| Identification of PAX6 and NFAT4 as the Transcriptional Regulators of the Long Noncoding RNA Mrhl in Neuronal Progenitors. | Identification of PAX6 and NFAT4 as the Transcriptional Regulators of the Long Noncoding RNA Mrhl in Neuronal Progenitors.
Pal D, Dutta S, Iyer DP, Shriram D, Bhaduri U, Rao MRS., Free PMC Article | 11/26/2022 |
| Macrophage NFATc3 prevents foam cell formation and atherosclerosis: evidence and mechanisms. | Macrophage NFATc3 prevents foam cell formation and atherosclerosis: evidence and mechanisms.
Liu X, Guo JW, Lin XC, Tuo YH, Peng WL, He SY, Li ZQ, Ye YC, Yu J, Zhang FR, Ma MM, Shang JY, Lv XF, Zhou AD, Ouyang Y, Wang C, Pang RP, Sun JX, Ou JS, Zhou JG, Liang SJ. | 12/25/2021 |
| Blocking NFATc3 ameliorates azoxymethane/dextran sulfate sodium induced colitis-associated colorectal cancer in mice via the inhibition of inflammatory responses and epithelial-mesenchymal transition. | Blocking NFATc3 ameliorates azoxymethane/dextran sulfate sodium induced colitis-associated colorectal cancer in mice via the inhibition of inflammatory responses and epithelial-mesenchymal transition.
Lin Y, Koumba MH, Qu S, Wang D, Lin L. | 10/23/2021 |
| NFATc3-dependent expression of miR-153-3p promotes mitochondrial fragmentation in cardiac hypertrophy by impairing mitofusin-1 expression. | NFATc3-dependent expression of miR-153-3p promotes mitochondrial fragmentation in cardiac hypertrophy by impairing mitofusin-1 expression.
Wang T, Zhai M, Xu S, Ponnusamy M, Huang Y, Liu CY, Wang M, Shan C, Shan PP, Gao XQ, Wang K, Chen XZ, Liu J, Xie JY, Zhang DY, Zhou LY, Wang K., Free PMC Article | 04/24/2021 |
| Orai1 inhibitor STIM2beta regulates myogenesis by controlling SOCE dependent transcriptional factors. | Orai1 inhibitor STIM2β regulates myogenesis by controlling SOCE dependent transcriptional factors.
Kim KM, Rana A, Park CY., Free PMC Article | 10/24/2020 |
| data indicated that NRON alleviates atrial fibrosis via promoting NFATc3 phosphorylation. | LncRNA NRON alleviates atrial fibrosis via promoting NFATc3 phosphorylation.
Wang Y, Xu P, Zhang C, Feng J, Gong W, Ge S, Guo Z. | 07/20/2019 |
| NFATc3-deletion attenuated metabolism syndrome, reduced inflammatory regulators expression, inactivated NF-kappaB (p65), Caspase-3 and p38/JNK signaling pathway. | NFATc3 deficiency protects against high fat diet (HFD)-induced hypothalamus inflammation and apoptosis via p38 and JNK suppression.
Liao MJ, Lin H, He YW, Zou C. | 10/13/2018 |
| FZD5 is a receptor for SFRP2 and mediates SFRP2-induced angiogenesis via calcineurin/NFATc3 pathway in endothelial cells. | Frizzled-5: a high affinity receptor for secreted frizzled-related protein-2 activation of nuclear factor of activated T-cells c3 signaling to promote angiogenesis.
Peterson YK, Nasarre P, Bonilla IV, Hilliard E, Samples J, Morinelli TA, Hill EG, Klauber-DeMore N., Free PMC Article | 06/23/2018 |
| Redirected splicing of calcineurin A to the fetal isoforms in adult muscle and in differentiated C2C12 slows the timing of muscle relaxation, promotes nuclear localization of calcineurin target Nfatc3, and/or affects expression of Nfatc transcription targets. | Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions.
Brinegar AE, Xia Z, Loehr JA, Li W, Rodney GG, Cooper TA., Free PMC Article | 06/2/2018 |
| Our study demonstrates that Orai1-Ca(2+)-calcineurin-NFATc4 signaling is an essential inflammatory pathway required for TNFalpha-induced endothelial cell activation and vascular inflammation. Therefore, Orai1 may be a potential therapeutic target for treatment of inflammatory diseases. | A new comprehensive method for detection of livestock-related pathogenic viruses using a target enrichment system.
Oba M, Tsuchiaka S, Omatsu T, Katayama Y, Otomaru K, Hirata T, Aoki H, Murata Y, Makino S, Nagai M, Mizutani T., Free PMC Article | 02/17/2018 |
| Both NFATc3 knock-out mice and ILK conditional-knockdown mice (cKD-ILK) display symptoms of NDI (polyuria and reduced AQP2 expression). | Integrin linked kinase regulates the transcription of AQP2 by NFATC3.
Hatem-Vaquero M, Griera M, Giermakowska W, Luengo A, Calleros L, Gonzalez Bosc LV, Rodríguez-Puyol D, Rodríguez-Puyol M, De Frutos S. | 11/4/2017 |
| we found that VIP inhibits NFAT nuclear translocation in primary human pulmonary artery smooth muscle cells (PASMC). Early activation of NFATc3 in IPF patients may contribute to disease progression and the increase in VIP expression could be a protective compensatory mechanism | NFATc3 and VIP in Idiopathic Pulmonary Fibrosis and Chronic Obstructive Pulmonary Disease.
Szema AM, Forsyth E, Ying B, Hamidi SA, Chen JJ, Hwang S, Li JC, Sabatini Dwyer D, Ramiro-Diaz JM, Giermakowska W, Gonzalez Bosc LV., Free PMC Article | 08/19/2017 |
| the transcription factor NFATC3 binds to IRF7 and functions synergistically to enhance IRF7-mediated IFN expression in Plasmacytoid dendritic cells. | NFATC3 promotes IRF7 transcriptional activity in plasmacy--toid dendritic cells.
Bao M, Wang Y, Liu Y, Shi P, Lu H, Sha W, Weng L, Hanabuchi S, Qin J, Plumas J, Chaperot L, Zhang Z, Liu YJ., Free PMC Article | 08/5/2017 |
| Ca(2+) influx through ASIC1 mediates chronic hypoxia and ET-1-induced NFATc3 nuclear import and 2) the scaffolding protein PICK1 is necessary for NFATc3 nuclear import. | ASIC1-mediated calcium entry stimulates NFATc3 nuclear translocation via PICK1 coupling in pulmonary arterial smooth muscle cells.
Gonzalez Bosc LV, Plomaritas DR, Herbert LM, Giermakowska W, Browning C, Jernigan NL., Free PMC Article | 06/3/2017 |
| AKAP150-calcineurin signaling dyad is essential for the activation of the phosphatase and the subsequent down-regulation of Kv channel currents following myocardial infarction. | AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction.
Nieves-Cintrón M, Hirenallur-Shanthappa D, Nygren PJ, Hinke SA, Dell'Acqua ML, Langeberg LK, Navedo M, Santana LF, Scott JD., Free PMC Article | 02/25/2017 |
| Study defines the NFAT4/ miR-324-5p/Mtfr1 axis, which participates in the regulation of mitochondrial fission and cardiomyocyte apoptosis. | NFAT4-dependent miR-324-5p regulates mitochondrial morphology and cardiomyocyte cell death by targeting Mtfr1.
Wang K, Zhang DL, Long B, An T, Zhang J, Zhou LY, Liu CY, Li PF., Free PMC Article | 10/1/2016 |
| Nuclear factor of activated T cells is activated in the endothelium of retinal microvessels in diabetic mice | Nuclear factor of activated T cells is activated in the endothelium of retinal microvessels in diabetic mice.
Zetterqvist AV, Blanco F, Öhman J, Kotova O, Berglund LM, de Frutos Garcia S, Al-Naemi R, Wigren M, McGuire PG, Gonzalez Bosc LV, Gomez MF., Free PMC Article | 12/19/2015 |
| Disrupting the calcineurin-NFAT axis by either genetic or pharmacologic approaches confers resistance to the development of social stress-induced voiding and dysfunction. | Genetic or pharmacologic disruption of the calcineurin-nuclear factor of activated T-cells axis prevents social stress-induced voiding dysfunction in a murine model.
Long CJ, Butler S, Fesi J, Frank C, Canning DA, Zderic SA. | 08/29/2015 |
| NFATc3 interacted in a SUMO-dependent manner with Trim17, an E3 ubiquitin ligase necessary for neuronal apoptosis | Control of neuronal apoptosis by reciprocal regulation of NFATc3 and Trim17.
Mojsa B, Mora S, Bossowski JP, Lassot I, Desagher S., Free PMC Article | 08/8/2015 |
| A calcineurin- and NFAT-dependent pathway is involved in alpha-synuclein-induced degeneration of midbrain dopaminergic neurons in a Parkinson's disease mouse model. | A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons.
Luo J, Sun L, Lin X, Liu G, Yu J, Parisiadou L, Xie C, Ding J, Cai H., Free PMC Article | 07/25/2015 |
| study demonstrates for the first time that NFATc3 is necessary for macrophage iNOS expression during sepsis, which is essential for containment of bacterial infections. | The transcription factor nuclear factor of activated T cells c3 modulates the function of macrophages in sepsis.
Ranjan R, Deng J, Chung S, Lee YG, Park GY, Xiao L, Joo M, Christman JW, Karpurapu M., Free PMC Article | 07/4/2015 |
| GRK5, acting in a kinase independent manner, is a facilitator of NFAT activity and part of a DNA-binding complex responsible for pathological hypertrophic gene transcription. | GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity.
Hullmann JE, Grisanti LA, Makarewich CA, Gao E, Gold JI, Chuprun JK, Tilley DG, Houser SR, Koch WJ., Free PMC Article | 02/14/2015 |
| Low intracellular hydrogen peroxide contributes to NFATc3 activation in pulmonary arterial smooth muscle. | Mechanisms of NFATc3 activation by increased superoxide and reduced hydrogen peroxide in pulmonary arterial smooth muscle.
Ramiro-Diaz JM, Giermakowska W, Weaver JM, Jernigan NL, Gonzalez Bosc LV., Free PMC Article | 01/31/2015 |
| NGF facilitates depolarization-induced NFAT activation by stimulating PI3K/Akt signaling, inactivating GSK3beta, and thereby slowing NFATc3 export from the nucleus | Nerve growth factor (NGF) regulates activity of nuclear factor of activated T-cells (NFAT) in neurons via the phosphatidylinositol 3-kinase (PI3K)-Akt-glycogen synthase kinase 3β (GSK3β) pathway.
Kim MS, Shutov LP, Gnanasekaran A, Lin Z, Rysted JE, Ulrich JD, Usachev YM., Free PMC Article | 01/24/2015 |
| Toxoplasma GRA6-dependent NFAT4 activation is required for T. gondii manipulation of host immune responses to maximize the parasite virulence in a strain-dependent manner. | Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6.
Ma JS, Sasai M, Ohshima J, Lee Y, Bando H, Takeda K, Yamamoto M., Free PMC Article | 11/22/2014 |