| Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia. | Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia.
Zapata RC, Zhang D, Libster A, Porcu A, Montilla-Perez P, Nur A, Xu B, Zhang Z, Correa SM, Liu C, Telese F, Osborn O., Free PMC Article | 11/16/2023 |
| AgRP neurons coordinate the mitigation of activity-based anorexia. | AgRP neurons coordinate the mitigation of activity-based anorexia.
Sutton Hickey AK, Duane SC, Mickelsen LE, Karolczak EO, Shamma AM, Skillings A, Li C, Krashes MJ., Free PMC Article | 05/30/2023 |
| Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at the hMC4R. | Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at the hMC4R.
Ericson MD, Haslach EM, Schnell SM, Freeman KT, Xiang ZM, Portillo FP, Speth R, Litherland SA, Haskell-Luevano C., Free PMC Article | 07/3/2021 |
| Mitochondrial Dynamics and Microglia as New Targets in Metabolism Regulation. | Mitochondrial Dynamics and Microglia as New Targets in Metabolism Regulation.
Chiurazzi M, Di Maro M, Cozzolino M, Colantuoni A., Free PMC Article | 02/13/2021 |
| The plasma AgRP levels were higher in those with active acromegaly than in the matched healthy subjects, and decreased after treatment with pegvisomant or with surgery. | Plasma Agouti-Related Protein Levels in Acromegaly and Effects of Surgical or Pegvisomant Therapy.
Freda PU, Reyes-Vidal C, Jin Z, Pugh M, Panigrahi SK, Bruce JN, Wardlaw SL., Free PMC Article | 06/6/2020 |
| Plasma agouti-related protein (AgRP) level is elevated in Cushing disease, tightly correlates with cortisol concentration, and decline with surgical cure. These data support the regulation of AgRP by glucocorticoids in humans. | Plasma Agouti-Related Protein and Cortisol Levels in Cushing Disease: Evidence for the Regulation of Agouti-Related Protein by Glucocorticoids in Humans.
Page-Wilson G, Peters JB, Panigrahi SK, Jacobs TP, Korner J, Otten M, Bruce JN, Wardlaw SL., Free PMC Article | 12/21/2019 |
| AgRP acted as a biased agonist in MC3R, decreasing cAMP activity of constitutively active mutant (F347A) MC3R but stimulating ERK1/2 activation in both wild type and F347A MC3Rs. | Biased signaling initiated by agouti-related peptide through human melanocortin-3 and -4 receptors.
Yang Z, Tao YX. | 02/2/2019 |
| AgRP is not associated with changes in hunger or satiety, and can change without corresponding changes in leptin. This suggests that AgRP may not be involved in the episodic control of appetite and the release of AgRP may involve signals other than leptin. | Regulation of plasma agouti-related protein and its relationship with hunger in lean and obese men.
Hazell TJ, Sawula L, Edgett BA, Walsh JJ, Gurd BJ. | 01/13/2018 |
| data provide compelling evidence that AgRP is a heparan sulfate-binding protein and localizes critical regions in the AgRP structure required for this interaction. | The agouti-related peptide binds heparan sulfate through segments critical for its orexigenic effects.
Palomino R, Lee HW, Millhauser GL., Free PMC Article | 06/10/2017 |
| The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R), pro-opiomelanocortin (POMC), apolipoprotein E (APOE) and agouti-related protein (AGRP) with obesity in the North Indian population. | Analysis of MC4R rs17782313, POMC rs1042571, APOE-Hha1 and AGRP rs3412352 genetic variants with susceptibility to obesity risk in North Indians.
Srivastava A, Mittal B, Prakash J, Srivastava P, Srivastava N. | 01/28/2017 |
| CSF AgRP was not different in lean vs. overweight/obese subjects; however, plasma AgRP was higher in lean subjects. | Proopiomelanocortin, agouti-related protein, and leptin in human cerebrospinal fluid: correlations with body weight and adiposity.
Page-Wilson G, Meece K, White A, Rosenbaum M, Leibel RL, Smiley R, Wardlaw SL., Free PMC Article | 12/5/2015 |
| human agouti-related protein has a role in enhancing expression and stability of human melanocortin-4 receptor | Co-expression of human agouti-related protein enhances expression and stability of human melanocortin-4 receptor.
Yun JH, Kim K, Jung Y, Park JH, Cho HS, Lee W. | 03/21/2015 |
| Variations in genes AGRP, CPE, GHRL, GLP1R, HTR2A, NPY1R, NPY5R, SOCS3 and STAT3 showed modest associations with BMI in European Americans. | Genetic association analysis of 30 genes related to obesity in a European American population.
Li P, Tiwari HK, Lin WY, Allison DB, Chung WK, Leibel RL, Yi N, Liu N., Free PMC Article | 02/7/2015 |
| Elevations in AgRP also favor the diagnosis of ectopic ACTH syndrome, suggesting AgRP should be further evaluated as a potential neuroendocrine tumor marker. | Clinical utility of plasma POMC and AgRP measurements in the differential diagnosis of ACTH-dependent Cushing's syndrome.
Page-Wilson G, Freda PU, Jacobs TP, Khandji AG, Bruce JN, Foo ST, Meece K, White A, Wardlaw SL., Free PMC Article | 01/24/2015 |
| AGRP SNP (rs1338993) was not associated with antipsychotic-induced weight gain in schizophrenia patients. | Investigation of melanocortin system gene variants in antipsychotic-induced weight gain.
Chowdhury NI, Souza RP, Tiwari AK, Brandl EJ, Sicard M, Meltzer HY, Lieberman JA, Kennedy JL, Müller DJ. | 11/8/2014 |
| Data suggest that prolonged steady-state exercise/physical activity at moderate intensity elicits substantial increases in blood lactate and cortisol concentrations without a significant change in AgRP; study was pilot project involving men. | Effects of prolonged exercise on agouti-related protein: a pilot study.
Kraemer RR, Castracane VD, Francois M, Ghanbari-Niaki A, Sirikul B, Valverde RA. | 04/6/2013 |
| Despite peripheral hyperleptinemia, positive energy balance is achieved during pregnancy by a relative decrease in central leptin concentrations and resistance to leptin's effects on target neuropeptides that regulate energy balance. | Cerebrospinal fluid levels of leptin, proopiomelanocortin, and agouti-related protein in human pregnancy: evidence for leptin resistance.
Page-Wilson G, Reitman-Ivashkov E, Meece K, White A, Rosenbaum M, Smiley RM, Wardlaw SL., Free PMC Article | 03/9/2013 |
| AgRP and NPY are correlated with body weight changes, rather than the presence of type 2 diabetes, whereas changes in alphaMSH immunoreactivity are related to the presence of type 2 diabetes, indicating separate hypothalamic mechanisms. | AgRP and NPY expression in the human hypothalamic infundibular nucleus correlate with body mass index, whereas changes in αMSH are related to type 2 diabetes.
Alkemade A, Yi CX, Pei L, Harakalova M, Swaab DF, la Fleur SE, Fliers E, Kalsbeek A. | 08/18/2012 |
| Cognitive flexibility plays an important role in anorexia nervosa and may be modulated by abnormal levels of the appetite-regulating peptide AGRP. | Cognitive flexibility and Agouti-related protein in adolescent patients with anorexia nervosa.
Sarrar L, Ehrlich S, Merle JV, Pfeiffer E, Lehmkuhl U, Schneider N. | 01/21/2012 |
| This review defines how peripheral signals (particularly leptin, insulin and glucose) converge on a molecular level in proopiomelanocortin (POMC)- and agouti-related protein (AgRP)-expressing arcuate nucleus neurons to control energy homeostasis. | Hormone and glucose signalling in POMC and AgRP neurons.
Belgardt BF, Okamura T, Brüning JC., Free PMC Article | 08/2/2010 |
| Only the patients with nonalcoholic fatty liver presented a positive correlation between the saturated fatty acids intake and the orexigenic neuropeptides NPY and agouti related protein, and carbohydrate with NPY | The role of nutritional profile in the orexigenic neuropeptide secretion in nonalcoholic fatty liver disease obese adolescents.
de Piano A, Tock L, Carnier J, Foschini D, Sanches Pde L, Corrêa FA, Oyama LM, do Nascimento CM, Lederman HM, Ernandes R, de Mello MT, Tufik S, Dâmaso A. | 07/12/2010 |
| AgRP may provide an important signal in the immune environment and the lymphocyte may be considered as an extra-hypothalamic source of plasma AgRP following exercise stress | Acute circuit-resistance exercise increases expression of lymphocyte agouti-related protein in young women.
Ghanbari-Niaki A, Saghebjoo M, Rashid-Lamir A, Fathi R, Kraemer RR. | 05/31/2010 |
| Agouti-related protein is neatively correlated with nonalcolic fatty liver disease in obese adolescents. | Negative correlation between neuropeptide Y/agouti-related protein concentration and adiponectinemia in nonalcoholic fatty liver disease obese adolescents submitted to a long-term interdisciplinary therapy.
de Piano A, Tock L, Carnier J, Oyama LM, Oller do Nascimento CM, Martinz AC, Foschini D, Sanches PL, Ernandes RM, de Mello MT, Tufik S, Dâmaso AR. | 05/10/2010 |
| This study presents an association of rare allele of AGRP polymorphism in heterozygous state with increased body mass index | Association between a rare SNP in the second intron of human Agouti related protein gene and increased BMI.
Kalnina I, Kapa I, Pirags V, Ignatovica V, Schiöth HB, Klovins J., Free PMC Article | 01/21/2010 |
| two adjacent enhancers inside the first intron of the neighboring (1.4 kb downstream) ATPase gene (ATP6V0D1) modulate the human AgRP promoter with profound spatiotemporal variation | Control elements in the neighboring ATPase gene influence spatiotemporal expression of the human agouti-related protein.
Ilnytska O, Sözen MA, Dauterive R, Argyropoulos G., Free PMC Article | 01/21/2010 |