| Recapitulation of anti-aging phenotypes by global, but not by muscle-specific, deletion of PAPP-A in mice. | Recapitulation of anti-aging phenotypes by global, but not by muscle-specific, deletion of PAPP-A in mice.
Li X, Hager M, McPherson M, Lee M, Hagalwadi R, Skinner ME, Lombard D, Miller RA., Free PMC Article | 02/4/2023 |
| Brain-specific PAPP-A knock-out mice? | Brain-specific PAPP-A knock-out mice?
Bale LK, West SA, Conover CA., Free PMC Article | 10/23/2021 |
| Inhibition of longevity regulator PAPP-A modulates tissue homeostasis via restraint of mesenchymal stromal cells. | Inhibition of longevity regulator PAPP-A modulates tissue homeostasis via restraint of mesenchymal stromal cells.
Mohrin M, Liu J, Zavala-Solorio J, Bhargava S, Maxwell Trumble J, Brito A, Hu D, Brooks D, Koukos G, Alabdulaaly L, Paw JS, Hake K, Kolumam G, Bouxsein ML, Baron R, Kutskova Y, Freund A., Free PMC Article | 10/9/2021 |
| Suppression of PAPP-A mitigates atherosclerosis by mediating macrophage polarization via STAT3 signaling. | Suppression of PAPP-A mitigates atherosclerosis by mediating macrophage polarization via STAT3 signaling.
Wang G, Liu X, Li X, Zhao Y. | 09/4/2021 |
| PAPPA-mediated adipose tissue remodeling mitigates insulin resistance and protects against gestational diabetes in mice and humans. | PAPPA-mediated adipose tissue remodeling mitigates insulin resistance and protects against gestational diabetes in mice and humans.
Rojas-Rodriguez R, Ziegler R, DeSouza T, Majid S, Madore AS, Amir N, Pace VA, Nachreiner D, Alfego D, Mathew J, Leung K, Moore Simas TA, Corvera S., Free PMC Article | 08/7/2021 |
| Genetic and Pharmacological Inhibition of PAPP-A Protects Against Visceral Obesity in Mice. | Genetic and Pharmacological Inhibition of PAPP-A Protects Against Visceral Obesity in Mice.
Ramakrishna A, Bale LK, West SA, Conover CA., Free PMC Article | 02/6/2021 |
| This work provides a comprehensive characterization of the surfaceome of EWS, credentials PAPP-A as a highly differentially expressed therapeutic target, and discovers a novel link between IGF-1 signaling and immune evasion in cancer, thus implicating shared mechanisms of immune evasion between EWS and the placenta. | Pregnancy-Associated Plasma Protein-A (PAPP-A) in Ewing Sarcoma: Role in Tumor Growth and Immune Evasion.
Heitzeneder S, Sotillo E, Shern JF, Sindiri S, Xu P, Jones R, Pollak M, Noer PR, Lorette J, Fazli L, Alag A, Meltzer P, Lau C, Conover CA, Oxvig C, Sorensen PH, Maris JM, Khan J, Mackall CL., Free PMC Article | 06/20/2020 |
| Inducible knockdown of PAPP-A gene expression in adult female mice extends life span. | Inducible knockdown of pregnancy-associated plasma protein-A gene expression in adult female mice extends life span.
Bale LK, West SA, Conover CA., Free PMC Article | 12/2/2017 |
| Intrinsic mitochondrial oxidative capacity was significantly increased in skeletal muscle of aged PAPP-A KO compared to WT mice. Moreover, 18-month-old PAPP-A KO mice exhibited significantly enhanced endurance running on a treadmill. Thus, PAPP-A deficiency in mice is associated with indices of healthy skeletal muscle function with age. | Comparative gene expression and phenotype analyses of skeletal muscle from aged wild-type and PAPP-A-deficient mice.
Conover CA, Bale LK, Nair KS., Free PMC Article | 09/30/2017 |
| Snell, GHKRO, and PAPPA-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT) and N-myc downstream-regulated gene 1 (NDRG1). | mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice.
Dominick G, Bowman J, Li X, Miller RA, Garcia GG., Free PMC Article | 06/10/2017 |
| STC2 is involved in regulating PAPP-A activity during the development of atherosclerosis | Stanniocalcin-2 overexpression reduces atherosclerosis in hypercholesterolemic mice.
Steffensen LB, Conover CA, Bjørklund MM, Ledet T, Bentzon JF, Oxvig C. | 03/11/2017 |
| Study demonstrates proof-of-principle and provides feasibility for a novel therapeutic strategy to inhibit atherosclerotic plaque burden by selective targeting of PAPP-A. | Targeted Inhibition of Pregnancy-Associated Plasma Protein-A Activity Reduces Atherosclerotic Plaque Burden in Mice.
Conover CA, Bale LK, Oxvig C. | 12/17/2016 |
| stimulation of PAPP-A expression by intermittent PTH treatment contributes to PTH bone anabolism in mice | Pregnancy-associated plasma protein-A modulates the anabolic effects of parathyroid hormone in mouse bone.
Clifton KB, Conover CA., Free PMC Article | 10/8/2016 |
| PAPP-A affects fascicle structure, thereby affecting tendon phenotype. | PAPP-A affects tendon structure and mechanical properties.
Yang TH, Thoreson AR, An KN, Zhao C, Conover CA, Amadio PC. | 07/30/2016 |
| tissue-specific expression differentially affected during aging | Tissue-specific changes in pregnancy associated plasma protein-A expression with age in mice.
Harstad SL, Conover CA., Free PMC Article | 05/30/2015 |
| PAPP-A has a role in development of advanced plaque with necrotic cores and buried fibrous caps in the brachiocephalic artery | Inducible reduction in pregnancy-associated plasma protein-A gene expression inhibits established atherosclerotic plaque progression in mice.
Bale LK, Chakraborty S, Conover CA., Free PMC Article | 05/24/2014 |
| these data indicate preferential impact of PAPP-A deficiency on visceral fat in the mouse that is associated with enhanced insulin receptor signaling | Preferential impact of pregnancy-associated plasma protein-A deficiency on visceral fat in mice on high-fat diet.
Conover CA, Harstad SL, Tchkonia T, Kirkland JL., Free PMC Article | 12/28/2013 |
| Studies show a conditional PAPP-A knockout (KO) model for efficacy of tamoxifen-induced floxed PAPP-A excision in various tissues and indicate a significant reduction of neointimal formation after unilateral carotid artery ligation. | Inducible knock out of pregnancy-associated plasma protein-a gene expression in the adult mouse: effect on vascular injury response.
Conover CA, Bale LK, Powell DR., Free PMC Article | 11/2/2013 |
| absence of PAPP-A is associated with resistance to the development of indicators of diabetic nephropathy in mice | Mice deficient in PAPP-A show resistance to the development of diabetic nephropathy.
Mader JR, Resch ZT, McLean GR, Mikkelsen JH, Oxvig C, Marler RJ, Conover CA., Free PMC Article | 11/2/2013 |
| Pregnancy-associated plasma protein (PAPP)-A expressed in the mammary gland controls epithelial cell proliferation and differentiation. | Pregnancy-associated plasma protein (PAPP)-A expressed in the mammary gland controls epithelial cell proliferation and differentiation.
Nakasato M, Kohsaka H, Mizutani T, Watanabe G, Taya K, Nagaoka K. | 09/28/2013 |
| Data conclude that PAPP-A proteolytic activity is required for the lesion-promoting effect of PAPP-A and that its specificity must be directed against IGFBP-4. | Effects of mutated pregnancy-associated plasma protein-a on atherosclerotic lesion development in mice.
Boldt HB, Bale LK, Resch ZT, Oxvig C, Overgaard MT, Conover CA., Free PMC Article | 02/23/2013 |
| observations revealed a novel function of prohibitin as a chaperone of p53. Further, they suggest that binding of denatured p53 in intron 1 causes an enhancer effect and increases the transcription of PAPP-A | Skp2B overexpression alters a prohibitin-p53 axis and the transcription of PAPP-A, the protease of insulin-like growth factor binding protein 4.
Chander H, Halpern M, Resnick-Silverman L, Manfredi JJ, Germain D., Free PMC Article | 12/31/2011 |
| PAPP-A increases bone formation primarily by increasing IGF bioavailability and other alternative pathways may play a negligible role in mediating the anabolic effect of PAPPA in bone. | Inactivation of insulin-like-growth factors diminished the anabolic effects of pregnancy-associated plasma protein-A (PAPP-A) on bone in mice.
Phang D, Rehage M, Bonafede B, Hou D, Xing W, Mohan S, Wergedal JE, Qin X. | 09/20/2010 |
| PAPPA modulates ovarian function and female fertility by controlling the bioavailability of ovarian insulin-like growth factors. | Lack of functional pregnancy-associated plasma protein-A (PAPPA) compromises mouse ovarian steroidogenesis and female fertility.
Nyegaard M, Overgaard MT, Su YQ, Hamilton AE, Kwintkiewicz J, Hsieh M, Nayak NR, Conti M, Conover CA, Giudice LC., Free PMC Article | 09/6/2010 |
| Renal expression of Irs1 and Mt1 was increased by PappA(-/-) as well as by mutations that reduce IGF-1 in serum. | In vivo analysis of gene expression in long-lived mice lacking the pregnancy-associated plasma protein A (PappA) gene.
Swindell WR, Masternak MM, Bartke A., Free PMC Article | 07/12/2010 |