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    AFP alpha fetoprotein [ Homo sapiens (human) ]

    Gene ID: 174, updated on 18-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Structural characteristics of alpha-fetoprotein, including N-glycosylation, metal ion and fatty acid binding sites.

    Structural characteristics of alpha-fetoprotein, including N-glycosylation, metal ion and fatty acid binding sites.
    Liu K, Wu C, Zhu M, Xu J, Lin B, Lin H, Liu Z, Li M., Free PMC Article

    05/22/2024
    Alpha-fetoprotein: Past, present, and future.

    Alpha-fetoprotein: Past, present, and future.
    Yeo YH, Lee YT, Tseng HR, Zhu Y, You S, Agopian VG, Yang JD., Free PMC Article

    04/18/2024
    Role of Alpha-Fetoprotein in the Pathogenesis of Cancer.

    Role of Alpha-Fetoprotein in the Pathogenesis of Cancer.
    Chaudhuri AG, Samanta S, Dey M, Raviraja NS, Dey S.

    03/21/2024
    Combination of serum alpha-fetoprotein, PIVKA- and glypican-3 in diagnosis of hepatocellular carcinoma: a meta-analysis.

    Combination of serum alpha-fetoprotein, PIVKA-Ⅱ and glypican-3 in diagnosis of hepatocellular carcinoma: a meta-analysis.
    Song H, Wang J, Zhang H, Wu Y, Wang K, Wang X, Xu X., Free PMC Article

    03/5/2024
    Cellular gp96 upregulates AFP expression by blocking NR5A2 SUMOylation and ubiquitination in hepatocellular carcinoma.

    Cellular gp96 upregulates AFP expression by blocking NR5A2 SUMOylation and ubiquitination in hepatocellular carcinoma.
    Qian L, Liang Z, Wang Z, Wang J, Li X, Zhao J, Li Z, Chen L, Liu Y, Ju Y, Li C, Meng S., Free PMC Article

    01/30/2024
    Maternal First-Trimester Alpha-Fetoprotein and Placenta-Mediated Pregnancy Complications.

    Maternal First-Trimester Alpha-Fetoprotein and Placenta-Mediated Pregnancy Complications.
    Melamed N, Okun N, Huang T, Mei-Dan E, Aviram A, Allen M, Abdulaziz KE, McDonald SD, Murray-Davis B, Ray JG, Barrett J, Kingdom J, Berger H, for DOH-NET (Diabetes, Obesity and Hypertension in Pregnancy Research Network) and SOON (Southern Ontario Obstetrical Network) Investigators.

    11/3/2023
    AFP deletion leads to anti-tumorigenic but pro-metastatic roles in liver cancers with concomitant CTNNB1 mutations.

    AFP deletion leads to anti-tumorigenic but pro-metastatic roles in liver cancers with concomitant CTNNB1 mutations.
    Xu Y, Zhang X, Zhang R, Sun Y, Liu J, Luo C, Yang J, Fang W, Guo Q, Wei L.

    06/25/2023
    AUF1 promotes hepatocellular carcinoma progression and chemo-resistance by post-transcriptionally upregulating alpha-fetoprotein expression.

    AUF1 promotes hepatocellular carcinoma progression and chemo-resistance by post-transcriptionally upregulating alpha-fetoprotein expression.
    Zhang J, Zhang T, Guan G, Wen J, Chen CC, Liu J, Duan Y, Liu Y, Chen X.

    05/19/2023
    Polyunsaturated Fatty Acid-Bound alpha-Fetoprotein Promotes Immune Suppression by Altering Human Dendritic Cell Metabolism.

    Polyunsaturated Fatty Acid-Bound α-Fetoprotein Promotes Immune Suppression by Altering Human Dendritic Cell Metabolism.
    Munson PV, Adamik J, Hartmann FJ, Favaro PMB, Ho D, Bendall SC, Combes AJ, Krummel MF, Zhang K, Kelley RK, Butterfield LH., Free PMC Article

    05/11/2023
    A Retrospective Multicentric Study of 34 Patients with Niemann-Pick Type C Disease and Early Liver Involvement in France.

    A Retrospective Multicentric Study of 34 Patients with Niemann-Pick Type C Disease and Early Liver Involvement in France.
    Gardin A, Mussini C, Héron B, Schiff M, Brassier A, Dobbelaere D, Broué P, Sevin C, Vanier MT, Habes D, Jacquemin E, Gonzales E.

    03/23/2023
    Alpha fetoprotein promotes polarization of macrophages towards M2-like phenotype and inhibits macrophages to phagocytize hepatoma cells.

    Alpha fetoprotein promotes polarization of macrophages towards M2-like phenotype and inhibits macrophages to phagocytize hepatoma cells.
    Zhang M, Liu K, Zhang Q, Xu J, Liu J, Lin H, Lin B, Zhu M, Li M., Free PMC Article

    03/16/2023
    Sequential Treatment with Activin and Hepatocyte Growth Factor Induces FOXM1 to Promote Colorectal Cancer Liver Metastasis.

    Sequential Treatment with Activin and Hepatocyte Growth Factor Induces FOXM1 to Promote Colorectal Cancer Liver Metastasis.
    Peng H, Ye T, Deng L, Yang X, Jiang Z, Guo J., Free PMC Article

    01/14/2023
    The predictive value of maternal serum AFP to PAPP-A or b-hCG ratios in spontaneous preterm birth.

    The predictive value of maternal serum AFP to PAPP-A or b-hCG ratios in spontaneous preterm birth.
    Celik E, Melekoğlu R, Baygül A, Kalkan U, Şimşek Y.

    10/8/2022
    Diagnostic value of maternal alpha-fetoprotein variants in second-trimester biochemical screening for trisomy 21 and 18.

    Diagnostic value of maternal alpha-fetoprotein variants in second-trimester biochemical screening for trisomy 21 and 18.
    Chen Y, Chen Y, Ning W, Zhang W, Li L, Wang X, Yin Y, Zhang H., Free PMC Article

    08/27/2022
    Alpha-Fetoprotein (AFP) and AFP-L3 Is Most Useful in Detection of Recurrence of Hepatocellular Carcinoma in Patients after Tumor Ablation and with Low AFP Level.

    Alpha-Fetoprotein (AFP) and AFP-L3 Is Most Useful in Detection of Recurrence of Hepatocellular Carcinoma in Patients after Tumor Ablation and with Low AFP Level.
    Force M, Park G, Chalikonda D, Roth C, Cohen M, Halegoua-DeMarzio D, Hann HW., Free PMC Article

    05/7/2022
    A Risk Model for Predicting Fetuses with Trisomy 21 Using Alpha-Fetoprotein Variants L2 Combined with Maternal Serum Biomarkers in Early Pregnancy.

    A Risk Model for Predicting Fetuses with Trisomy 21 Using Alpha-Fetoprotein Variants L2 Combined with Maternal Serum Biomarkers in Early Pregnancy.
    Chen Y, Wu B, Chen Y, Ning W, Zhang H., Free PMC Article

    04/30/2022
    Clinicopathological and molecular characteristics of the alpha-fetoprotein-producing gastric cancer: emphasis on two major subtypes.

    Clinicopathological and molecular characteristics of the alpha-fetoprotein-producing gastric cancer: emphasis on two major subtypes.
    Lu J, Jin M, Zhou X, Chen X, Shao Y, Jiang X.

    03/5/2022
    Potentiality of alpha-fetoprotein (AFP) and soluble intercellular adhesion molecule-1 (sICAM-1) in prognosis prediction and immunotherapy response for patients with hepatocellular carcinoma.

    Potentiality of α-fetoprotein (AFP) and soluble intercellular adhesion molecule-1 (sICAM-1) in prognosis prediction and immunotherapy response for patients with hepatocellular carcinoma.
    Cao W, Chen Y, Han W, Yuan J, Xie W, Liu K, Qiu Y, Wang X, Li X., Free PMC Article

    02/19/2022
    [Structural Analysis of the 5'-Flanking Region of Human Alpha-Fetoprotein Encoding Gene].

    [Structural Analysis of the 5'-Flanking Region of Human Alpha-Fetoprotein Encoding Gene].
    Zhang C, Zhao HJ, Wang J, Zhou WY, Zhang TJ, Zhang СВ.

    02/5/2022
    alpha-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study.

    α-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study.
    Lu SX, Huang YH, Liu LL, Zhang CZ, Yang X, Yang YZ, Shao CK, Li JM, Xie D, Zhang X, Jain D, Yun JP., Free PMC Article

    12/11/2021
    Serum Alpha-fetoprotein Levels and Clinical Outcomes in the Phase III CELESTIAL Study of Cabozantinib versus Placebo in Patients with Advanced Hepatocellular Carcinoma.

    Serum Alpha-fetoprotein Levels and Clinical Outcomes in the Phase III CELESTIAL Study of Cabozantinib versus Placebo in Patients with Advanced Hepatocellular Carcinoma.
    Kelley RK, Meyer T, Rimassa L, Merle P, Park JW, Yau T, Chan SL, Blanc JF, Tam VC, Tran A, Dadduzio V, Markby DW, Kaldate R, Cheng AL, El-Khoueiry AB, Abou-Alfa GK., Free PMC Article

    12/11/2021
    Clinical Significance of Alpha-Fetoprotein in Alpha-Fetoprotein Negative Hepatocellular Carcinoma Underwent Curative Resection.

    Clinical Significance of Alpha-Fetoprotein in Alpha-Fetoprotein Negative Hepatocellular Carcinoma Underwent Curative Resection.
    Lin K, Huang Q, Zeng J, Ding Z, Wang L, Chen Z, Guo P, Zeng Y, Zhou W, Liu J., Free PMC Article

    12/11/2021
    AFP and eGFR are related to early and late recurrence of HCC following antiviral therapy.

    AFP and eGFR are related to early and late recurrence of HCC following antiviral therapy.
    Watanabe T, Tokumoto Y, Joko K, Michitaka K, Horiike N, Tanaka Y, Tada F, Kisaka Y, Nakanishi S, Yamauchi K, Ochi H, Hiraoka A, Yagi S, Yukimoto A, Hirooka M, Abe M, Hiasa Y., Free PMC Article

    11/6/2021
    Transcription factor FOXA3 promotes the development of Hepatoblastoma via regulating HNF1A, AFP, and ZFHX3 expression.

    Transcription factor FOXA3 promotes the development of Hepatoblastoma via regulating HNF1A, AFP, and ZFHX3 expression.
    Zhan X, Zhao A., Free PMC Article

    11/6/2021
    The Diagnostic Value of Serum PIVKA-II Alone or in Combination with AFP in Chinese Hepatocellular Carcinoma Patients.

    The Diagnostic Value of Serum PIVKA-II Alone or in Combination with AFP in Chinese Hepatocellular Carcinoma Patients.
    Xu F, Zhang L, He W, Song D, Ji X, Shao J., Free PMC Article

    10/30/2021
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