| hMSCs-derived exosome circCDK13 inhibits liver fibrosis by regulating the expression of MFGE8 through miR-17-5p/KAT2B. | hMSCs-derived exosome circCDK13 inhibits liver fibrosis by regulating the expression of MFGE8 through miR-17-5p/KAT2B.
Ma J, Li Y, Chen M, Wang W, Zhao Q, He B, Zhang M, Jiang Y. | 06/9/2023 |
| NCOA2 coordinates with the transcriptional KAT2B-NF-kappaB partner to trigger inflammation response in acute kidney injury. | NCOA2 coordinates with the transcriptional KAT2B-NF-κB partner to trigger inflammation response in acute kidney injury.
Zhou P, Li D, Luo F, Wan X. | 06/11/2022 |
| Age-dependent attenuation of spatial memory deficits by the histone acetyltransferase p300/CBP-associated factor (PCAF) in 3xTG Alzheimer's disease mice. | Age-dependent attenuation of spatial memory deficits by the histone acetyltransferase p300/CBP-associated factor (PCAF) in 3xTG Alzheimer's disease mice.
Creighton SD, Jardine KH, Desimone A, Zmetana M, Castellano S, Milite C, Sbardella G, Winters BD., Free PMC Article | 04/23/2022 |
| Acetyltransferases GCN5 and PCAF Are Required for B Lymphocyte Maturation in Mice. | Acetyltransferases GCN5 and PCAF Are Required for B Lymphocyte Maturation in Mice.
Oksenych V, Su D, Daniel JA., Free PMC Article | 04/9/2022 |
| MicroRNA-29a represses osteoclast formation and protects against osteoporosis by regulating PCAF-mediated RANKL and CXCL12. | MicroRNA-29a represses osteoclast formation and protects against osteoporosis by regulating PCAF-mediated RANKL and CXCL12.
Lian WS, Ko JY, Chen YS, Ke HJ, Hsieh CK, Kuo CW, Wang SY, Huang BW, Tseng JG, Wang FS., Free PMC Article | 09/26/2020 |
| Study reveals that SIRT6 regulates BMP signaling in a PCAF dependent manner, and that this regulation might extend beyond osteogenic differentiation and have significant implications in undiscovered cellular processes. | SIRT6 promotes osteogenic differentiation of mesenchymal stem cells through BMP signaling.
Zhang P, Liu Y, Wang Y, Zhang M, Lv L, Zhang X, Zhou Y., Free PMC Article | 06/15/2019 |
| histone H3K9 acetyltransferase PCAF plays a critical role in osteogenic differentiation of mesenchymal stem cells. | Histone H3K9 Acetyltransferase PCAF Is Essential for Osteogenic Differentiation Through Bone Morphogenetic Protein Signaling and May Be Involved in Osteoporosis.
Zhang P, Liu Y, Jin C, Zhang M, Lv L, Zhang X, Liu H, Zhou Y. | 12/23/2017 |
| These results uncover p300 as a direct target of mTORC1 and suggest that the mTORC1-p300 pathway plays a pivotal role in cell metabolism by coordinately controlling cell anabolism and catabolism | mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis.
Wan W, You Z, Xu Y, Zhou L, Guan Z, Peng C, Wong CCL, Su H, Zhou T, Xia H, Liu W. | 10/28/2017 |
| The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development. | The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development.
de Jong RCM, Ewing MM, de Vries MR, Karper JC, Bastiaansen AJNM, Peters HAB, Baghana F, van den Elsen PJ, Gongora C, Jukema JW, Quax PHA., Free PMC Article | 10/21/2017 |
| This study demonstrated that pcaf increase in skeletal muscle in muscle atrophy. | Differential expression of HDAC and HAT genes in atrophying skeletal muscle.
Beharry AW, Judge AR., Free PMC Article | 05/14/2016 |
| Treatment with a pan-acetylase inhibitor, anacardic acid, reduced the binding affinity of p300 and PCAF to the NKX2.5, beta-MHC, Cx43 promoters and attenuated H3K9 hyperacetylation. | Alcohol-induced histone H3K9 hyperacetylation and cardiac hypertrophy are reversed by a histone acetylases inhibitor anacardic acid in developing murine hearts.
Peng C, Zhang W, Zhao W, Zhu J, Huang X, Tian J. | 02/6/2016 |
| Gcn5 and PCAF repress IFN-beta production in an enzymatic activity-independent and non-transcriptional manner: by inhibiting the innate immune signaling kinase TBK1 in the cytoplasm. | Gcn5 and PCAF negatively regulate interferon-β production through HAT-independent inhibition of TBK1.
Jin Q, Zhuang L, Lai B, Wang C, Li W, Dolan B, Lu Y, Wang Z, Zhao K, Peng W, Dent SY, Ge K., Free PMC Article | 08/18/2015 |
| PCAF acetylates two lysine residues K328 and K450 in PGC-1alpha. PCAF in the obese mouse liver greatly represses gluconeogenic enzyme activation and glucose production and improves glucose homeostasis and insulin sensitivity. | PCAF improves glucose homeostasis by suppressing the gluconeogenic activity of PGC-1α.
Sun C, Wang M, Liu X, Luo L, Li K, Zhang S, Wang Y, Yang Y, Ding F, Gu X. | 07/25/2015 |
| Study reveals that Gcn5/PCAF facilitate adipogenesis through regulation of PPARgamma expression and regulate brown adipogenesis by influencing Prdm16 expression. | Gcn5 and PCAF regulate PPARγ and Prdm16 expression to facilitate brown adipogenesis.
Jin Q, Wang C, Kuang X, Feng X, Sartorelli V, Ying H, Ge K, Dent SY., Free PMC Article | 11/22/2014 |
| KLF10, functions as a toggle to integrate antagonistic signals regulating FOXP3 via Sin3-HDAC/PCAF pathway and, thus, immune activation. | Differential coupling of KLF10 to Sin3-HDAC and PCAF regulates the inducibility of the FOXP3 gene.
Xiong Y, Svingen PA, Sarmento OO, Smyrk TC, Dave M, Khanna S, Lomberk GA, Urrutia RA, Faubion WA Jr., Free PMC Article | 11/8/2014 |
| PCAF is necessary for axonal regeneration and also promotes regeneration after spinal cord injury. | PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system.
Puttagunta R, Tedeschi A, Sória MG, Hervera A, Lindner R, Rathore KI, Gaub P, Joshi Y, Nguyen T, Schmandke A, Laskowski CJ, Boutillier AL, Bradke F, Di Giovanni S. | 09/27/2014 |
| These data unveil a p53/PCAF/Gli1 circuitry centered on PCAF that limits Gli1-enhanced mitogenic and prosurvival response. | PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress.
Mazzà D, Infante P, Colicchia V, Greco A, Alfonsi R, Siler M, Antonucci L, Po A, De Smaele E, Ferretti E, Capalbo C, Bellavia D, Canettieri G, Giannini G, Screpanti I, Gulino A, Di Marcotullio L., Free PMC Article | 06/7/2014 |
| PCAF is an important regulator for promoting osteoblast differentiation via acetylation modification of Runx2. | PCAF acetylates Runx2 and promotes osteoblast differentiation.
Wang CY, Yang SF, Wang Z, Tan JM, Xing SM, Chen DC, Xu SM, Yuan W. | 02/1/2014 |
| CSB and PCAF play cooperative roles to establish the active state of rRNA genes by histone acetylation | The chromatin remodeling factor CSB recruits histone acetyltransferase PCAF to rRNA gene promoters in active state for transcription initiation.
Shen M, Zhou T, Xie W, Ling T, Zhu Q, Zong L, Lyu G, Gao Q, Zhang F, Tao W., Free PMC Article | 12/14/2013 |
| Depletion of KAT2B or WDR5 decreased gluconeogenic gene expression. | Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects.
Ravnskjaer K, Hogan MF, Lackey D, Tora L, Dent SY, Olefsky J, Montminy M., Free PMC Article | 11/30/2013 |
| PCAF acts as master switch in the inflammatory processes required for effective arteriogenesis. | Lysine acetyltransferase PCAF is a key regulator of arteriogenesis.
Bastiaansen AJ, Ewing MM, de Boer HC, van der Pouw Kraan TC, de Vries MR, Peters EA, Welten SM, Arens R, Moore SM, Faber JE, Jukema JW, Hamming JF, Nossent AY, Quax PH., Free PMC Article | 09/28/2013 |
| Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner. | Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner.
Xiong Y, Khanna S, Grzenda AL, Sarmento OF, Svingen PA, Lomberk GA, Urrutia RA, Faubion WA Jr., Free PMC Article | 01/5/2013 |
| Within the context of fear extinction, p300/CBP-associated factor functions as a transcriptional coactivator. | p300/CBP-associated factor selectively regulates the extinction of conditioned fear.
Wei W, Coelho CM, Li X, Marek R, Yan S, Anderson S, Meyers D, Mukherjee C, Sbardella G, Castellano S, Milite C, Rotili D, Mai A, Cole PA, Sah P, Kobor MS, Bredy TW., Free PMC Article | 11/17/2012 |
| p300 and PCAF cooperate in the control of microRNA 200c/141 transcription and epithelial characteristics | Cooperation of p300 and PCAF in the control of microRNA 200c/141 transcription and epithelial characteristics.
Mizuguchi Y, Specht S, Lunz JG 3rd, Isse K, Corbitt N, Takizawa T, Demetris AJ., Free PMC Article | 09/1/2012 |
| downregulation of PCAF by TNF-alpha provides negative feedback regulation to inflammatory reactions in liver epithelial cells; upregulated microRNAs in TNF-alpha-treated cells, miR-181a/b (miR-181a and miR-181b) suppressed translation of PCAF mRNA | Downregulation of PCAF by miR-181a/b provides feedback regulation to TNF-α-induced transcription of proinflammatory genes in liver epithelial cells.
Zhao J, Gong AY, Zhou R, Liu J, Eischeid AN, Chen XM., Free PMC Article | 06/16/2012 |