| Mycn ameliorates cardiac hypertrophy-induced heart failure in mice by mediating the USP2/JUP/Akt/beta-catenin cascade. | Mycn ameliorates cardiac hypertrophy-induced heart failure in mice by mediating the USP2/JUP/Akt/β-catenin cascade.
Gao W, Guo N, Yan H, Zhao S, Sun Y, Chen Z., Free PMC Article | 06/25/2024 |
| MTHFD1 regulates the NADPH redox homeostasis in MYCN-amplified neuroblastoma. | MTHFD1 regulates the NADPH redox homeostasis in MYCN-amplified neuroblastoma.
Guan J, Li M, Wang Y, Zhang Y, Que Y, Lu S, Wang J, Zhu J, Huang J, Zhen Z, Sun F, Song M, Zhang Y., Free PMC Article | 02/27/2024 |
| Development of an osteosarcoma model with MYCN amplification and TP53 mutation in hiPS cell-derived neural crest cells. | Development of an osteosarcoma model with MYCN amplification and TP53 mutation in hiPS cell-derived neural crest cells.
Mukae K, Takenobu H, Endo Y, Haruta M, Shi T, Satoh S, Ohira M, Funato M, Toguchida J, Osafune K, Nakahata T, Kanda H, Kamijo T., Free PMC Article | 05/5/2023 |
| Mycn deficiency underlies the development of orofacial clefts in mice and humans. | Mycn deficiency underlies the development of orofacial clefts in mice and humans.
Yang R, Li R, Huang Z, Zuo Y, Yue H, Wu H, Gu F, Wang F, He M, Bian Z. | 05/7/2022 |
| Mesenchymal Mycn participates in odontoblastic lineage commitment by regulating Kruppel-like Factor 4 (Klf4) in mice. | Mesenchymal Mycn participates in odontoblastic lineage commitment by regulating Krüppel-like Factor 4 (Klf4) in mice.
Huang Z, Yang R, Li R, Zuo Y, Gu F, He M, Bian Z., Free PMC Article | 04/2/2022 |
| Simultaneous Brg1 Knockout and MYCN Overexpression in Cerebellar Granule Neuron Precursors Is Insufficient to Drive Tumor Formation but Temporarily Enhances their Proliferation and Delays their Migration. | Simultaneous Brg1 Knockout and MYCN Overexpression in Cerebellar Granule Neuron Precursors Is Insufficient to Drive Tumor Formation but Temporarily Enhances their Proliferation and Delays their Migration.
Holdhof D, On JH, Schoof M, Göbel C, Schüller U., Free PMC Article | 12/11/2021 |
| A role of Hey2 transcription factor for right ventricle development through regulation of Tbx2-Mycn pathway during cardiac morphogenesis. | A role of Hey2 transcription factor for right ventricle development through regulation of Tbx2-Mycn pathway during cardiac morphogenesis.
Seya D, Ihara D, Shirai M, Kawamura T, Watanabe Y, Nakagawa O. | 10/30/2021 |
| Reduced Granule Cell Proliferation and Molecular Dysregulation in the Cerebellum of Lysosomal Acid Phosphatase 2 (ACP2) Mutant Mice. | Reduced Granule Cell Proliferation and Molecular Dysregulation in the Cerebellum of Lysosomal Acid Phosphatase 2 (ACP2) Mutant Mice.
Jiao X, Rahimi Balaei M, Abu-El-Rub E, Casoni F, Pezeshgi Modarres H, Dhingra S, Kong J, Consalez GG, Marzban H., Free PMC Article | 04/24/2021 |
| MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity. | MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity.
Grunblatt E, Wu N, Zhang H, Liu X, Norton JP, Ohol Y, Leger P, Hiatt JB, Eastwood EC, Thomas R, Ibrahim AH, Jia D, Basom R, Eaton KD, Martins R, Houghton AM, MacPherson D., Free PMC Article | 04/17/2021 |
| Authors identified a panel of genes with altered expression in Th-MYCN/Casp2(-/-) tumors that are strongly associated with neuroblastoma outcome, with roles in melanogenesis, Wnt and Hippo pathway signaling, that also contribute to neuronal differentiation. | Transcriptome profiling of caspase-2 deficient EμMyc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling.
Dorstyn L, Hackett-Jones E, Nikolic A, Norris MD, Lim Y, Toubia J, Haber M, Kumar S., Free PMC Article | 06/6/2020 |
| Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis. | Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis.
Moon S, Im SK, Kim N, Youn H, Park UH, Kim JY, Kim AR, An SJ, Kim JH, Sun W, Hwang JT, Kim EJ, Um SJ., Free PMC Article | 12/14/2019 |
| cardiomyocytes compete according to their combined Myc and Mycn levels and that cell competition eliminates flawed cardiomyocytes, suggesting its relevance as a quality control mechanism in cardiac development. | Myc is dispensable for cardiomyocyte development but rescues Mycn-deficient hearts through functional replacement and cell competition.
Muñoz-Martín N, Sierra R, Schimmang T, Villa Del Campo C, Torres M. | 10/26/2019 |
| MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to a reactive oxygen species-augmenting agent. | MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent.
Wang T, Liu L, Chen X, Shen Y, Lian G, Shah N, Davidoff AM, Yang J, Wang R., Free PMC Article | 09/14/2019 |
| Studied effect of CX-5461 on downregulation of MYCN in neuroblastoma cell lines and mouse models. | Down-regulation of MYCN protein by CX-5461 leads to neuroblastoma tumor growth suppression.
Taylor JS, Zeki J, Ornell K, Coburn J, Shimada H, Ikegaki N, Chiu B., Free PMC Article | 08/31/2019 |
| IL-32epsilon induces caspase-independent apoptosis mediated by N-Myc interactor in macrophages infected with Mycobacterium tuberculosis. | Interleukin-32ε induces caspase-independent apoptosis mediated by N-Myc interactor in macrophages infected with Mycobacterium tuberculosis.
Li Z, Wang Y, Liu X, Xing X, Zhang Y. | 08/10/2019 |
| A common pathway connecting n-MYC, NAMPT and SIRT1 may be active in basal cell carcinomas and in their cells of origin, contributing to their development. | Expression of n-MYC, NAMPT and SIRT1 in Basal Cell Carcinomas and their Cells of Origin.
Brandl L, Hartmann D, Kirchner T, Menssen A. | 04/27/2019 |
| Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models. | Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models.
Mirzamohammadi F, Kozlova A, Papaioannou G, Paltrinieri E, Ayturk UM, Kobayashi T., Free PMC Article | 11/24/2018 |
| MYCN-promoted SGO1 transcription and SGO1 expression tended to be higher in MYCN- or MYC-overexpressing cancers. Together, these findings indicate that SGO1 plays a role in the DNA damage response in interphase. | SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells.
Murakami-Tonami Y, Ikeda H, Yamagishi R, Inayoshi M, Inagaki S, Kishida S, Komata Y, Jan Koster, Takeuchi I, Kondo Y, Maeda T, Sekido Y, Murakami H, Kadomatsu K., Free PMC Article | 05/12/2018 |
| interactions of NF-kappaB and N-myc with GLT-1/EAAT2 promoter sequences was significantly elevated in the ipsi-lateral cortex of both adult and old Traumatic brain injury mice. | Age-Dependent Alterations in the Interactions of NF-κB and N-myc with GLT-1/EAAT2 Promoter in the Pericontusional Cortex of Mice Subjected to Traumatic Brain Injury.
Gupta RK, Prasad S. | 12/23/2017 |
| beta-catenin cooperates with the transcription factor Myc to activate the progenitor renewal program. | Myc cooperates with β-catenin to drive gene expression in nephron progenitor cells.
Pan X, Karner CM, Carroll TJ., Free PMC Article | 12/2/2017 |
| we report the isolation and propagation of neuroblastoma sphere-forming cells with self-renewal and differentiation potential from tumors of the TH-MYCN mouse, an animal model of high-risk neuroblastoma with MYCN amplification | Transcriptional Profiling Reveals a Common Metabolic Program in High-Risk Human Neuroblastoma and Mouse Neuroblastoma Sphere-Forming Cells.
Liu M, Xia Y, Ding J, Ye B, Zhao E, Choi JH, Alptekin A, Yan C, Dong Z, Huang S, Yang L, Cui H, Zha Y, Ding HF., Free PMC Article | 12/2/2017 |
| miR-34a contributes to the expansion of Myeloid-derived suppressor cells by inhibiting the apoptosis via suppressing the expression of N-myc. | miR-34a inhibits the apoptosis of MDSCs by suppressing the expression of N-myc.
Chen S, Huang A, Chen H, Yang Y, Xia F, Jin L, Zhang J. | 12/2/2017 |
| the role of N-myc in mouse lens development, was examined. | N-myc regulates growth and fiber cell differentiation in lens development.
Cavalheiro GR, Matos-Rodrigues GE, Zhao Y, Gomes AL, Anand D, Predes D, de Lima S, Abreu JG, Zheng D, Lachke SA, Cvekl A, Martins RAP., Free PMC Article | 10/14/2017 |
| Using comparative genomic hybridization, authors found that NCC-derived NBL tumors in mice acquired copy number gains and losses that are syntenic to those observed in human MYCN-amplified NBL including 17q gain, 2p gain and loss of 1p36. | MYCN induces neuroblastoma in primary neural crest cells.
Olsen RR, Otero JH, García-López J, Wallace K, Finkelstein D, Rehg JE, Yin Z, Wang YD, Freeman KW., Free PMC Article | 10/14/2017 |
| a Mycn target gene encoding the miR cluster miR-17~92, while most retinoblastomas reemerged without clear genetic alterations in either Mycn or known Mycn targets. This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor. | A mouse model of MYCN-driven retinoblastoma reveals MYCN-independent tumor reemergence.
Wu N, Jia D, Bates B, Basom R, Eberhart CG, MacPherson D., Free PMC Article | 09/9/2017 |