| Developmentally regulated GTP-binding protein 2 levels in prostate cancer cell lines impact docetaxel-induced apoptosis. | Developmentally regulated GTP-binding protein 2 levels in prostate cancer cell lines impact docetaxel-induced apoptosis.
Kim SC, Lee WH, Kim SH, Abdulkhayevich AA, Park JW, Kim YM, Moon KH, Lee SH, Park S., Free PMC Article | 02/5/2022 |
| Developmentally regulated GTP-binding protein-2 regulates adipocyte differentiation. | Developmentally regulated GTP-binding protein-2 regulates adipocyte differentiation.
Park BS, Im HL, Yoon NA, Tu TH, Park JW, Kim JG, Lee BJ. | 01/29/2022 |
| Developmentally regulated GTPases: structure, function and roles in disease. | Developmentally regulated GTPases: structure, function and roles in disease.
Westrip CAE, Zhuang Q, Hall C, Eaton CD, Coleman ML., Free PMC Article | 12/11/2021 |
| DRG2 supports the growth of primary tumors and metastases of melanoma by enhancing VEGF-A expression. | DRG2 supports the growth of primary tumors and metastases of melanoma by enhancing VEGF-A expression.
Yoon NA, Jung SJ, Choi SH, Ryu JH, Mani M, Lee UH, Vo MT, Jeon DY, Chung SW, Ju Lee B, Koh YW, Park SE, Shin YJ, Kang SS, Cho WJ, Cha HJ, Park JW. | 04/24/2021 |
| Knockdown of DRG2 in HeLa cells treated with epidermal growth factor (EGF) affects microtubule dynamics, perinuclear Golgi stacking, and cell migration. | DRG2 knockdown induces Golgi fragmentation via GSK3β phosphorylation and microtubule stabilization.
Mani M, Thao DT, Kim BC, Lee UH, Kim DJ, Jang SH, Back SH, Lee BJ, Cho WJ, Han IS, Park JW. | 01/25/2020 |
| Using immunoprecipitation, authors show that DRG2 interacts with tau, which regulates microtubule polymerization. Collectively, these data demonstrate that DRG2 may aid in affecting microtubule dynamics in HeLa cells. | DRG2 Deficiency Causes Impaired Microtubule Dynamics in HeLa Cells.
Dang T, Jang SH, Back SH, Park JW, Han IS., Free PMC Article | 02/23/2019 |
| Results show that the SNP (rs2257609 C>T) located in the intron region of SLC5A10 variant does not affect the expression of SLC5A10 mRNA, but alters the mRNA expression and promoter activity of DRG2. It is significantly associated with worse overall and disease-free survival of non-small-cell lung cancer (NSCLC) patients. | Functional intronic variant of SLC5A10 affects DRG2 expression and survival outcomes of early-stage non-small-cell lung cancer.
Hong MJ, Yoo SS, Choi JE, Kang HG, Do SK, Lee JH, Lee WK, Lee J, Lee SY, Cha SI, Kim CH, Lee EB, Cho S, Jheon S, Park JY., Free PMC Article | 01/5/2019 |
| Taken together, our data demonstrate that DRG2 acts as a regulator of mitochondrial fission by controlling the expression of Drp1. | Developmentally regulated GTP-binding protein 2 depletion leads to mitochondrial dysfunction through downregulation of dynamin-related protein 1.
Vo MT, Ko MS, Lee UH, Yoon EH, Lee BJ, Cho WJ, Ha CM, Kim K, Park JW. | 06/24/2017 |
| Authors observed that knockdown of DRG2 in HeLa cells affected growth in a wound-healing assay, and tumorigenicity in nude mice xenografts. | DRG2 Regulates G2/M Progression via the Cyclin B1-Cdk1 Complex.
Jang SH, Kim AR, Park NH, Park JW, Han IS., Free PMC Article | 04/29/2017 |
| Results demonstrate that DRG2 is an endosomal protein and a key regulator of Rab5 deactivation and Tfn recycling. | Developmentally regulated GTP-binding protein 2 coordinates Rab5 activity and transferrin recycling.
Mani M, Lee UH, Yoon NA, Kim HJ, Ko MS, Seol W, Joe Y, Chung HT, Lee BJ, Moon CH, Cho WJ, Park JW., Free PMC Article | 12/17/2016 |
| miR19153p functions as a silencer of apoptosis, which regulates lung cancer apoptosis via targeting DRG2/PBX2. | MicroRNA‑1915‑3p prevents the apoptosis of lung cancer cells by downregulating DRG2 and PBX2.
Xu C, Li H, Zhang L, Jia T, Duan L, Lu C. | 10/1/2016 |
| Basal expression level of DRG2 is regulated by the Sp1 transcription factor. | Transcription factor Sp1 regulates basal transcription of the human DRG2 gene.
Kim HJ, Ko MS, Kim HK, Cho WJ, Lee SH, Lee BJ, Park JW. | 05/7/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| overexpression of DRG2 in Jurkat cells affects genes regulating cell-cycle arrest and apoptosis, and that these molecular changes may be important in the growth or differentiation of cells | Overexpression of DRG2 increases G2/M phase cells and decreases sensitivity to nocodazole-induced apoptosis.
Song H, Kim SI, Ko MS, Kim HJ, Heo JC, Lee HJ, Lee HS, Han IS, Kwack K, Park JW. | 01/21/2010 |