| PAK3 activation promotes the tangential to radial migration switch of cortical interneurons by increasing leading process dynamics and disrupting cell polarity. | PAK3 activation promotes the tangential to radial migration switch of cortical interneurons by increasing leading process dynamics and disrupting cell polarity.
Viou L, Atkins M, Rousseau V, Launay P, Masson J, Pace C, Murakami F, Barnier JV, Métin C., Free PMC Article | 09/25/2024 |
| Tgif1-deficiency impairs cytoskeletal architecture in osteoblasts by activating PAK3 signaling. | Tgif1-deficiency impairs cytoskeletal architecture in osteoblasts by activating PAK3 signaling.
Bolamperti S, Saito H, Heerdmann S, Hesse E, Taipaleenmäki H., Free PMC Article | 05/17/2024 |
| PAK3 downregulation induces cognitive impairment following cranial irradiation. | PAK3 downregulation induces cognitive impairment following cranial irradiation.
Lee H, Kang H, Moon C, Youn B., Free PMC Article | 01/3/2024 |
| Disruption of PAK3 Signaling in Social Interaction Induced cFos Positive Cells Impairs Social Recognition Memory. | Disruption of PAK3 Signaling in Social Interaction Induced cFos Positive Cells Impairs Social Recognition Memory.
Zhou S, Jia Z., Free PMC Article | 01/1/2022 |
| The intellectual disability PAK3 R67C mutation impacts cognitive functions and adult hippocampal neurogenesis. | The intellectual disability PAK3 R67C mutation impacts cognitive functions and adult hippocampal neurogenesis.
Castillon C, Gonzalez L, Domenichini F, Guyon S, Da Silva K, Durand C, Lestaevel P, Vaillend C, Laroche S, Barnier JV, Poirier R. | 08/28/2021 |
| Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation. | Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation.
Tan X, Tong L, Li L, Xu J, Xie S, Ji L, Fu J, Liu Q, Shen S, Liu Y, Xiao Y, Gao F, Moses RE, Bardeesy N, Wang Y, Zhang J, Tang L, Li L, Wong KK, Song D, Yang X, Liu J, Li X., Free PMC Article | 08/28/2021 |
| Furthermore, pharmacological inhibition of PAKs decreases ATXN1 levels in a mouse model of SCA1. To explore the potential of using PAK inhibitors in combination therapy, we combined the pharmacological inhibition of PAK with MSK1, a previously identified modulator of ATXN1, and examined their effects on ATXN1 levels. We found that inhibition of both pathways results in an additive decrease in ATXN1 levels. | PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1.
Bondar VV, Adamski CJ, Onur TS, Tan Q, Wang L, Diaz-Garcia J, Park J, Orr HT, Botas J, Zoghbi HY., Free PMC Article | 03/9/2019 |
| Pak3 knockout (KO) mice had defects of oligodendrocyte differentiation in developing corpus callosum and to a lesser extent in anterior commissure, which were compensated at the adult stage. In vitro experiments in oligodendrocyte precursor (OPC) cultures, derived from Pak3 KO and wild type brains, support a developmental and cell-autonomous role for PAK3 in regulating OPC differentiation into mature oligodendrocytes. | The intellectual disability protein PAK3 regulates oligodendrocyte precursor cell differentiation.
Maglorius Renkilaraj MRL, Baudouin L, Wells CM, Doulazmi M, Wehrlé R, Cannaya V, Bachelin C, Barnier JV, Jia Z, Nait Oumesmar B, Dusart I, Bouslama-Oueghlani L. | 03/3/2018 |
| Our results indicate that Pak3 is a novel regulator of beta-cell differentiation and function. Pak3 acts downstream of Ngn3 to promote cell cycle exit and differentiation in the embryo by a mechanism that might involve repression of Ccnd1. | Pak3 promotes cell cycle exit and differentiation of β-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice.
Piccand J, Meunier A, Merle C, Jia Z, Barnier JV, Gradwohl G., Free PMC Article | 03/1/2014 |
| Pak proteins are key components of multiple engraftment-associated hematopoietic stem cells functions and play a direct role in activation of ERK in hematopoietic stem cells. | The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.
Dorrance AM, De Vita S, Radu M, Reddy PN, McGuinness MK, Harris CE, Mathieu R, Lane SW, Kosoff R, Milsom MD, Chernoff J, Williams DA., Free PMC Article | 06/8/2013 |
| PAK1 inhibits the activity of PAK3a but not of the splice variant PAK3b in a trans-regulatory manner. Altogether, these results show that PAK3 and PAK1 signaling may be coordinated by heterodimerization. | The p21-activated kinase PAK3 forms heterodimers with PAK1 in brain implementing trans-regulation of PAK3 activity.
Combeau G, Kreis P, Domenichini F, Amar M, Fossier P, Rousseau V, Barnier JV., Free PMC Article | 11/24/2012 |
| PAK3 regulates activity-mediated rearrangement of synaptic connectivity associated with learning suggesting that defects in spine formation and refinement during development could account for intellectual disability. | Alteration of synaptic network dynamics by the intellectual disability protein PAK3.
Dubos A, Combeau G, Bernardinelli Y, Barnier JV, Hartley O, Gaertner H, Boda B, Muller D., Free PMC Article | 03/10/2012 |
| These results reveal an essential in vivo role of PAK1 and PAK3 in coordinating neuronal complexity and synaptic properties. | p21-Activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties.
Huang W, Zhou Z, Asrar S, Henkelman M, Xie W, Jia Z., Free PMC Article | 02/26/2011 |
| potential role of PAK3 in the progression of ACTH-producing thymic carcinoid | p21-activated kinase 3 is overexpressed in thymic neuroendocrine tumors (carcinoids) with ectopic ACTH syndrome and participates in cell migration.
Liu RX, Wang WQ, Ye L, Bi YF, Fang H, Cui B, Zhou WW, Dai M, Zhang J, Li XY, Ning G. | 02/5/2011 |
| Regulation and role of p21-activated kinase 3 by corticotropin-releasing factor in mouse pituitary | Regulation and role of p21-activated kinase 3 by corticotropin-releasing factor in mouse pituitary.
Kageyama K, Sakihara S, Suda T. | 01/21/2010 |
| A new PAK3 alternatively spliced exon called c is located upstream of previously identified exon b. Exon b is detected in all tetrapods; exon c is only present in mammals. | The four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological properties.
Kreis P, Rousseau V, Thévenot E, Combeau G, Barnier JV. | 01/21/2010 |
| PAK3 regulates dendritic spines morphogenesis. | Sequential implication of the mental retardation proteins ARHGEF6 and PAK3 in spine morphogenesis.
Nodé-Langlois R, Muller D, Boda B. | 01/21/2010 |
| PAK3 is a key regulator of synapse formation and plasticity in the hippocampus. | The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus.
Boda B, Alberi S, Nikonenko I, Node-Langlois R, Jourdain P, Moosmayer M, Parisi-Jourdain L, Muller D., Free PMC Article | 01/21/2010 |
| A dramatic reduction in the active form of transcription factor cAMP-responsive element-binding protein in Pak3 knock-out mice implicates a novel signaling mechanism by which PAK3 and Rho signaling regulate synaptic function and cognition. | Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3.
Meng J, Meng Y, Hanna A, Janus C, Jia Z., Free PMC Article | 01/21/2010 |
| determination of modified specificities toward Rac and Cdc42 GTPase | A new constitutively active brain PAK3 isoform displays modified specificities toward Rac and Cdc42 GTPases.
Rousseau V, Goupille O, Morin N, Barnier JV. | 01/21/2010 |
| This study results provide evidence for critical relationships between synaptic morphology and bidirectional modifiability of synaptic strength in the cortex and consolidation of long-term memory. | Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice.
Hayashi ML, Choi SY, Rao BS, Jung HY, Lee HK, Zhang D, Chattarji S, Kirkwood A, Tonegawa S. | 01/21/2010 |