| Isolated dentinogenesis imperfecta: Novel DSPP variants and insights on genetic counselling. | Isolated dentinogenesis imperfecta: Novel DSPP variants and insights on genetic counselling.
Hassib NF, Mehrez M, Mostafa MI, Abdel-Hamid MS., Free PMC Article | 05/1/2024 |
| The Role of DSPP in Dentine Formation and Hereditary Dentine Defects. | The Role of DSPP in Dentine Formation and Hereditary Dentine Defects.
Jia J, Bian Z, Song Y. | 04/2/2024 |
| A novel DSPP frameshift mutation causing dentin dysplasia type 2 and disease management strategies. | A novel DSPP frameshift mutation causing dentin dysplasia type 2 and disease management strategies.
Yuan M, Zheng X, Xue Y, He Z, Song G, Song Y. | 08/23/2023 |
| Identification of DSPP novel variants and phenotype analysis in dentinogenesis dysplasia Shields type II patients. | Identification of DSPP novel variants and phenotype analysis in dentinogenesis dysplasia Shields type II patients.
Du Q, Cao L, Yan N, Kang S, Lin M, Cao P, Jia R, Wang C, Qi H, Yu Y, Zou J, Yang J. | 07/23/2023 |
| Novel dentin sialophosphoprotein gene frameshift mutations affect dentin mineralization. | Novel dentin sialophosphoprotein gene frameshift mutations affect dentin mineralization.
Zhang Z, Huang G, Huang Y, Liu S, Chen F, Gao X, Dong Y, Tian H. | 05/17/2023 |
| [Mutation of dentin sialophosphoprotein and hereditary malformations of dentin]. | [Mutation of dentin sialophosphoprotein and hereditary malformations of dentin].
Zhu QL, Duan XH, Yu Q. | 01/21/2023 |
| Mouse Dspp frameshift model of human dentinogenesis imperfecta. | Mouse Dspp frameshift model of human dentinogenesis imperfecta.
Liang T, Hu Y, Zhang H, Xu Q, Smith CE, Zhang C, Kim JW, Wang SK, Saunders TL, Lu Y, Hu JC, Simmer JP., Free PMC Article | 02/12/2022 |
| Significantly high expression levels of MMP20 and DSPP were observed in the malignant breast, colon, prostate, thyroid, and cervical neoplasms compared with their benign and normal counterparts. Furthermore, MMP20 levels increased with advanced stages of colon and thyroid cancers. DSPP expression increased significantly with tumor stage in all cancers examined. | Survey of dentin sialophosphoprotein and its cognate matrix metalloproteinase-20 in human cancers.
Aseervatham J, Geetu S, Anunobi CC, Koli K, Ogbureke KUE., Free PMC Article | 07/4/2020 |
| Novel frameshift mutations in DSPP cause dentin dysplasia type II | Novel frameshift mutations in DSPP cause dentin dysplasia type II.
Lee JW, Hong J, Seymen F, Kim YJ, Kang J, Koruyucu M, Tuloglu N, Bayrak S, Song JS, Shin TJ, Hyun HK, Kim YJ, Lee JC, Park JC, Hu J, Simmer J, Kim JW., Free PMC Article | 04/18/2020 |
| A heterozygous c.50C to T (p.P17L) mutation was identified in exon 2 of the DSPP gene in hereditary dentinogenesis imperfecta | [Analysis of DSPP gene mutation in a Chinese pedigree affected with hereditary dentinogenesis imperfecta].
Hu A, Li X, Chen D, Lu T, Huang J, Xu X, Chen D, Xiong F. | 06/29/2019 |
| Taken together, these findings indicate that knockdown of DSPP inhibits glioma cells migration and invasion, suggesting that targeting DSPP might be a potentially effective therapeutic strategy for treating glioma. | Knockdown of DSPP inhibits the migration and invasion of glioma cells.
Fan S, Gao H, Sun L, Zhu F, Zhou R, Zhang W, Yan Y, Gao Y. | 12/22/2018 |
| Study provide evidence to suggest that DSPP may be involved in endoplasmic reticulum (ER) stress mechanisms in oral squamous cell carcinoma, since its downregulation in OSC2 cells led to significant alterations in the levels of major ER stress-associated proteins, and subsequent collapse of the unfolded protein response system. | The tumorigenic role of DSPP and its potential regulation of the unfolded protein response and ER stress in oral cancer cells.
Gkouveris I, Nikitakis NG, Aseervatham J, Ogbureke KUE. | 12/22/2018 |
| mutations c.3085A > G and c.3087C > T resulted in p.N1029D and co-segregated with deafness phenotype in Chinese family | Familial nonsyndromic hearing loss with incomplete partition type II caused by novel DSPP gene mutations.
Li WX, Peng H, Yang L, Hao QQ, Sun W, Ji F, Guo WW, Yang SM. | 11/17/2018 |
| The levels of DSPP silencing-induced downregulation differed amongst CSC markers, with ABCG2 and CD44 showing more pronounced downregulations. | DSPP-MMP20 gene silencing downregulates cancer stem cell markers in human oral cancer cells.
Nikitakis NG, Gkouveris I, Aseervatham J, Barahona K, Ogbureke KUE., Free PMC Article | 10/20/2018 |
| the transgenic expression of DPP significantly improved the dentin defects in Dspp-null mice. These data provide in vivo evidence that DPP may promote the deposition of hydroxyapatite crystals during the formation and mineralization of dentin, which is in agreement with the in vitro findings described in earlier reports. | Transgenic expression of dentin phosphoprotein (DPP) partially rescued the dentin defects of DSPP-null mice.
Zhang H, Xie X, Liu P, Liang T, Lu Y, Qin C., Free PMC Article | 07/28/2018 |
| Data demonstrate for the first time that the dentin sialoprotein (DSP) domain acts as a ligand in a Arg-Gly-Asp (RGD)-independent manner and is involved in intracellular signaling via interacting with integrin beta6. The DSP domain regulates DSPP expression and odontoblast homeostasis via a positive feedback loop. | The Dentin Sialoprotein (DSP) Domain Regulates Dental Mesenchymal Cell Differentiation through a Novel Surface Receptor.
Wan C, Yuan G, Luo D, Zhang L, Lin H, Liu H, Chen L, Yang G, Chen S, Chen Z., Free PMC Article | 05/26/2018 |
| This study expands the spectrum of DSPP variants, highlighting their associated phenotypic continuum. | Phenotype and genotype analyses in seven families with dentinogenesis imperfecta or dentin dysplasia.
Li F, Liu Y, Liu H, Yang J, Zhang F, Feng H. | 10/21/2017 |
| These data indicate that secretome derived from salivary gland cancer cells can influence the expression of two potential biomarkers of oral cancer-namely, bone sialoprotein (BSP) and dentin sialoprotein (DSP)-in normal salivary gland cells. | Cancer Secretome May Influence BSP and DSP Expression in Human Salivary Gland Cells.
Hamilton SL, Ferando B, Eapen AS, Yu JC, Joy AR., Free PMC Article | 06/3/2017 |
| DSPP-MMP20 pair may play a role in the normal turnover of cell surface proteins and/or repair of pericellular matrix proteins of the basement membranes in the metabolically active duct epithelial system of the nephrons. | Matrix Metalloproteinase 20 Co-expression With Dentin Sialophosphoprotein in Human and Monkey Kidneys.
Ogbureke KU, Koli K, Saxena G., Free PMC Article | 05/27/2017 |
| BMP2 and RUNX2 are expressed exclusively by osteoblasts whereas DSPP and LOXL2 are expressed exclusively by odontoblasts. (Review) | A Perspective on Stem Cells as Biological Systems that Produce Differentiated Osteoblasts and Odontoblasts.
Ariffin SH, Manogaran T, Abidin IZ, Wahab RM, Senafi S. | 03/18/2017 |
| A novel pathogenic splicing-mutation c.52-1G>A of DSPP is associated with dentinogenesis imperfecta shields type II. | [Identification of a novel mutation of DSPP gene in a Chinese family affected with dentinogenesis imperfecta shields type II].
Liu Y, Huang Y, Gao J, Li S, Zhao X, Zhang X. | 04/23/2016 |
| Adhesive and migratory effects of phosphophoryn are modulated by flanking peptides of the integrin binding motif. | Adhesive and migratory effects of phosphophoryn are modulated by flanking peptides of the integrin binding motif.
Suzuki S, Kobuke S, Haruyama N, Hoshino H, Kulkarni AB, Nishimura F., Free PMC Article | 01/2/2016 |
| expression of MMP-20 and co-expression and potential interaction with DSPP in human major salivary gland tissues | Expression of Matrix Metalloproteinase (MMP)-20 and Potential Interaction with Dentin Sialophosphoprotein (DSPP) in Human Major Salivary Glands.
Koli K, Saxena G, Ogbureke KU. | 09/5/2015 |
| mutations of the DSP-PP P4 to P4' cleavage site can block, impair or accelerate dentin sialoprotein phosphophoryn cleavage, and suggest that its Bone morphogenic protein 1 cleavage site is conserved in order to regulate its cleavage efficiency | Site specificity of DSP-PP cleavage by BMP1.
Yang RT, Lim GL, Yee CT, Fuller RS, Ritchie HH., Free PMC Article | 08/15/2015 |
| DMP1 and DSPP were more abundant in carious than in sound samples. | Dentin matrix protein 1 and dentin sialophosphoprotein in human sound and carious teeth: an immunohistochemical and colorimetric assay.
Martini D, Trirè A, Breschi L, Mazzoni A, Teti G, Falconi M, Ruggeri A Jr., Free PMC Article | 10/25/2014 |