| Disruption of COMMD1 accelerates diabetic atherosclerosis by promoting glycolysis. | Disruption of COMMD1 accelerates diabetic atherosclerosis by promoting glycolysis.
Zhang L, Li L, Li Y, Jiang H, Sun Z, Zang G, Qian Y, Shao C, Wang Z., Free PMC Article | 02/23/2023 |
| Cardiomyocyte-Specific COMMD1 Deletion Suppresses Ischemia-Induced Myocardial Apoptosis. | Cardiomyocyte-Specific COMMD1 Deletion Suppresses Ischemia-Induced Myocardial Apoptosis.
Li C, Peng H, Kang YJ. | 02/12/2022 |
| COMMD1 upregulation is involved in copper efflux from ischemic hearts. | COMMD1 upregulation is involved in copper efflux from ischemic hearts.
Li C, Wang T, Xiao Y, Li K, Meng X, James Kang Y., Free PMC Article | 09/25/2021 |
| Behavioral Effects of Neuronal, Parent-specific Commd1 Knockout in Mice. | Behavioral Effects of Neuronal, Parent-specific Commd1 Knockout in Mice.
Chase KA, Mallari JE, Tan Y, Sittig L. | 06/19/2021 |
| The efflux of copper from the ischemic heart results at least in part from the upregulation of copper metabolism MURR domain 1 (COMMD1) in the heart upon ischemic insult. | The loss of copper is associated with the increase in copper metabolism MURR domain 1 in ischemic hearts of mice.
Li K, Li C, Xiao Y, Wang T, James Kang Y., Free PMC Article | 01/26/2019 |
| Results indicate that Commed1 transcribed through the DMR in the growing oocyte and that its predominant maternal expression is likely caused by transcriptional interference by paternal Zrsr1 expression. | Growing oocyte-specific transcription-dependent de novo DNA methylation at the imprinted Zrsr1-DMR.
Joh K, Matsuhisa F, Kitajima S, Nishioka K, Higashimoto K, Yatsuki H, Kono T, Koseki H, Soejima H., Free PMC Article | 10/6/2018 |
| this study shows COMMD1 suppresses bone loss in inflammatory arthritis and osteolysis models of rheumatoid arthritis | Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis.
Murata K, Fang C, Terao C, Giannopoulou EG, Lee YJ, Lee MJ, Mun SH, Bae S, Qiao Y, Yuan R, Furu M, Ito H, Ohmura K, Matsuda S, Mimori T, Matsuda F, Park-Min KH, Ivashkiv LB., Free PMC Article | 09/30/2017 |
| Liver specific Commd1 knockout results in elevated plasma LDL cholesterol. | CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.
Bartuzi P, Billadeau DD, Favier R, Rong S, Dekker D, Fedoseienko A, Fieten H, Wijers M, Levels JH, Huijkman N, Kloosterhuis N, van der Molen H, Brufau G, Groen AK, Elliott AM, Kuivenhoven JA, Plecko B, Grangl G, McGaughran J, Horton JD, Burstein E, Hofker MH, van de Sluis B., Free PMC Article | 07/30/2016 |
| Alteration of COMMD1 concentration influences copper and zinc homeostasis as well as ProSAP/Shank protein levels. | Loss of COMMD1 and copper overload disrupt zinc homeostasis and influence an autism-associated pathway at glutamatergic synapses.
Baecker T, Mangus K, Pfaender S, Chhabra R, Boeckers TM, Grabrucker AM. | 04/4/2015 |
| Copper metabolism domain-containing 1 represses genes that promote inflammation and protects mice from colitis and colitis-associated cancer. | Copper metabolism domain-containing 1 represses genes that promote inflammation and protects mice from colitis and colitis-associated cancer.
Li H, Chan L, Bartuzi P, Melton SD, Weber A, Ben-Shlomo S, Varol C, Raetz M, Mao X, Starokadomskyy P, van Sommeren S, Mokadem M, Schneider H, Weisberg R, Westra HJ, Esko T, Metspalu A, Kumar V, Faubion WA, Yarovinsky F, Hofker M, Wijmenga C, Kracht M, Franke L, Aguirre V, Weersma RK, Gluck N, van de Sluis B, Burstein E., Free PMC Article | 10/4/2014 |
| results provide the first genetic evidence for COMMD1 to play an essential role in hepatic copper homeostasis and present a valuable mouse model for further understanding of the molecular mechanisms underlying hepatic copper homeostasis | Liver-specific Commd1 knockout mice are susceptible to hepatic copper accumulation.
Vonk WI, Bartuzi P, de Bie P, Kloosterhuis N, Wichers CG, Berger R, Haywood S, Klomp LW, Wijmenga C, van de Sluis B., Free PMC Article | 05/26/2012 |
| Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B. | Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B.
Materia S, Cater MA, Klomp LW, Mercer JF, La Fontaine S., Free PMC Article | 03/17/2012 |
| COMMD1 as a novel protein regulating SOD1 activation and associate COMMD1 function with the production of free radicals. | Cu,Zn superoxide dismutase maturation and activity are regulated by COMMD1.
Vonk WI, Wijmenga C, Berger R, van de Sluis B, Klomp LW., Free PMC Article | 10/23/2010 |
| COMMD1 is required to shuttle the liver copper transporter (Atp7b) when the intracellular copper level falls below the threshold. | Roles of COMM-domain-containing 1 in stability and recruitment of the copper-transporting ATPase in a mouse hepatoma cell line.
Miyayama T, Hiraoka D, Kawaji F, Nakamura E, Suzuki N, Ogra Y. | 07/5/2010 |
| RNA polymerase II phosphorylated at serine 2 of the carboxyl-terminal domain repeats, a marker of transcription elongation, is enriched on the paternal allele than on the maternal allele in the Commd1 promoter | Antisense transcription occurs at the promoter of a mouse imprinted gene, commd1, on the repressed paternal allele.
Joh K, Yatsuki H, Higashimoto K, Mukai T, Soejima H. | 04/12/2010 |
| Tumour necrosis factor-induced phosphorylation of p65 at Ser468 allows binding of COMMD1 and cullin 2, components of a multimeric ubiquitin ligase complex mediating p65 ubiquitination. | Phosphorylation of NF-kappaB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination.
Geng H, Wittwer T, Dittrich-Breiholz O, Kracht M, Schmitz ML., Free PMC Article | 01/21/2010 |
| hepatic copper accumulation leads to decreased Xiap, increased Commd1 | Developmental expression of Commd1 in the liver of the Jackson toxic milk mouse.
Roberts EA, Lau CH, da Silveira TR, Yang S. | 01/21/2010 |
| Inhibition of histone deacetylases alters allelic chromatin conformation at the imprinted U2af1-rs1 locus in mouse embryonic stem cells | Inhibition of histone deacetylases alters allelic chromatin conformation at the imprinted U2af1-rs1 locus in mouse embryonic stem cells.
Gregory RI, O'Neill LP, Randall TE, Fournier C, Khosla S, Turner BM, Feil R. | 01/21/2010 |
| A novel transcript (U2mu) in mouse is transcribed from the portions of two independent genes, U2af1-rs1 and Murr1. | Identification of a novel isoform of Murr1 transcript, U2mu, which is transcribed from the portions of two closely located but oppositely oriented genes.
Wang Y, Joh K, Mukai T. | 01/21/2010 |
| Results identify COMMD1 as a novel regulator of HIF-1 activity and shows that Commd1 deficiency in mice leads to embryonic lethality associated with dysregulated placenta vascularization. | Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null mice.
van de Sluis B, Muller P, Duran K, Chen A, Groot AJ, Klomp LW, Liu PP, Wijmenga C., Free PMC Article | 01/21/2010 |