| Discovery of two new isoforms of the human DUT gene. | Discovery of two new isoforms of the human DUT gene.
Rácz GA, Nagy N, Várady G, Tóvári J, Apáti Á, Vértessy BG., Free PMC Article | 05/18/2023 |
| DUT enhances drug resistance to proteasome inhibitors via promoting mitochondrial function in multiple myeloma. | DUT enhances drug resistance to proteasome inhibitors via promoting mitochondrial function in multiple myeloma.
Wang Y, Gao S, Chen L, Liu S, Ma J, Cao Z, Li Q. | 02/13/2023 |
| Redox status of cysteines does not alter functional properties of human dUTPase but the Y54C mutation involved in monogenic diabetes decreases protein stability. | Redox status of cysteines does not alter functional properties of human dUTPase but the Y54C mutation involved in monogenic diabetes decreases protein stability.
Szabó JE, Nyíri K, Andrási D, Matejka J, Ozohanics O, Vértessy B., Free PMC Article | 01/1/2022 |
| These findings suggested that the homozygous GG allele of rs3784619 and the TT allele of rs11637235 in the DUT gene significantly increased the risk of cervical intraepithelial neoplasia III and cervical squamous cell carcinomas. | Genetic variants of the dUTPase-encoding gene DUT increase HR-HPV infection rate and cervical squamous cell carcinoma risk.
Ye F, Wang H, Liu J, Cheng Q, Chen X, Chen H., Free PMC Article | 08/1/2020 |
| This study reports that the Staphylococcal repressor protein StlSaPIBov1 (Stl) forms strong complex with human dUTPase. | Structural model of human dUTPase in complex with a novel proteinaceous inhibitor.
Nyíri K, Mertens HDT, Tihanyi B, Nagy GN, Kőhegyi B, Matejka J, Harris MJ, Szabó JE, Papp-Kádár V, Németh-Pongrácz V, Ozohanics O, Vékey K, Svergun DI, Borysik AJ, Vértessy BG., Free PMC Article | 09/21/2019 |
| A single homozygous missense mutation (chr15.hg19:g.48,626,619A>G) located in the dUTPase (DUT) gene was associated with a syndrome of bone marrow failure and diabetes. | dUTPase (DUT) Is Mutated in a Novel Monogenic Syndrome With Diabetes and Bone Marrow Failure.
Dos Santos RS, Daures M, Philippi A, Romero S, Marselli L, Marchetti P, Senée V, Bacq D, Besse C, Baz B, Marroquí L, Ivanoff S, Masliah-Planchon J, Nicolino M, Soulier J, Socié G, Eizirik DL, Gautier JF, Julier C. | 06/24/2017 |
| Comparison of the cellular distribution of wild-type dUTPase with those of hyperphosphorylation- and hypophosphorylation-mimicking mutants suggests that phosphorylation at Ser11 leads to the exclusion of dUTPase from the nucleus. | Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights.
Róna G, Marfori M, Borsos M, Scheer I, Takács E, Tóth J, Babos F, Magyar A, Erdei A, Bozóky Z, Buday L, Kobe B, Vértessy BG. | 07/12/2014 |
| EBV-encoded dUTPase may act as an intercellular signaling molecule capable of modulating the cellular microenvironment | Epstein-Barr virus encoded dUTPase containing exosomes modulate innate and adaptive immune responses in human dendritic cells and peripheral blood mononuclear cells.
Ariza ME, Rivailler P, Glaser R, Chen M, Williams MV., Free PMC Article | 03/1/2014 |
| Data sugget that inhibition of dUTPase is a mechanism-based therapeutic approach to significantly enhance the efficacy of thymidylate synthase (TS)-targeted chemotherapeutic agents. | Inhibition of dUTPase induces synthetic lethality with thymidylate synthase-targeted therapies in non-small cell lung cancer.
Wilson PM, LaBonte MJ, Lenz HJ, Mack PC, Ladner RD. | 07/14/2012 |
| Repression of dUTPase induced specific expression level increments for thymidylate kinase and thymidine kinase, and also an increased sensitization to 5-fluoro-2'-deoxyuridine and 5-fluoro-uracil. | Cellular response to efficient dUTPase RNAi silencing in stable HeLa cell lines perturbs expression levels of genes involved in thymidylate metabolism.
Merényi G, Kovári J, Tóth J, Takács E, Zagyva I, Erdei A, Vértessy BG. | 11/12/2011 |
| High dUTP pyrophosphatase is associated with recurrence in colorectal cancer patients undergoing 5-fluorouracil adjuvant chemotherapy | Identification of potential pharmacogenomic markers of clinical efficacy of 5-fluorouracil in colorectal cancer.
Nobili S, Napoli C, Landini I, Morganti M, Cianchi F, Valanzano R, Tonelli F, Cortesini C, Mazzei T, Mini E. | 04/23/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| nuclear dUTPase may be a good biomarker for predicting prognosis in HCC patients after surgical resection | dUTP pyrophosphatase expression correlates with a poor prognosis in hepatocellular carcinoma.
Takatori H, Yamashita T, Honda M, Nishino R, Arai K, Yamashita T, Takamura H, Ohta T, Zen Y, Kaneko S. | 09/6/2010 |
| significant differences between the human and Plasmodium dUTPases | Kinetic properties and specificity of trimeric Plasmodium falciparum and human dUTPases.
Quesada-Soriano I, Casas-Solvas JM, Recio E, Ruiz-Pérez LM, Vargas-Berenguel A, González-Pacanowska D, García-Fuentes L. | 05/3/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Polymorphisms in uracil-processing genes, but not one-carbon nutrients, are associated with altered DNA uracil concentrations in an urban Puerto Rican population.
Chanson A, Parnell LD, Ciappio ED, Liu Z, Crott JW, Tucker KL, Mason JB., Free PMC Article | 05/17/2009 |
| hinge proline destabilize human and Escherichia coli dUTPases without preventing trimeric organization | Molecular shape and prominent role of beta-strand swapping in organization of dUTPase oligomers.
Takács E, Barabás O, Petoukhov MV, Svergun DI, Vértessy BG. | 01/21/2010 |
| Establishment of a direct role for both mutant and wild-type forms of p53 in modulating dUTPase promoter activity. | Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage.
Wilson PM, Fazzone W, LaBonte MJ, Lenz HJ, Ladner RD., Free PMC Article | 01/21/2010 |
| kinetic model of the human dUTPase catalytic cycle | Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme.
Tóth J, Varga B, Kovács M, Málnási-Csizmadia A, Vértessy BG. | 01/21/2010 |
| determined the crystal structure of the enzyme:alpha,beta-imino-dUTP | Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase.
Varga B, Barabás O, Kovári J, Tóth J, Hunyadi-Gulyás E, Klement E, Medzihradszky KF, Tölgyesi F, Fidy J, Vértessy BG. | 01/21/2010 |
| Nuclear dUTPase may contain a complex nuclear localization signal that is located throughout the entire protein. | Identification of sequence determinants of human nuclear dUTPase isoform localization.
Tinkelenberg BA, Fazzone W, Lynch FJ, Ladner RD. | 01/21/2010 |
| dUTPase staining provides a useful measure of cell proliferation distinct from that offered by Ki-67 labeling. It proved particularly useful for the evaluation of diffuse astrocytomas. | Immunohistochemical detection of dUTPase in intracranial tumors.
Romeike BF, Böckeler A, Kremmer E, Sommer P, Krick C, Grässer F. | 01/21/2010 |
| Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil. | Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil.
Pugacheva EN, Ivanov AV, Kravchenko JE, Kopnin BP, Levine AJ, Chumakov PM. | 01/21/2010 |