| The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF-alpha. | The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF-α.
Song D, Peng K, Palmer BE, Lee FS., Free PMC Article | 11/29/2022 |
| The data suggest that skNAC and Smyd1 might be major players in the processes of myofibrillogenesis and sarcomerogenesis, probably specifically at later stages. | siRNA-mediated inhibition of skNAC and Smyd1 expression disrupts myofibril organization: Immunofluorescence and electron microscopy study in C2C12 cells.
Berkholz J, Eberle R, Boller K, Munz B. | 04/6/2019 |
| Data show that reduction of alpha chain of nascent polypeptide associated complex (alphaNAC) levels decreased basal expression of Low density lipoprotein receptor-Related Protein 6 (Lrp6) by 30%. | Lrp6 is a target of the PTH-activated αNAC transcriptional coregulator.
Pellicelli M, Hariri H, Miller JA, St-Arnaud R. | 05/12/2018 |
| the skNAC-Smyd1 complex is involved in transcriptional regulation both via the control of histone methylation and histone (de)acetylation. | skNAC and Smyd1 in transcriptional control.
Berkholz J, Orgeur M, Stricker S, Munz B. | 10/31/2015 |
| skNAC binds to the E3 SUMO ligase mammalian Mms21/Nse2 and that knockdown of Nse2 expression inhibits specific aspects of myogenic differentiation, accompanied by a partial blockade of the nuclear-to-cytoplasmic translocation of the skNAC-Smyd1 complex | The E3 SUMO ligase Nse2 regulates sumoylation and nuclear-to-cytoplasmic translocation of skNAC-Smyd1 in myogenesis.
Berkholz J, Michalick L, Munz B. | 08/15/2015 |
| depletion of alphaNAC in multiple types of cancer cells induce typical apoptotic cell death. This anti-apoptotic function is mediated by the FADD/c-Jun N-terminal kinase pathway. | αNAC inhibition of the FADD-JNK axis plays anti-apoptotic role in multiple cancer cells.
Zeng W, Zhang J, Qi M, Peng C, Su J, Chen X, Yuan Z., Free PMC Article | 02/14/2015 |
| We propose that maximal transcriptional repression by FIAT requires its interaction with SUMOylated, HDAC2-interacting aNAC | SUMOylated αNAC potentiates transcriptional repression by FIAT.
Hekmatnejad B, Akhouayri O, Jafarov T, St-Arnaud R. | 11/8/2014 |
| Altered gene dosages for Galphas and alpha- NAC in compound heterozygous mice result in reduced bone mass, increased numbers of osteocytes, and enhanced expression of Sost. | The PTH-Gαs-protein kinase A cascade controls αNAC localization to regulate bone mass.
Pellicelli M, Miller JA, Arabian A, Gauthier C, Akhouayri O, Wu JY, Kronenberg HM, St-Arnaud R., Free PMC Article | 06/7/2014 |
| The bone phenotype of compound Naca(+/-); Fiat(+/-) heterozygotes confirms that FIAT and alphaNAC are part of a common genetic pathway and support a role for the FIAT/alphaNAC interaction in normal bone physiology. | Altered gene dosage confirms the genetic interaction between FIAT and αNAC.
Hekmatnejad B, Mandic V, Yu VW, Akhouayri O, Arabian A, St-Arnaud R., Free PMC Article | 04/19/2014 |
| data suggest that skNAC controls myoblast migration and sarcomere architecture in a calpain-dependent manner | skNAC depletion stimulates myoblast migration and perturbs sarcomerogenesis by enhancing calpain 1 and 3 activity.
Berkholz J, Zakrzewicz A, Munz B. | 09/21/2013 |
| alphaNAC plays a role in regulating gene transcription during mesenchymal cell differentiation by differentially recruiting corepressors at target promoters. | αNAC interacts with histone deacetylase corepressors to control Myogenin and Osteocalcin gene expression.
Jafarov T, Alexander JW, St-Arnaud R. | 02/16/2013 |
| nascent polypeptide associated complex regulates specific aspects of myogenesis. | Skeletal muscle-specific variant of nascent polypeptide associated complex alpha (skNAC): implications for a specific role in mammalian myoblast differentiation.
Berger F, Berkholz J, Breustedt T, Ploen D, Munz B. | 04/28/2012 |
| The muscle-specific transcription factor skNAC is the major binding partner for Smyd1 in the developing heart. | skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration.
Park CY, Pierce SA, von Drehle M, Ivey KN, Morgan JA, Blau HM, Srivastava D., Free PMC Article | 01/8/2011 |
| Inhibition of alpha NAC nuclear translocation results in an osteopenic phenotype caused by reduced expression of osteocalcin and type I collagen, accelerated mineralization, and immature woven-bone formation. | Nuclear alpha NAC influences bone matrix mineralization and osteoblast maturation in vivo.
Meury T, Akhouayri O, Jafarov T, Mandic V, St-Arnaud R., Free PMC Article | 01/21/2010 |
| Similar kinetics of induction and localization of m-Bop and skNAC during the induction of myogenesis in cultured C2C12 cells suggests a possible associated role for these proteins during this process. | m-Bop, a repressor protein essential for cardiogenesis, interacts with skNAC, a heart- and muscle-specific transcription factor.
Sims RJ 3rd, Weihe EK, Zhu L, O'Malley S, Harriss JV, Gottlieb PD. | 01/21/2010 |
| The osteocalcin gene is a target for the alphaNAC coactivating function and is specifically targeted to the osteocalcin promoter through its DNA-binding activity as a means to achieve increased specificity in gene transcription. | Sequence-specific DNA binding by the alphaNAC coactivator is required for potentiation of c-Jun-dependent transcription of the osteocalcin gene.
Akhouayri O, Quélo I, St-Arnaud R., Free PMC Article | 01/21/2010 |