| Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac Repair by Reprogramming Reparative Macrophage Metabolism. | Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac Repair by Reprogramming Reparative Macrophage Metabolism.
Zhang S, Zhang Y, Duan X, Wang B, Zhan Z., Free PMC Article | 07/2/2024 |
| MANF Promotes Unexplained Recurrent Miscarriages by Interacting with NPM1 and Downregulating Trophoblast Cell Migration and Invasion. | MANF Promotes Unexplained Recurrent Miscarriages by Interacting with NPM1 and Downregulating Trophoblast Cell Migration and Invasion.
Fang Y, Zhang J, Zhu D, Mei Q, Liao T, Cheng H, He Y, Cao Y, Wei Z., Free PMC Article | 06/26/2024 |
| The acetylation of STAT3 at K685 attenuates NPM-ALK-induced tumorigenesis. | The acetylation of STAT3 at K685 attenuates NPM-ALK-induced tumorigenesis.
Korai A, Lin X, Tago K, Funakoshi-Tago M. | 01/16/2024 |
| Nucleophosmin 1 cooperates with the methyltransferase DOT1L to preserve peri-nucleolar heterochromatin organization by regulating H3K27me3 levels and DNA repeats expression. | Nucleophosmin 1 cooperates with the methyltransferase DOT1L to preserve peri-nucleolar heterochromatin organization by regulating H3K27me3 levels and DNA repeats expression.
Izzo A, Akol I, Villarreal A, Lebel S, Garcia-Miralles M, Cheffer A, Bovio P, Heidrich S, Vogel T., Free PMC Article | 12/20/2023 |
| Dot1l cooperates with Npm1 to repress endogenous retrovirus MERVL in embryonic stem cells. | Dot1l cooperates with Npm1 to repress endogenous retrovirus MERVL in embryonic stem cells.
Zhao X, Li X, Sun H, Zhao X, Gao T, Shi P, Chen F, Liu L, Lu X., Free PMC Article | 09/26/2023 |
| IL33-mediated NPM1 promotes fibroblast-to-myofibroblast transition via ERK/AP-1 signaling in silica-induced pulmonary fibrosis. | IL33-mediated NPM1 promotes fibroblast-to-myofibroblast transition via ERK/AP-1 signaling in silica-induced pulmonary fibrosis.
Wang Y, Cheng D, Li Z, Sun W, Zhou S, Peng L, Xiong H, Jia X, Li W, Han L, Liu Y, Ni C. | 08/31/2023 |
| Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice. | Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice.
Muranyi A, Ammer T, Kechter A, Rawat VPS, Sinha A, Gonzalez-Menendez I, Quintanilla-Martinez L, Azoitei A, Günes C, Mupo A, Vassiliou G, Bamezai S, Buske C., Free PMC Article | 02/4/2023 |
| Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML. | Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML.
Meyer AE, Stelloh C, Pulakanti K, Burns R, Fisher JB, Heimbruch KE, Tarima S, Furumo Q, Brennan J, Zheng Y, Viny AD, Vassiliou GS, Rao S., Free PMC Article | 08/6/2022 |
| Cell origin-dependent cooperativity of mutant Dnmt3a and Npm1 in clonal hematopoiesis and myeloid malignancy. | Cell origin-dependent cooperativity of mutant Dnmt3a and Npm1 in clonal hematopoiesis and myeloid malignancy.
SanMiguel JM, Eudy E, Loberg MA, Miles LA, Stearns T, Mistry JJ, Rauh MJ, Levine RL, Trowbridge JJ., Free PMC Article | 07/2/2022 |
| NPM1 ablation induces HSC aging and inflammation to develop myelodysplastic syndrome exacerbated by p53 loss. | NPM1 ablation induces HSC aging and inflammation to develop myelodysplastic syndrome exacerbated by p53 loss.
Morganti C, Ito K, Yanase C, Verma A, Teruya-Feldstein J, Ito K., Free PMC Article | 05/7/2022 |
| Mechanisms of nucleophosmin (NPM)-mediated regulated cell death elucidated by Hsp70 during renal ischemia. | Mechanisms of nucleophosmin (NPM)-mediated regulated cell death elucidated by Hsp70 during renal ischemia.
Wang Z, Havasi A, Beeler AA, Borkan SC. | 04/2/2022 |
| Nucleophosmin contributes to vascular inflammation and endothelial dysfunction in atherosclerosis progression. | Nucleophosmin contributes to vascular inflammation and endothelial dysfunction in atherosclerosis progression.
Rao C, Liu B, Huang D, Chen R, Huang K, Li F, Dong N. | 07/10/2021 |
| SIRT7-dependent deacetylation of NPM promotes p53 stabilization following UV-induced genotoxic stress. | SIRT7-dependent deacetylation of NPM promotes p53 stabilization following UV-induced genotoxic stress.
Ianni A, Kumari P, Tarighi S, Simonet NG, Popescu D, Guenther S, Hölper S, Schmidt A, Smolka C, Yue S, Krüger M, Fiorillo C, Vaquero A, Bober E, Braun T., Free PMC Article | 06/19/2021 |
| Data indicate that NPM is essential for HuR-mediated nuclear accumulation of Rac1 in the intestinal epithelium. | RNA-Binding Protein HuR Regulates Rac1 Nucleocytoplasmic Shuttling Through Nucleophosmin in the Intestinal Epithelium.
Liu L, Xiao L, Chung HK, Kwon MS, Li XX, Wu N, Rao JN, Wang JY., Free PMC Article | 07/25/2020 |
| Germline NPM1 mutations lead to altered rRNA 2'-O-methylation and cause dyskeratosis congenital. | Germline NPM1 mutations lead to altered rRNA 2'-O-methylation and cause dyskeratosis congenita.
Nachmani D, Bothmer AH, Grisendi S, Mele A, Bothmer D, Lee JD, Monteleone E, Cheng K, Zhang Y, Bester AC, Guzzetti A, Mitchell CA, Mendez LM, Pozdnyakova O, Sportoletti P, Martelli MP, Vulliamy TJ, Safra M, Schwartz S, Luzzatto L, Bluteau O, Soulier J, Darnell RB, Falini B, Dokal I, Ito K, Clohessy JG, Pandolfi PP., Free PMC Article | 01/25/2020 |
| NPM is upregulated in insulin resistant mice livers and hepatocytes. | Nucleophosmin/B23 contributes to hepatic insulin resistance through the modulation of NF-κB pathway.
Wang X, Ma H, Wang X. | 12/28/2019 |
| Induction of mutant Npm1 after development of Dnmt3a-mutant Clonal hematopoiesis causes progression to myeloproliferative disorder and acceleration to acute myeloid leukemia. | Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis.
Loberg MA, Bell RK, Goodwin LO, Eudy E, Miles LA, SanMiguel JM, Young K, Bergstrom DE, Levine RL, Schneider RK, Trowbridge JJ., Free PMC Article | 11/16/2019 |
| B23 expression in developing neurons is essential for neuritogenesis and axon growth. | B23/Nucleophosmin promotes reconstitution of synaptic path in hippocampus after injury.
Yun T, Ko HR, Ahn J, Jin EJ, Jo JM, Kwon IS, Cho SW, Chang YS, Park WS, Ahn JY. | 09/14/2019 |
| Study shows that in acute myeloid leukemia (AML) cells loss of NPM1c from the cytoplasm, either through nuclear relocalization or targeted degradation, results in immediate downregulation of homeobox genes followed by differentiation. XPO1 inhibition relocalizes NPM1c to the nucleus, promotes differentiation of AML cells, and prolongs survival of Npm1-mutated leukemic mice. | Mutant NPM1 Maintains the Leukemic State through HOX Expression.
Brunetti L, Gundry MC, Sorcini D, Guzman AG, Huang YH, Ramabadran R, Gionfriddo I, Mezzasoma F, Milano F, Nabet B, Buckley DL, Kornblau SM, Lin CY, Sportoletti P, Martelli MP, Falini B, Goodell MA., Free PMC Article | 06/29/2019 |
| In the current study, we demonstrate the existence of a negative feedback loop through which an increased B23 expression suppresses ERalpha. Because suppression of ERalpha expression is a late event during estrogen-dependent endometrial tumorigenesis, the inhibition of nucleophisminmay represent a strategy to promote ERalpha re-expression that ultimately restores tumor sensitivity to hormonal therapy | Nucleophosmin/B23 is a negative regulator of estrogen receptor α expression via AP2γ in endometrial cancer cells.
Lin CY, Chao A, Wang TH, Lee LY, Yang LY, Tsai CL, Wang HS, Lai CH., Free PMC Article | 02/10/2018 |
| molecular complementarity underlies the higher frequency and significantly worse prognosis associated with NPM1c/FLT3-internal tandem duplications vs NPM1/NRAS-G12D-mutant acute myeloid leukemia (AML) and functionally confirm the role of HOXA genes in NPM1c-driven AML. | Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia.
Dovey OM, Cooper JL, Mupo A, Grove CS, Lynn C, Conte N, Andrews RM, Pacharne S, Tzelepis K, Vijayabaskar MS, Green P, Rad R, Arends M, Wright P, Yusa K, Bradley A, Varela I, Vassiliou GS., Free PMC Article | 11/11/2017 |
| NPM1-dependent nucleolar PIDDosome is a key initiator of the caspase-2 activation cascade. | NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus.
Ando K, Parsons MJ, Shah RB, Charendoff CI, Paris SL, Liu PH, Fassio SR, Rohrman BA, Thompson R, Oberst A, Sidi S, Bouchier-Hayes L., Free PMC Article | 09/16/2017 |
| NPM1 knockdown decreased NF-kappaB-mediated transcription of selected target genes by decreasing the recruitment of NF-kappaB p65 to the gene promoters. | Efficient DNA binding of NF-κB requires the chaperone-like function of NPM1.
Lin J, Kato M, Nagata K, Okuwaki M., Free PMC Article | 08/26/2017 |
| study suggests that although neurons need NPM1 for survival, an increase in its expression beyond physiological levels and its translocation to the cytoplasm leads to death through abortive cell cycle induction. | Regulation of Neuronal Survival by Nucleophosmin 1 (NPM1) Is Dependent on Its Expression Level, Subcellular Localization, and Oligomerization Status.
Pfister JA, D'Mello SR., Free PMC Article | 05/20/2017 |
| The levels of B23 expression are directly regulated by EGR1. | The expression of B23 and EGR1 proteins is functionally linked in tumor cells under stress conditions.
Ponti D, Bastianelli D, Rosa P, Pacini L, Ibrahim M, Rendina EA, Ragona G, Calogero A., Free PMC Article | 06/28/2016 |