| Type 1 interferon suppresses expression and glucocorticoid induction of glucocorticoid-induced leucine zipper (GILZ). | Type 1 interferon suppresses expression and glucocorticoid induction of glucocorticoid-induced leucine zipper (GILZ).
Dankers W, Northcott M, Bennett T, D'Cruz A, Sherlock R, Gearing LJ, Hertzog P, Russ B, Miceli I, Scheer S, Fujishiro M, Hayakawa K, Ikeda K, Morand EF, Jones SA., Free PMC Article | 01/11/2023 |
| Expression Profiles of GILZ and Annexin A1 in Human Oral Candidiasis and Lichen Planus. | Expression Profiles of GILZ and Annexin A1 in Human Oral Candidiasis and Lichen Planus.
Mozaffari MS, Abdelsayed R., Free PMC Article | 05/21/2022 |
| Glucocorticoid-induced leucine zipper regulates liver fibrosis by suppressing CCL2-mediated leukocyte recruitment. | Glucocorticoid-induced leucine zipper regulates liver fibrosis by suppressing CCL2-mediated leukocyte recruitment.
Flamini S, Sergeev P, Viana de Barros Z, Mello T, Biagioli M, Paglialunga M, Fiorucci C, Prikazchikova T, Pagano S, Gagliardi A, Riccardi C, Zatsepin T, Migliorati G, Bereshchenko O, Bruscoli S., Free PMC Article | 10/16/2021 |
| Glucocorticoid-transactivated TSC22D3 attenuates hypoxia- and diabetes-induced Muller glial galectin-1 expression via HIF-1alpha destabilization. | Glucocorticoid-transactivated TSC22D3 attenuates hypoxia- and diabetes-induced Müller glial galectin-1 expression via HIF-1α destabilization.
Kanda A, Hirose I, Noda K, Murata M, Ishida S., Free PMC Article | 05/1/2021 |
| MiR-222-3p ameliorates glucocorticoid-induced inhibition of airway epithelial cell repair through down-regulating GILZ expression. | MiR-222-3p ameliorates glucocorticoid-induced inhibition of airway epithelial cell repair through down-regulating GILZ expression.
He N, Liu L, Ding J, Sun Y, Xing H, Wang S. | 04/24/2021 |
| Short-Chain Alcohols Upregulate GILZ Gene Expression and Attenuate LPS-Induced Septic Immune Response. | Short-Chain Alcohols Upregulate GILZ Gene Expression and Attenuate LPS-Induced Septic Immune Response.
Ng HP, Jennings S, Nelson S, Wang G., Free PMC Article | 03/6/2021 |
| Glucocorticoids and Glucocorticoid-Induced-Leucine-Zipper (GILZ) in Psoriasis. | Glucocorticoids and Glucocorticoid-Induced-Leucine-Zipper (GILZ) in Psoriasis.
Sevilla LM, Pérez P., Free PMC Article | 10/24/2020 |
| Implicating the Role of GILZ in Glucocorticoid Modulation of T-Cell Activation. | Implicating the Role of GILZ in Glucocorticoid Modulation of T-Cell Activation.
Cannarile L, Delfino DV, Adorisio S, Riccardi C, Ayroldi E., Free PMC Article | 10/10/2020 |
| Dramatic alterations in GILZ occur in those exposed to a stressor in early life, adulthood or both. | Glucocorticoid-induced leucine zipper "quantifies" stressors and increases male susceptibility to PTSD.
Lebow MA, Schroeder M, Tsoory M, Holzman-Karniel D, Mehta D, Ben-Dor S, Gil S, Bradley B, Smith AK, Jovanovic T, Ressler KJ, Binder EB, Chen A., Free PMC Article | 02/8/2020 |
| L-GILZ regulates thyroid cancer cell proliferation. | Long glucocorticoid-induced leucine zipper regulates human thyroid cancer cell proliferation.
Ayroldi E, Petrillo MG, Marchetti MC, Cannarile L, Ronchetti S, Ricci E, Cari L, Avenia N, Moretti S, Puxeddu E, Riccardi C., Free PMC Article | 11/30/2019 |
| these results indicate that stress-induced glucocorticoid surge and Tsc22d3 upregulation can subvert therapy-induced anticancer immunosurveillance. | Stress-glucocorticoid-TSC22D3 axis compromises therapy-induced antitumor immunity.
Yang H, Xia L, Chen J, Zhang S, Martin V, Li Q, Lin S, Chen J, Calmette J, Lu M, Fu L, Yang J, Pan Z, Yu K, He J, Morand E, Schlecht-Louf G, Krzysiek R, Zitvogel L, Kang B, Zhang Z, Leader A, Zhou P, Lanfumey L, Shi M, Kroemer G, Ma Y. | 11/16/2019 |
| Study in primary human and murine macrophages provides evidence for dual regulation of GILZ upon MyD88- and TRIF-dependent TLR activation and link GILZ expression levels with pivotal macrophage defense mechanisms, such as phagocytosis and bactericidal activity. | Amplified Host Defense by Toll-Like Receptor-Mediated Downregulation of the Glucocorticoid-Induced Leucine Zipper (GILZ) in Macrophages.
Hoppstädter J, Diesel B, Linnenberger R, Hachenthal N, Flamini S, Minet M, Leidinger P, Backes C, Grässer F, Meese E, Bruscoli S, Riccardi C, Huwer H, Kiemer AK., Free PMC Article | 10/26/2019 |
| The mRNA expression of GILZ was significantly correlated with Systemic Lupus Erythematosus Disease Activity Index score. | Glucocorticoid-induced leucine zipper expression is associated with response to treatment and immunoregulation in systemic lupus erythematosus.
Mohammadi S, Ebadpour MR, Sedighi S, Saeedi M, Memarian A. | 04/28/2018 |
| We propose a novel role of GILZ in contributing to corticoid-induced leptin and leptin receptor expression in osteoarthritis synovial fibroblasts | Glucocorticoid-induced leucine zipper (GILZ) is involved in glucocorticoid-induced and mineralocorticoid-induced leptin production by osteoarthritis synovial fibroblasts.
Malaise O, Relic B, Charlier E, Zeddou M, Neuville S, Deroyer C, Gillet P, Louis E, Malaise MG, de Seny D., Free PMC Article | 11/11/2017 |
| TSC22D3 gene expression is significantly associated with long-term changes in Blood Pressure, providing a link between gene expression and Blood Pressure. | Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure.
Zeller T, Schurmann C, Schramm K, Müller C, Kwon S, Wild PS, Teumer A, Herrington D, Schillert A, Iacoviello L, Kratzer A, Jagodzinski A, Karakas M, Ding J, Neumann JT, Kuulasmaa K, Gieger C, Kacprowski T, Schnabel RB, Roden M, Wahl S, Rotter JI, Ojeda F, Carstensen-Kirberg M, Tregouet DA, Dörr M, Meitinger T, Lackner KJ, Wolf P, Felix SB, Landmesser U, Costanzo S, Ziegler A, Liu Y, Völker U, Palmas W, Prokisch H, Guo X, Herder C, Blankenberg S, Homuth G., Free PMC Article | 09/30/2017 |
| Overall, these results suggest that GILZ antagonizes the pro-inflammatory effects of TNFa in human adipocytes, and its downregulation in obesity may contribute to adipose inflammation and dysregulated adipokine production, and thereby systemic metabolism. | Low expression of the GILZ may contribute to adipose inflammation and altered adipokine production in human obesity.
Lee MJ, Yang RZ, Karastergiou K, Smith SR, Chang JR, Gong DW, Fried SK., Free PMC Article | 08/26/2017 |
| Under endoplasmic reticulum stress conditions, overexpression of GILZ significantly reduced activation of mitochondrial pathway of apoptosis by maintaining Bcl-xl level. GILZ protein affects the unfolded protein response signaling shifting the balance towards pro-survival signals as judged by down-regulation of CHOP, ATF4, XBP1s mRNA and increase in GRP78 protein level. | GILZ overexpression attenuates endoplasmic reticulum stress-mediated cell death via the activation of mitochondrial oxidative phosphorylation.
André F, Corazao-Rozas P, Idziorek T, Quesnel B, Kluza J, Marchetti P. | 05/27/2017 |
| results reveal GILZ to be a new actor in apoptosis regulation in neutrophil-like cells involving JNK and Mcl-1. | Glucocorticoid-Induced Leucine Zipper Is Expressed in Human Neutrophils and Promotes Apoptosis through Mcl-1 Down-Regulation.
Espinasse MA, Pépin A, Virault-Rocroy P, Szely N, Chollet-Martin S, Pallardy M, Biola-Vidamment A., Free PMC Article | 10/29/2016 |
| GILZ is a non-redundant regulator of B cell activity, with important potential clinical implications in systemic lupus erythematosus. | Glucocorticoid-induced leucine zipper (GILZ) inhibits B cell activation in systemic lupus erythematosus.
Jones SA, Toh AE, Odobasic D, Oudin MA, Cheng Q, Lee JP, White SJ, Russ BE, Infantino S, Light A, Tarlinton DM, Harris J, Morand EF. | 07/30/2016 |
| our data suggest that GILZ is a key regulator of macrophage functions. | Glucocorticoid-induced leucine zipper: a critical factor in macrophage endotoxin tolerance.
Hoppstädter J, Kessler SM, Bruscoli S, Huwer H, Riccardi C, Kiemer AK. | 08/22/2015 |
| L-GILZ stabilizes p53 proteins by decreasing p53 ubiquitination and increasing MDM2 ubiquitination. | L-GILZ binds p53 and MDM2 and suppresses tumor growth through p53 activation in human cancer cells.
Ayroldi E, Petrillo MG, Bastianelli A, Marchetti MC, Ronchetti S, Nocentini G, Ricciotti L, Cannarile L, Riccardi C., Free PMC Article | 08/1/2015 |
| The N-terminal part of L-GILZ protein is responsible for Ras/L-GILZ protein-to-protein interaction, important for the control of proliferation rate of spermatogonia. | Recombinant long-glucocorticoid-induced leucine zipper (L-GILZ) protein restores the control of proliferation in gilz KO spermatogonia.
Venanzi A, Di Sante M, Bruscoli S, Biagioli M, Sorcini D, Cimino M, Frammartino T, Bereshchenko O, Franconi F, Riccardi C. | 06/6/2015 |
| PUVA directly stimulates GILZ expression. | Activation of GILZ gene by photoactivated 8-methoxypsoralen: potential role of immunoregulatory dendritic cells in extracorporeal photochemotherapy.
Futterleib JS, Feng H, Tigelaar RE, Choi J, Edelson RL., Free PMC Article | 04/18/2015 |
| Data show a diminished expression of the anti-inflammatory mediator GILZ in the inflamed vasculature and indicate that GILZ downregulation requires the mRNA binding protein ZFP36. | Downregulation of the glucocorticoid-induced leucine zipper (GILZ) promotes vascular inflammation.
Hahn RT, Hoppstädter J, Hirschfelder K, Hachenthal N, Diesel B, Kessler SM, Huwer H, Kiemer AK. | 01/17/2015 |
| Inhibition of epithelial injury repair by dexamethasone is mediated in part by activation of GILZ. | Dexamethasone inhibits repair of human airway epithelial cells mediated by glucocorticoid-induced leucine zipper (GILZ).
Liu J, Zhang M, Niu C, Luo Z, Dai J, Wang L, Liu E, Fu Z., Free PMC Article | 10/26/2013 |