| Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus. | Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus.
Lloyd BA, Han Y, Roth R, Zhang B, Aoto J., Free PMC Article | 08/7/2023 |
| Alternative splicing and heparan sulfation converge on neurexin-1 to control glutamatergic transmission and autism-related behaviors. | Alternative splicing and heparan sulfation converge on neurexin-1 to control glutamatergic transmission and autism-related behaviors.
Lu H, Zuo L, Roddick KM, Zhang P, Oku S, Garden J, Ge Y, Bellefontaine M, Delhaye M, Brown RE, Craig AM. | 08/3/2023 |
| Allelic contribution of Nrxn1alpha to autism-relevant behavioral phenotypes in mice. | Allelic contribution of Nrxn1α to autism-relevant behavioral phenotypes in mice.
Xu B, Ho Y, Fasolino M, Medina J, O'Brien WT, Lamonica JM, Nugent E, Brodkin ES, Fuccillo MV, Bucan M, Zhou Z., Free PMC Article | 03/15/2023 |
| Neurexin1 differentially regulates synaptic efficacy within striatal circuits. | Neurexin1⍺ differentially regulates synaptic efficacy within striatal circuits.
Davatolhagh MF, Fuccillo MV., Free PMC Article | 01/29/2022 |
| Ketamine Restores Thalamic-Prefrontal Cortex Functional Connectivity in a Mouse Model of Neurodevelopmental Disorder-Associated 2p16.3 Deletion. | Ketamine Restores Thalamic-Prefrontal Cortex Functional Connectivity in a Mouse Model of Neurodevelopmental Disorder-Associated 2p16.3 Deletion.
B Hughes R, Whittingham-Dowd J, Simmons RE, Clapcote SJ, Broughton SJ, Dawson N., Free PMC Article | 08/21/2021 |
| Dopaminergic neurons establish a distinctive axonal arbor with a majority of non-synaptic terminals. | Dopaminergic neurons establish a distinctive axonal arbor with a majority of non-synaptic terminals.
Ducrot C, Bourque MJ, Delmas CVL, Racine AS, Guadarrama Bello D, Delignat-Lavaud B, Domenic Lycas M, Fallon A, Michaud-Tardif C, Burke Nanni S, Herborg F, Gether U, Nanci A, Takahashi H, Parent M, Trudeau LE. | 08/14/2021 |
| Alternative splicing of neurexins 1-3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis. | Alternative splicing of neurexins 1-3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis.
Marchese E, Valentini M, Di Sante G, Cesari E, Adinolfi A, Corvino V, Ria F, Sette C, Geloso MC. | 04/24/2021 |
| Disruption of Nrxn1alpha within excitatory forebrain circuits drives value-based dysfunction. | Disruption of Nrxn1α within excitatory forebrain circuits drives value-based dysfunction.
Alabi OO, Davatolhagh MF, Robinson M, Fortunato MP, Vargas Cifuentes L, Kable JW, Fuccillo MV., Free PMC Article | 04/3/2021 |
| Specific Neuroligin3-alphaNeurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus. | Specific Neuroligin3-αNeurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus.
Uchigashima M, Konno K, Demchak E, Cheung A, Watanabe T, Keener DG, Abe M, Le T, Sakimura K, Sasaoka T, Uemura T, Imamura Kawasawa Y, Watanabe M, Futai K., Free PMC Article | 03/28/2021 |
| Assessing the developmental trajectory of mouse models of neurodevelopmental disorders: Social and communication deficits in mice with Neurexin 1alpha deletion. | Assessing the developmental trajectory of mouse models of neurodevelopmental disorders: Social and communication deficits in mice with Neurexin 1α deletion.
Armstrong EC, Caruso A, Servadio M, Andreae LC, Trezza V, Scattoni ML, Fernandes C. | 02/6/2021 |
| A rare autism-associated MINT2/APBA2 mutation disrupts neurexin trafficking and synaptic function. | A rare autism-associated MINT2/APBA2 mutation disrupts neurexin trafficking and synaptic function.
Lin AY, Henry S, Reissner C, Neupert C, Kenny C, Missler M, Beffert U, Ho A., Free PMC Article | 10/10/2020 |
| Nrx1gamma is a potent synapse organizer and LRRTM4 is its postsynaptic ligand. PTPsigma forms a robust complex with Nrx, revealing an unexpected interaction between the two presynaptic hubs. | LRRTMs Organize Synapses through Differential Engagement of Neurexin and PTPσ.
Roppongi RT, Dhume SH, Padmanabhan N, Silwal P, Zahra N, Karimi B, Bomkamp C, Patil CS, Champagne-Jorgensen K, Twilley RE, Zhang P, Jackson MF, Siddiqui TJ. | 08/1/2020 |
| These results reveal an unexpected nanodomain organization of synapses in which neurexin-1 is assembled into discrete presynaptic nanoclusters. | Synaptic neurexin-1 assembles into dynamically regulated active zone nanoclusters.
Trotter JH, Hao J, Maxeiner S, Tsetsenis T, Liu Z, Zhuang X, Südhof TC., Free PMC Article | 05/23/2020 |
| In hippocampal synapses, alternative splicing of presynaptic neurexin-1 at splice site 4 (SS4) dramatically enhanced postsynaptic NMDA-receptor-mediated, but not AMPA-receptor-mediated, synaptic responses without altering synapse density. | Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses.
Dai J, Aoto J, Südhof TC., Free PMC Article | 03/28/2020 |
| SorCS1-mediated sorting in dendritic endosomes controls Nrxn axonal surface polarization required for proper synapse development and function. | SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function.
Ribeiro LF, Verpoort B, Nys J, Vennekens KM, Wierda KD, de Wit J., Free PMC Article | 02/29/2020 |
| Study found that Nrxn1b oligomerization by SALM1 was dependent on F-actin and PIP2. | SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering.
Brouwer M, Farzana F, Koopmans F, Chen N, Brunner JW, Oldani S, Li KW, van Weering JR, Smit AB, Toonen RF, Verhage M., Free PMC Article | 12/28/2019 |
| CA10 directly binds in a cis configuration to a conserved membrane-proximal, extracellular sequence of alpha- and beta-neurexins. | Carbonic anhydrase-related protein CA10 is an evolutionarily conserved pan-neurexin ligand.
Sterky FH, Trotter JH, Lee SJ, Recktenwald CV, Du X, Zhou B, Zhou P, Schwenk J, Fakler B, Südhof TC., Free PMC Article | 04/13/2019 |
| The Nrxn1beta-LRRTM2 interface involves Ca(2+)-mediated interactions and overlaps with the Nrxn-neuroligin interface. | Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction.
Yamagata A, Goto-Ito S, Sato Y, Shiroshima T, Maeda A, Watanabe M, Saitoh T, Maenaka K, Terada T, Yoshida T, Uemura T, Fukai S., Free PMC Article | 01/5/2019 |
| Data report that the expression of nrxn1alpha in primary cortical neuron cultures underwent activity-dependent repression and found that Ash1L binds to nrxn1alpha promoter in neurons to regulate its expression. | Histone methyltransferase Ash1L mediates activity-dependent repression of neurexin-1α.
Zhu Τ, Liang C, Li D, Tian M, Liu S, Gao G, Guan JS., Free PMC Article | 05/19/2018 |
| After pan-neurexin deletions, we observed in these synapses severe but dramatically different synaptic phenotypes that ranged from major impairments in their distribution and function (climbing-fiber synapses) to large decreases in synapse numbers (parvalbumin-positive synapses) and severe alterations in action potential-induced presynaptic Ca(2+) transients (somatostatin-positive synapses). | Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins.
Chen LY, Jiang M, Zhang B, Gokce O, Südhof TC., Free PMC Article | 07/29/2017 |
| Findings demonstrate that the heterozygous loss of alpha-neurexin I and alpha-neurexin II in mice leads to phenotypes relevant to autism and schizophrenia | Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia.
Dachtler J, Ivorra JL, Rowland TE, Lever C, Rodgers RJ, Clapcote SJ., Free PMC Article | 09/3/2016 |
| Study shows that astrocyte-secreted hevin is a trans-synaptic linker that bridges presynaptic NRX1alpha with postsynaptic NL1B. This way, hevin organizes both pre- and postsynaptic specializations and aligns them across the synapse. | Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin.
Singh SK, Stogsdill JA, Pulimood NS, Dingsdale H, Kim YH, Pilaz LJ, Kim IH, Manhaes AC, Rodrigues WS Jr, Pamukcu A, Enustun E, Ertuz Z, Scheiffele P, Soderling SH, Silver DL, Ji RR, Medina AE, Eroglu C., Free PMC Article | 06/4/2016 |
| Nlgn3 and Nrxn1 are differentially expressed in cerebral cortex and hippocampus which might be responsible for alterations in synaptic plasticity during agine. | Age-related expression of Neurexin1 and Neuroligin3 is correlated with presynaptic density in the cerebral cortex and hippocampus of male mice.
Kumar D, Thakur MK., Free PMC Article | 02/13/2016 |
| This study identify distinct differences between major Nrxn variants both in surface mobility and during intracellular transport. | Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals.
Neupert C, Schneider R, Klatt O, Reissner C, Repetto D, Biermann B, Niesmann K, Missler M, Heine M., Free PMC Article | 01/16/2016 |
| Mutant neurexin-1beta expression in mouse adult brain leads to core autism symptoms. | Neurexin dysfunction in adult neurons results in autistic-like behavior in mice.
Rabaneda LG, Robles-Lanuza E, Nieto-González JL, Scholl FG. | 08/22/2015 |