| Inpp5d haplodeficiency alleviates tau pathology in the PS19 mouse model of Tauopathy. | Inpp5d haplodeficiency alleviates tau pathology in the PS19 mouse model of Tauopathy.
Soni DM, Lin PB, Lee-Gosselin A, Lloyd CD, Mason E, Ingraham CM, Perkins A, Moutinho M, Lamb BT, Chu S, Oblak AL., Free PMC Article | 07/22/2024 |
| Sleep Disruption Precedes Forebrain Synaptic Tau Burden and Contributes to Cognitive Decline in a Sex-Dependent Manner in the P301S Tau Transgenic Mouse Model. | Sleep Disruption Precedes Forebrain Synaptic Tau Burden and Contributes to Cognitive Decline in a Sex-Dependent Manner in the P301S Tau Transgenic Mouse Model.
Martin SC, Joyce KK, Lord JS, Harper KM, Nikolova VD, Cohen TJ, Moy SS, Diering GH., Free PMC Article | 07/16/2024 |
| Oligomeric Tau-induced oxidative damage and functional alterations in cerebral endothelial cells: Role of RhoA/ROCK signaling pathway. | Oligomeric Tau-induced oxidative damage and functional alterations in cerebral endothelial cells: Role of RhoA/ROCK signaling pathway.
Hossen F, Sun GY, Lee JC., Free PMC Article | 07/15/2024 |
| Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tau. | Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tau.
de Veij Mestdagh CF, Witte ME, Scheper W, Smit AB, Henning RH, van Kesteren RE., Free PMC Article | 06/12/2024 |
| Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway. | Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway.
Yakout DW, Shroff A, Wei W, Thaker V, Allen ZD, Sajish M, Nazarko TY, Mabb AM., Free PMC Article | 06/5/2024 |
| AbetaPP-tau-HAS1 axis trigger HAS1-related nuclear speckles and gene transcription in Alzheimer's disease. | AβPP-tau-HAS1 axis trigger HAS1-related nuclear speckles and gene transcription in Alzheimer's disease.
Zhang YH, Sun XT, Guo RF, Feng GY, Gao HL, Zhong ML, Tian LW, Qiu ZY, Cui YW, Li JY, Zhao P. | 06/5/2024 |
| DLK-MAPK Signaling Coupled with DNA Damage Promotes Intrinsic Neurotoxicity Associated with Non-Mutated Tau. | DLK-MAPK Signaling Coupled with DNA Damage Promotes Intrinsic Neurotoxicity Associated with Non-Mutated Tau.
Li S, Roy ER, Wang Y, Watkins T, Cao W., Free PMC Article | 05/13/2024 |
| P25/CDK5-mediated Tau Hyperphosphorylation in Both Ipsilateral and Contralateral Cerebra Contributes to Cognitive Deficits in Post-stroke Mice. | P25/CDK5-mediated Tau Hyperphosphorylation in Both Ipsilateral and Contralateral Cerebra Contributes to Cognitive Deficits in Post-stroke Mice.
Yu J, Zhao Y, Gong XK, Liang Z, Zhao YN, Li X, Chen YJ, Yang YH, Wu MJ, Wang XC, Shu XJ, Bao J. | 01/4/2024 |
| Tau suppresses microtubule-regulated pancreatic insulin secretion. | Tau suppresses microtubule-regulated pancreatic insulin secretion.
Mangiafico SP, Tuo QZ, Li XL, Liu Y, Haralambous C, Ding XL, Ayton S, Wang Q, Laybutt DR, Chan JY, Zhang X, Kos C, Thomas HE, Loudovaris T, Yang CH, Joannides CN, Lamont BJ, Dai L, He HH, Dong B, Andrikopoulos S, Bush AI, Lei P. | 12/23/2023 |
| Synaptic oligomeric tau in Alzheimer's disease - A potential culprit in the spread of tau pathology through the brain. | Synaptic oligomeric tau in Alzheimer's disease - A potential culprit in the spread of tau pathology through the brain.
Colom-Cadena M, Davies C, Sirisi S, Lee JE, Simzer EM, Tzioras M, Querol-Vilaseca M, Sánchez-Aced É, Chang YY, Holt K, McGeachan RI, Rose J, Tulloch J, Wilkins L, Smith C, Andrian T, Belbin O, Pujals S, Horrocks MH, Lleó A, Spires-Jones TL. | 11/22/2023 |
| Caspase-3 cleaved tau impairs mitochondrial function through the opening of the mitochondrial permeability transition pore. | Caspase-3 cleaved tau impairs mitochondrial function through the opening of the mitochondrial permeability transition pore.
Pérez MJ, Ibarra-García-Padilla R, Tang M, Porter GA Jr, Johnson GVW, Quintanilla RA., | 11/16/2023 |
| Chronic kidney disease causes blood-brain barrier breakdown via urea-activated matrix metalloproteinase-2 and insolubility of tau protein. | Chronic kidney disease causes blood-brain barrier breakdown via urea-activated matrix metalloproteinase-2 and insolubility of tau protein.
Matsuki H, Mandai S, Shiwaku H, Koide T, Takahashi N, Yanagi T, Inaba S, Ida S, Fujiki T, Mori Y, Ando F, Mori T, Susa K, Iimori S, Sohara E, Takahashi H, Uchida S., Free PMC Article | 11/14/2023 |
| Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau. | Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau.
Schweighauser M, Murzin AG, Macdonald J, Lavenir I, Crowther RA, Scheres SHW, Goedert M., Free PMC Article | 10/12/2023 |
| Tau fibrils induce glial inflammation and neuropathology via TLR2 in Alzheimer's disease-related mouse models. | Tau fibrils induce glial inflammation and neuropathology via TLR2 in Alzheimer's disease-related mouse models.
Dutta D, Jana M, Paidi RK, Majumder M, Raha S, Dasarathy S, Pahan K., Free PMC Article | 09/19/2023 |
| Discrepancy of synaptic and microtubular protein phosphorylation in the hippocampus of APP/PS1 and MAPTxP301S transgenic mice at the early stage of Alzheimer's disease. | Discrepancy of synaptic and microtubular protein phosphorylation in the hippocampus of APP/PS1 and MAPT×P301S transgenic mice at the early stage of Alzheimer's disease.
Wang Q, Xia C, Zhu A, Bao Y, Lu J, Chen Y, Xu J, Wang B, Naman CB, Li L, Wang Q, Liu H, Liang H, Cui W. | 09/12/2023 |
| A direct interaction between RhoGDIalpha/Tau alleviates hyperphosphorylation of Tau in Alzheimer's disease and vascular dementia. | A direct interaction between RhoGDIα/Tau alleviates hyperphosphorylation of Tau in Alzheimer's disease and vascular dementia.
Zhang H, Lu F, Liu P, Qiu Z, Li J, Wang X, Xu H, Zhao Y, Li X, Wang H, Lu D, Qi R. | 09/8/2023 |
| Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy. | Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy.
Hussong SA, Banh AQ, Van Skike CE, Dorigatti AO, Hernandez SF, Hart MJ, Ferran B, Makhlouf H, Gaczynska M, Osmulski PA, McAllen SA, Dineley KT, Ungvari Z, Perez VI, Kayed R, Galvan V., Free PMC Article | 08/25/2023 |
| Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience. | Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.
Udeochu JC, Amin S, Huang Y, Fan L, Torres ERS, Carling GK, Liu B, McGurran H, Coronas-Samano G, Kauwe G, Mousa GA, Wong MY, Ye P, Nagiri RK, Lo I, Holtzman J, Corona C, Yarahmady A, Gill MT, Raju RM, Mok SA, Gong S, Luo W, Zhao M, Tracy TE, Ratan RR, Tsai LH, Sinha SC, Gan L., Free PMC Article | 08/25/2023 |
| Localization, induction, and cellular effects of tau phosphorylated at threonine 217. | Localization, induction, and cellular effects of tau phosphorylated at threonine 217.
Rajbanshi B, Guruacharya A, Mandell JW, Bloom GS., Free PMC Article | 07/27/2023 |
| Mutant Tau protein-induced abnormalities in the Na[+]-dependent glutamine translocation and recycling and their impact on astrocyte-neuron integrity in vitro. | Mutant Tau protein-induced abnormalities in the Na(+)-dependent glutamine translocation and recycling and their impact on astrocyte-neuron integrity in vitro.
Sidoryk-Węgrzynowicz M, Dąbrowska-Bouta B, Sulkowski G, Strużyńska L. | 07/13/2023 |
| Concomitant Neuronal Tau Deposition and FKBP52 Decrease Is an Early Feature of Different Human and Experimental Tauopathies. | Concomitant Neuronal Tau Deposition and FKBP52 Decrease Is an Early Feature of Different Human and Experimental Tauopathies.
Meduri G, Guillemeau K, Daguinot C, Dounane O, Genet M, Ferrara L, Chambraud B, Baulieu EE, Giustiniani J., Free PMC Article | 07/7/2023 |
| Soluble form of the APP fragment, sAPPbeta, positively regulates tau secretion. | Soluble form of the APP fragment, sAPPβ, positively regulates tau secretion.
Sato H, Kasuga K, Isoo N, Hayashi T, Ikeuchi T, Hori Y, Tomita T. | 07/6/2023 |
| Tau pathology epigenetically remodels the neuron-glial cross-talk in Alzheimer's disease. | Tau pathology epigenetically remodels the neuron-glial cross-talk in Alzheimer's disease.
Zhou LT, Liu D, Kang HC, Lu L, Huang HZ, Ai WQ, Zhou Y, Deng MF, Li H, Liu ZQ, Zhang WF, Hu YZ, Han ZT, Zhang HH, Jia JJ, Sarkar AK, Sharaydeh S, Wang J, Man HY, Schilling M, Bertram L, Lu Y, Guo Z, Zhu LQ., Free PMC Article | 05/8/2023 |
| Chronic Sleep Disturbances Alters Sleep Structure and Tau Phosphorylation in AbetaPP/PS1 AD Mice and Their Wild-Type Littermates. | Chronic Sleep Disturbances Alters Sleep Structure and Tau Phosphorylation in AβPP/PS1 AD Mice and Their Wild-Type Littermates.
Zhang F, Niu L, Zhong R, Li S, Le W. | 05/8/2023 |
| APP mediates tau uptake and its overexpression leads to the exacerbated tau pathology. | APP mediates tau uptake and its overexpression leads to the exacerbated tau pathology.
Chen J, Fan A, Li S, Xiao Y, Fu Y, Chen JS, Zi D, Zeng LH, Tan J., Free PMC Article | 04/20/2023 |