| Salt-inducible kinase 1-CREB-regulated transcription coactivator 1 signalling in the paraventricular nucleus of the hypothalamus plays a role in depression by regulating the hypothalamic-pituitary-adrenal axis. | Salt-inducible kinase 1-CREB-regulated transcription coactivator 1 signalling in the paraventricular nucleus of the hypothalamus plays a role in depression by regulating the hypothalamic-pituitary-adrenal axis.
Wang Y, Liu L, Gu JH, Wang CN, Guan W, Liu Y, Tang WQ, Ji CH, Chen YM, Huang J, Li WY, Shi TS, Chen WJ, Zhu BL, Jiang B. | 10/11/2024 |
| An Epilepsy-Associated Mutation of Salt-Inducible Kinase 1 Increases the Susceptibility to Epileptic Seizures and Interferes with Adrenocorticotropic Hormone Therapy for Infantile Spasms in Mice. | An Epilepsy-Associated Mutation of Salt-Inducible Kinase 1 Increases the Susceptibility to Epileptic Seizures and Interferes with Adrenocorticotropic Hormone Therapy for Infantile Spasms in Mice.
Pang B, Mori T, Badawi M, Zhou M, Guo Q, Suzuki-Kouyama E, Yanagawa T, Shirai Y, Tabuchi K., Free PMC Article | 08/6/2022 |
| Long noncoding RNA SNHG1 protects brain microvascular endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury by sponging miR-298 and upregulating SIK1 expression. | Long noncoding RNA SNHG1 protects brain microvascular endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury by sponging miR-298 and upregulating SIK1 expression.
Zhou X, Xu B, Gu Y, Ji N, Meng P, Dong L. | 12/4/2021 |
| Salt-inducible kinases are required for the IL-33-dependent secretion of cytokines and chemokines in mast cells. | Salt-inducible kinases are required for the IL-33-dependent secretion of cytokines and chemokines in mast cells.
Darling NJ, Arthur JSC, Cohen P., Free PMC Article | 08/28/2021 |
| Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway. | Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway.
Liu S, Huang S, Wu X, Feng Y, Shen Y, Zhao QS, Leng Y., Free PMC Article | 08/21/2021 |
| Antagonistic modulation of SIK1 and SIK2 isoforms in high blood pressure and cardiac hypertrophy triggered by high-salt intake. | Antagonistic modulation of SIK1 and SIK2 isoforms in high blood pressure and cardiac hypertrophy triggered by high-salt intake.
Pires NM, Igreja B, Soares-da-Silva P. | 07/17/2021 |
| Role of SIK1 in the transition of acute kidney injury into chronic kidney disease. | Role of SIK1 in the transition of acute kidney injury into chronic kidney disease.
Hu J, Qiao J, Yu Q, Liu B, Zhen J, Liu Y, Ma Q, Li Y, Wang Q, Wang C, Lv Z., Free PMC Article | 07/10/2021 |
| Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling. | Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.
Hsu A, Duan Q, McMahon S, Huang Y, Wood SA, Gray NS, Wang B, Bruneau BG, Haldar SM., Free PMC Article | 02/6/2021 |
| Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need. | Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need.
Park M, Miyoshi C, Fujiyama T, Kakizaki M, Ikkyu A, Honda T, Choi J, Asano F, Mizuno S, Takahashi S, Yanagisawa M, Funato H., Free PMC Article | 12/12/2020 |
| Acute salt loading induces sympathetic nervous system overdrive in mice lacking salt-inducible kinase 1 (SIK1). | Acute salt loading induces sympathetic nervous system overdrive in mice lacking salt-inducible kinase 1 (SIK1).
Pires NM, Igreja B, Serrão MP, Matias EF, Moura E, António T, Campos FL, Brion L, Bertorello A, Soares-da-Silva P. | 09/26/2020 |
| Salt-inducible kinase 1 regulates bone anabolism via the CRTC1-CREB-Id1 axis. | Salt-inducible kinase 1 regulates bone anabolism via the CRTC1-CREB-Id1 axis.
Kim MK, Kwon JO, Song MK, Kim B, Kim H, Lee ZH, Koo SH, Kim HH., Free PMC Article | 08/29/2020 |
| The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC. | The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC.
Hollstein PE, Eichner LJ, Brun SN, Kamireddy A, Svensson RU, Vera LI, Ross DS, Rymoff TJ, Hutchins A, Galvez HM, Williams AE, Shokhirev MN, Screaton RA, Berdeaux R, Shaw RJ., Free PMC Article | 08/22/2020 |
| Mutant Gnas is critical for pancreatic tumour tumorigenesis, driven by protein-kinase-A-mediated suppression of salt-inducible kinases (Sik1-3), and associated with induction of lipid remodelling and fatty acid oxidation. | Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.
Patra KC, Kato Y, Mizukami Y, Widholz S, Boukhali M, Revenco I, Grossman EA, Ji F, Sadreyev RI, Liss AS, Screaton RA, Sakamoto K, Ryan DP, Mino-Kenudson M, Castillo CF, Nomura DK, Haas W, Bardeesy N., Free PMC Article | 04/13/2019 |
| This study establishes for the first time not only that SIK1 is crucial to regulating alcohol-induced microglial apoptosis, but also that the NF-kappaB signaling pathway is required for its activity. Overall, our results help elucidate mechanisms of alcohol-induced neuroinflammation. | Salt-Inducible Kinase 1 (SIK1) is Induced by Alcohol and Suppresses Microglia Inflammation via NF-κB Signaling.
Zhang Y, Gao W, Yang K, Tao H, Yang H. | 08/18/2018 |
| Our findings highlight the critical roles of SIK1 and its targets in the regulation of HCC development and provides potential new candidates for HCC therapy. | Salt-inducible Kinase (SIK1) regulates HCC progression and WNT/β-catenin activation.
Qu C, He D, Lu X, Dong L, Zhu Y, Zhao Q, Jiang X, Chang P, Jiang X, Wang L, Zhang Y, Bi L, He J, Peng Y, Su J, Zhang H, Huang H, Li Y, Zhou S, Qu Y, Zhao Y, Zhang Z. | 01/14/2017 |
| cAMP, SIK and CRTC mediate StAR expression through activation of individual StAR gene loci. | Stimulation of StAR expression by cAMP is controlled by inhibition of highly inducible SIK1 via CRTC2, a co-activator of CREB.
Lee J, Tong T, Takemori H, Jefcoate C., Free PMC Article | 02/13/2016 |
| SIK1 serves as a part of a self-regulatory circuit to modulate insulin secretion from pancreatic beta-cells by controlling cAMP concentration through modulation of PDE4D activity. | Salt-Inducible Kinase 1 Terminates cAMP Signaling by an Evolutionarily Conserved Negative-Feedback Loop in β-Cells.
Kim MJ, Park SK, Lee JH, Jung CY, Sung DJ, Park JH, Yoon YS, Park J, Park KG, Song DK, Cho H, Kim ST, Koo SH. | 11/21/2015 |
| Sik1, Sik2, and Sik3 play a key role as gluconeogenesis suppressors downstream of LKB1 in the liver. | The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver.
Patel K, Foretz M, Marion A, Campbell DG, Gourlay R, Boudaba N, Tournier E, Titchenell P, Peggie M, Deak M, Wan M, Kaestner KH, Göransson O, Viollet B, Gray NS, Birnbaum MJ, Sutherland C, Sakamoto K., Free PMC Article | 11/7/2015 |
| Vascular SIK1 activation may be involved in the prevention of high blood pressure development triggered by high-salt intake through the modulation of the contractile phenotype of VSMCs via transforming growth factor-beta1-signaling inhibition. | Increased arterial blood pressure and vascular remodeling in mice lacking salt-inducible kinase 1 (SIK1).
Bertorello AM, Pires N, Igreja B, Pinho MJ, Vorkapic E, Wågsäter D, Wikström J, Behrendt M, Hamsten A, Eriksson P, Soares-da-Silva P, Brion L. | 04/11/2015 |
| SIK1 and SIK3 negatively regulate TLR4-mediated signaling through the interruption of TAB2-TRAF6 complex. | Salt-inducible kinases 1 and 3 negatively regulate Toll-like receptor 4-mediated signal.
Yong Kim S, Jeong S, Chah KH, Jung E, Baek KH, Kim ST, Shim JH, Chun E, Lee KY., Free PMC Article | 06/21/2014 |
| Study shows that knockdown of Sik1 within the suprachiasmatic nuclei results in extended light-induced phase shifts and an enhanced rate of re-entrainment to an advanced light/dark cycle | The CRTC1-SIK1 pathway regulates entrainment of the circadian clock.
Jagannath A, Butler R, Godinho SIH, Couch Y, Brown LA, Vasudevan SR, Flanagan KC, Anthony D, Churchill GC, Wood MJA, Steiner G, Ebeling M, Hossbach M, Wettstein JG, Duffield GE, Gatti S, Hankins MW, Foster RG, Peirson SN., Free PMC Article | 11/16/2013 |
| These results provide evidence that SIK1 is present in lung epithelial cells and that its function is relevant for the action of isoproterenol during regulation of active sodium transport. | Salt-inducible kinase 1 is present in lung alveolar epithelial cells and regulates active sodium transport.
Eneling K, Chen J, Welch LC, Takemori H, Sznajder JI, Bertorello AM., Free PMC Article | 08/6/2011 |
| Intracellular sodium sensing: SIK1 network, hormone action and high blood pressure. | Intracellular sodium sensing: SIK1 network, hormone action and high blood pressure.
Jaitovich A, Bertorello AM. | 01/1/2011 |
| Data provide evidence that sik1 via p57Kip2 plays a central role in the time clock mechanism that regulates cardiac cell proliferation and differentiation. | Lack of sik1 in mouse embryonic stem cells impairs cardiomyogenesis by down-regulating the cyclin-dependent kinase inhibitor p57kip2.
Romito A, Lonardo E, Roma G, Minchiotti G, Ballabio A, Cobellis G., Free PMC Article | 10/4/2010 |
| GSK-3 beta and SIK1 may play important roles in the regulation of PGC-1alpha gene expression by inactivating HDAC5 followed by activation of MEF2C. | Inactivation of HDAC5 by SIK1 in AICAR-treated C2C12 myoblasts.
Takemori H, Katoh Hashimoto Y, Nakae J, Olson EN, Okamoto M. | 01/21/2010 |