| Rab8A promotes breast cancer progression by increasing surface expression of Tropomyosin-related kinase B. | Rab8A promotes breast cancer progression by increasing surface expression of Tropomyosin-related kinase B.
Liu Y, Zhang Z, Gao X, Ma Q, Yu Z, Huang S. | 04/16/2022 |
| Rab8 attenuates Wnt signaling and is required for mesenchymal differentiation into adipocytes. | Rab8 attenuates Wnt signaling and is required for mesenchymal differentiation into adipocytes.
Stypulkowski E, Feng Q, Joseph I, Farrell V, Flores J, Yu S, Sakamori R, Sun J, Bandyopadhyay S, Das S, Dobrowolski R, Bonder EM, Chen MH, Gao N., Free PMC Article | 09/11/2021 |
| These data indicated that RAB8A was required for Golgi distribution, spindle migration, and polar body extrusion via ROCK-mediated actin assembly in mouse oocyte meiosis. | RAB8A GTPase regulates spindle migration and Golgi apparatus distribution via ROCK-mediated actin assembly in mouse oocyte meiosis†.
Pan ZN, Lu Y, Tang F, Pan MH, Wan X, Lan M, Zhang Y, Sun SC. | 05/30/2020 |
| regulates Kir6.2 trafficking in a beta cell line | Rab8a is involved in membrane trafficking of Kir6.2 in the MIN6 insulinoma cell line.
Uchida K, Nomura M, Yamamoto T, Ogawa Y, Teramoto N. | 05/9/2020 |
| GFP-Rab8a expressed in macrophages is associated with intracellular vesicles and macropinosomes but, in addition, Rab8a is found on sections of the plasma membrane, particularly ruffling edges and dorsal ruffles on the cell surface near adjacent macropinosomes. | Rab8a localisation and activation by Toll-like receptors on macrophage macropinosomes.
Wall AA, Condon ND, Luo L, Stow JL., Free PMC Article | 01/25/2020 |
| overexpression of Rab11a and Rab8a increases the number of tunneling nanotubes-connected cells. | Rab11a-Rab8a cascade regulates the formation of tunneling nanotubes through vesicle recycling.
Zhu S, Bhat S, Syan S, Kuchitsu Y, Fukuda M, Zurzolo C. | 10/19/2019 |
| Disruption of Rab8a and Rab11a causes formation of basolateral microvilli in neonatal enteropathy. | Disruption of Rab8a and Rab11a causes formation of basolateral microvilli in neonatal enteropathy.
Feng Q, Bonder EM, Engevik AC, Zhang L, Tyska MJ, Goldenring JR, Gao N., Free PMC Article | 04/21/2018 |
| The small GTPase Rab8a regulates lipid uptake and storage in skeletal muscle. | Rab8a Deficiency in Skeletal Muscle Causes Hyperlipidemia and Hepatosteatosis by Impairing Muscle Lipid Uptake and Storage.
Chen Q, Rong P, Xu D, Zhu S, Chen L, Xie B, Du Q, Quan C, Sheng Y, Zhao TJ, Li P, Wang HY, Chen S. | 10/21/2017 |
| Rab8a and Rab11a Are Dispensable for Rhodopsin Transport in Mouse Photoreceptors | Small GTPases Rab8a and Rab11a Are Dispensable for Rhodopsin Transport in Mouse Photoreceptors.
Ying G, Gerstner CD, Frederick JM, Boye SL, Hauswirth WW, Baehr W., Free PMC Article | 08/5/2017 |
| With CRISPR/Cas9-mediated gene editing to stably knock out and recover Rab8a in macrophage cell lines, this study matches Akt signaling profiles with cytokine outputs, confirming that Rab8a is a novel regulator of the Akt/mammalian target of rapamycin (mTOR) pathway downstream of multiple Toll-like Receptors. | Small GTPase Rab8a-recruited Phosphatidylinositol 3-Kinase γ Regulates Signaling and Cytokine Outputs from Endosomal Toll-like Receptors.
Wall AA, Luo L, Hung Y, Tong SJ, Condon ND, Blumenthal A, Sweet MJ, Stow JL., Free PMC Article | 06/10/2017 |
| these results indicate an indispensable role for Rab8A in insulin-regulated GLUT4 trafficking in C2C12 cells. | Rab8A regulates insulin-stimulated GLUT4 translocation in C2C12 myoblasts.
Li H, Ou L, Fan J, Xiao M, Kuang C, Liu X, Sun Y, Xu Y. | 05/27/2017 |
| Results highlight a novel role of Rab8, downstream of IFT20, in the pathway that regulates T cell receptor (TCR) recycling, through recruiting VAMP-3 and promoting the fusion with the synaptic membrane of endosomes carrying TCR cargoes. | The Rab GTPase Rab8 as a shared regulator of ciliogenesis and immune synapse assembly: From a conserved pathway to diverse cellular structures.
Patrussi L, Baldari CT., Free PMC Article | 12/17/2016 |
| Data demonstrate that EHBP1L1 links Rab8 and the Bin1-dynamin complex, which generates membrane curvature and excises the vesicle at the endocytic recycling compartment for apical transport. | EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells.
Nakajo A, Yoshimura S, Togawa H, Kunii M, Iwano T, Izumi A, Noguchi Y, Watanabe A, Goto A, Sato T, Harada A., Free PMC Article | 06/28/2016 |
| The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling T-cell receptors to the immune synapse. | The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling T-cell receptors to the immune synapse.
Finetti F, Patrussi L, Galgano D, Cassioli C, Perinetti G, Pazour GJ, Baldari CT., Free PMC Article | 05/21/2016 |
| Rab8a thus controls Wnt delivery in producing cells and is crucial for Paneth cell maturation. | Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche.
Das S, Yu S, Sakamori R, Vedula P, Feng Q, Flores J, Hoffman A, Fu J, Stypulkowski E, Rodriguez A, Dobrowolski R, Harada A, Hsu W, Bonder EM, Verzi MP, Gao N., Free PMC Article | 09/12/2015 |
| Rab8a acts as an activator of Fsp27-mediated LD fusion and growth. | Rab8a-AS160-MSS4 regulatory circuit controls lipid droplet fusion and growth.
Wu L, Xu D, Zhou L, Xie B, Yu L, Yang H, Huang L, Ye J, Deng H, Yuan YA, Chen S, Li P. | 11/22/2014 |
| Simultaneous loss of Rab8a and Rab8b has little effect on ciliogenesis, whereas additional loss of Rab10 greatly affects ciliogenesis. | Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis.
Sato T, Iwano T, Kunii M, Matsuda S, Mizuguchi R, Jung Y, Hagiwara H, Yoshihara Y, Yuzaki M, Harada R, Harada A., Free PMC Article | 10/18/2014 |
| acidosis-induced NBCe1-A, but not NBCe1-B/C, trafficking is mediated by Rab8a. | Variants of the electrogenic sodium bicarbonate cotransporter 1 (NBCe1) in mouse hippocampal neurons are regulated by extracellular pH changes: evidence for a Rab8a-dependent mechanism.
Oehlke O, Speer JM, Roussa E. | 01/18/2014 |
| AS160 and Rab8a regulate membrane recruitment of CD36. | Insulin and AMPK regulate FA translocase/CD36 plasma membrane recruitment in cardiomyocytes via Rab GAP AS160 and Rab8a Rab GTPase.
Samovski D, Su X, Xu Y, Abumrad NA, Stahl PD., Free PMC Article | 07/7/2012 |
| Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice | Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice.
Sakamori R, Das S, Yu S, Feng S, Stypulkowski E, Guan Y, Douard V, Tang W, Ferraris RP, Harada A, Brakebusch C, Guo W, Gao N., Free PMC Article | 05/5/2012 |
| Rab8a colocalizes with IL-1b and LC3 and controls IL-1b secretion | Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β.
Dupont N, Jiang S, Pilli M, Ornatowski W, Bhattacharya D, Deretic V., Free PMC Article | 02/25/2012 |
| Rab13 and Rab8A are Rab-GTPases activated by insulin and downstream of AS160 they regulate traffic of GLUT4 vesicles. | Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells.
Sun Y, Bilan PJ, Liu Z, Klip A., Free PMC Article | 01/1/2011 |
| Ahi1 is required for Rab8a localization, ciliogenesis and vesicle trafficking. | Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle trafficking.
Hsiao YC, Tong ZJ, Westfall JE, Ault JG, Page-McCaw PS, Ferland RJ., Free PMC Article | 01/21/2010 |
| These results suggest that the interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions. | The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T., Free PMC Article | 01/21/2010 |
| GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells. | GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells.
Randhawa VK, Ishikura S, Talior-Volodarsky I, Cheng AW, Patel N, Hartwig JH, Klip A. | 01/21/2010 |