| Repurposing of the enhancer-promoter communication underlies the compensation of Mesp2 by Mesp1. | Repurposing of the enhancer-promoter communication underlies the compensation of Mesp2 by Mesp1.
Okada H, Saga Y., Free PMC Article | 02/19/2022 |
| Formal proof of the requirement of MESP1 and MESP2 in mesoderm specification and their transcriptional control via specific enhancers in mice. | Formal proof of the requirement of MESP1 and MESP2 in mesoderm specification and their transcriptional control via specific enhancers in mice.
Ajima R, Sakakibara Y, Sakurai-Yamatani N, Muraoka M, Saga Y. | 12/18/2021 |
| Studies indicate that mesodermal posterior 1 (Mesp1) and mesodermal posterior 2 (Mesp2) double-knockout embryos exhibited defective development of the embryonic mesoderm. | The roles of Mesp family proteins: functional diversity and redundancy in differentiation of pluripotent stem cells and mammalian mesodermal development.
Liang Q, Xu C, Chen X, Li X, Lu C, Zhou P, Yin L, Qian R, Chen S, Ling Z, Sun N., Free PMC Article | 04/23/2016 |
| conclusion was supported by analyses of Mesp2 KO and Ripply1/2 double KO embryos lacking rostral and caudal properties, respectively | Metameric pattern of intervertebral disc/vertebral body is generated independently of Mesp2/Ripply-mediated rostro-caudal patterning of somites in the mouse embryo.
Takahashi Y, Yasuhiko Y, Takahashi J, Takada S, Johnson RL, Saga Y, Kanno J. | 09/14/2013 |
| current observations of the spatiotemporal disorder of vertebral organogenesis in the Mesp2-null mice provide further insight into the pathogenesis of SCDO and STDO, and the physiological development of the axial skeleton | Spatiotemporal disorder in the axial skeleton development of the Mesp2-null mouse: a model of spondylocostal dysostosis and spondylothoracic dysostosis.
Makino Y, Takahashi Y, Tanabe R, Tamamura Y, Watanabe T, Haraikawa M, Hamagaki M, Hata K, Kanno J, Yoneda T, Saga Y, Goseki-Sone M, Kaneko K, Yamaguchi A, Iimura T. | 08/31/2013 |
| Data demonstrate that Mesp2 is a novel component involved in the suppression of Notch target genes. | The repression of Notch signaling occurs via the destabilization of mastermind-like 1 by Mesp2 and is essential for somitogenesis.
Sasaki N, Kiso M, Kitagawa M, Saga Y. | 01/8/2011 |
| Data propose a novel function of Notch signaling, in which a progressive oscillating wave of Notch activity is translated into the rostral-caudal polarity of a somite by regulating Mesp2 expression in the anterior presomitic mesoderm. | The oscillation of Notch activation, but not its boundary, is required for somite border formation and rostral-caudal patterning within a somite.
Oginuma M, Takahashi Y, Kitajima S, Kiso M, Kanno J, Kimura A, Saga Y. | 05/3/2010 |
| An Mesp2 enhancer knockout mouse bearing mutations in two crucial Tbx6 binding sites does not express Mesp2 in the presomitic mesoderm. | Functional importance of evolutionally conserved Tbx6 binding sites in the presomitic mesoderm-specific enhancer of Mesp2.
Yasuhiko Y, Kitajima S, Takahashi Y, Oginuma M, Kagiwada H, Kanno J, Saga Y. | 01/21/2010 |
| Mesp2 protein leads to the suppression of Tbx6 protein expression post-translationally via rapid degradation mediated by the ubiquitin-proteasome pathway | Mesp2 and Tbx6 cooperatively create periodic patterns coupled with the clock machinery during mouse somitogenesis.
Oginuma M, Niwa Y, Chapman DL, Saga Y. | 01/21/2010 |
| analysis of the roles of Mesp1 and Mesp2 through knockout mouse models | Identification of presomitic mesoderm (PSM)-specific Mesp1 enhancer and generation of a PSM-specific Mesp1/Mesp2-null mouse using BAC-based rescue technology.
Oginuma M, Hirata T, Saga Y. | 01/21/2010 |
| developmental protein "wavefront" is generated by suppression of Notch activity by mesoderm posterior 2 (Mesp2) through induction of the lunatic fringe gene (Lfng) | The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity.
Morimoto M, Takahashi Y, Endo M, Saga Y. | 01/21/2010 |
| Forced expression of Mesp2 in somitic cells results in the activation of Epha4. | Identification of Epha4 enhancer required for segmental expression and the regulation by Mesp2.
Nakajima Y, Morimoto M, Takahashi Y, Koseki H, Saga Y. | 01/21/2010 |
| spondylocostal dysostosis (SCD) is caused by mutation in Delta-like 3 (DLL3), Mesoderm posterior 2 (MESP2), and Lunatic fringe (LFNG); three genes that are components of the Notch signaling pathway. | Disruption of the somitic molecular clock causes abnormal vertebral segmentation.
Sparrow DB, Chapman G, Turnpenny PD, Dunwoodie SL. | 01/21/2010 |
| Data describe the genetic interactions between Dll1, Dll3, Mesp2 and Psen1, and the roles of Dll1- and Dll3-Notch pathways, with or without Psen1, in rostrocaudal patterning. | Feedback loops comprising Dll1, Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites.
Takahashi Y, Inoue T, Gossler A, Saga Y. | 01/21/2010 |
| A bHLH-type transcription factor, Mesp2, plays an essential role in somite segmentation in mice. | Hypomorphic Mesp allele distinguishes establishment of rostrocaudal polarity and segment border formation in somitogenesis.
Nomura-Kitabayashi A, Takahashi Y, Kitajima S, Inoue T, Takeda H, Saga Y. | 01/21/2010 |
| Tbx6 directly binds to the Mesp2 gene upstream region and mediates Notch signaling, and subsequent Mesp2 transcription, in the anterior presomitic mesoderm. | Tbx6-mediated Notch signaling controls somite-specific Mesp2 expression.
Yasuhiko Y, Haraguchi S, Kitajima S, Takahashi Y, Kanno J, Saga Y., Free PMC Article | 01/21/2010 |
| patterning events by basic helix-loop-helix-type transcription factors have deep impacts on regional chondrogenic and myogenic differentiation of somitic cells | Transcription factors Mesp2 and Paraxis have critical roles in axial musculoskeletal formation.
Takahashi Y, Takagi A, Hiraoka S, Koseki H, Kanno J, Rawls A, Saga Y. | 01/21/2010 |
| Mesp2 is responsible for the rostro-caudal patterning process itself in the anterior presomitic mesoderm, via cellular interaction. | Differential contributions of Mesp1 and Mesp2 to the epithelialization and rostro-caudal patterning of somites.
Takahashi Y, Hiraoka S, Kitajima S, Inoue T, Kanno J, Saga Y. | 01/21/2010 |
| appropriate suppression of Notch signaling by Mesp1 and Mesp2 factors is essential for stripe pattern formation leading to segment boundary formation | Appropriate suppression of Notch signaling by Mesp factors is essential for stripe pattern formation leading to segment boundary formation.
Takahashi Y, Yasuhiko Y, Kitajima S, Kanno J, Saga Y. | 01/21/2010 |
| Ripply2-Mesp2 negative-feedback loop is essential for the periodic generation of the rostro-caudal polarity within a somite. | The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostro-caudal patterning within a somite.
Morimoto M, Sasaki N, Oginuma M, Kiso M, Igarashi K, Aizaki K, Kanno J, Saga Y. | 01/21/2010 |