| NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation. | NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation.
Cobo I, Paliwal S, Bodas C, Felipe I, Melià-Alomà J, Torres A, Martínez-Villarreal J, Malumbres M, García F, Millán I, Del Pozo N, Park JC, MacDonald RJ, Muñoz J, Méndez R, Real FX., Free PMC Article | 06/30/2023 |
| NFIC attenuates rheumatoid arthritis-induced inflammatory response in mice by regulating PTEN/SENP8 transcription. | NFIC attenuates rheumatoid arthritis-induced inflammatory response in mice by regulating PTEN/SENP8 transcription.
Jia P, Zhang W, Shi Y. | 03/22/2023 |
| Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects. | Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects.
Huang W, Huang T, Liu Y, Fu J, Wei X, Liu D, Ma W, Gu H, Yuan Z., Free PMC Article | 03/26/2022 |
| Overexpression of mm9_circ_013935 alleviates renal inflammation and fibrosis in diabetic nephropathy via the miR-153-3p/NFIC axis. | Overexpression of mm9_circ_013935 alleviates renal inflammation and fibrosis in diabetic nephropathy via the miR-153-3p/NFIC axis.
Zhang L, Zhang L, Li S, Zhang Q, Luo Y, Zhang C, Huan Q, Zhang C. | 02/26/2022 |
| NFI-C Is Required for Epiphyseal Chondrocyte Proliferation during Postnatal Cartilage Development. | NFI-C Is Required for Epiphyseal Chondrocyte Proliferation during Postnatal Cartilage Development.
Lee DS, Roh SY, Choi H, Park JC., Free PMC Article | 07/3/2021 |
| the Runx2-Nfic-Osx pathway is one of the key factors that regulate ameloblast differentiation. | The Nfic-osterix pathway regulates ameloblast differentiation and enamel formation.
Lee DS, Roh SY, Park JC. | 01/19/2019 |
| An Nfic-Hhip-Hh signaling pathway is crucial for apical papilla growth and proper root formation. | An Nfic-hedgehog signaling cascade regulates tooth root development.
Liu Y, Feng J, Li J, Zhao H, Ho TV, Chai Y., Free PMC Article | 02/6/2016 |
| NFI-C acts as a regulator of the phased hepatocyte proliferation during liver regeneration. | Nuclear Factor I-C acts as a regulator of hepatocyte proliferation at the onset of liver regeneration.
Edelmann S, Fahrner R, Malinka T, Song BH, Stroka D, Mermod N. | 12/19/2015 |
| Results suggest that NFI-C acts as a transcriptional switch in cell fate determination between osteoblast and adipocyte differentiation in BMSCs. | NFI-C regulates osteoblast differentiation via control of osterix expression.
Lee DS, Choung HW, Kim HJ, Gronostajski RM, Yang YI, Ryoo HM, Lee ZH, Kim HH, Cho ES, Park JC. | 12/12/2015 |
| The purpose of this study was to identify the molecular interactions between NFI-C and TGF-beta1 signaling in mouse odontoblasts. | Crosstalk between nuclear factor I-C and transforming growth factor-β1 signaling regulates odontoblast differentiation and homeostasis.
Lee DS, Yoon WJ, Cho ES, Kim HJ, Gronostajski RM, Cho MI, Park JC., Free PMC Article | 09/1/2012 |
| The data suggest that zinc equilibrium is required for odontoblast differentiation and dentin formation during dentinogenesis through the nuclear accumulation and modulation of NFI-C. | Zinc balance is critical for NFI-C mediated regulation of odontoblast differentiation.
Oh HJ, Lee HK, Park SJ, Cho YS, Bae HS, Cho MI, Park JC. | 06/30/2012 |
| Nuclear factor I-C regulates TGF-{beta}-dependent hair follicle cycling | Nuclear factor I-C regulates TGF-{beta}-dependent hair follicle cycling.
Plasari G, Edelmann S, Högger F, Dusserre Y, Mermod N, Calabrese A., Free PMC Article | 11/27/2010 |
| elongation of dental epithelial cells, HERS, is essential for root development and that TGF-beta/BMP signaling relies on a Smad4-dependent signaling mechanism to regulate Nfic expression via Shh signaling to control root formation. | Smad4-Shh-Nfic signaling cascade-mediated epithelial-mesenchymal interaction is crucial in regulating tooth root development.
Huang X, Xu X, Bringas P Jr, Hung YP, Chai Y., Free PMC Article | 09/6/2010 |
| loss of Nfic leads to the suppression of odontogenic cell proliferation and differentiation and induces apoptosis of aberrant odontoblasts during root formation, thereby contributing to the formation of short roots | Nuclear factor I-C is essential for odontogenic cell proliferation and odontoblast differentiation during tooth root development.
Lee DS, Park JT, Kim HM, Ko JS, Son HH, Gronostajski RM, Cho MI, Choung PH, Park JC., Free PMC Article | 01/21/2010 |
| Loss of the Nfic gene interferes with the formation of intercellular junctions that causes aberrant odontoblast differentiation and abnormal dentin formation. | Disruption of Nfic causes dissociation of odontoblasts by interfering with the formation of intercellular junctions and aberrant odontoblast differentiation.
Lee TY, Lee DS, Kim HM, Ko JS, Gronostajski RM, Cho MI, Son HH, Park JC., Free PMC Article | 01/21/2010 |
| may be a key regulator of root odontoblast differentiation and root formation | Nfic gene disruption inhibits differentiation of odontoblasts responsible for root formation and results in formation of short and abnormal roots in mice.
Park JC, Herr Y, Kim HJ, Gronostajski RM, Cho MI. | 01/21/2010 |
| the chromatin architecture of the promoters does not permit strong association of GR in the absence of NF1 | Chromatin-dependent cooperativity between site-specific transcription factors in vivo.
Hebbar PB, Archer TK., Free PMC Article | 01/21/2010 |
| NF1-C2 protein is present in the epithelial compartment at the virgin stage and throughout mammary gland development and its transcripts are expressed in the whole epithelium at pregnancy as well as the lactation stage. | Nuclear factor 1-C2 is regulated by prolactin and shows a distinct expression pattern in the mouse mammary epithelial cells during development.
Johansson EM, Kannius-Janson M, Gritli-Linde A, Bjursell G, Nilsson J. | 01/21/2010 |
| first report demostrating the importance of NF1 proteins in the p53 gene activation in the mouse mammary gland; also, first time that p53 gene activation shown to be coupled to a specific, endogenously expressed NF1 isoform | The p53 tumor suppressor gene is regulated in vivo by nuclear factor 1-C2 in the mouse mammary gland during pregnancy.
Johansson EM, Kannius-Janson M, Bjursell G, Nilsson J. | 01/21/2010 |
| Nfic(-/-) mice have unique tooth pathologies: molars lacking roots, thin and brittle mandibular incisors, and weakened abnormal maxillary incisors. | Essential role for NFI-C/CTF transcription-replication factor in tooth root development.
Steele-Perkins G, Butz KG, Lyons GE, Zeichner-David M, Kim HJ, Cho MI, Gronostajski RM., Free PMC Article | 01/21/2010 |
| Data demonstrate that nuclear Jak2 regulates the amount of active NF1-C2 through tyrosine phosphorylation and proteasomal degradation. | Nuclear Jak2 and transcription factor NF1-C2: a novel mechanism of prolactin signaling in mammary epithelial cells.
Nilsson J, Bjursell G, Kannius-Janson M., Free PMC Article | 01/21/2010 |