, Nakashima Y, Nakamura Y, Tsuji A, Kojima M. | 02/8/2010 |
| PC2 expression levels were compared among brain cortex tissue, NS20Y tumor cells and its differentiated cells; differentiated cells or tissues had higher or highest PC2 activity | PC2/CPE-mediated pro-protein processing in tumor cells and its differentiated cells or tissues.
Tang SS, Zhang JH, Liu HX, Li HZ., Free PMC Article | 01/21/2010 |
| Expression of PCSK2 in mouse small intestine. | Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine.
Gagnon J, Mayne J, Mbikay M, Woulfe J, Chrétien M. | 01/21/2010 |
| Lack of PC1/3 was without effect on the third dibasic site (Lys(53)Lys(54)), which is the only processing site for PC2. The complementary cleavages of PC1/3 and 2, however, suffice to explain most of the normal endoproteolysis of progastrin. | Prohormone convertases 1/3 and 2 together orchestrate the site-specific cleavages of progastrin to release gastrin-34 and gastrin-17.
Rehfeld JF, Zhu X, Norrbom C, Bundgaard JR, Johnsen AH, Nielsen JE, Vikesaa J, Stein J, Dey A, Steiner DF, Friis-Hansen L. | 01/21/2010 |
| 7B2 possesses chaperone activity that blocks partially unfolded pro-PC2 forms from losing catalytic competence and then aggregating. | 7B2 prevents unfolding and aggregation of prohormone convertase 2.
Lee SN, Lindberg I., Free PMC Article | 01/21/2010 |
| PC1/3 governs the endocrine and PC2 the neuronal processing of proCCK, whereas PC5/6 contributes only to a modest endocrine synthesis of CCK-22. | The cell-specific pattern of cholecystokinin peptides in endocrine cells versus neurons is governed by the expression of prohormone convertases 1/3, 2, and 5/6.
Rehfeld JF, Bundgaard JR, Hannibal J, Zhu X, Norrbom C, Steiner DF, Friis-Hansen L., Free PMC Article | 01/21/2010 |
| prohormone convertase (PC)2 in cerebral neurons, compared to PC1, which governs the processing of procholecystokinin in intestinal endocrine cells. | On the tissue-specific processing of procholecystokinin in the brain and gut--a short review.
Rehfeld JF, Bungaard JR, Friis-Hansen L, Goetze JP. | 01/21/2010 |
| Expression of PC1/3 rather than PC2 in alpha-cells induces GLP-1 and GLP-2 production and converts the alpha-cell from a hyperglycemia-promoting cell to one that lowers blood glucose levels and promotes islet survival. | A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice.
Wideman RD, Covey SD, Webb GC, Drucker DJ, Kieffer TJ. | 01/21/2010 |