| Disruption of neuromedin B receptor improves mitochondrial oxidative phosphorylation capacity in gastrocnemius muscle of female mice. | Disruption of neuromedin B receptor improves mitochondrial oxidative phosphorylation capacity in gastrocnemius muscle of female mice.
Bento-Bernardes T, Rossetti CL, Borba Vieira de Andrade C, Lopes de Souza L, Wilieman Cabral M, Silva Monteiro de Paula G, Woyames J, Jesus Oliveira K, Seixas da-Silva W, Cabanelas Pazos-Moura C. | 05/14/2022 |
| Data show genetically disruption of NB-R in mice ASC or pharmacological antagonism of NB-R in 3T3-L1 cells impairs adipogenesis. | Neuromedin B receptor disruption impairs adipogenesis in mice and 3T3-L1 cells.
de Paula GSM, Wilieman M, Silva KR, Baptista LS, Boudina S, de Souza LL, Bento-Bernardes T, Asensi KD, Goldenberg RCDS, Pazos-Moura CC., Free PMC Article | 07/18/2020 |
| NMB-treated mice were less susceptible to virus challenge, as evidenced by increased survival, increased body weight, and decreased viral NP expression compared with the control animals. As expected, opposing effects were observed in the NMBR antagonist-treated cells and mice, which further confirmed the effects of NMB. | Role of neuromedin B and its receptor in the innate immune responses against influenza A virus infection in vitro and in vivo.
Yang G, Huang H, Tang M, Cai Z, Huang C, Qi B, Chen JL., Free PMC Article | 02/8/2020 |
| Neuromedin B expression identifies retrotrapezoid nucleus neurons in the mouse. | Neuromedin B Expression Defines the Mouse Retrotrapezoid Nucleus.
Shi Y, Stornetta RL, Stornetta DS, Onengut-Gumuscu S, Farber EA, Turner SD, Guyenet PG, Bayliss DA., Free PMC Article | 12/9/2017 |
| NMB or NMBR silencing inhibited M-CSF/c-Fms-mediated downstream signaling pathways like activation of ERK and Akt and induction of D-type cyclins, cyclin D1 and D2. | Neuromedin B and its receptor silencing suppresses osteoclast generation by modulating precursor proliferation via M-CSF/c-Fms/D-type cyclins.
Yeo CE, Kang WY, Seong SJ, Cho S, Lee HW, Yoon YR, Kim HJ. | 10/21/2017 |
| mice with deletion of NB receptor have lower insulinemia, especially in response to oral glucose, and females also exhibited a better glucose tolerance, suggesting the involvement of neuromedin b and its receptor in regulation of insulin secretion induced by incretins, and also, in insulin sensitivity. | Mice with Deletion of Neuromedin B Receptor Exhibit Decreased Oral Glucose-Stimulated Insulin Release.
Paula GS, Souza LL, Bressane NO, Maravalhas R, Wilieman M, Bento-Bernardes T, Silva KR, Mendonca LS, Oliveira KJ, Pazos-Moura CC. | 03/18/2017 |
| ablating NMB receptor-expressing neurons eliminated basal and hypoxia-induced sighing, but left breathing otherwise intact initially | The peptidergic control circuit for sighing.
Li P, Janczewski WA, Yackle K, Kam K, Pagliardini S, Krasnow MA, Feldman JL., Free PMC Article | 03/12/2016 |
| The neuromedin B pathways are importantly involved in secretory pathways of TSH and revealed its participation in the in vivo regulation of gene expression of TSH beta-subunit and pituitary MCT8 and Thrb and hypothalamic TRH and type 2 deiodinase. | Hypothalamic-pituitary thyroid axis alterations in female mice with deletion of the neuromedin B receptor gene.
Oliveira KJ, Paula GS, Império GE, Bressane NO, Magalhães CM, Miranda-Alves L, Ortiga-Carvalho TM, Pazos-Moura CC. | 01/2/2016 |
| Together, we define the respective function of NMBR and GRPR in itch transmission, and reveal an unexpected relationship not only between the two receptors but also between the two populations of interneurons in itch signaling. | Cross-inhibition of NMBR and GRPR signaling maintains normal histaminergic itch transmission.
Zhao ZQ, Wan L, Liu XY, Huo FQ, Li H, Barry DM, Krieger S, Kim S, Liu ZC, Xu J, Rogers BE, Li YQ, Chen ZF., Free PMC Article | 01/10/2015 |
| spinal GRPr and NMBr independently drive itch neurotransmission in mice. | Physiological function of gastrin-releasing peptide and neuromedin B receptors in regulating itch scratching behavior in the spinal cord of mice.
Sukhtankar DD, Ko MC., Free PMC Article | 02/8/2014 |
| Results implicate that NMB is involved in cartilage development, either in an autocrine or paracrine manner. | Neuromedin B stimulates proliferation of mouse chondrogenic cell line ATDC5.
Saito H, Ikeda R, Inoue K, Nagata S, Kitamura K, Minamino N, Kangawa K, Miyata A. | 12/29/2012 |
| The data demonstrated that the neuromedin B-neuromedian B receptor interaction in pregnant myometrial primary cells in vitro predominantly influenced uterine activity through regulation of Il6 expression via the Rela/p65 pathway. | Neuromedin B and its receptor influence the activity of myometrial primary cells in vitro through regulation of Il6 expression via the Rela/p65 pathway in mice.
Zhang WS, Fei KL, Wu MT, Wu XH, Liang QH. | 09/22/2012 |
| These data demonstrate that neuromedin B and its receptor can induce the onset of labor via a RELA/IL6-mediated pathway. | Neuromedin B and its receptor induce labor onset and are associated with the RELA (NFKB P65)/IL6 pathway in pregnant mice.
Zhang WS, Xie QS, Wu XH, Liang QH. | 05/21/2011 |
| The mRNA and protein expressions of NMBR reach a peak at the onset of labor. | [Expression of NMBR in myometrium in pregnant mice at different gestational ages and its relation with parturition].
Zhang W, Xie Q, Wu Z, Wu X, Liang Q. | 04/30/2011 |
| disruption of the neuromedin B receptor pathway did not change body weight homeostasis in female mice fed a normolipid diet | Female mice target deleted for the neuromedin B receptor have partial resistance to diet-induced obesity.
Paula GS, Souza LL, Cabanelas A, Bloise FF, Mello-Coelho V, Wada E, Ortiga-Carvalho TM, Oliveira KJ, Pazos-Moura CC., Free PMC Article | 08/2/2010 |
| Selectivity of NMBR for neuromedin B over the gastrin-releasing peptide receptor depends primarily on differences in amino acids in the third extracellular domains of the receptors and in the adjacent upper fifth transmembrane region of the two receptors. | Molecular basis for the selectivity of the mammalian bombesin peptide, neuromedin B, for its receptor.
González N, Nakagawa T, Mantey SA, Sancho V, Uehara H, Katsuno T, Jensen RT., Free PMC Article | 01/21/2010 |
| NMB-R-deficient mice exhibited decreased behavior in both the L-D box and elevated plus maze tests. | Role of bombesin (BN)-like peptides/receptors in emotional behavior by comparison of three strains of BN-like peptide receptor knockout mice.
Yamada K, Santo-Yamada Y, Wada E, Wada K. | 01/21/2010 |
| NMBR and BRS-3 genes were expressed from embryonic days 13-16 and on multiple postnatal days for lungs | Bombesin-like peptide receptor gene expression, regulation, and function in fetal murine lung.
Shan L, Emanuel RL, Dewald D, Torday JS, Asokanathan N, Wada K, Wada E, Sunday ME. | 01/21/2010 |
| 5-HT expression in the dorsal raphe (DR)nucleus is elevated in NMB-R-deficient mice. NMB/NMB-R may modulate 5-HT neuronal activity by affecting DR function. | Decreased marble burying behavior in female mice lacking neuromedin-B receptor (NMB-R) implies the involvement of NMB/NMB-R in 5-HT neuron function.
Yamada K, Wada E, Yamano M, Sun YJ, Ohara-Imaizumi M, Nagamatsu S, Wada K. | 01/21/2010 |
| Impaired memory in stressed neuromedin B receptor-deficient mice not consequence of changes in activity, anxiety, or pain response. NMB/NMB-R pathway may have role in regulating stress response via neural system controlling learning and memory. | Stress-induced impairment of inhibitory avoidance learning in female neuromedin B receptor-deficient mice.
Yamada K, Santo-Yamada Y, Wada K. | 01/21/2010 |