| Natriuretic peptide receptor-C perturbs mitochondrial respiration in white adipose tissue. | Natriuretic peptide receptor-C perturbs mitochondrial respiration in white adipose tissue.
Li SJ, Wei JQ, Kang YY, Wang RQ, Rong WW, Zhao JJ, Deng QW, Gao PJ, Li XD, Wang JG., Free PMC Article | 10/3/2024 |
| Circular RNA circPRDX3 mediates neuronal survival apoptosis in ischemic stroke by targeting miR-641 and NPR3. | Circular RNA circPRDX3 mediates neuronal survival apoptosis in ischemic stroke by targeting miR-641 and NPR3.
Chen W, Zhang Y, Yin M, Cheng Z, Li D, Luo X, Liu X, Tu J. | 11/15/2023 |
| NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice. | NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice.
Cheng C, Zhang J, Li X, Xue F, Cao L, Meng L, Sui W, Zhang M, Zhao Y, Xi B, Yu X, Xu F, Yang J, Zhang Y, Zhang C., Free PMC Article | 08/10/2023 |
| NPRC deletion attenuates cardiac fibrosis in diabetic mice by activating PKA/PKG and inhibiting TGF-beta1/Smad pathways. | NPRC deletion attenuates cardiac fibrosis in diabetic mice by activating PKA/PKG and inhibiting TGF-β1/Smad pathways.
Meng L, Lu Y, Wang X, Cheng C, Xue F, Xie L, Zhang Y, Sui W, Zhang M, Zhang Y, Zhang C., Free PMC Article | 08/4/2023 |
| Natriuretic peptide receptor-C mediates the inhibitory effect of atrial natriuretic peptide on neutrophil recruitment to the lung during acute lung injury. | Natriuretic peptide receptor-C mediates the inhibitory effect of atrial natriuretic peptide on neutrophil recruitment to the lung during acute lung injury.
Harrington EO, Kumar A, Leandre V, Wilson ZS, Guarino B, Braza J, Lefort CT, Klinger JR., Free PMC Article | 10/8/2022 |
| Deletion of natriuretic peptide receptor C alleviates adipose tissue inflammation in hypercholesterolemic Apolipoprotein E knockout mice. | Deletion of natriuretic peptide receptor C alleviates adipose tissue inflammation in hypercholesterolemic Apolipoprotein E knockout mice.
Cheng C, Xue F, Sui W, Meng L, Xie L, Zhang C, Yang J, Zhang Y., Free PMC Article | 02/26/2022 |
| Oxygen and steroids affect the regulatory role of natriuretic peptide receptor-C on surfactant secretion by type II cells. | Oxygen and steroids affect the regulatory role of natriuretic peptide receptor-C on surfactant secretion by type II cells.
Ryan RM, Paintlia MK, Newton DA, Spyropoulos DD, Kemp M, Jobe AH, Baatz JE., Free PMC Article | 02/19/2022 |
| Renal Natriuretic Peptide Receptor-C Deficiency Attenuates NaCl Cotransporter Activity in Angiotensin II-Induced Hypertension. | Renal Natriuretic Peptide Receptor-C Deficiency Attenuates NaCl Cotransporter Activity in Angiotensin II-Induced Hypertension.
Shao S, Li XD, Lu YY, Li SJ, Chen XH, Zhou HD, He S, Guo YT, Lu X, Gao PJ, Wang JG. | 09/11/2021 |
| Gene expression of proliferator-activated receptor delta and estrogen-related receptor alpha, which upregulate oxidative metabolism, was increased in the gastrocnemius muscle of NPR-C- mice, irrespective of diet. | Natriuretic peptide signaling is involved in the expression of oxidative metabolism-related and muscle fiber constitutive genes in the gastrocnemius muscle.
Ishikawa K, Hara T, Mizukawa M, Fukano Y, Shimomura T. | 05/30/2020 |
| Absence of natriuretic peptide clearance receptor attenuates TGF-beta1-induced selective atrial fibrosis and atrial fibrillation. | Absence of natriuretic peptide clearance receptor attenuates TGF-β1-induced selective atrial fibrosis and atrial fibrillation.
Rahmutula D, Zhang H, Wilson EE, Olgin JE. | 03/7/2020 |
| NPRC plays a critical role in the progression of angiotensin II-mediated atrial fibrillation and atrial dysfunction. | NPR-C (Natriuretic Peptide Receptor-C) Modulates the Progression of Angiotensin II-Mediated Atrial Fibrillation and Atrial Remodeling in Mice.
Jansen HJ, Mackasey M, Moghtadaei M, Liu Y, Kaur J, Egom EE, Tuomi JM, Rafferty SA, Kirkby AW, Rose RA. | 11/2/2019 |
| It was the aim to investigate the expression of natriuretic peptide receptors NPR-A, NPR-B and NPR-C during adipocyte differentiation (AD), upon stimulation with fatty acids (FA), and in murine and human adipose tissue depots. | Regulation of natriuretic peptides postprandially in vivo and of their receptors in adipocytes by fatty acids in vitro.
Schmid A, Albrecht J, Brock J, Koukou M, Arapogianni E, Schäffler A, Karrasch T. | 04/27/2019 |
| this study shows that sensory axon bifurcation is insensitive to increases of C-type natriuretic peptide induced cyclic GMP levels and the guanylate cyclase receptor Npr3 does not have an important scavenging function in this axonal system. | Dorsal root ganglion axon bifurcation tolerates increased cyclic GMP levels: the role of phosphodiesterase 2A and scavenger receptor Npr3.
Schmidt H, Peters S, Frank K, Wen L, Feil R, Rathjen FG. | 11/18/2017 |
| A model of kyphosis due to a novel NPR3 Tyr209Asn mutation is established. | Mice with an N-Ethyl-N-Nitrosourea (ENU) Induced Tyr209Asn Mutation in Natriuretic Peptide Receptor 3 (NPR3) Provide a Model for Kyphosis Associated with Activation of the MAPK Signaling Pathway.
Esapa CT, Piret SE, Nesbit MA, Loh NY, Thomas G, Croucher PI, Brown MA, Brown SD, Cox RD, Thakker RV., Free PMC Article | 07/1/2017 |
| Npr3 is expressed in hard calluses of wild-type mice, suggesting a possible role of CNP signaling in fracture repair, especially in bone remodeling stage. | Increased Bone Turnover and Possible Accelerated Fracture Healing in a Murine Model With an Increased Circulating C-Type Natriuretic Peptide.
Kondo E, Yasoda A, Fujii T, Nakao K, Yamashita Y, Ueda-Sakane Y, Kanamoto N, Miura M, Arai H, Mukoyama M, Inagaki N, Nakao K. | 08/29/2015 |
| NPR-C is required to control DNA damage-induced p53 levels to maintain embryonic stem cell self-renewal. | NPR-C protects embryonic stem cells from apoptosis by regulating p53 levels.
Abdelalim EM, Tooyama I. | 09/1/2012 |
| Results demonstrate the opposite effects of NPR-A and NPR-C in LPS-mediated endothelial permeability and lung injury. | Opposite effects of ANP receptors in attenuation of LPS-induced endothelial permeability and lung injury.
Xing J, Yakubov B, Poroyko V, Birukova AA., Free PMC Article | 06/9/2012 |
| A stratified transcriptomics analysis of polygenic fat and lean mouse adipose tissues identifies Npr3 as novel candidate obesity genes. | A stratified transcriptomics analysis of polygenic fat and lean mouse adipose tissues identifies novel candidate obesity genes.
Morton NM, Nelson YB, Michailidou Z, Di Rollo EM, Ramage L, Hadoke PW, Seckl JR, Bunger L, Horvat S, Kenyon CJ, Dunbar DR., Free PMC Article | 02/18/2012 |
| Upregulation of NPR-C mRNA in the kidney and heart of eNOS knockout mice. | Upregulation of ANP and NPR-C mRNA in the kidney and heart of eNOS knockout mice.
Yuan K, Kim SY, Oh YB, Yu J, Shah A, Park BH, Kim SH. | 09/20/2010 |
| Musclin binds to NPR3 competitively with ANP and may affect ANP concentrations in a local or systemic manner. | Competitive binding of musclin to natriuretic peptide receptor 3 with atrial natriuretic peptide.
Kita S, Nishizawa H, Okuno Y, Tanaka M, Yasui A, Matsuda M, Yamada Y, Shimomura I. | 01/21/2010 |
| Ostn is a naturally occurring ligand of the NPR-C clearance receptor and may act to locally modulate the actions of the natriuretic system in bone by blocking the clearance action of NPR-C, thus locally elevating levels of C-type natriuretic peptide. | Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth.
Moffatt P, Thomas G, Sellin K, Bessette MC, Lafrenière F, Akhouayri O, St-Arnaud R, Lanctôt C. | 01/21/2010 |
| discussion of neuronal regulation and function of natriuretic peptide receptor C [review] | Neuronal regulation and function of natriuretic peptide receptor C.
Trachte G. | 01/21/2010 |
| CNP has negative chronotropic effect on heart rate, and this effect is mediated by selectively activating NPR-C and reducing L-type Ca2+ current through coupling to Gi protein. | Effects of C-type natriuretic peptide on ionic currents in mouse sinoatrial node: a role for the NPR-C receptor.
Rose RA, Lomax AE, Kondo CS, Anand-Srivastava MB, Giles WR. | 01/21/2010 |
| circulating ANP levels and data from NPR1(-/-) and NPR3(-/-) mice suggest that the ANP pathway may not be involved in the cardiovascular response to caloric restriction | Hypotension and bradycardia during caloric restriction in mice are independent of salt balance and do not require ANP receptor.
Hunt LM, Hogeland EW, Henry MK, Swoap SJ. | 01/21/2010 |