| IGF2BP2 Maintains Retinal Pigment Epithelium Homeostasis by Stabilizing PAX6 and OTX2. | IGF2BP2 Maintains Retinal Pigment Epithelium Homeostasis by Stabilizing PAX6 and OTX2.
Wu S, Li F, Mo K, Huang H, Yu Y, Huang Y, Liu J, Li M, Tan J, Lin Z, Han Z, Wang L, Ouyang H., Free PMC Article | 07/11/2024 |
| c-Jun N-terminal kinase 1 (JNK1) phosphorylates OTX2 transcription factor that regulates early retinal development. | c-Jun N-terminal kinase 1 (JNK1) phosphorylates OTX2 transcription factor that regulates early retinal development.
An MJ, Lee HM, Kim CH, Shin GS, Jo AR, Kim JY, Kim MJ, Kim J, Park J, Hwangbo Y, Kim J, Kim JW. | 03/24/2023 |
| Orthodenticle homeobox 2 is transported to lysosomes by nuclear budding vesicles. | Orthodenticle homeobox 2 is transported to lysosomes by nuclear budding vesicles.
Park JW, Lee EJ, Moon E, Kim HL, Kim IB, Hodzic D, Kim N, Kweon HS, Kim JW., Free PMC Article | 03/6/2023 |
| Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas. | Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas.
Goschzik T, Mynarek M, Doerner E, Schenk A, Spier I, Warmuth-Metz M, Bison B, Obrecht D, Struve N, Kortmann RD, Schmid M, Aretz S, Rutkowski S, Pietsch T., Free PMC Article | 01/28/2023 |
| Exogenous Otx2 protects midbrain dopaminergic neurons from MPP(+) by interacting with ATP5a1 and promoting ATP synthesis. | Exogenous Otx2 protects midbrain dopaminergic neurons from MPP(+) by interacting with ATP5a1 and promoting ATP synthesis.
Xue J, Li Y, Qi Y, Zhang Z, Tang X. | 07/30/2022 |
| Non-cell-autonomous OTX2 transcription factor regulates anxiety-related behavior in the mouse. | Non-cell-autonomous OTX2 transcription factor regulates anxiety-related behavior in the mouse.
Vincent C, Gilabert-Juan J, Gibel-Russo R, Alvarez-Fischer D, Krebs MO, Le Pen G, Prochiantz A, Di Nardo AA., Free PMC Article | 03/19/2022 |
| Transcription factor OTX2 silences the expression of cleavage embryo genes and transposable elements. | Transcription factor OTX2 silences the expression of cleavage embryo genes and transposable elements.
Guo SM, Mei NH, Yang J, Zhou LQ., Free PMC Article | 12/11/2021 |
| Photoreceptor cKO of OTX2 Enhances OTX2 Intercellular Transfer in the Retina and Causes Photophobia. | Photoreceptor cKO of OTX2 Enhances OTX2 Intercellular Transfer in the Retina and Causes Photophobia.
Pensieri P, Mantilleri A, Plassard D, Furukawa T, Moya KL, Prochiantz A, Lamonerie T., Free PMC Article | 10/23/2021 |
| Direct repression of Nanog and Oct4 by OTX2 modulates the contribution of epiblast-derived cells to germline and somatic lineage. | Direct repression of Nanog and Oct4 by OTX2 modulates the contribution of epiblast-derived cells to germline and somatic lineage.
Di Giovannantonio LG, Acampora D, Omodei D, Nigro V, Barba P, Barbieri E, Chambers I, Simeone A. | 10/9/2021 |
| Initiation of Otx2 expression in the developing mouse retina requires a unique enhancer and either Ascl1 or Neurog2 activity. | Initiation of Otx2 expression in the developing mouse retina requires a unique enhancer and either Ascl1 or Neurog2 activity.
Kaufman ML, Goodson NB, Park KU, Schwanke M, Office E, Schneider SR, Abraham J, Hensley A, Jones KL, Brzezinski JA., Free PMC Article | 08/7/2021 |
| OTX2 Non-Cell Autonomous Activity Regulates Inner Retinal Function. | OTX2 Non-Cell Autonomous Activity Regulates Inner Retinal Function.
Torero Ibad R, Mazhar B, Vincent C, Bernard C, Dégardin J, Simonutti M, Lamonerie T, Di Nardo AA, Prochiantz A, Moya KL., Free PMC Article | 07/3/2021 |
| Reconsideration of the Semaphorin-3A Binding Motif Found in Chondroitin Sulfate Using Galnac4s-6st-Knockout Mice. | Reconsideration of the Semaphorin-3A Binding Motif Found in Chondroitin Sulfate Using Galnac4s-6st-Knockout Mice.
Nadanaka S, Miyata S, Yaqiang B, Tamura JI, Habuchi O, Kitagawa H., Free PMC Article | 06/26/2021 |
| Cell type- and stage-specific expression of Otx2 is regulated by multiple transcription factors and cis-regulatory modules in the retina. | Cell type- and stage-specific expression of Otx2 is regulated by multiple transcription factors and cis-regulatory modules in the retina.
Chan CSY, Lonfat N, Zhao R, Davis AE, Li L, Wu MR, Lin CH, Ji Z, Cepko CL, Wang S., Free PMC Article | 03/27/2021 |
| Functional and Evolutionary Diversification of Otx2 and Crx in Vertebrate Retinal Photoreceptor and Bipolar Cell Development. | Functional and Evolutionary Diversification of Otx2 and Crx in Vertebrate Retinal Photoreceptor and Bipolar Cell Development.
Yamamoto H, Kon T, Omori Y, Furukawa T. | 03/20/2021 |
| Non-cell Autonomous OTX2 Homeoprotein Regulates Visual Cortex Plasticity Through Gadd45b/g. | Non-cell Autonomous OTX2 Homeoprotein Regulates Visual Cortex Plasticity Through Gadd45b/g.
Apulei J, Kim N, Testa D, Ribot J, Morizet D, Bernard C, Jourdren L, Blugeon C, Di Nardo AA, Prochiantz A. | 09/26/2020 |
| Heterozygous deletion of Otx2, Vax1, or Six3 is sufficient to produce subfertility. Review shows that that all 3 have reduced numbers of GnRH neurons and are subfertile. However, there is specificity to the subfertility by sex and by mechanisms of action. | Haploinsufficiency of Homeodomain Proteins Six3, Vax1, and Otx2 Causes Subfertility in Mice via Distinct Mechanisms.
Hoffmann HM, Pandolfi EC, Larder R, Mellon PL., Free PMC Article | 06/20/2020 |
| confirmed the requirement for Otx2 in GnRH neuron development, fertility and correct gonadotropin hormone release in Otx2:Lhrh-cre males | Differential CRE Expression in Lhrh-cre and GnRH-cre Alleles and the Impact on Fertility in Otx2-Flox Mice.
Hoffmann HM, Larder R, Lee JS, Hu RJ, Trang C, Devries BM, Clark DD, Mellon PL., Free PMC Article | 12/28/2019 |
| the Otx2 conditional knock-out animals used in this study might represent a new genetic model of psychiatric diseases | Developmental Requirement of Homeoprotein Otx2 for Specific Habenulo-Interpeduncular Subcircuits.
Ruiz-Reig N, Rakotobe M, Bethus I, Le Menn G, Huditz HI, Marie H, Lamonerie T, D'Autréaux F., Free PMC Article | 12/14/2019 |
| Here, we show that initiation of ocular dominance plasticity was impaired with reduced CS, using mice lacking a key CS-synthesizing enzyme, CSGalNAcT1. Two-photon in vivo imaging showed a weaker visual response of PV-cells with reduced CS compared to wild-type mice. Plasticity onset was restored by a homeoprotein Otx2, which binds the major CS-proteoglycan aggrecan and promotes its further expression. | Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex.
Hou X, Yoshioka N, Tsukano H, Sakai A, Miyata S, Watanabe Y, Yanagawa Y, Sakimura K, Takeuchi K, Kitagawa H, Hensch TK, Shibuki K, Igarashi M, Sugiyama S., Free PMC Article | 06/29/2019 |
| data demonstrate that OTX2 functions repressively upstream of primordial germ cell transcription factors, acting as a roadblock to limit entry of epiblast cells to the germline to a small window in space and time, thereby ensuring correct numerical segregation of germline cells from the soma | OTX2 restricts entry to the mouse germline.
Zhang J, Zhang M, Acampora D, Vojtek M, Yuan D, Simeone A, Chambers I., Free PMC Article | 04/6/2019 |
| In adult and aged tau(+/+), tau(+/-), tau(-/-) mice tau deficiency could not induce significant motor disorders. However, found lower expression levels of transcription factors Orthodenticle homeobox 2 (OTX2) of midbrain dopaminergic neurons in older aged mice. Results suggested that tau deficiency alone might not be enough to mimic the pathology of Parkinson's disease. | Tau Deficiency Down-Regulated Transcription Factor Orthodenticle Homeobox 2 Expression in the Dopaminergic Neurons in Ventral Tegmental Area and Caused No Obvious Motor Deficits in Mice.
Tang X, Jiao L, Zheng M, Yan Y, Nie Q, Wu T, Wan X, Zhang G, Li Y, Wu S, Jiang B, Cai H, Xu P, Duan J, Lin X., Free PMC Article | 12/1/2018 |
| Transient juvenile-but not adult-knockdown of Otx2 in VTA mimics early life stress by increasing stress susceptibility, whereas its overexpression reverses the effects of early life stress | Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2.
Peña CJ, Kronman HG, Walker DM, Cates HM, Bagot RC, Purushothaman I, Issler O, Loh YE, Leong T, Kiraly DD, Goodman E, Neve RL, Shen L, Nestler EJ., Free PMC Article | 01/27/2018 |
| we confirmed that the activation of OTX2, a determinant of DA neuron development and the expression of which is induced by thyroid hormone, is dependent on TRPC1-mediated calcium signaling. | Critical role of TRPC1 in thyroid hormone-dependent dopaminergic neuron development.
Chen C, Ma Q, Deng P, Yang J, Yang L, Lin M, Yu Z, Zhou Z. | 12/9/2017 |
| These results suggest that tau haploinsufficiency, without the compensation effect of MAP1A, induces reduction of Otx2 expression, increases prenatal cell death, and accordingly leads to selective loss of VTA DA neurons in the early postnatal stage. | Tau haploinsufficiency causes prenatal loss of dopaminergic neurons in the ventral tegmental area and reduction of transcription factor orthodenticle homeobox 2 expression.
Zheng M, Jiao L, Tang X, Xiang X, Wan X, Yan Y, Li X, Zhang G, Li Y, Jiang B, Cai H, Lin X., Free PMC Article | 10/14/2017 |
| Otx2-mediated Nanog regulation contributes to the integrity of the embryonic stem cell state and cell lineage specification in preimplantation development. | Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast.
Acampora D, Omodei D, Petrosino G, Garofalo A, Savarese M, Nigro V, Di Giovannantonio LG, Mercadante V, Simeone A. | 10/14/2017 |