| Polarity protein AF6 functions as a modulator of necroptosis by regulating ubiquitination of RIPK1 in liver diseases. | Polarity protein AF6 functions as a modulator of necroptosis by regulating ubiquitination of RIPK1 in liver diseases.
Xinyu W, Qian W, Yanjun W, Jingwen K, Keying X, Jiazheng J, Haibing Z, Kai W, Xiao X, Lixing Z., Free PMC Article | 11/18/2023 |
| Rap1 regulates lumen continuity via Afadin in renal epithelia. | Rap1 regulates lumen continuity via Afadin in renal epithelia.
Hiremath C, Gao L, Geshow K, Patterson Q, Barlow H, Cleaver O, Marciano DK., Free PMC Article | 07/12/2023 |
| s-Afadin binds to MAGUIN/Cnksr2 and regulates the localization of the AMPA receptor and glutamatergic synaptic response in hippocampal neurons. | s-Afadin binds to MAGUIN/Cnksr2 and regulates the localization of the AMPA receptor and glutamatergic synaptic response in hippocampal neurons.
Maruo T, Mizutani K, Miyata M, Kuriu T, Sakakibara S, Takahashi H, Kida D, Maesaka K, Sugaya T, Sakane A, Sasaki T, Takai Y, Mandai K., Free PMC Article | 05/17/2023 |
| Dynamic interplay between Afadin(S1795) phosphorylation and diet regulates glucose homeostasis in obese mice. | Dynamic interplay between Afadin(S1795) phosphorylation and diet regulates glucose homeostasis in obese mice.
Tozzi M, Brown EL, Petersen PSS, Lundh M, Isidor MS, Plucińska K, Nielsen TS, Agueda-Oyarzabal M, Small L, Treebak JT, Emanuelli B. | 02/26/2022 |
| Cold-induction of afadin in brown fat supports its thermogenic capacity. | Cold-induction of afadin in brown fat supports its thermogenic capacity.
Lundh M, Altıntaş A, Tozzi M, Fabre O, Ma T, Shamsi F, Gerhart-Hines Z, Barrès R, Tseng YH, Emanuelli B., Free PMC Article | 10/23/2021 |
| Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection. | Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection.
Skarlatou S, Hérent C, Toscano E, Mendes CS, Bouvier J, Zampieri N. | 05/22/2021 |
| Afadin regulates actomyosin organization through alphaE-catenin at adherens junctions. | Afadin regulates actomyosin organization through αE-catenin at adherens junctions.
Sakakibara S, Mizutani K, Sugiura A, Sakane A, Sasaki T, Yonemura S, Takai Y., Free PMC Article | 02/20/2021 |
| Disruption of the nectin-afadin complex recapitulates features of the human cleft lip/palate syndrome CLPED1. | Disruption of the nectin-afadin complex recapitulates features of the human cleft lip/palate syndrome CLPED1.
Lough KJ, Spitzer DC, Bergman AJ, Wu JJ, Byrd KM, Williams SE., Free PMC Article | 12/26/2020 |
| mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division. | mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division.
Bonucci M, Kuperwasser N, Barbe S, Koka V, de Villeneuve D, Zhang C, Srivastava N, Jia X, Stokes MP, Bienaimé F, Verkarre V, Lopez JB, Jaulin F, Pontoglio M, Terzi F, Delaval B, Piel M, Pende M., Free PMC Article | 08/29/2020 |
| Afadin binding with interaction partners in adipocytes, among which HDAC6 preferentially interacts with phosphorylated Afadin and acts as a key intermediate to suppress insulin receptor protein levels. | Afadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue.
Lundh M, Petersen PS, Isidor MS, Kazoka-Sørensen DN, Plucińska K, Shamsi F, Ørskov C, Tozzi M, Brown EL, Andersen E, Ma T, Müller U, Barrès R, Kristiansen VB, Gerhart-Hines Z, Tseng YH, Emanuelli B., Free PMC Article | 05/2/2020 |
| These results demonstrate a novel function for hepatic AF6 in the regulation of insulin sensitivity. | Polarity Protein AF6 Controls Hepatic Glucose Homeostasis and Insulin Sensitivity by Modulating IRS1/AKT Insulin Pathway in an SHP2-Dependent Manner.
Dai C, Wang X, Wu Y, Xu Y, Zhuo S, Qi M, Ji W, Zhan L. | 02/15/2020 |
| nuclear organization of motor neurons is dependent on inside-out positioning, orchestrated by N-cadherin, catenin, and afadin activities, controlling cell body layering on the medio-lateral axis. | Nuclear Organization in the Spinal Cord Depends on Motor Neuron Lamination Orchestrated by Catenin and Afadin Function.
Dewitz C, Pimpinella S, Hackel P, Akalin A, Jessell TM, Zampieri N. | 06/8/2019 |
| This study demonstrated that differential regional and subcellular localization patterns of l- and s-afadin isoforms in the mouse central nervous system. | Differential regional and subcellular localization patterns of afadin splice variants in the mouse central nervous system.
Ohama D, Matsuda T, Oinuma I. | 05/11/2019 |
| l-afadin, but not s-afadin regulates the formation of puncta adherentia junctions of hippocampal synapses. | Involvement of l-afadin, but not s-afadin, in the formation of puncta adherentia junctions of hippocampal synapses.
Maruo T, Sakakibara S, Miyata M, Itoh Y, Kurita S, Mandai K, Sasaki T, Takai Y. | 03/9/2019 |
| Spatiotemporal and dynamic alternative splicing produces differential expression patterns of afadin isoforms and alternative splicing of afadin is controlled by the neuron-specific regulator(s) whose activity is triggered and dynamically altered during neuronal differentiation and maturation. | Dynamic spatiotemporal patterns of alternative splicing of an F-actin scaffold protein, afadin, during murine development.
Matsuda T, Namura A, Oinuma I. | 02/9/2019 |
| afadin is a critical molecule for cardiac protection against chronic pressure overload | Protective effects of intercalated disk protein afadin on chronic pressure overload-induced myocardial damage.
Zankov DP, Shimizu A, Tanaka-Okamoto M, Miyoshi J, Ogita H., Free PMC Article | 10/27/2018 |
| Loss of AFDN impaired the formation of adherens junctions and tight junctions. | Requirement of the F-actin-binding activity of l-afadin for enhancing the formation of adherens and tight junctions.
Sakakibara S, Maruo T, Miyata M, Mizutani K, Takai Y. | 09/29/2018 |
| In the 2 pressure overload models, myocardial afadin is involved in mechanical stress-induced, but not pharmacological Ang II-related, compensated cardiac hypertrophy. | Differential Effects of Myocardial Afadin on Pressure Overload-Induced Compensated Cardiac Hypertrophy.
Zankov DP, Sato A, Shimizu A, Ogita H. | 08/18/2018 |
| These results indicate that afadin plays multiple roles in the complex ultrastructural morphogenesis of hippocampal mossy fiber synapses. | Multiple roles of afadin in the ultrastructural morphogenesis of mouse hippocampal mossy fiber synapses.
Sai K, Wang S, Kaito A, Fujiwara T, Maruo T, Itoh Y, Miyata M, Sakakibara S, Miyazaki N, Murata K, Yamaguchi Y, Haruta T, Nishioka H, Motojima Y, Komura M, Kimura K, Mandai K, Takai Y, Mizoguchi A. | 04/28/2018 |
| Findings indicate that afadin plays an essential role in regulating apical-basal polarity and adherens junction integrity of radial glial cells. | Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia.
Rakotomamonjy J, Brunner M, Jüschke C, Zang K, Huang EJ, Reichardt LF, Chenn A., Free PMC Article | 03/31/2018 |
| Codepletion of the actomyosin regulator RhoA and Afadin results in defects in the central lumens and arrests lumen remodeling | Afadin and RhoA control pancreatic endocrine mass via lumen morphogenesis.
Azizoglu DB, Braitsch C, Marciano DK, Cleaver O., Free PMC Article | 02/10/2018 |
| Glutamate release and the postsynaptic responsiveness to glutamate were markedly reduced, but not completely lost, in the afadin-deficient mossy fiber synapse, whereas neither long-term potentiation nor long-term depression was affected. | Roles of afadin in functional differentiations of hippocampal mossy fiber synapse.
Geng X, Maruo T, Mandai K, Supriyanto I, Miyata M, Sakakibara S, Mizoguchi A, Takai Y, Mori M. | 01/20/2018 |
| Afadin regulates the differentiation of the CA3 pyramidal cells, elongation of the mossy fiber trajectory and the density of mossy fiber synapses. | Roles of afadin in the formation of the cellular architecture of the mouse hippocampus and dentate gyrus.
Miyata M, Maruo T, Kaito A, Wang S, Yamamoto H, Fujiwara T, Mizoguchi A, Mandai K, Takai Y. | 01/13/2018 |
| afadin determines lumen placement by directing apical-basal spindle orientation, resulting in a continuous lumen and normal tubule morphogenesis. | Afadin orients cell division to position the tubule lumen in developing renal tubules.
Gao L, Yang Z, Hiremath C, Zimmerman SE, Long B, Brakeman PR, Mostov KE, Bryant DM, Luby-Phelps K, Marciano DK., Free PMC Article | 10/28/2017 |
| Results indicate that afadin is required for the maintenance of the radial glial scaffold for neuronal migration and that the genetic ablation of afadin leads to the formation of double cortex | Impairment of radial glial scaffold-dependent neuronal migration and formation of double cortex by genetic ablation of afadin.
Yamamoto H, Mandai K, Konno D, Maruo T, Matsuzaki F, Takai Y. | 05/21/2016 |