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    clk-1 5-demethoxyubiquinone hydroxylase, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 175729, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Elevated mitochondrial DNA copy number found in ubiquinone-deficient clk-1 mutants is not rescued by ubiquinone precursor 2-4-dihydroxybenzoate.

    Elevated mitochondrial DNA copy number found in ubiquinone-deficient clk-1 mutants is not rescued by ubiquinone precursor 2-4-dihydroxybenzoate.
    Kirby CS, Patel MR., Free PMC Article

    01/15/2022
    Loss of ubiquinone biosynthesis is responsible for all phenotypes resulting from loss of CLK-1, including behavioral phenotypes, altered expression of mitochondrial quality control genes, and lifespan.

    A single biochemical activity underlies the pleiotropy of the aging-related protein CLK-1.
    Liu JL, Yee C, Wang Y, Hekimi S., Free PMC Article

    09/8/2018
    Nuclear CLK-1 mediates a retrograde signalling pathway that is conserved from Caenorhabditis elegans to humans and is responsive to mitochondrial reactive oxygen species, thus acting as a barometer of oxidative metabolism.

    A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity.
    Monaghan RM, Barnes RG, Fisher K, Andreou T, Rooney N, Poulin GB, Whitmarsh AJ., Free PMC Article

    09/5/2015
    no measurable intrinsic ETC defect exists in clk-1 mitochondria. The data indicate that DMQ(9) specifically inhibits electron transfer from complex I to ubiquinone.

    The role of DMQ(9) in the long-lived mutant clk-1.
    Yang YY, Vasta V, Hahn S, Gangoiti JA, Opheim E, Sedensky MM, Morgan PG., Free PMC Article

    12/10/2011
    action of clioquinol on several age-dependent neurodegenerative diseases with distinct etiologies might result from a slowing down of the aging process through action of the drug on CLK-1.

    The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1.
    Wang Y, Branicky R, Stepanyan Z, Carroll M, Guimond MP, Hihi A, Hayes S, McBride K, Hekimi S.

    01/21/2010
    in maternally resqued animals, the effect of clk-1 mutations on adult lifespan in uncoupled from their effects on development and reproduction

    Molecular mechanism of maternal rescue in the clk-1 mutants of Caenorhabditis elegans.
    Burgess J, Hihi AK, Benard CY, Branicky R, Hekimi S.

    01/21/2010
    Caenorhabditis elegans clk-1 mutants are sensitive to ubiquinone side-chain length

    Sensitivity of Caenorhabditis elegans clk-1 mutants to ubiquinone side-chain length reveals multiple ubiquinone-dependent processes.
    Hihi AK, Kebir H, Hekimi S.

    01/21/2010
    Complementation of Escherichia coli ubiF mutation by Caenorhabditis elegans CLK-1.

    Complementation of Escherichia coli ubiF mutation by Caenorhabditis elegans CLK-1, a product of the longevity gene of the nematode worm.
    Adachi A, Shinjyo N, Fujita D, Miyoshi H, Amino H, Watanabe Yi, Kita K.

    01/21/2010
    Suppressors of the missense mutation of clk-1 were identified; each mutant suppresses a different subset of phenotypes.

    Uncoupling the pleiotropic phenotypes of clk-1 with tRNA missense suppressors in Caenorhabditis elegans.
    Branicky R, Nguyen PA, Hekimi S., Free PMC Article

    01/21/2010
    Prolonged life span of Clk mutants cannot be attributed to reduced metabolic rate or an increased activity of the major antioxidant enzymes catalase and SOD.

    No reduction of energy metabolism in Clk mutants.
    Braeckman BP, Houthoofd K, Brys K, Lenaerts I, De Vreese A, Van Eygen S, Raes H, Vanfleteren JR.

    01/21/2010
    differential fertility of clk-1 mutant nematodes fed Q isoforms may result from changes in Q localization, altered recognition by Q-binding proteins, and/or potential defects in mitochondrial function resulting from the mutant CLK-1 polypeptide itself.

    Reproductive fitness and quinone content of Caenorhabditis elegans clk-1 mutants fed coenzyme Q isoforms of varying length.
    Jonassen T, Davis DE, Larsen PL, Clarke CF.

    01/21/2010
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