| Adverse maternal environment alters Oprl1 variant expression in mouse hippocampus. | Adverse maternal environment alters Oprl1 variant expression in mouse hippocampus.
Ke X, Huang Y, Fu Q, Majnik A, Sampath V, Lane RH., Free PMC Article | 03/5/2023 |
| Behavioral and neurochemical effects of nociceptin/orphanin FQ receptor activation in the social defeat protocol. | Behavioral and neurochemical effects of nociceptin/orphanin FQ receptor activation in the social defeat protocol.
Câmara AB, Brandão IA. | 02/4/2023 |
| Peripheral ablation of type III adenylyl cyclase induces hyperalgesia and eliminates KOR-mediated analgesia in mice. | Peripheral ablation of type III adenylyl cyclase induces hyperalgesia and eliminates KOR-mediated analgesia in mice.
Zhang WW, Cao H, Li Y, Fu XJ, Zhang YQ., Free PMC Article | 03/26/2022 |
| nociceptin opioid receptor agonists are promising drugs for treating pain in sickle cell anemia. | Small-molecule nociceptin receptor agonist ameliorates mast cell activation and pain in sickle mice.
Vang D, Paul JA, Nguyen J, Tran H, Vincent L, Yasuda D, Zaveri NT, Gupta K., Free PMC Article | 10/1/2016 |
| These knock-in mice have NOP receptors that function both in vitro and in vivo and have provided a detailed characterization of NOP receptors in brain, spinal cord, and DRG neurons. | Knock-In Mice with NOP-eGFP Receptors Identify Receptor Cellular and Regional Localization.
Ozawa A, Brunori G, Mercatelli D, Wu J, Cippitelli A, Zou B, Xie XS, Williams M, Zaveri NT, Low S, Scherrer G, Kieffer BL, Toll L., Free PMC Article | 11/7/2015 |
| Oprl1 is associated with amygdala function, fear processing, and posttraumatic stress disorder symptoms. | Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD.
Andero R, Brothers SP, Jovanovic T, Chen YT, Salah-Uddin H, Cameron M, Bannister TD, Almli L, Stevens JS, Bradley B, Binder EB, Wahlestedt C, Ressler KJ., Free PMC Article | 01/25/2014 |
| the present results suggest that the endogenous OFQ/N/NOP receptor system may modulate the development of cocaine-induced locomotor sensitization. | The role of NOP receptors in psychomotor stimulation and locomotor sensitization induced by cocaine and amphetamine in mice.
Marquez P, Hamid A, Lutfy K., Free PMC Article | 11/30/2013 |
| Data suggest that NOPR and MOPR (mu-type opioid receptor) in spinal cord independently drive antinociception; NOPR/MOPR ligands attenuate neuropathic/inflammatory pain and have high antinociceptive potency with low tolerance development. | Effects of spinally administered bifunctional nociceptin/orphanin FQ peptide receptor/μ-opioid receptor ligands in mouse models of neuropathic and inflammatory pain.
Sukhtankar DD, Zaveri NT, Husbands SM, Ko MC., Free PMC Article | 08/31/2013 |
| Data suggest that nociceptin receptor/nociceptin signaling plays a role in the disease pathogenesis of inflammatory bowel diseases. | Nociceptin/orphanin FQ inhibition with SB612111 ameliorates dextran sodium sulfate-induced colitis.
Alt C, Lam JS, Harrison MT, Kershaw KM, Samuelsson S, Toll L, D'Andrea A., Free PMC Article | 09/15/2012 |
| The results of this study demonstrated the contribution of the NOP receptor in controlling food intake and meal pattern, as well as glutamate release and GIRK1 channel activity at POMC synapses. | The role of the NOP receptor in regulating food intake, meal pattern, and the excitability of proopiomelanocortin neurons.
Farhang B, Pietruszewski L, Lutfy K, Wagner EJ., Free PMC Article | 10/23/2010 |
| N/OFQ and NOP receptors have an important role in hippocampus-dependent spatial learning and memory, probably by modulation of glutamatergic functions | The nociceptin system and hippocampal cognition in mice: a pharmacological and genetic analysis.
Kuzmin A, Madjid N, Johansson B, Terenius L, Ogren SO. | 03/8/2010 |
| These results suggest differential requirements for ORL(1) in the mediation of neuroimmune effects exerted at different times after an immune challenge. | Role of opioid receptor like-1 receptor in modulation of endocrine, immunological, and behavioral responses to the T-cell superantigen staphylococcal enterotoxin A.
Mallimo EM, Ansonoff MA, Pintar JE, Kusnecov AW., Free PMC Article | 03/1/2010 |
| Mice lacking the influence of endogenous N/OFQ are hypersensitive to nicotine in most measures, showing a role of endogenous nociceptin in modulating or mediating the acute effects of nicotine, and possibly nicotine addiction. | Enhanced nicotine sensitivity in nociceptin/orphanin FQ receptor knockout mice.
Sakoori K, Murphy NP. | 01/21/2010 |
| findings demonstrate the existence of functional antagonism between nociceptin opioid peptide receptor and NMDA receptors that predominantly contributes to modulation of conditioned fear learning which involves spatial-processing demands | Activation of nociceptin opioid peptide (NOP) receptor impairs contextual fear learning in mice through glutamatergic mechanisms.
Goeldner C, Reiss D, Wichmann J, Kieffer BL, Ouagazzal AM., Free PMC Article | 01/21/2010 |
| the ability of buprenorphine to interact with the ORL1 receptor modulates its acute motor stimulatory and rewarding effects. | The role of the opioid receptor-like (ORL1) receptor in motor stimulatory and rewarding actions of buprenorphine and morphine.
Marquez P, Borse J, Nguyen AT, Hamid A, Lutfy K., Free PMC Article | 01/21/2010 |
| Place cells in nociceptin receptor knockout mice were abnormal in several ways: they were less stable, had noisier positional firing patterns, larger firing fields and higher discharge rates inside and outside the firing fields | Defective place cell activity in nociceptin receptor knockout mice with elevated NMDA receptor-dependent long-term potentiation.
Taverna FA, Georgiou J, McDonald RJ, Hong NS, Kraev A, Salter MW, Takeshima H, Muller RU, Roder JC., Free PMC Article | 01/21/2010 |
| OPR is not crucial for development of either acute or neuropathic nociceptive responses, or for the regulation of full receptor-mediated responses to opioid agonists | Lack of the nociceptin receptor does not affect acute or chronic nociception in mice.
Bertorelli R, Bastia E, Citterio F, Corradini L, Forlani A, Ongini E. | 01/21/2010 |
| NOC receptor is involved in hippocampal cholinergic function | Enhanced hippocampal acetylcholine release in nociceptin-receptor knockout mice.
Uezu K, Sano A, Sei H, Toida K, Houtani T, Sugimoto T, Suzuki-Yamamoto T, Takeshima H, Ishimura K, Morita Y. | 01/21/2010 |
| nociceptin receptor has a role in the antinociceptive action of nitrous oxide | The involvement of the nociceptin receptor in the antinociceptive action of nitrous oxide.
Himukashi S, Takeshima H, Koyanagi S, Shichino T, Fukuda K. | 01/21/2010 |
| RGS19 prefers regulating ORL1 receptor signaling over other opioid receptors, and the N-terminal domain of RGS19 plays a crucial role in its receptor preference | N-terminally truncated variant of the mouse GAIP/RGS19 lacks selectivity of full-length GAIP/RGS19 protein in regulating ORL1 receptor signaling.
Xie GX, Yanagisawa Y, Ito E, Maruyama K, Han X, Kim KJ, Han KR, Moriyama K, Palmer PP. | 01/21/2010 |
| NOP receptors in the substantia nigra pars reticulata, activated by endogenous N/OFQ, drive a physiologically inhibitory control on motor behavior, possibly via modulation of the nigrostriatal dopaminergic pathway. | Blockade of nociceptin/orphanin FQ receptor signaling in rat substantia nigra pars reticulata stimulates nigrostriatal dopaminergic transmission and motor behavior.
Marti M, Mela F, Veronesi C, Guerrini R, Salvadori S, Federici M, Mercuri NB, Rizzi A, Franchi G, Beani L, Bianchi C, Morari M., Free PMC Article | 01/21/2010 |
| The region-specific up-regulation of the opioid receptor-like 1 receptor indicates a tonic role for nociceptin/orphanin FQ in some brain structures and may suggest the peptide regulates the receptor expression in these regions. | Nociceptin/orphanin FQ knockout mice display up-regulation of the opioid receptor-like 1 receptor and alterations in opioid receptor expression in the brain.
Clarke S, Chen Z, Hsu MS, Hill RG, Pintar JE, Kitchen I. | 01/21/2010 |
| Nociceptin released from interneurons by their high-frequency activation is a novel endogenous neuromodulator that negatively regulates induction of long-term potentiation in the hippocampus through direct modulation of pyramidal cells. | The neuropeptide nociceptin is a synaptically released endogenous inhibitor of hippocampal long-term potentiation.
Bongsebandhu-phubhakdi S, Manabe T., Free PMC Article | 01/21/2010 |