| metabolic efficiency in arylamine N-acetyltransferase-deficient mice | A readout of metabolic efficiency in arylamine N-acetyltransferase-deficient mice reveals minor energy metabolism changes.
Denis RGP, Busi F, Castel J, Morel C, Zhang W, Bui LC, Sugamori KS, Prokopec SD, Boutros PC, Grant DM, Rodrigues-Lima F, Luquet S, Dupret JM. | 05/16/2020 |
| miR-217 inhibits proliferation adn promotes apoptosis and autophagy in hepatocytes in CCL4-induced liver injury through targeting NAT2 expression. | Effects of microRNA-217 on proliferation, apoptosis, and autophagy of hepatocytes in rat models of CCL4-induced liver injury by targeting NAT2.
Yang CL, Zheng XL, Ye K, Sun YN, Lu YF, Ge H, Liu H. | 03/21/2020 |
| This study illustrated that deficiency of NAT1/2 decreases isoniazid (INH) acetylation, but increases the interactions of INH with endobiotics in the liver. | Deficiency of N-acetyltransferase increases the interactions of isoniazid with endobiotics in mouse liver.
Wang P, Shehu AI, Lu J, Joshi RH, Venkataramanan R, Sugamori KS, Grant DM, Zhong XB, Ma X., Free PMC Article | 12/9/2017 |
| It was concluded that an acute colonic inflammation impairs the expression and function of NAT2 enzyme, thereby diminishing the capacity for 5-aminosalisylic acid metabolism by colonic mucosa. | Acute murine colitis reduces colonic 5-aminosalicylic acid metabolism by regulation of N-acetyltransferase-2.
Ramírez-Alcántara V, Montrose MH., Free PMC Article | 07/19/2014 |
| Hyperhomocysteinemia-induced decrease of peroxynitrite level is associated with an increase of hepatic Nat2 isoform activity with a reversal effect of wine polyphenol extract supplementation. | Effect of red wine polyphenol dietary supplementation on two phase II enzymes in liver of hyperhomocysteinemic mice.
Noll C, Dairou J, Ripoll C, Paul JL, Dupret JM, Delabar JM, Rodrigues-Lima F, Janel N. | 10/1/2011 |
| Mouse NAT2 is likely to influence epigenetic gene control, particularly of its own locus, and this is consistent with recent evidence associating aberrant mouse Nat2/human NAT1 gene expression with certain developmental malformations and cancers. | Characterisation of CpG methylation in the upstream control region of mouse Nat2: evidence for a gene-environment interaction in a polymorphic gene implicated in folate metabolism.
Wakefield L, Boukouvala S, Sim E. | 02/22/2010 |
| study reports the detailed expression of the Nat2 gene and encoded protein in mouse embryos | Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system.
Wakefield L, Cornish V, Long H, Kawamura A, Zhang X, Hein DW, Sim E., Free PMC Article | 01/21/2010 |
| Mouse N-acetyltransferase-2 was produced as a recombinant protein and found to have a substrate specificity profile similar to human N-acetyltransferase type 1. | Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1.
Kawamura A, Westwood I, Wakefield L, Long H, Zhang N, Walters K, Redfield C, Sim E., Free PMC Article | 01/21/2010 |
| These ocular phenotypes and their association with Nat2 genotype indicate that the Nat2 locus may be responsible for the previously described microphthalmic Cat4 phenotype. | Ocular defects associated with a null mutation in the mouse arylamine N-acetyltransferase 2 gene.
Wakefield L, Long H, Lack N, Sim E. | 01/21/2010 |
| expression and down-regulation of this enzyme complex plays an important role in the generation and differentiation of neurons | An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development.
Sugiura N, Adams SM, Corriveau RA. | 01/21/2010 |
| Results suggest that peroxynitrite-dependent inactivation of NAT1 and 2 may contribute to muscle dysfunction by impairing the biotransformation activity of this key cellular defense enzyme system. | Impairment of the activity of the xenobiotic-metabolizing enzymes arylamine N-acetyltransferases 1 and 2 (NAT1/NAT2) by peroxynitrite in mouse skeletal muscle cells.
Dairou J, Dupret JM, Rodrigues-Lima F. | 01/21/2010 |
| Variation in capacity for acetylation of 4ABP and PABA resulting from endogenous murine NAT2 alleles is insufficient to affect 4ABP genotoxicity in liver. | The effects of genetic variation in N-acetyltransferases on 4-aminobiphenyl genotoxicity in mouse liver.
McQueen CA, Chau B, Erickson RP, Tjalkens RB, Philbert MA. | 01/21/2010 |
| Nat2 knockout mouse line demonstrates that different Nat2 isoforms have distinct functions with no compensatory expression, in Nat2 knockout animals, of the other isoforms. | Generation and analysis of mice with a targeted disruption of the arylamine N-acetyltransferase type 2 gene.
Cornish VA, Pinter K, Boukouvala S, Johnson N, Labrousse C, Payton M, Priddle H, Smith AJ, Sim E. | 01/21/2010 |