| NCF1-dependent production of ROS protects against lupus by regulating plasmacytoid dendritic cell development and functions. | NCF1-dependent production of ROS protects against lupus by regulating plasmacytoid dendritic cell development and functions.
Luo H, Urbonaviciute V, Saei AA, Lyu H, Gaetani M, Végvári Á, Li Y, Zubarev RA, Holmdahl R., Free PMC Article | 04/12/2023 |
| Two major genes associated with autoimmune arthritis, Ncf1 and Fcgr2b, additively protect mice by strengthening T cell tolerance. | Two major genes associated with autoimmune arthritis, Ncf1 and Fcgr2b, additively protect mice by strengthening T cell tolerance.
Li Q, Zhong J, Luo H, Urbonaviciute V, Xu Z, He C, Holmdahl R., Free PMC Article | 08/27/2022 |
| The NCF1 variant p.R90H aggravates autoimmunity by facilitating the activation of plasmacytoid dendritic cells. | The NCF1 variant p.R90H aggravates autoimmunity by facilitating the activation of plasmacytoid dendritic cells.
Meng Y, Ma J, Yao C, Ye Z, Ding H, Liu C, Li J, Li G, He Y, Li J, Yin Z, Wu L, Zhou H, Shen N., Free PMC Article | 08/20/2022 |
| Exercise Affects the Formation and Recovery of Alcoholic Liver Disease through the IL-6-p47(phox) Oxidative-Stress Axis. | Exercise Affects the Formation and Recovery of Alcoholic Liver Disease through the IL-6-p47(phox) Oxidative-Stress Axis.
Cui W, Li X, Xue W, Wei H, Zhou G, Qiu Y, Cui D., Free PMC Article | 05/7/2022 |
| Ncf1 Governs Immune Niches in the Lung to Mediate Pulmonary Inflammation in Mice. | Ncf1 Governs Immune Niches in the Lung to Mediate Pulmonary Inflammation in Mice.
Li M, Zhang W, Zhang J, Li X, Zhang F, Zhu W, Meng L, Holmdahl R, Lu S., Free PMC Article | 02/19/2022 |
| Natural Loss-of-Function Mutations in Qa2 and NCF1 Cause the Spread of Mannan-Induced Psoriasis. | Natural Loss-of-Function Mutations in Qa2 and NCF1 Cause the Spread of Mannan-Induced Psoriasis.
Zhong J, Li Q, Holmdahl R. | 11/27/2021 |
| The atypical small GTPase GEM/Kir is a negative regulator of the NADPH oxidase and NETs production through macroautophagy. | The atypical small GTPase GEM/Kir is a negative regulator of the NADPH oxidase and NETs production through macroautophagy.
Johnson JL, Ramadass M, Rahman F, Meneses-Salas E, Zgajnar NR, Carvalho Gontijo R, Zhang J, Kiosses WB, Zhu YP, Hedrick CC, Perego M, Gunton JE, Pestonjamasp K, Napolitano G, Catz SD. | 10/23/2021 |
| Independent and inter-dependent immunoregulatory effects of NCF1 and NOS2 in experimental autoimmune encephalomyelitis. | Independent and inter-dependent immunoregulatory effects of NCF1 and NOS2 in experimental autoimmune encephalomyelitis.
Zhong J, Yau ACY, Holmdahl R., Free PMC Article | 02/13/2021 |
| Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47(phox). | Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47(phox).
Polytarchou C, Hatziapostolou M, Yau TO, Christodoulou N, Hinds PW, Kottakis F, Sanidas I, Tsichlis PN., Free PMC Article | 01/16/2021 |
| Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8(+) T Cell Activation via Cross-Presentation in Type 1 Diabetes. | Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8(+) T Cell Activation via Cross-Presentation in Type 1 Diabetes.
Liu C, Whitener RL, Lin A, Xu Y, Chen J, Savinov A, Leiding JW, Wallet MA, Mathews CE., Free PMC Article | 09/12/2020 |
| The results suggest that Ncf1 is an essential regulator of innate lymphoid cells transdifferentiation, and it may mediate this process in a redox-dependent manner through IL1B production in the inflamed joint. | Increased ILC3s associated with higher levels of IL-1β aggravates inflammatory arthritis in mice lacking phagocytic NADPH oxidase.
Chan TY, Yen CL, Huang YF, Lo PC, Nigrovic PA, Cheng CY, Wang WZ, Wu SY, Shieh CC. | 05/30/2020 |
| we propose that SRF integrates transcriptional activation of NCF1/NCF2 and ROS production to promote liver fibrosis. | Serum response factor (SRF) promotes ROS generation and hepatic stellate cell activation by epigenetically stimulating NCF1/2 transcription.
Kong M, Chen X, Lv F, Ren H, Fan Z, Qin H, Yu L, Shi X, Xu Y., Free PMC Article | 02/29/2020 |
| AT2R, via PP2A-mediated inhibition of PKC, prevents the NOX activation, reactive oxygen species generation, and subsequent pro-inflammatory activation of microglia. | AT2R Activation Prevents Microglia Pro-inflammatory Activation in a NOX-Dependent Manner: Inhibition of PKC Activation and p47(phox) Phosphorylation by PP2A.
Bhat SA, Sood A, Shukla R, Hanif K. | 08/10/2019 |
| oxLDL-mediated cellular senescence is associated with increased p47phox recruitment to caveolae and its binding to Cav1. | oxLDL-mediated cellular senescence is associated with increased NADPH oxidase p47phox recruitment to caveolae.
Wang J, Bai Y, Zhao X, Ru J, Kang N, Tian T, Tang L, An Y, Li P., Free PMC Article | 03/9/2019 |
| ROS production stimulated by NoxO1 and p47phox limit endothelium-dependent relaxation and maintain blood pressure in mice. However, NoxO1 and p47phox cannot substitute each other despite their similar effect on vascular function. Deletion of NoxO1 induced an anti-inflammatory phenotype, whereas p47phox deletion rather elicited a hyper-inflammatory response. | The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice.
Rezende F, Moll F, Walter M, Helfinger V, Hahner F, Janetzko P, Ringel C, Weigert A, Fleming I, Weissmann N, Kuenne C, Looso M, Rieger MA, Nawroth P, Fleming T, Brandes RP, Schröder K., Free PMC Article | 10/13/2018 |
| we found that ROS formation and expression of p47(phox) and p67(phox), subunits of NADPH oxidase, were increased in AppTg mice but attenuated in AppTg/Cebpd(-/-) mice. Cebpd can up-regulate p47(phox) and p67(phox) transcription via a direct binding on their promoters, which results in an increase in intracellular oxidative stress | Astrocytic CCAAT/Enhancer-binding protein delta contributes to reactive oxygen species formation in neuroinflammation.
Wang SM, Lim SW, Wang YH, Lin HY, Lai MD, Ko CY, Wang JM., Free PMC Article | 10/13/2018 |
| p47phox, but not p67phox or p40phox, binds to and activates Nrf2, enhancing the function of Nrf2 in suppressing inflammation. | Suppressed ubiquitination of Nrf2 by p47(phox) contributes to Nrf2 activation.
Ha Kim K, Sadikot RT, Yeon Lee J, Jeong HS, Oh YK, Blackwell TS, Joo M., Free PMC Article | 09/15/2018 |
| Myricitrin attenuated the generation of intracellular ROS by inhibiting the assembly of components of the gp91(phox) and p47(phox). Suppression of ROS generation using NAC or apocynin or by silencing gp91(phox) and p47(phox) all demonstrated that decreasing the level of ROS inhibited the LPS-induced inflammatory response. | Myricitrin Modulates NADPH Oxidase-Dependent ROS Production to Inhibit Endotoxin-Mediated Inflammation by Blocking the JAK/STAT1 and NOX2/p47(phox) Pathways.
Qi S, Feng Z, Li Q, Qi Z, Zhang Y., Free PMC Article | 04/21/2018 |
| Results show that Ncf1 is not needed during juvenility to protect from autoimmune arthritis later on, but conditional Ncf1 suppresses arthritis even if activated after the disease priming. The study presents in vivo evidence that Ncf1/reactive oxygen species-regulated mechanisms are different in priming than in the effector phase. | Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms.
Sareila O, Hagert C, Kelkka T, Linja M, Xu B, Kihlberg J, Holmdahl R. | 03/10/2018 |
| we used the Ang II infused hph-1 mice to examine the roles of NOX isoforms in the development of AAA. We generated double mutants of hph-1-NOX1, hph-1-NOX2, hph-1-p47phox, and hph-1-NOX4 | NOX isoforms in the development of abdominal aortic aneurysm.
Siu KL, Li Q, Zhang Y, Guo J, Youn JY, Du J, Cai H., Free PMC Article | 12/2/2017 |
| Mice bearing point mutation in the Ncf1-gene develop fewer osteoclasts after ovariectomy (ovx) than wild-type mice. However, irrespective of genotype, bone mineral density decreases after ovx, indicating that a compensatory mechanism retains bone degradation after ovx. | Ncf1 affects osteoclast formation but is not critical for postmenopausal bone loss.
Stubelius A, Andersson A, Holmdahl R, Ohlsson C, Islander U, Carlsten H., Free PMC Article | 11/18/2017 |
| The authors demonstrated a significant role of the host NADPH oxidase in promoting chronic inflammatory pathology in the oviduct following chlamydial infection. | The p47phox deficiency significantly attenuates the pathogenicity of Chlamydia muridarum in the mouse oviduct but not uterine tissues.
Dai J, Tang L, Chen J, Yu P, Chen Z, Zhong G. | 12/17/2016 |
| Colitis susceptibility in p47(phox-/-) mice is mediated by the microbiome. | Colitis susceptibility in p47(phox-/-) mice is mediated by the microbiome.
Falcone EL, Abusleme L, Swamydas M, Lionakis MS, Ding L, Hsu AP, Zelazny AM, Moutsopoulos NM, Kuhns DB, Deming C, Quiñones M, Segre JA, Bryant CE, Holland SM., Free PMC Article | 10/8/2016 |
| data partly explains the discrepancy of the phenotypes reported earlier utilizing the Ncf1m1J mice or Ncf1 knockout mice. | Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes.
Sareila O, Hagert C, Rantakari P, Poutanen M, Holmdahl R., Free PMC Article | 06/11/2016 |
| Data (including data from studies in transgenic mice) suggest that ability to generate Ncf1-derived superoxide, specifically in CD4-positive T-lymphocytes, is key for development of autoimmune responses in type 1 diabetes. | Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes.
Padgett LE, Anderson B, Liu C, Ganini D, Mason RP, Piganelli JD, Mathews CE, Tse HM., Free PMC Article | 03/19/2016 |