| Changes in gut microbiome correlate with intestinal barrier dysfunction and inflammation following a 3-day ethanol exposure in aged mice. | Changes in gut microbiome correlate with intestinal barrier dysfunction and inflammation following a 3-day ethanol exposure in aged mice.
McMahan RH, Hulsebus HJ, Najarro KM, Giesy LE, Frank DN, Kovacs EJ., Free PMC Article | 03/22/2023 |
| REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway. | REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway.
Zhang H, Corredor ALG, Messina-Pacheco J, Li Q, Zogopoulos G, Kaddour N, Wang Y, Shi BY, Gregorieff A, Liu JL, Gao ZH., Free PMC Article | 08/14/2021 |
| HIP/PAP protects against bleomycin-induced lung injury and inflammation and subsequent fibrosis in mice. | HIP/PAP protects against bleomycin-induced lung injury and inflammation and subsequent fibrosis in mice.
Zheng X, Li Q, Tian H, Li H, Lv Y, Wang Y, He L, Huo Y, Hao Z., Free PMC Article | 05/1/2021 |
| Intestinal microbiota transplantation reveals the role of microbiota in dietary regulation of RegIIIbeta and RegIIIgamma expression in mouse intestine. | Intestinal microbiota transplantation reveals the role of microbiota in dietary regulation of RegIIIβ and RegIIIγ expression in mouse intestine.
Udomsopagit T, Miwa A, Seki M, Shimbori E, Kadota Y, Tochio T, Sonoyama K. | 02/13/2021 |
| Cardiomyocytes situated in close proximity to the infarcted region produce large amounts of Reg3b, Reg3g, and Reg4, thereby forming a chemokine gradient that might direct interstitial migration of MHCIIhi/Ly6Clo and MHC-IIlo/Ly6Clo macrophage subsets. | Reg proteins direct accumulation of functionally distinct macrophage subsets after myocardial infarction.
Lörchner H, Hou Y, Adrian-Segarra JM, Kulhei J, Detzer J, Günther S, Gajawada P, Warnecke H, Niessen HW, Pöling J, Braun T. | 11/16/2019 |
| Reg3beta is a prognostic biomarker for acute coronary syndrome and is strongly associated with the intensity of cardiac inflammation. | Reg3β is associated with cardiac inflammation and provides prognostic information in patients with acute coronary syndrome.
Lörchner H, Widera C, Hou Y, Elsässer A, Warnecke H, Giannitsis E, Hulot JS, Braun T, Wollert KC, Pöling J. | 10/27/2018 |
| The pancreas reacts to remote lesions and septic insults in mice and rats with increased PSP synthesis, while PAP is selectively responsive to septic events. Furthermore, our results suggest that serum PSP in septic patients is predominantly derived through an acute phase response of the pancreas. | The pancreas responds to remote damage and systemic stress by secretion of the pancreatic secretory proteins PSP/regI and PAP/regIII.
Reding T, Palmiere C, Pazhepurackel C, Schiesser M, Bimmler D, Schlegel A, Süss U, Steiner S, Mancina L, Seleznik G, Graf R., Free PMC Article | 03/10/2018 |
| BMI1 and MEL18 contribute to the development of colitis-associated cancer in mice by promoting proliferation and reducing apoptosis via suppressing expression of Reg3b. REG3B negatively regulates cytokine-induced activation of STAT3 in colon epithelial cells. | BMI1 and MEL18 Promote Colitis-Associated Cancer in Mice via REG3B and STAT3.
Liu X, Wei W, Li X, Shen P, Ju D, Wang Z, Zhang R, Yang F, Chen C, Cao K, Zhu G, Chen H, Chen L, Sui J, Zhang E, Wu K, Wang F, Zhao L, Xi R. | 12/9/2017 |
| Intestinal deficiency in REG3B or REG3G increases numbers of mucosa-associated bacteria and enhances bacterial translocation to the mesenteric lymph nodes and liver. | Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation.
Wang L, Fouts DE, Stärkel P, Hartmann P, Chen P, Llorente C, DePew J, Moncera K, Ho SB, Brenner DA, Hooper LV, Schnabl B., Free PMC Article | 11/5/2016 |
| our findings reveal a dual and contextual pathophysiologic role for REG3beta during pancreatitis and pancreatic ductal adenocarcinoma initiation | IL17 Functions through the Novel REG3β-JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer.
Loncle C, Bonjoch L, Folch-Puy E, Lopez-Millan MB, Lac S, Molejon MI, Chuluyan E, Cordelier P, Dubus P, Lomberk G, Urrutia R, Closa D, Iovanna JL., Free PMC Article | 03/5/2016 |
| our findings unveil a new metabolic role for Reg3beta in protein nitration and a new biosynthesis control of GPX1 by a completely "unrelated" regenerating protein, Reg3beta, via transcriptional activation of Scly | A novel upregulation of glutathione peroxidase 1 by knockout of liver-regenerating protein Reg3β aggravates acetaminophen-induced hepatic protein nitration.
Yun JW, Lum K, Lei XG., Free PMC Article | 08/15/2015 |
| Reg3beta-dependent accumulation of macrophages in the ischemic heart has a role in myocardial healing | Myocardial healing requires Reg3β-dependent accumulation of macrophages in the ischemic heart.
Lörchner H, Pöling J, Gajawada P, Hou Y, Polyakova V, Kostin S, Adrian-Segarra JM, Boettger T, Wietelmann A, Warnecke H, Richter M, Kubin T, Braun T. | 06/20/2015 |
| High Reg3B expression is associated with pancreatic tumor growth. | Reg3β deficiency impairs pancreatic tumor growth by skewing macrophage polarization.
Gironella M, Calvo C, Fernández A, Closa D, Iovanna JL, Rosello-Catafau J, Folch-Puy E. | 11/16/2013 |
| Direct stimulation of Reg2 and Reg3beta genes by glucocorticoids. | Transcriptional activation of Reg2 and Reg3β genes by glucocorticoids and interleukin-6 in pancreatic acinar and islet cells.
Luo C, Li B, Liu L, Yin HP, Wang M, Liu JL. | 06/22/2013 |
| Pancreatic STAT3 is indispensable for PAP1 production. | Pancreatic STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction.
Shigekawa M, Hikita H, Kodama T, Shimizu S, Li W, Uemura A, Miyagi T, Hosui A, Kanto T, Hiramatsu N, Tatsumi T, Takeda K, Akira S, Takehara T. | 05/4/2013 |
| Expression of Reg3 proteins and Ang4 by goblet cells point to an important role for goblet cells in innate defense. | Mucin Muc2 deficiency and weaning influences the expression of the innate defense genes Reg3β, Reg3γ and angiogenin-4.
Burger-van Paassen N, Loonen LM, Witte-Bouma J, Korteland-van Male AM, de Bruijn AC, van der Sluis M, Lu P, Van Goudoever JB, Wells JM, Dekker J, Van Seuningen I, Renes IB., Free PMC Article | 12/22/2012 |
| Reg-IIIbeta is expressed in specific subsets of primary sensory neurons and motor neurons; expression is transient during the embryonic and perinatal periods. | Expression analysis of the regenerating gene (Reg) family members Reg-IIIβ and Reg-IIIγ in the mouse during development.
Matsumoto S, Konishi H, Maeda R, Kiryu-Seo S, Kiyama H. | 08/25/2012 |
| Reg3b plays a protective role against intestinal translocation of the gram-negative bacterium Salmonella enteritidis in mice but not against the gram-positive bacterium Listeria monocytogenes. | Intestinally secreted C-type lectin Reg3b attenuates salmonellosis but not listeriosis in mice.
van Ampting MT, Loonen LM, Schonewille AJ, Konings I, Vink C, Iovanna J, Chamaillard M, Dekker J, van der Meer R, Wells JM, Bovee-Oudenhoven IM., Free PMC Article | 04/14/2012 |
| RegIIIbeta production by the host can promote S. Typhimurium infection by eliminating inhibitory gut microbiota. | Salmonella-induced mucosal lectin RegIIIβ kills competing gut microbiota.
Stelter C, Käppeli R, König C, Krah A, Hardt WD, Stecher B, Bumann D., Free PMC Article | 11/5/2011 |
| Reg2, Reg3alpha, and Reg3beta were abundantly expressed in most acinar cells of the pancreas with clear age-dependent and isoform-specific patterns. | Coordinated age-dependent and pancreatic-specific expression of mouse Reg2Reg3α, and Reg3β genes.
Wang Y, Jacovetti C, Li B, Siddique T, Xiong X, Yin H, Wang M, Zhao H, Liu JL. | 10/1/2011 |
| These data are consistent with a pleiotropic role for INGAP and reveal new pathways to target in the discovery of improved diabetic therapies | Targeted expression of islet neogenesis associated protein to beta cells enhances glucose tolerance and confers resistance to streptozotocin-induced hyperglycemia.
Chang TJ, Weaver JR, Bowman A, Leone K, Raab R, Vinik AI, Pittenger GL, Taylor-Fishwick DA. | 06/25/2011 |
| Reg3beta is unlikely an islet growth factor but a putative protector that prevents streptozotocin-induced damage by inducing the expression of specific genes. | Pancreatic islet-specific overexpression of Reg3β protein induced the expression of pro-islet genes and protected the mice against streptozotocin-induced diabetes mellitus.
Xiong X, Wang X, Li B, Chowdhury S, Lu Y, Srikant CB, Ning G, Liu JL. | 06/4/2011 |
| Deletion of the mouse RegIIIbeta (Reg2) gene disrupts ciliary neurotrophic factor signaling and delays myelination of mouse cranial motor neurons | Deletion of the mouse RegIIIbeta (Reg2) gene disrupts ciliary neurotrophic factor signaling and delays myelination of mouse cranial motor neurons.
Tebar LA, Géranton SM, Parsons-Perez C, Fisher AS, Bayne R, Smith AJ, Turmaine M, Perez-Luz S, Sheasby A, De Felipe C, Ruff C, Raivich G, Hunt SP., Free PMC Article | 01/21/2010 |
| the expression of the anti-inflammatory protein pancreatitis-associated protein I is enhanced by p8 | p8 improves pancreatic response to acute pancreatitis by enhancing the expression of the anti-inflammatory protein pancreatitis-associated protein I.
Vasseur S, Folch-Puy E, Hlouschek V, Garcia S, Fiedler F, Lerch MM, Dagorn JC, Closa D, Iovanna JL. | 01/21/2010 |