| Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state. | Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state.
Bhalla M, Lee CJ., Free PMC Article | 01/27/2024 |
| Ornithine decarboxylase, the rate-limiting enzyme of polyamine synthesis, modifies brain pathology in a mouse model of tuberous sclerosis complex. | Ornithine decarboxylase, the rate-limiting enzyme of polyamine synthesis, modifies brain pathology in a mouse model of tuberous sclerosis complex.
Kapfhamer D, McKenna J, Yoon CJ, Murray-Stewart T, Casero RA, Gambello MJ., Free PMC Article | 08/21/2021 |
| ODC (Ornithine Decarboxylase)-Dependent Putrescine Synthesis Maintains MerTK (MER Tyrosine-Protein Kinase) Expression to Drive Resolution. | ODC (Ornithine Decarboxylase)-Dependent Putrescine Synthesis Maintains MerTK (MER Tyrosine-Protein Kinase) Expression to Drive Resolution.
Yurdagul A Jr, Kong N, Gerlach BD, Wang X, Ampomah P, Kuriakose G, Tao W, Shi J, Tabas I., Free PMC Article | 03/20/2021 |
| Amyloid beta may contribute to M1-like activation by disrupting the balance between ODC and AZ in microglia. | Aβ stimulates microglial activation through antizyme-dependent downregulation of ornithine decarboxylase.
Cheng YW, Chang CC, Chang TS, Li HH, Hung HC, Liu GY, Lin CL. | 04/18/2020 |
| Findings indicated that ornithine decarboxylase (ODC1) was involved in attenuating the inflammatory response upon stimulation of macrophages, making it a potential therapeutic target for inflammatory diseases. | ODC1 inhibits the inflammatory response and ROS-induced apoptosis in macrophages.
Jiang F, Gao Y, Dong C, Xiong S. | 03/30/2019 |
| We demonstrate that ornithine decarboxylase (ODC) regulates M1 activation during Helicobacter pylori and Citrobacter rodentium infection. Deletion of Odc in macrophages resulted in increased inflammation and decreased bacterial persistence in mouse models. The enhanced M1 response was due to alterations in histone modifications, resulting in changes in chromatin structure and up-regulated transcription. | Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications.
Hardbower DM, Asim M, Luis PB, Singh K, Barry DP, Yang C, Steeves MA, Cleveland JL, Schneider C, Piazuelo MB, Gobert AP, Wilson KT., Free PMC Article | 04/14/2018 |
| these data support the hypothesis that TTP plays a role in the post-transcriptional regulation of the ODC mRNA transcript. | Destabilization of the ornithine decarboxylase mRNA transcript by the RNA-binding protein tristetraprolin.
Nowotarski SL, Origanti S, Sass-Kuhn S, Shantz LM. | 12/9/2017 |
| Ornithine decarboxylase (ODC) plays a key role in prostate tumorigenesis and that the polyamine pathway is altered as early as high-grade prostate intraepithelial neoplasia (HGPIN). | Ornithine Decarboxylase Is Sufficient for Prostate Tumorigenesis via Androgen Receptor Signaling.
Shukla-Dave A, Castillo-Martin M, Chen M, Lobo J, Gladoun N, Collazo-Lorduy A, Khan FM, Ponomarev V, Yi Z, Zhang W, Pandolfi PP, Hricak H, Cordon-Cardo C., Free PMC Article | 09/23/2017 |
| the Myc-ODC axis plays a critical role in the cellular transformation induced by myeloproliferative neoplasm-associated JAK2 V617F mutant | Critical roles of Myc-ODC axis in the cellular transformation induced by myeloproliferative neoplasm-associated JAK2 V617F mutant.
Funakoshi-Tago M, Sumi K, Kasahara T, Tago K., Free PMC Article | 08/31/2013 |
| Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway. | Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.
Balzarini J, Gago F, Kulik W, van Kuilenburg AB, Karlsson A, Peterson MA, Robins MJ., Free PMC Article | 11/24/2012 |
| Androgens act via the AR to upregulate Odc1 in skeletal muscle myoblasts, and Odc1 promotes myoblast proliferation and delays differentiation. | Ornithine decarboxylase is upregulated by the androgen receptor in skeletal muscle and regulates myoblast proliferation.
Lee NK, Skinner JP, Zajac JD, MacLean HE. | 09/10/2011 |
| the immunosuppression promoted by increased epidermal ODC is mediated by a reduction in cytokine levels, which suppresses dendritic cell migration and reduces immune cell infiltration to the site of hapten application | Elevated epidermal ornithine decarboxylase activity suppresses contact hypersensitivity.
Keough MP, Hayes CS, DeFeo K, Gilmour SK., Free PMC Article | 01/29/2011 |
| HuR plays a causative role in ODC up-regulation during nonmelanoma skin cancer development by binding to and stabilizing the ODC transcript. | Cytoplasmic accumulation of the RNA-binding protein HuR stabilizes the ornithine decarboxylase transcript in a murine nonmelanoma skin cancer model.
Nowotarski SL, Shantz LM., Free PMC Article | 11/6/2010 |
| The data-driven docking results suggest that both proteins occupy the same binding site on Az1, with Az1 binding within a large groove in antizyme inhibitor (AzI) and Ornithine Decarboxylase (ODC). | Docking of antizyme to ornithine decarboxylase and antizyme inhibitor using experimental mutant and double-mutant cycle data.
Cohavi O, Tobi D, Schreiber G. | 01/21/2010 |
| Results show that transglutaminase-catalyzed polyamination of rhoA regulates its activity, and that ornithine decarboxylase influences the intracellular distribution of rhoA. | Ornithine decarboxylase regulates the activity and localization of rhoA via polyamination.
Mäkitie LT, Kanerva K, Andersson LC. | 01/21/2010 |
| de novo suprabasal induction of ODC activity in adult mouse skin activates keratinocytes and stimulates vascularization in the dermal layer in a manner similar to skin undergoing wound healing. | Suprabasal induction of ornithine decarboxylase in adult mouse skin is sufficient to activate keratinocytes.
Lan L, Hayes CS, Laury-Kleintop L, Gilmour SK. | 01/21/2010 |
| In B16-F1 cells HGF increased AP-1 activity and the mRNA expression of various AP-1 subunits. HGF-induced transcription of mouse ODC was largely due to triggering of AP-1 pathway. | A cluster region of AP-1 responsive elements is required for transcriptional activity of mouse ODC gene by hepatocyte growth factor.
Bianchi L, Tacchini L, Matteucci E, Desiderio MA. | 01/21/2010 |
| Overexpression of a dominant-negative ornithine decarboxylase in mouse skin: effect on enzyme activity and papilloma formation | Overexpression of a dominant-negative ornithine decarboxylase in mouse skin: effect on enzyme activity and papilloma formation.
Shantz LM, Guo Y, Sawicki JA, Pegg AE, O'Brien TG. | 01/21/2010 |
| cell constituents required for mODC degradation are conserved between animals and fungi, and that both mammalian and fungal ODC are subject to proteasome-mediated proteolysis by ubiquitin-independent mechanisms | Ubiquitin-independent mechanisms of mouse ornithine decarboxylase degradation are conserved between mammalian and fungal cells.
Hoyt MA, Zhang M, Coffino P. | 01/21/2010 |
| elevated ODC values found in the ovary of immature and adult mice play a relevant function in ovarian physiology | Influence of ovarian ornithine decarboxylase in folliculogenesis and luteinization.
Bastida CM, Cremades A, Castells MT, López-Contreras AJ, López-García C, Tejada F, Peñafiel R. | 01/21/2010 |
| gene expression regulation by testosterone in mouse kidney | Influence of testosterone on regulation of ODC, antizyme, and N1-SSAT gene expression in mouse kidney.
Levillain O, Greco A, Diaz JJ, Augier R, Didier A, Kindbeiter K, Catez F, Cayre M. | 01/21/2010 |
| The preovulatory rise is required for progesterone secretion by the corpus luteum | The preovulatory rise of ovarian ornithine decarboxylase is required for progesterone secretion by the corpus luteum.
Bastida CM, Tejada F, Cremades A, Peñafiel R. | 01/21/2010 |
| The role of ODC in the Citrobacter rodentium model of colitis was studied. ODC was induced in the colon during the infection. Inhibition of ODC exacerbated the colitis. | Protective role of arginase in a mouse model of colitis.
Gobert AP, Cheng Y, Akhtar M, Mersey BD, Blumberg DR, Cross RK, Chaturvedi R, Drachenberg CB, Boucher JL, Hacker A, Casero RA Jr, Wilson KT. | 01/21/2010 |
| Odc is a critical Myc transcription target that regulates checkpoints that guard against tumorigenesis and is an effective target for cancer chemoprevention. | Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation.
Nilsson JA, Keller UB, Baudino TA, Yang C, Norton S, Old JA, Nilsson LM, Neale G, Kramer DL, Porter CW, Cleveland JL. | 01/21/2010 |
| c-Myc is an important mediator of macrophage activation and may contribute to the mucosal inflammatory response to pathogens such as H. pylori by its effect on ornithine decarboxylase | Helicobacter pylori-induced macrophage apoptosis requires activation of ornithine decarboxylase by c-Myc.
Cheng Y, Chaturvedi R, Asim M, Bussière FI, Scholz A, Xu H, Casero RA Jr, Wilson KT. | 01/21/2010 |