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    AFM afamin [ Homo sapiens (human) ]

    Gene ID: 173, updated on 18-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Comparison of Afamin Values in Umbilical Cord Blood After Delivery in Pregnancies With and Without Gestational Diabetes Mellitus.

    Comparison of Afamin Values in Umbilical Cord Blood After Delivery in Pregnancies With and Without Gestational Diabetes Mellitus.
    Dogan Y, Arslan O, Oztas B, Kurtali A, Daryal AS, Eser MD.

    04/17/2024
    Investigation of serum afamin concentration in pregnant women diagnosed with late fetal growth restriction or small for gestational age fetus.

    Investigation of serum afamin concentration in pregnant women diagnosed with late fetal growth restriction or small for gestational age fetus.
    Alakbarova L, Kale İ, Muhcu M.

    08/4/2023
    AFM negatively regulates the infiltration of monocytes to mediate sepsis-associated acute kidney injury.

    AFM negatively regulates the infiltration of monocytes to mediate sepsis-associated acute kidney injury.
    Guo C, Fan Y, Cheng J, Deng Y, Zhang X, Chen Y, Jing H, Li W, Liu P, Xie J, Ning W, Chen H, Zhou J., Free PMC Article

    02/17/2023
    Afamin Levels and Their Correlation with Oxidative and Lipid Parameters in Non-diabetic, Obese Patients.

    Afamin Levels and Their Correlation with Oxidative and Lipid Parameters in Non-diabetic, Obese Patients.
    Juhász I, Ujfalusi S, Seres I, Lőrincz H, Varga VE, Paragh G Jr, Somodi S, Harangi M, Paragh G., Free PMC Article

    04/9/2022
    Novel metabolic marker Afamin: A predictive factor for Large-for-Gestational-Age (LGA) fetus estimation in pregnancies with gestational diabetes mellitus?

    Novel metabolic marker Afamin: A predictive factor for Large-for-Gestational-Age (LGA) fetus estimation in pregnancies with gestational diabetes mellitus?
    Atakul N, Atamer Y, Selek Ş, Kılıç BS, Unal F.

    02/12/2022
    Seminal Plasma and Serum Afamin Levels Are Associated with Infertility in Men with Oligoasthenoteratozoospermia.

    Seminal Plasma and Serum Afamin Levels Are Associated with Infertility in Men with Oligoasthenoteratozoospermia.
    Nuñez-Calonge R, Cortes S, Caballero Peregrín P, Gutierrez Gonzalez LM, Kireev R.

    01/29/2022
    Serum Afamin a Novel Marker of Increased Hepatic Lipid Content.

    Serum Afamin a Novel Marker of Increased Hepatic Lipid Content.
    Kurdiova T, Balaz M, Kovanicova Z, Zemkova E, Kuzma M, Belan V, Payer J, Gasperikova D, Dieplinger H, Ukropcova B, Ukropec J., Free PMC Article

    12/25/2021
    Identification and Validation of Combination Plasma Biomarker of Afamin, Fibronectin and Sex Hormone-Binding Globulin to Predict Pre-eclampsia.

    Identification and Validation of Combination Plasma Biomarker of Afamin, Fibronectin and Sex Hormone-Binding Globulin to Predict Pre-eclampsia.
    Uchida Y, Higuchi T, Shirota M, Kagami S, Saigusa D, Koshiba S, Yasuda J, Tamiya G, Kuriyama S, Kinoshita K, Yaegashi N, Yamamoto M, Terasaki T, Sugawara J.

    12/4/2021
    Serum afamin concentrations are elevated in the first trimester among patients developing preeclampsia later in pregnancy compared to controls

    Afamin: an early predictor of preeclampsia.
    Köninger A, Enekwe A, Mach P, Andrikos D, Schmidt B, Frank M, Birdir C, Kimmig R, Gellhaus A, Dieplinger H., Free PMC Article

    09/14/2019
    The results showed significantly higher serum afamin levels in women with pre-eclampsia and gestational diabetes mellitus compared to healthy pregnant women.

    Combination of first trimester serum afamin levels and three-dimensional placental bed vascularization as a possible screening method to detect women at-risk for adverse pregnancy complications like pre-eclampsia and gestational diabetes mellitus in low-risk pregnancies.
    Tramontana A, Pablik E, Stangl G, Hartmann B, Dieplinger H, Hafner E.

    12/22/2018
    LDL apheresis moderately decreases the circulating levels of afamin parallel to lowering HDL-C and ApoA1 levels.

    Changes in serum afamin and vitamin E levels after selective LDL apheresis.
    Varga VE, Lőrincz H, Szentpéteri A, Juhász L, Seres I, Paragh G Jr, Balla J, Paragh G, Harangi M.

    12/1/2018
    The concentration of afamin decreases with the severity of alcoholic liver cirrhosis.

    Afamin and adropin in patients with alcohol-induced liver cirrhosis.
    Prystupa A, Kiciński P, Luchowska-Kocot D, Sak J, Prystupa T, Chen KH, Chen YC, Panasiuk L, Załuska W.

    10/20/2018
    Afamin binds palmitoylated serine 209 of Wnt3a, providing a structural basis how afamin solubilizes hydrophobic and poorly soluble Wnt proteins.

    Structural Evidence for a Role of the Multi-functional Human Glycoprotein Afamin in Wnt Transport.
    Naschberger A, Orry A, Lechner S, Bowler MW, Nurizzo D, Novokmet M, Keller MA, Oemer G, Seppi D, Haslbeck M, Pansi K, Dieplinger H, Rupp B.

    07/21/2018
    Results provide evidence that afamin could promote glycometabolism by up-regulating the glucose metabolism key enzymes in papillary thyroid carcinoma.

    Afamin promotes glucose metabolism in papillary thyroid carcinoma.
    Shen CT, Wei WJ, Qiu ZL, Song HJ, Luo QY.

    11/11/2017
    Data suggest that up-regulation of AFM levels in serum in women with polycystic ovary syndrome can be used as a biological markers of those women with increased risk of developing metabolic syndrome, especially those with insulin resistance.

    Afamin serum concentrations are associated with insulin resistance and metabolic syndrome in polycystic ovary syndrome.
    Seeber B, Morandell E, Lunger F, Wildt L, Dieplinger H., Free PMC Article

    04/4/2015
    A linear increase in afamin during pregnancy may serve as basic reference for subsequent investigations of afamin in pregnancy-related disorders.

    The vitamin E-binding protein afamin increases in maternal serum during pregnancy.
    Hubalek M, Buchner H, Mörtl MG, Schlembach D, Huppertz B, Firulovic B, Köhler W, Hafner E, Dieplinger B, Wildt L, Dieplinger H., Free PMC Article

    01/17/2015
    Afamin levels were altered significantly in the peritoneal fluid of women with endometriosis compared with disease-free controls.

    The vitamin E-binding protein afamin is altered significantly in the peritoneal fluid of women with endometriosis.
    Seeber BE, Czech T, Buchner H, Barnhart KT, Seger C, Daxenbichler G, Wildt L, Dieplinger H., Free PMC Article

    01/15/2011
    Reduced Afamin expression is associated with ovarian cancer.

    Afamin and apolipoprotein A-IV: novel protein markers for ovarian cancer.
    Dieplinger H, Ankerst DP, Burges A, Lenhard M, Lingenhel A, Fineder L, Buchner H, Stieber P.

    01/21/2010
    afamin might be a new family member of binding/transport proteins contributing to alpha-tocopherol homeostasis at the blood-brain barrier

    Afamin is synthesized by cerebrovascular endothelial cells and mediates alpha-tocopherol transport across an in vitro model of the blood-brain barrier.
    Kratzer I, Bernhart E, Wintersperger A, Hammer A, Waltl S, Malle E, Sperk G, Wietzorrek G, Dieplinger H, Sattler W., Free PMC Article

    01/21/2010
    Binding of bilirubin with human serum albumin was studied by absorption, fluorescence and CD spectroscopy

    Bilirubin binding properties of pigeon serum albumin and its comparison with human serum albumin.
    Khan MA, Kumar Y, Tayyab S.

    01/21/2010
    vitamin E-binding properties were confirmed; found abundant presence of this protein in plasma, extravascular fluids such as follicular, and cerebrospinal fluids

    Afamin is a novel human vitamin E-binding glycoprotein characterization and in vitro expression.
    Jerkovic L, Voegele AF, Chwatal S, Kronenberg F, Radcliffe CM, Wormald MR, Lobentanz EM, Ezeh B, Eller P, Dejori N, Dieplinger B, Lottspeich F, Sattler W, Uhr M, Mechtler K, Dwek RA, Rudd PM, Baier G, Dieplinger H.

    01/21/2010
    The protein structure of afamin has been determined by homology modeling and its in vitro binding properties confirmed by docking calculations on the proposed structure.

    Characterization of the vitamin E-binding properties of human plasma afamin.
    Voegele AF, Jerković L, Wellenzohn B, Eller P, Kronenberg F, Liedl KR, Dieplinger H.

    01/21/2010
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