| Titration of RAS alters senescent state and influences tumour initiation. | Titration of RAS alters senescent state and influences tumour initiation.
Chan ASL, Zhu H, Narita M, Cassidy LD, Young ARJ, Bermejo-Rodriguez C, Janowska AT, Chen HC, Gough S, Oshimori N, Zender L, Aitken SJ, Hoare M, Narita M., Free PMC Article | 09/26/2024 |
| NRAS[Q61R] mutation drives elevated angiopoietin-2 expression in human endothelial cells and a genetic mouse model. | NRAS(Q61R) mutation drives elevated angiopoietin-2 expression in human endothelial cells and a genetic mouse model.
Pastura P, McDaniel CG, Alharbi S, Fox D, Coleman B, Malik P, Adams DM, Le Cras TD., | 09/4/2024 |
| Combined HRAS and NRAS ablation induces a RASopathy phenotype in mice. | Combined HRAS and NRAS ablation induces a RASopathy phenotype in mice.
Fuentes-Mateos R, García-Navas R, Fernández-Infante C, Hernández-Cano L, Calzada-Nieto N, Juan AO, Guerrero C, Santos E, Fernández-Medarde A., Free PMC Article | 07/2/2024 |
| A gain-of-function p53 mutant synergizes with oncogenic NRAS to promote acute myeloid leukemia in mice. | A gain-of-function p53 mutant synergizes with oncogenic NRAS to promote acute myeloid leukemia in mice.
Rajagopalan A, Feng Y, Gayatri MB, Ranheim EA, Klungness T, Matson DR, Lee MH, Jung MM, Zhou Y, Gao X, Nadiminti KV, Yang DT, Tran VL, Padron E, Miyamoto S, Bresnick EH, Zhang J., Free PMC Article | 12/26/2023 |
| RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia. | RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.
Ren JG, Xing B, Lv K, O'Keefe RA, Wu M, Wang R, Bauer KM, Ghazaryan A, Burslem GM, Zhang J, O'Connell RM, Pillai V, Hexner EO, Philips MR, Tong W., Free PMC Article | 08/28/2023 |
| Neuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis. | Neuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis.
Zheng K, Hao F, Medrano-Garcia S, Chen C, Guo F, Morán-Blanco L, Rodríguez-Perales S, Torres-Ruiz R, Peligros MI, Vaquero J, Bañares R, Gómez Del Moral M, Regueiro JR, Martínez-Naves E, Mohamed MR, Gallego-Durán R, Maya D, Ampuero J, Romero-Gómez M, Gilbert-Ramos A, Guixé-Muntet S, Fernández-Iglesias A, Gracia-Sancho J, Coll M, Graupera I, Ginès P, Ciudin A, Rivera-Esteban J, Pericàs JM, Frutos MD, Ramos Molina B, Herranz JM, Ávila MA, Nevzorova YA, Fernández-Malavé E, Cubero FJ., Free PMC Article | 08/16/2023 |
| Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in Nras(Q61R/+) mice. | Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in Nras(Q61R/+) mice.
Wen Z, Finn R, Gao X, Li L, Hebert A, Ranheim EA, Zhou Y, Yun G, Roose JP, Coon JJ, Shiang R, Wen R, Yu M, Wang D, Zhang J., Free PMC Article | 07/9/2022 |
| Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation. | Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation.
Murphy BM, Terrell EM, Chirasani VR, Weiss TJ, Lew RE, Holderbaum AM, Dhakal A, Posada V, Fort M, Bodnar MS, Carey LM, Chen M, Burd CJ, Coppola V, Morrison DK, Campbell SL, Burd CE., Free PMC Article | 06/11/2022 |
| Epigenetic downregulation of Socs2 contributes to mutant N-Ras-mediated hematopoietic dysregulation. | Epigenetic downregulation of Socs2 contributes to mutant N-Ras-mediated hematopoietic dysregulation.
Jin X, Ng V, Zhao M, Liu L, Higashimoto T, Lee ZH, Chung J, Chen V, Ney G, Kandarpa M, Talpaz M, Li Q., Free PMC Article | 05/21/2022 |
| Senescent bone marrow microenvironment promotes Nras-mutant leukemia. | Senescent bone marrow microenvironment promotes Nras-mutant leukemia.
Zhou P, Xia C, Wang T, Dong Y, Weng Q, Liu X, Geng Y, Wang J, Du J., Free PMC Article | 01/29/2022 |
| Oncogenic NRAS Accelerates Rhabdomyosarcoma Formation When Occurring within a Specific Time Frame during Tumor Development in Mice. | Oncogenic NRAS Accelerates Rhabdomyosarcoma Formation When Occurring within a Specific Time Frame during Tumor Development in Mice.
Ragab N, Bauer J, Botermann DS, Uhmann A, Hahn H., Free PMC Article | 01/22/2022 |
| Targeted Therapy Given after Anti-PD-1 Leads to Prolonged Responses in Mouse Melanoma Models through Sustained Antitumor Immunity. | Targeted Therapy Given after Anti-PD-1 Leads to Prolonged Responses in Mouse Melanoma Models through Sustained Antitumor Immunity.
Phadke MS, Chen Z, Li J, Mohamed E, Davies MA, Smalley I, Duckett DR, Palve V, Czerniecki BJ, Forsyth PA, Noyes D, Adeegbe DO, Eroglu Z, Nguyen KT, Tsai KY, Rix U, Burd CE, Chen YA, Rodriguez PC, Smalley KSM., Free PMC Article | 01/8/2022 |
| Nras Q61R/+ and Kras-/- cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors. | Nras Q61R/+ and Kras-/- cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors.
Wen Z, Yun G, Hebert A, Kong G, Ranheim EA, Finn R, Rajagoplan A, Li S, Zhou Y, Yu M, Damnernsawad A, Roose JP, Coon JJ, Wen R, Wang D, Zhang J., Free PMC Article | 12/4/2021 |
| Classification and Grading of Melanocytic Lesions in a Mouse Model of NRAS-driven Melanomagenesis. | Classification and Grading of Melanocytic Lesions in a Mouse Model of NRAS-driven Melanomagenesis.
Assenmacher CA, Santagostino SF, Oyama MA, Marine JC, Bonvin E, Radaelli E., Free PMC Article | 08/28/2021 |
| Ras isoforms: signaling specificities in CD40 pathway. | Ras isoforms: signaling specificities in CD40 pathway.
Nair A, Chakraborty S, Banerji LA, Srivastava A, Navare C, Saha B., Free PMC Article | 06/12/2021 |
| Oncogenic N-Ras Mitigates Oxidative Stress-Induced Apoptosis of Hematopoietic Stem Cells. | Oncogenic N-Ras Mitigates Oxidative Stress-Induced Apoptosis of Hematopoietic Stem Cells.
Ney GM, Yang KB, Ng V, Liu L, Zhao M, Kuk W, Alaka L, Sampang L, Ross A, Jones MA, Jin X, McKay LM, Evarts H, Li Q., Free PMC Article | 05/22/2021 |
| Murine Long Noncoding RNA Morrbid Contributes in the Regulation of NRAS Splicing in Hepatocytes In Vitro. | Murine Long Noncoding RNA Morrbid Contributes in the Regulation of NRAS Splicing in Hepatocytes In Vitro.
Fefilova A, Melnikov P, Prikazchikova T, Abakumova T, Kurochkin I, Mazin PV, Ziganshin R, Sergeeva O, Zatsepin TS., Free PMC Article | 02/20/2021 |
| Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice. | Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice.
Zambetti NA, Firestone AJ, Remsberg JR, Huang BJ, Wong JC, Long AM, Predovic M, Suciu RM, Inguva A, Kogan SC, Haigis KM, Cravatt BF, Shannon K., Free PMC Article | 12/26/2020 |
| Concomitant deletion of HRAS and NRAS leads to pulmonary immaturity, respiratory failure and neonatal death in mice. | Concomitant deletion of HRAS and NRAS leads to pulmonary immaturity, respiratory failure and neonatal death in mice.
Fuentes-Mateos R, Jimeno D, Gómez C, Calzada N, Fernández-Medarde A, Santos E., Free PMC Article | 08/22/2020 |
| The NrasG12D mutation distinctly altered multiple pathways involving the cell cycle, cell division, and DNA replication, and distinctly regulated stemness-related genes including Hoxa9, Prdm16, Hoxb4, Trim27, and Smarcc1 in the context of hematopoietic stem cells. | Synergy of NUP98-HOXA10 Fusion Gene and NrasG12D Mutation Preserves the Stemness of Hematopoietic Stem Cells on Culture Condition.
Dong Y, Xia C, Weng Q, Wang T, Hu F, Wang K, Liu X, Geng Y, Liu L, Wu H, Du J., Free PMC Article | 05/23/2020 |
| Cooperation of DNMT3A mutation and NRAS mutation could promote the onset of acute myeloid leukemia by synergistically disturbing the transcriptional profiling with Myc pathway involvement in DKI mice. | Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study.
Shi X, Yang Y, Shang S, Wu S, Zhang W, Peng L, Huang T, Zhang R, Ren R, Mi J, Wang Y., Free PMC Article | 04/11/2020 |
| Oncogenic N-Ras and Tet2 haploinsufficiency collaborate to dysregulate hematopoietic stem and progenitor cells. | Oncogenic N-Ras and Tet2 haploinsufficiency collaborate to dysregulate hematopoietic stem and progenitor cells.
Jin X, Qin T, Zhao M, Bailey N, Liu L, Yang K, Ng V, Higashimoto T, Coolon R, Ney G, Figueroa ME, Li Q., Free PMC Article | 03/9/2019 |
| Tet2/Nras double-mutant leukemia showed preferential sensitivity to MAPK kinase (MEK) inhibition in both mouse model and patient samples | Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity.
Kunimoto H, Meydan C, Nazir A, Whitfield J, Shank K, Rapaport F, Maher R, Pronier E, Meyer SC, Garrett-Bakelman FE, Tallman M, Melnick A, Levine RL, Shih AH., Free PMC Article | 12/22/2018 |
| Results indicate specific and compensatory functions for proto-oncogene B-Raf (BRAF) and proto-oncogene c-RAF (CRAF) and highlight an addiction to RAF signalling in NRAS-driven melanoma. | RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma.
Dorard C, Estrada C, Barbotin C, Larcher M, Garancher A, Leloup J, Beermann F, Baccarini M, Pouponnot C, Larue L, Eychène A, Druillennec S., Free PMC Article | 12/1/2018 |
| gene expression profiles of each of the Ras isoforms in a panel of mouse tissues derived from a full developmental time course, are reported. | Quantification of spatiotemporal patterns of Ras isoform expression during development.
Newlaczyl AU, Coulson JM, Prior IA., Free PMC Article | 11/3/2018 |